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Latest & greatest articles for colorectal cancer
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on colorectal cancer or other clinical topics then use Trip today.
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approach to identify their changes linked to cancer pathobiology.Human coloncancer HCT116 cells, control and ρ0, were used for qPCR. Bioinformatics analysis: GeneCards, Kaplan-Meier Survival, GENT, cBioPortal.The colonic ρ0 transcriptome was linked with proliferation, DNA replication, survival, tumormorphology, and cancer. Among differentially expressed transcripts, 281 were regulators or biomarkers of human coloncancer especially those with inflammatory microsatellite instability (MSI). We (...) In colonic Ï0 (rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer Mitochondrial reprogramming has emerged as a hallmark of cancer pathobiology. Although it is believed this reprogramming is essential for cancer cells to thrive, how it supports cancer pathobiology is unclear. We previously generated colonic ρ0 (rho0) cells with reduced mitochondrial energy function and acquired their transcriptional signature. Here, we utilized a bioinformatics
Rare gastrointestinal stromal tumors (GIST): omentum and retroperitoneum Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms that arise in the gastrointestinal tract and rarely elsewhere in the abdomen. GISTs that develop outside the digestive tract are called extra-GISTs (EGISTs). The incidence of EGISTs is reported to be approximately 10% of all GISTs, and the median age is younger than that of conventional GISTs. EGISTs have similar histology (...) and immunohistochemical features as conventional GISTs, with the majority of them in the omentum and mesentery. Most GISTs harbor a kinase-activating mutation in either KIT or PDGFRA. For EGISTs, the incidence of this type of mutation is 40-50%, which is somewhat lower than for conventional GISTs. EGISTs may have a worse prognosis compared with conventional GISTs with high mitotic indices, large size, and distant metastasis including lymph node involvement. In largeabdominaltumors, the visceral origin is almost
Endoscopic resection of gastric gastrointestinal stromal tumorsGastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract, and about 60% of them are found in the stomach. With the widespread application of endoscopy and endoscopic ultrasonography (EUS), more and more gastric GISTs are being found in an early stage (with a relative small diameter and no metastasis), giving the chance of complete resection. Endoscopic resection such as endoscopic
Erbitux for Left Sided Metastatic ColorectalCancer – Details Erbitux for Left Sided Metastatic ColorectalCancer – Details | CADTH.ca Find the information you need Erbitux for Left Sided Metastatic ColorectalCancer – Details Erbitux for Left Sided Metastatic ColorectalCancer – Details Project Number pCODR 10128 Brand Name Erbitux Generic Name Cetuximab Strength 2 mg/mL Tumour Type Gastrointestinal Indication Left Sided Metastatic ColorectalCancer Funding Request For the first-line treatment (...) of RAS wild-type metastatic colorectalcarcinoma (mCRC) patients with left sided primary tumours Review Status File-Closed Not Submitted Clarification The submitter notified pCODR that they will not be filing the submission. Pre Noc Submission No NOC Date September 9, 2005 Manufacturer Eli Lilly Canada Inc. Submitter Eli Lilly Canada Inc. Submission Date (Target Date) Submission Type New Indication Prioritization Requested Stakeholder Input Deadline (target date based on target submission date
Minimally invasive surgery for gastric gastrointestinal stromal tumors Minimally invasive surgery has been increasingly performed for gastric gastrointestinal stromal tumors (GIST). In this review we discuss and summarize the current evidence on minimally invasive surgery for gastric GISTs. Laparoscopic resection for gastric GIST has been consistently shown to be associated with superior perioperative outcomes with no compromise in oncological outcomes when compared to open resection (...) in numerous retrospective case-control studies. It has also been shown to be safe and feasible for largetumors or tumors located in unfavorable sites. However, to date, there remains a lack of level 1 evidence from prospective randomized control trials in support of laparoscopic resection.
