Latest & greatest articles for clopidogrel

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Top results for clopidogrel

221. Increased mortality after coronary stenting in patients treated with clopidogrel without loading dose: evidence from a meta-analysis

Increased mortality after coronary stenting in patients treated with clopidogrel without loading dose: evidence from a meta-analysis Increased mortality after coronary stenting in patients treated with clopidogrel without loading dose: evidence from a meta-analysis Increased mortality after coronary stenting in patients treated with clopidogrel without loading dose: evidence from a meta-analysis Biondi-Zoccai G G, Agostoni P, Testa L, Abbate A, Parisi Q, Burzotta F, Trani C, Mongiardo R (...) , Vassanelli C, Biasucci L M CRD summary This review compared clopidogrel with ticlopidine, in addition to aspirin, for the prevention of complications in patients undergoing implantation of coronary stent devices. The results indicated that clopidogrel with a loading regimen was as good as or better than ticlopidine, whereas without a loading regimen it was worse. However, with only five studies included in the review, these findings may not be definitive. Authors' objectives To compare the efficacy

2004 DARE.

222. Clopidogrel versus aspirin for secondary prophylaxis of vascular events: a cost-effectiveness analysis

Clopidogrel versus aspirin for secondary prophylaxis of vascular events: a cost-effectiveness analysis Clopidogrel versus aspirin for secondary prophylaxis of vascular events: a cost-effectiveness analysis Clopidogrel versus aspirin for secondary prophylaxis of vascular events: a cost-effectiveness analysis Schleinitz M D, Weiss J P, Owens D K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief (...) summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Two alternative antiplatelet therapies, aspirin (325 mg orally per day) and clopidogrel (75 mg orally per day), were examined. Type of intervention Secondary prevention. Economic study type Cost-utility analysis. Study population The study population comprised a hypothetical cohort of patients with peripheral arterial disease, a non

2004 NHS Economic Evaluation Database.

223. The cost-effectiveness of the use of clopidogrel in acute coronary syndromes in five countries based upon the CURE study

The cost-effectiveness of the use of clopidogrel in acute coronary syndromes in five countries based upon the CURE study The cost-effectiveness of the use of clopidogrel in acute coronary syndromes in five countries based upon the CURE study The cost-effectiveness of the use of clopidogrel in acute coronary syndromes in five countries based upon the CURE study Lamy A, Jonsson B, Weintraub W S, Zhao F, Chrolavicius S, Bakhai A, Culler S, Gafni A, Lindgren P, Mahoney E, Yusuf S Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of clopidogrel, compared with placebo, in the treatment of acute coronary syndromes (ACS). Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study

2004 NHS Economic Evaluation Database.

224. Clopidogrel used in combination with aspirin compared with aspirin alone in the treatment of non-ST-segment-elevation acute coronary syndromes: a systematic review and economic evaluation

Clopidogrel used in combination with aspirin compared with aspirin alone in the treatment of non-ST-segment-elevation acute coronary syndromes: a systematic review and economic evaluation Clopidogrel used in combination with aspirin compared with aspirin alone in the treatment of non-ST-segment-elevation acute coronary syndromes: a systematic review and economic evaluation Clopidogrel used in combination with aspirin compared with aspirin alone in the treatment of non-ST-segment-elevation acute (...) the use of 12-month clopidogrel in combination with aspirin for the prevention of morbidity and mortality associated with non-ST-segment elevation acute coronary syndrome (ACS). The combined therapy was compared with standard therapy including aspirin. Three alternative strategies (representing treatment with clopidogrel over a 1-, 3- or 6-month duration) were also considered. Type of intervention Secondary prevention. Economic study type Cost-utility analysis Study population The study population

2004 NHS Economic Evaluation Database.

225. Cost-effectiveness analysis of clopidogrel versus aspirin in patients with atherothrombosis based on the CAPRIE trial

Cost-effectiveness analysis of clopidogrel versus aspirin in patients with atherothrombosis based on the CAPRIE trial Cost-effectiveness analysis of clopidogrel versus aspirin in patients with atherothrombosis based on the CAPRIE trial Cost-effectiveness analysis of clopidogrel versus aspirin in patients with atherothrombosis based on the CAPRIE trial Annemans L, Lamotte M, Levy E, Lenne X Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion (...) on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of clopidogrel, an antiplatelet agent, in patients with atherothrombosis. Type of intervention Secondary prevention. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients with vascular disease with recent stroke, myocardial

2003 NHS Economic Evaluation Database.

226. Safety and efficacy evaluation of clopidogrel compared to ticlopidine after stent implantation: an updated meta-analysis

