Latest & greatest articles for clopidogrel

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Top results for clopidogrel

81. The Incidence of Bradyarrhythmias and Clinical Bradyarrhythmic Events in Patients With Acute Coronary Syndromes Treated With Ticagrelor or Clopidogrel in the PLATO (Platelet Inhibition and Patient Outcomes) Trial Results of the Continuous Electrocardiogra Full Text available with Trip Pro

The Incidence of Bradyarrhythmias and Clinical Bradyarrhythmic Events in Patients With Acute Coronary Syndromes Treated With Ticagrelor or Clopidogrel in the PLATO (Platelet Inhibition and Patient Outcomes) Trial Results of the Continuous Electrocardiogra The aim of this study was to determine whether ticagrelor increased the risk of ventricular pauses compared with clopidogrel and whether these pauses were associated with any clinical bradycardic events in patients presenting with acute (...) coronary syndromes.Ticagrelor, an oral reversibly binding P2Y(12) inhibitor, provides more potent and consistent inhibition of platelet aggregation than clopidogrel but in a phase II study was associated with increased risk for ventricular pauses. A prospective continuous electrocardiographic (cECG) assessment was therefore performed within the PLATO (Platelet Inhibition and Patient Outcomes) study comparing ticagrelor and clopidogrel in patients hospitalized with acute coronary syndromes.Patients

2011 EvidenceUpdates Controlled trial quality: uncertain

82. A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 Trial. Full Text available with Trip Pro

A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 Trial. Patients with diabetes mellitus (DM) have increased platelet reactivity and reduced platelet response to clopidogrel compared with patients without DM. Prasugrel, a more potent antiplatelet agent, is associated with greater reductions in ischaemic events compared (...) with clopidogrel, particularly in patients with DM. The aim of this study was to perform serial pharmacodynamic assessments of prasugrel with high-dose clopidogrel in patients with DM.Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 was a prospective, randomized, double-blind, crossover study in patients with type 2 DM and coronary artery disease (CAD). Patients (n= 35) were randomly assigned to either prasugrel 60 mg loading dose (LD)/10 mg maintenance dose (MD) or clopidogrel 600 mg LD/150

2011 EvidenceUpdates Controlled trial quality: uncertain

83. Effect of concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention (Abstract)

Effect of concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention The aim of the present study was to analyze the effect of drug exposure patterns of clopidogrel and proton pump inhibitors (PPIs) on the clinical outcomes after percutaneous coronary intervention (PCI). Previous analyses predominantly included discharge medications and did not explore the effect of the drug exposure patterns. We analyzed all-cause death, nonfatal myocardial infarction (...) , repeat revascularization, and major adverse cardiovascular events (MACE) in a cohort of 23,200 post-PCI patients (January 2003 to December 2008) using a multivariate adjusted Cox model and propensity-matched case-control analysis. The adjusted hazard ratio for MACE on PPI according to the exposure patterns of clopidogrel after PCI for 6 years was 1.24 (95% confidence interval [CI] 1.11 to 1.38) and 1.12 (95% CI 1.03 to 1.22) for "continuous" (consistent clopidogrel with or without PPIs) and "switched

2011 EvidenceUpdates

84. Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis (Abstract)

Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis We performed a prospective, randomized, controlled study to compare the combination of esomeprazole and clopidogrel vs clopidogrel alone in preventing recurrent peptic ulcers in patients with atherosclerosis and a history of peptic ulcers. We also investigated the effects of esomeprazole on the antiplatelet action of clopidogrel.From January 2008 to January 2010, long (...) -term clopidogrel users with histories of peptic ulcers who did not have peptic ulcers at an initial endoscopy examination were assigned randomly to receive the combination of esomeprazole (20 mg/day, before breakfast) and clopidogrel (75 mg/day, at bedtime), or clopidogrel alone for 6 months. A follow-up endoscopy examination was performed at the end of the sixth month and whenever severe symptoms occurred. Platelet aggregation tests were performed on days 1 and 28 for 42 consecutive patients who