Initial clinical experience using a novel Pd-103 surface applicator for the treatment of retroperitoneal and abdominal wall malignancies 29904748 2019 02 26 2452-1094 3 2 2018 Apr-Jun Advances in radiation oncology Adv Radiat Oncol Initial clinical experience using a novel Pd-103 surface applicator for the treatment of retroperitoneal and abdominal wall malignancies. 216-220 10.1016/j.adro.2017.11.005 Zhen Heming H Department of Radiation Oncology, Boston Medical Center, Boston, Massachusetts
Surgical treatment of gastrointestinal stromal tumors of the stomach: current status and future perspective Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, with the majority found in the stomach. Surgical resection of the primary gastric GISTs with complete resection margin has been the forefront of curative treatment. The indications for surgical resection are usually related to symptomatic gastric GISTs at presentation. Primary (...) factors (size and mitotic index), patient factors (older age, male) and surgical factors (incomplete resection margin, tumor rupture or spillage) play an important role in stratifying the malignant potential risk of primary gastric GISTs and their chances of recurrence. The understanding of gene mutation driving the growth of GISTs and the discovery of tyrosine kinase inhibitors (TKIs) has altered the surgical management of advanced and metastatic GISTs. Multi-modal therapy incorporating the surgical
Experience with an abdominal compression band for radiotherapy of upper abdominaltumours Radiotherapy outcomes are influenced by treatment delivery geometric accuracy and organ-at-risk dose. The location of abdominal structures such as the liver, kidneys and tumour volumes can be strongly influenced by respiratory motion. This increases geometric uncertainty and dose to organs-at-risk. One common method of minimising respiratory motion is abdominal compression (AC).Fifteen patients being (...) treated for radiotherapy to upper abdominaltumours were analysed. Each patient underwent 2 four-dimensional computerised tomography (4D-CT) scans, one with and one without AC with a pneumatic compression belt. Liver and kidney positions were measured on the 4DCT scans at the peak inspiratory and expiratory respiratory phases. The patient received radiation therapy treatment planned on the CT data set with the technique (compression or no compression) that provided the least respiratory motion.There
The proof is in the pudding: improving adenoma detection rates reduces interval coloncancer development 29264437 2018 11 13 2415-1289 2 2017 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol The proof is in the pudding: improving adenoma detection rates reduces interval coloncancer development. 99 10.21037/tgh.2017.11.10 Umar Sarah B SB Division of Gastroenterology and Hepatology, Mayo Clinic, Arizona, USA. Ramirez Francisco C FC Division of Gastroenterology
Bevacizumab (Kyomarc) - for the treatment of cancer of the colon or rectum, breast cancer, non-small cell lung cancer (NSCLC), kidney cancer, cervical cancer, and cancer of the ovary, the fallopian tube, or the peritoneum.
QTWiST analysis of the RECOURSE trial of trifluridine/tipiracil in metastatic colorectalcancer A Quality-adjusted Time WIthout Symptoms of disease or Toxicity (QTWiST) analysis was carried out to assess quality-adjusted survival time in the RECOURSE trial of trifluridine/tipiracil versus placebo in pretreated metastatic colorectalcancer (mCRC).Duration of overall survival in the RECOURSE trial (n=798 patients) was partitioned into three discrete health states: toxicity (TOX), time without (...) . A sensitivity analysis using large variations in utility coefficients for TOX and REL produced a range of only approximately 0.5 months from minimum to maximum QTWiST.Quality-adjusted survival, as measured by QTWiST, shows clinically meaningful improvements in patients treated with trifluridine/tipiracil versus placebo in pretreated mCRC.
