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Latest & greatest articles for colorectal cancer
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on colorectal cancer or other clinical topics then use Trip today.
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First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectalcancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectalcancer has clinical benefit in patients with colorectal liver metastases with liver-dominant disease after chemotherapy. The FOXFIRE (...) , SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy with SIRT using yttrium-90 resin microspheres in patients with metastatic colorectalcancer with liver metastases. The studies were designed for combined analysis of overall survival.FOXFIRE, SIRFLOX, and FOXFIRE-Global were randomised, phase 3 trials done in hospitals and specialist liver centres in 14 countries worldwide (Australia, Belgium, France, Germany, Israel, Italy, New Zealand, Portugal
Human microbiome signatures of differential colorectalcancer drug metabolism It is well appreciated that microbial metabolism of drugs can influence treatment efficacy. Microbial β-glucuronidases in the gut can reactivate the excreted, inactive metabolite of irinotecan, a first-line chemotherapeutic for metastatic colorectalcancer. Reactivation causes adverse drug responses, including severe diarrhea. However, a direct connection between irinotecan metabolism and the composition (...) in targeted subsets of patients. In total, this study reveals metagenomic mining of the microbiome, combined with metabolomics, as a non-invasive approach to develop biomarkers for colorectalcancer treatment outcomes.
age 54.6 years; 61.4% women; 22.1% had a family history of colorectalcancer. The main risk factors mentioned by the respondents were family history of CRC, previous history of intestinal polyps, and intestinal infection. Screening was considered useful by all respondents. About 60% of the respondents had been counselled, at least, on one screening technique, mainly by their general practitioner: colonoscopy in 31, fecal occult blood test in 44, and flexible sigmoidoscopy in 9. Most (...) ColorectalCancer Screening: What Is the Population's Opinion Colorectalcancer (CRC) is the first cause of death by cancer in Portugal and mortality has been increasing in the last 30 years.During a raising awareness campaign performed by our Gastroenterology Department, in Setúbal, Portugal, an anonymous written questionnaire was developed and presented in order to evaluate the population's knowledge and attitude regarding CRC screening.The following results were reported: 140 persons; mean
P-Cadherin (CDH3) is overexpressed in colorectaltumors and has potential as a serum marker for colorectalcancer monitoring Placental-Cadherin (CDH3) is a cell adhesion molecule vital to cellular localization and tissue integrity. It is highly expressed in the placenta (PLC)and is overexpressed by many types of cancer. P-cadherin levels in colorectalcancer (CRC) remains poorly characterized. This study's purpose was to determine P-cadherin expression in CRC and normal tissues and to assess (...) plasma CDH3 levels in order to determine the relationship, if any, between cancer stage, P-cadherin expression and plasma CDH3 levels.An IRB approved plasma, tumor, and prospective data bank was utilized. CRC patients for whom tumor and normal colon tissue samples were available were enrolled. Tumor samples were OCT embedded and stored at -80C°. Total purified RNA was isolated from tissue samples and cDNA synthesized. CDH3 expression was analyzed by quantitative PCR (QPCR) using the SYBR Green
Neuroendocrine Tumors of the Gastrointestinal Tract 29177159 2019 01 18 2297-4725 33 5 2017 Oct Visceral medicine Visc Med Neuroendocrine Tumors of the Gastrointestinal Tract. 321-322 10.1159/000481766 Bartsch Detlef K DK Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Marburg, Germany. Scherübl Hans H Department of Gastroenterology, Gastrointestinal Oncology and Infectious Diseases, Vivantes Klinikum Am Urban, Berlin, Germany. eng Editorial 2017 10 16
The big, the bad, and the exon 11: adjuvant imatinib for all gastro-intestinal stromal tumors or just the ugly? 29167828 2018 11 13 2415-1289 2 2017 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol The big, the bad, and the exon 11: adjuvant imatinib for all gastro-intestinal stromal tumors or just the ugly? 81 10.21037/tgh.2017.09.10 Groisberg Roman R Department of Investigational Cancer Therapeutics (Phase 1 Program), Division of Cancer Medicine, The University (...) of Texas MD Anderson Cancer Center, Houston, TX, USA. Subbiah Vivek V Department of Investigational Cancer Therapeutics (Phase 1 Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. eng Editorial Comment 2017 10 13 China Transl Gastroenterol Hepatol 101683450 2415-1289 JAMA Oncol. 2017 May 1;3(5):602-609 28334365 Conflicts of Interest: The authors have no conflicts of interest to declare. 2017 09 03 2017 09 18 2017 11 24 6 0 2017 11 24 6 0 2017 11
Surgical Treatment of Small Intestinal Neuroendocrine Tumors G1/G2 Although the majority of neuroendocrine tumors of the small intestine (siNETs) classified as low-grade G1 or G2 show slow local growth, they are frequently diagnosed at an advanced stage of metastatic disease. The surgical treatment is curative in stages I-III or palliative in stage IV in an attempt to avoid local complications of bowel obstruction and ischemia of the small bowel by unremoved lymph node metastases (...) . Individualized surgical procedures performed by experienced surgeons considering tumor multifocality and the primary extent of lymph node metastases along the mesenteric vessels are recommended to remove as much tumor volume as possible, while avoiding major complications intraoperatively and small bowel syndrome postoperatively.