2011 EvidenceUpdates Controlled trial quality: uncertain

85. CYP2C19 Genotype and Outcomes of Clopidogrel Treatment. Full Text available with Trip Pro

CYP2C19 Genotype and Outcomes of Clopidogrel Treatment. 21288101 2011 02 10 2018 12 01 1533-4406 364 5 2011 02 03 The New England journal of medicine N. Engl. J. Med. CYP2C19 genotype and outcomes of clopidogrel treatment. 481-2 10.1056/NEJMc1013331 Siasos Gerasimos G Tousoulis Dimitris D Stefanadis Christodoulos C eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Platelet Aggregation Inhibitors 9035-51-2 Cytochrome P-450 Enzyme System A74586SNO7 Clopidogrel EC 1.14.14.1 Aryl (...) Hydrocarbon Hydroxylases EC 1.14.14.1 CYP2C19 protein, human EC 1.14.14.1 Cytochrome P-450 CYP2C19 EC 1.14.14.1 Cytochrome P-450 CYP3A OM90ZUW7M1 Ticlopidine AIM IM N Engl J Med. 2010 Oct 28;363(18):1704-14 20979470 Acute Coronary Syndrome drug therapy Aryl Hydrocarbon Hydroxylases genetics Clopidogrel Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP3A metabolism Cytochrome P-450 Enzyme System genetics Humans Mutation Platelet Aggregation Inhibitors therapeutic use Ticlopidine analogs & derivatives

2011 NEJM

86. CYP2C19 Genotype and Outcomes of Clopidogrel Treatment. Full Text available with Trip Pro

CYP2C19 Genotype and Outcomes of Clopidogrel Treatment. 21288102 2011 02 10 2018 12 01 1533-4406 364 5 2011 02 03 The New England journal of medicine N. Engl. J. Med. CYP2C19 genotype and outcomes of clopidogrel treatment. 481; author reply 482 10.1056/NEJMc1013331 Geisler Tobias T Bigalke Boris B Schwab Matthias M eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Platelet Aggregation Inhibitors A74586SNO7 Clopidogrel EC 1.14.14.1 Aryl Hydrocarbon Hydroxylases EC 1.14.14.1 (...) CYP2C19 protein, human EC 1.14.14.1 Cytochrome P-450 CYP2C19 OM90ZUW7M1 Ticlopidine AIM IM N Engl J Med. 2010 Oct 28;363(18):1704-14 20979470 Acute Coronary Syndrome drug therapy Aryl Hydrocarbon Hydroxylases genetics Atrial Fibrillation drug therapy Clopidogrel Cytochrome P-450 CYP2C19 Genotype Humans Mutation Platelet Aggregation Inhibitors therapeutic use Risk Factors Ticlopidine analogs & derivatives therapeutic use 2011 2 4 6 0 2011 2 4 6 0 2011 2 11 6 0 ppublish 21288102 10.1056/NEJMc1013331

2011 NEJM

88. Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial Full Text available with Trip Pro

Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial patients with diabetes mellitus (DM) have high platelet reactivity and are at increased risk of ischaemic events and bleeding post-acute coronary syndromes (ACS). In the PLATelet inhibition and patient Outcomes (PLATO) trial, ticagrelor reduced the primary composite endpoint of cardiovascular death, myocardial infarction, or stroke (...) , but with similar rates of major bleeding compared with clopidogrel. We aimed to investigate the outcome with ticagrelor vs. clopidogrel in patients with DM or poor glycaemic control.we analysed patients with pre-existing DM (n = 4662), including 1036 patients on insulin, those without DM (n = 13 951), and subgroups based on admission levels of haemoglobin A1c (HbA1c; n = 15 150). In patients with DM, the reduction in the primary composite endpoint (HR: 0.88, 95% CI: 0.76-1.03), all-cause mortality (HR: 0.82

2011 EvidenceUpdates Controlled trial quality: uncertain

89. Comparison of adverse cardiovascular events and bleeding complications of loading dose of clopidogrel 300 mg versus 600 mg in stable patients undergoing elective percutaneous intervention (from the CADICE study) (Abstract)