Proxies of quality of life in metastatic colorectalcancer: analyses in the RECOURSE trial In the pivotal phase III, randomised, double-blind, placebo-controlled RECOURSE study, treatment with trifluridine/tipiracil was well tolerated and associated with prolonged progression-free and overall survival in patients with metastatic colorectalcancer (mCRC). There was no formal analysis of quality of life (QoL) in RECOURSE. The aim of the present analysis was to assess proxies of QoL during
2017ESMO openControlled trial quality: predicted high
Novel Stool-Based Protein Biomarkers for Improved ColorectalCancer Screening: A Case-Control Study. The fecal immunochemical test (FIT) for detecting hemoglobin is used widely for noninvasive colorectalcancer (CRC) screening, but its sensitivity leaves room for improvement.To identify novel protein biomarkers in stool that outperform or complement hemoglobin in detecting CRC and advanced adenomas.Case-control study.Colonoscopy-controlled referral population from several centers.315 stool (...) samples from one series of 12 patients with CRC and 10 persons without colorectalneoplasia (control samples) and a second series of 81 patients with CRC, 40 with advanced adenomas, and 43 with nonadvanced adenomas, as well as 129 persons without colorectalneoplasia (control samples); 72 FIT samples from a third independent series of 14 patients with CRC, 16 with advanced adenomas, and 18 with nonadvanced adenomas, as well as 24 persons without colorectalneoplasia (control samples).Stool samples
Pediatric gastrointestinal stromal tumors: a commentary on the value of referral clinics for rare pediatric tumors 29264434 2018 11 13 2415-1289 2 2017 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol Pediatric gastrointestinal stromal tumors: a commentary on the value of referral clinics for rare pediatric tumors. 96 10.21037/tgh.2017.11.01 Fernandez-Pineda Israel I Department of Surgery, St Jude Children's Research Hospital, Memphis, TN, USA. Rao Bhaskar N BN (...) 5:v98-102 20555113 Cancer. 2004 Jul 1;101(1):39-50 15221987 Ann Oncol. 2012 Oct;23 Suppl 7:vii49-55 22997454 Am J Surg Pathol. 2005 Oct;29(10):1373-81 16160481 Pediatr Blood Cancer. 2004 Feb;42(2):186-9 14752885 J Clin Oncol. 2017 Feb 10;35(5):523-528 28029307
Understanding the critical role for surgery in the management of wild-type gastrointestinal stromal tumor (GIST) 29264429 2018 11 13 2415-1289 2 2017 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol Understanding the critical role for surgery in the management of wild-type gastrointestinal stromal tumor (GIST). 91 10.21037/tgh.2017.11.03 Kim Bradford J BJ Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Kays Joshua K JK Department (...) 10 30 2017 11 06 2017 12 22 6 0 2017 12 22 6 0 2017 12 22 6 1 epublish 29264429 10.21037/tgh.2017.11.03 tgh-02-2017.11.03 PMC5723733 J Clin Oncol. 2006 Oct 10;24(29):4764-74 16954519 J Am Coll Surg. 2006 Apr;202(4):623-9 16571433 Cancer Res. 2007 Oct 1;67(19):9084-8 17909012 J Natl Compr Canc Netw. 2007 Jul;5 Suppl 2:S1-29; quiz S30 17624289 Surgery. 2015 Nov;158(5):1149-64 26243346 Hematol Oncol Clin North Am. 2009 Feb;23(1):15-34, vii 19248968 Lancet Oncol. 2012 Mar;13(3):265-74 22153892 EMBO J
Exploration of time points and cut-off values for early tumour shrinkage to predict survival outcomes of patients with metastatic colorectalcancer treated with first-line chemotherapy using a biexponential model for change in tumour size Several studies reported that early tumour shrinkage (ETS) was associated with overall survival in patients with metastatic colorectalcancer (mCRC) treated with first-line chemotherapy. However, appropriate time point and cut-off value for ETS remain unclear (...) because these varied in previous studies.We investigated patients with mCRC who received FOLFOX or FOLFIRI with/without molecular-targeted agents as first-line treatment between 2005 and 2014. Using a biexponential model for change in tumour size, a relative change in the sum of the longest diameters of target lesions from baseline was estimated at a certain time point in each individual patient. Associations of survival outcomes with ETS at various time points based on various cut-off values were