Safety and efficacy evaluation of clopidogrel compared to ticlopidine after stent implantation: an updated meta-analysis Safety and efficacy evaluation of clopidogrel compared to ticlopidine after stent implantation: an updated meta-analysis Safety and efficacy evaluation of clopidogrel compared to ticlopidine after stent implantation: an updated meta-analysis Casella G, Ottani F, Pavesi P C, Sangiorgio P, Rubboli A, Galvani M, Fontanelli A, Bracchetti D CRD summary This review concluded (...) that clopidogrel plus aspirin was more effective and had a better safety profile than ticlodipine plus aspirin in patients who had undergone coronary stenting. The review has a number of methodological limitations, which mean that the conclusions cannot be relied upon. Authors' objectives To determine the efficacy and safety of clopidogrel plus aspirin compared with ticlodipine plus aspirin after coronary stenting. Searching MEDLINE was searched until December 2001 for papers written in English; some

2003 DARE.

227. Cost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease. Full Text available with Trip Pro

Cost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease. Both aspirin and clopidogrel reduce the rate of cardiovascular events in patients with coronary heart disease. We estimated the cost effectiveness of the increased use of aspirin, clopidogrel, or both for secondary prevention in patients with coronary heart disease.We used the Coronary Heart Disease Policy Model, a computer simulation of the U.S. population, to estimate the incremental cost (...) effectiveness (in dollars per quality-adjusted years of life gained) of four strategies in patients over 35 years of age with coronary disease from 2003 to 2027: aspirin for all eligible patients (i.e., those who were not allergic to or intolerant of aspirin), aspirin for all eligible patients plus clopidogrel for patients who were ineligible for aspirin, clopidogrel for all patients, and the combination of aspirin for all eligible patients plus clopidogrel for all patients.The extension of aspirin therapy

2002 NEJM

230. The role of clopidogrel in the secondary prevention of recurrent ischemic vascular events after acute myocardial ischemia: a critical appraisal of the CURE trial.

The role of clopidogrel in the secondary prevention of recurrent ischemic vascular events after acute myocardial ischemia: a critical appraisal of the CURE trial. The role of clopidogrel in the secondary prevention of recurrent ischemic vascular events after acute myocardial ischemia: a critical appraisal of the CURE trial. The role of clopidogrel in the secondary prevention of recurrent ischemic vascular events after acute myocardial ischemia: a critical appraisal of the CURE trial. Boucher M (...) , Armstrong P, Pharand C, Skidmore B Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Boucher M, Armstrong P, Pharand C, Skidmore B. The role of clopidogrel in the secondary prevention of recurrent ischemic vascular events after acute myocardial ischemia: a critical appraisal of the CURE trial. Ottawa: Canadian Coordinating Office for Health

2002 Health Technology Assessment (HTA) Database.

231. Do cardiac surgical patients on Clopidogrel bleed more and require more blood transfusions than those not on Clopidogrel?

Do cardiac surgical patients on Clopidogrel bleed more and require more blood transfusions than those not on Clopidogrel? Do cardiac surgical patients on Clopidogrel bleed more and require more blood transfusions than those not on Clopidogrel? Do cardiac surgical patients on Clopidogrel bleed more and require more blood transfusions than those not on Clopidogrel? Abdulwadud O Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation Abdulwadud O. Do cardiac surgical patients on Clopidogrel bleed more and require more blood transfusions than those not on Clopidogrel? Clayton, Victoria: Centre for Clinical Effectiveness (CCE) 2002: 10 Authors' objectives This aim of this critical appraisal was to assess whether cardiac surgical patients on Clopidogrel bleed more and require more blood transfusions than those not on Clopidogrel. Project page URL Indexing Status Subject indexing

2002 Health Technology Assessment (HTA) Database.

232. Cost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease

Cost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2002 NHS Economic Evaluation Database.

233. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. Full Text available with Trip Pro

Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. Despite current treatments, patients who have acute coronary syndromes without ST-segment elevation have high rates of major vascular events. We evaluated the efficacy and safety of the antiplatelet agent clopidogrel when given with aspirin in such patients.We randomly assigned 12,562 patients who had presented within 24 hours after the onset of symptoms to receive clopidogrel (...) (300 mg immediately, followed by 75 mg once daily) (6259 patients) or placebo (6303 patients) in addition to aspirin for 3 to 12 months.The first primary outcome--a composite of death from cardiovascular causes, nonfatal myocardial infarction, or stroke--occurred in 9.3 percent of the patients in the clopidogrel group and 11.4 percent of the patients in the placebo group (relative risk with clopidogrel as compared with placebo, 0.80; 95 percent confidence interval, 0.72 to 0.90; P<0.001