Comparison of adverse cardiovascular events and bleeding complications of loading dose of clopidogrel 300 mg versus 600 mg in stable patients undergoing elective percutaneous intervention (from the CADICE study) In large clinical trials enrolling patients with acute coronary syndromes, a high loading dose of clopidogrel (600 mg) has been found to be more effective compared to a low loading dose (300 mg). However, the applicability of these data to stable patients who undergo elective (...) percutaneous coronary intervention is still unclear. A total of 400 patients who underwent elective PCI were prospectively randomized to receive either 600 mg (n = 200) or 300 mg (n = 200) of clopidogrel, followed by a daily maintenance dose of 75 mg. The primary end point was the presence of major adverse cardiovascular events (combined death, myocardial infarction, acute neurologic event, stent thrombosis, and need for percutaneous or surgical revascularization of the target vessel) during

2011 EvidenceUpdates Controlled trial quality: uncertain

90. Clopidogrel Teva Pharma B.V.

Clopidogrel Teva Pharma B.V. 7 Westferry Circus ? Canary Wharf ? London E14 4HB ? United Kingdom Telephone +44 (0)20 7418 8400 Facsimile +44 (0)20 7418 8545 E-mail info@ema.europa.eu Website www.ema.europa.eu An agency of the European Union © European Medicines Agency, 2011. Reproduction is authorised provided the source is acknowledged. EMA/439548/2011 Committee for Medicinal Products for Human Use (CHMP) CHMP assessment report Clopidogrel Teva Pharma B.V. International non proprietary name (...) : clopidogrel Procedure No. EMEA/H/C/001226 Assessment Report as adopted by the CHMP with all information of a commercially confidential nature deleted Medicinal product no longer authorisedTable of contents Page 1. Background information on the procedure 3 1.1. Submission of the dossier 3 Scientific Advice: 3 Licensing status: 4 1.2. Steps taken for the assessment of the product 4 2. Scientific discussion 5 2.1. Introduction 5 2.2. Quality aspects 6 2.2.1. Introduction 6 2.2.2. Active Substance 6 2.2.3

2011 European Medicines Agency - EPARs

91. Plavix (clopidogrel bisulfate)

Plavix (clopidogrel bisulfate) Drug Approval Package: Brand Name (Generic Name) NDA # Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Plavix (clopidogrel bisulfate) 75 mg Tablets Company: sanofi-aventis U.S. LLC Application No.: 020839s051 Approval Date: 05/06/2011 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date

2011 FDA - Drug Approval Package

92. Use of the VerifyNow point of care test to detect nonresponsiveness to clopidogrel and aspirin

Use of the VerifyNow point of care test to detect nonresponsiveness to clopidogrel and aspirin Use of the VerifyNow point of care test to detect nonresponsiveness to clopidogrel and aspirin Use of the VerifyNow point of care test to detect nonresponsiveness to clopidogrel and aspirin Xie X, McGregor M Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Xie X (...) , McGregor M. Use of the VerifyNow point of care test to detect nonresponsiveness to clopidogrel and aspirin. Montreal: Technology Assessment Unit of the McGill University Health Centre (MUHC). Report no. 53. 2011 Authors' conclusions • The applicant intends to use the VerifyNow test to detect those patients at increased risk of arterial thrombotic events due to Clopidogrel resistance. Patients found to be clopidogrel resistant will be treated with other thienopyridine drugs. • The VerifyNow test is easy

2011 Health Technology Assessment (HTA) Database.

93. Randomised controlled trial: Addition of omeprazole to dual antiplatelet therapy with clopidogrel plus aspirin lowers the risk of upper gastrointestinal bleeding

Randomised controlled trial: Addition of omeprazole to dual antiplatelet therapy with clopidogrel plus aspirin lowers the risk of upper gastrointestinal bleeding Addition of omeprazole to dual antiplatelet therapy with clopidogrel plus aspirin lowers the risk of upper gastrointestinal bleeding | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about (...) how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Addition of omeprazole to dual antiplatelet therapy with clopidogrel plus aspirin lowers

2011 Evidence-Based Medicine

94. Tirofiban use with clopidogrel and aspirin decreases adverse cardiovascular events after percutaneous coronary intervention for ST-elevation myocardial infarction: a meta-analysis of randomized trials