2001 NEJM Controlled trial quality: predicted high

234. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. (Abstract)

Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Despite the use of aspirin, there is still a risk of ischaemic events after percutaneous coronary intervention (PCI). We aimed to find out whether, in addition to aspirin, pretreatment with clopidogrel followed by long-term therapy after PCI is superior to a strategy of no pretreatment and short-term therapy for only 4 weeks after PCI (...) .2658 patients with non-ST-elevation acute coronary syndrome undergoing PCI in the CURE study had been randomly assigned double-blind treatment with clopidogrel (n=1313) or placebo (n=1345). Patients were pretreated with aspirin and study drug for a median of 6 days before PCI during the initial hospital admission, and for a median of 10 days overall. After PCI, most patients (>80%) in both groups received open-label thienopyridine for about 4 weeks, after which study drug was restarted for a mean

2001 Lancet Controlled trial quality: predicted high

235. Thienopyridine derivatives (ticlopidine, clopidogrel) versus aspirin for preventing stroke and other serious vascular events in high vascular risk patients. Full Text available with Trip Pro

Thienopyridine derivatives (ticlopidine, clopidogrel) versus aspirin for preventing stroke and other serious vascular events in high vascular risk patients. The most widely studied and prescribed antiplatelet agent for the prevention of stroke and other serious vascular events among high vascular risk patients is aspirin. Aspirin inhibits platelet activation by inhibiting platelet cyclooxygenase and thromboxane production, and reduces the odds of a serious vascular event by about a quarter (...) . The thienopyridines (ticlopidine and clopidogrel) inhibit platelet activation by a different mechanism to aspirin (blocking the ADP receptor on platelets), and so may be more effective than aspirin.The objective of this review was to determine the effectiveness and safety of thienopyridine derivatives (ticlopidine and clopidogrel) versus aspirin for the prevention of serious vascular events (stroke, myocardial infarction (MI) or vascular death) in patients at high risk of such events, and specifically in patients

2000 Cochrane

236. Aspirin plus extended-release dipyridamole or clopidogrel compared with aspirin monotherapy for the prevention of recurrent ischemic stroke: a cost-effectiveness analysis

Aspirin plus extended-release dipyridamole or clopidogrel compared with aspirin monotherapy for the prevention of recurrent ischemic stroke: a cost-effectiveness analysis Aspirin plus extended-release dipyridamole or clopidogrel compared with aspirin monotherapy for the prevention of recurrent ischemic stroke: a cost-effectiveness analysis Aspirin plus extended-release dipyridamole or clopidogrel compared with aspirin monotherapy for the prevention of recurrent ischemic stroke: a cost (...) -effectiveness analysis Shah H, Gondek K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of antiplatelet therapy for the prevention of recurrent ischaemic stroke was studied. The antiplatelet agents considered were clopidogrel (75

2000 NHS Economic Evaluation Database.

237. Antiplatelet agents – clopidogrel (Plavix)

Antiplatelet agents – clopidogrel (Plavix) Antiplatelet agents – clopidogrel (Plavix) We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Antiplatelet agents – clopidogrel (Plavix) Share: Reading time approx. 2 minutes This document was published more than 2 years ago. The nature of the evidence may have changed. Findings by SBU Alert (...) This is a translation of version 1, published on October 29, 1999. The latest version of this report is not available in English. Clopidogrel is a recently approved drug which helps prevent the formation of blood clots in vascular diseases resulting from atherosclerosis. There is strong evidence that drugs which inhibit blood clots, eg, acetylsalicylic acid (ASA), have prophylactic effects in patients with atherosclerotic disease. The effects of clopidogrel have been compared to the effects of ASA in a randomized

2000 Swedish Council on Technology Assessement

238. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. (Abstract)

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Many clinical trials have evaluated the benefit of long-term use of antiplatelet drugs in reducing the risk of clinical thrombotic events. Aspirin and ticlopidine have been shown to be effective, but both have potentially serious adverse effects. Clopidogrel, a new thienopyridine derivative similar to ticlopidine, is an inhibitor of platelet aggregation induced (...) by adenosine diphosphate.CAPRIE was a randomised, blinded, international trial designed to assess the relative efficacy of clopidogrel (75 mg once daily) and aspirin (325 mg once daily) in reducing the risk of a composite outcome cluster of ischaemic stroke, myocardial infarction, or vascular death; their relative safety was also assessed. The population studied comprised subgroups of patients with atherosclerotic vascular disease manifested as either recent ischaemic stroke, recent myocardial infarction

1996 Lancet Controlled trial quality: predicted high