Tirofiban use with clopidogrel and aspirin decreases adverse cardiovascular events after percutaneous coronary intervention for ST-elevation myocardial infarction: a meta-analysis of randomized trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

95. Clopidogrel 150 vs 75 mg/day in patients undergoing percutaneous coronary intervention: a meta-analysis

Clopidogrel 150 vs 75 mg/day in patients undergoing percutaneous coronary intervention: a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

96. Systematic review: Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel

Systematic review: Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel | BMJ Evidence-Based Medicine We use cookies (...) Username * Password * your user name or password? You are here Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel Article Text Prognosis Systematic review Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention

2011 Evidence-Based Medicine

97. Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (review of technology appraisal no.90): a systematic review and economic analysis

Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (review of technology appraisal no.90): a systematic review and economic analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

98. Randomised controlled trial: Percutaneous coronary intervention for acute coronary syndromes: no difference in 30-day efficacy or safety of high- and low-dose aspirin; double-dose clopidogrel reduces 30-day risk of cardiovascular death, myocardial infarct

Randomised controlled trial: Percutaneous coronary intervention for acute coronary syndromes: no difference in 30-day efficacy or safety of high- and low-dose aspirin; double-dose clopidogrel reduces 30-day risk of cardiovascular death, myocardial infarct Percutaneous coronary intervention for acute coronary syndromes: no difference in 30-day efficacy or safety of high- and low-dose aspirin; double-dose clopidogrel reduces 30-day risk of cardiovascular death, myocardial infarction or stroke (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Percutaneous coronary intervention for acute coronary syndromes: no difference in 30-day efficacy or safety of high- and low-dose aspirin; double-dose clopidogrel reduces 30-day risk of cardiovascular death, myocardial infarction or stroke compared with … Article Text Therapeutics Randomised controlled trial Percutaneous coronary intervention for acute coronary syndromes: no difference

2011 Evidence-Based Medicine

99. Clopidogrel versus other antiplatelet agents for secondary prevention of vascular events in adults with acute coronary syndrome or peripheral vascular disease: clinical and cost-effectiveness analyses

Clopidogrel versus other antiplatelet agents for secondary prevention of vascular events in adults with acute coronary syndrome or peripheral vascular disease: clinical and cost-effectiveness analyses Canadian Agency for Drugs and Technologies in Health Agence canadienne des médicaments et des technologies de la santé Supporting Informed Decisions CADTH Technology Report Clopidogrel versus Other Antiplatelet Agents for Secondary Prevention of Vascular Events in Adults with Acute Coronary (...) Syndrome or Peripheral Vascular Disease: Clinical and Cost-Effectiveness Analyses Issue 133 November 2010Until April 2006, the Canadian Agency for Drugs and Technologies in Health (CADTH) was known as the Canadian Coordinating Office for Health Technology Assessment (CCOHTA). Cite as: Banerjee S, Brown A, McGahan L, Asakawa K, Hutton B, Clark M, Severn M, Sharma M, Cox JL. Clopidogrel versus Other Antiplatelet Agents for Secondary Prevention of Vascular Events in Adults with Acute Coronary Syndrome

2011 EvidenceUpdates

100. Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease. Full Text available with Trip Pro

Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease. Variants in the CYP2C19 gene influence the pharmacologic and clinical response to the standard 75-mg daily maintenance dose of the antiplatelet drug clopidogrel.To test whether higher doses (up to 300 mg daily) improve the response to clopidogrel in the setting of loss-of-function CYP2C19 genotypes.ELEVATE-TIMI 56 was a multicenter, randomized, double-blind trial (...) that enrolled and genotyped 333 patients with cardiovascular disease across 32 sites from October 2010 until September 2011.Maintenance doses of clopidogrel for 4 treatment periods, each lasting approximately 14 days, based on genotype. In total, 247 noncarriers of a CYP2C19*2 loss-of-function allele were to receive 75 and 150 mg daily of clopidogrel (2 periods each), whereas 86 carriers (80 heterozygotes, 6 homozygotes) were to receive 75, 150, 225, and 300 mg daily.Platelet function test results

2011 JAMA Controlled trial quality: predicted high