Screening for ColorectalCancer With Fecal Immunochemical Testing With and Without Postpolypectomy Surveillance Colonoscopy: A Cost-Effectiveness Analysis. Population-based screening to prevent colorectalcancer (CRC) death is effective, but the effectiveness of postpolypectomy surveillance is unclear.To evaluate the additional benefit in terms of cost-effectiveness of colonoscopy surveillance in a screening setting.Microsimulation using the ASCCA (Adenoma and Serrated pathway to Colorectal (...) CAncer) model.Dutch CRC screening program and published literature.Asymptomatic persons aged 55 to 75 years without a prior CRC diagnosis.Lifetime.Health care payer.Fecal immunochemical test (FIT) screening with colonoscopy surveillance performed according to the Dutch guideline was simulated. The comparator was no screening or surveillance. FIT screening without colonoscopy surveillance and the effect of extending surveillance intervals were also evaluated.CRC burden, colonoscopy demand, life-years
Patient navigation to reduce social inequalities in colorectalcancer screening participation: A cluster randomized controlled trial Despite free colorectalcancer screening in France, participation remains low and low socioeconomic status is associated with a low participation. Our aim was to assess the effect of a screening navigation program on participation and the reduction in social inequalities in a national-level organized mass screening program for colorectalcancer by fecal-occult
The clinical effectiveness and cost-effectiveness of cetuximab (review of technology appraisal no. 176) and panitumumab (partial review of technology appraisal no. 240) for previously untreated metastatic colorectalcancer: a systematic review and economi The clinical effectiveness and cost-effectiveness of cetuximab (review of technology appraisal no. 176) and panitumumab (partial review of technology appraisal no. 240) for previously untreated metastatic colorectalcancer: a systematic review (...) and economic evaluation The clinical effectiveness and cost-effectiveness of cetuximab (review of technology appraisal no. 176) and panitumumab (partial review of technology appraisal no. 240) for previously untreated metastatic colorectalcancer: a systematic review and economic evaluation Huxley N, Crathorne L, Varley-Campbell J, Tikhonova I, Snowsill T, Briscoe S, Peters J, Bond M, Napier M & Hoyle M. Record Status This is a bibliographic record of a published health technology assessment from a member
of colorectalcancer (CRC), gynaecological cancers and other cancers, known as Lynch syndrome (LS). Risk-reducing interventions can be offered to individuals with known LS-causing mutations. The mutations can be identified by comprehensive testing of the MMR genes, but this would be prohibitively expensive in the general population. Tumour-based tests – microsatellite instability (MSI) and MMR immunohistochemistry (IHC) – are used in CRC patients to identify individuals at high risk of LS for genetic (...) , the number of relatives identified for cascade testing, colonoscopic surveillance effectiveness and the acceptance of genetic testing. Future work should investigate screening for more causes of hereditary CRC and screening for LS in endometrial cancer patients. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH ColorectalNeoplasms; ColorectalNeoplasms, Hereditary Nonpolyposis; Cost-Benefit Analysis; Genetic Testing; Humans Language Published English Country of organisation
An Unusual Gastrointestinal Stromal Tumor Presentain: Breast, Liver and Lymph Node Metastasis Gastrointestinal Stromal Tumors (GIST) are the common mesenchymal tumors of gastrointestinal tract. They can display benign and malignant clinical behavior. The most common metastasis sites of malignant stromal tumor are liver, peritoneum, lung and bones. Metastasis to breast is extremely rare. Here, we present a case of GIST with liver, bone, lymph node and breast metastasis by reviewing
Colorectal Stenting for Obstruction due to Retrorectal Tumor in a Patient Unsuitable for Surgery Fund of knowledge on palliative treatment of unresectable retrorectal tumors is scare. Here, we reported a non-surgical treatment of a huge retrorectal malignanttumor in an aged and debilitated patient complicated with colorectal obstruction. An 86-year-old male with severe comorbidities was admitted with acute colorectal obstruction owing to an untreated retrorectal malign epithelial tumor (...) tumor can be feasible in patients who are not suitable for surgery (aged, debilitated, advanced tumor). It avoided the surgical trauma to a high-risk patient and ensured the continuity of continence. As far as we know, this was the first report on colorectal stenting for a retrorectal tumor.
Innovative Disease Model: Zebrafish as an In Vivo Platform for Intestinal Disorder and TumorsColorectalcancer (CRC) is one of the world's most common cancers and is the second leading cause of cancer deaths, causing more than 50,000 estimated deaths each year. Several risk factors are highly associated with CRC, including being overweight, eating a diet high in red meat and over-processed meat, having a history of inflammatory boweldisease, and smoking. Previous zebrafish studies have (...) demonstrated that multiple oncogenes and tumor suppressor genes can be regulated through genetic or epigenetic alterations. Zebrafish research has also revealed that the activation of carcinogenesis-associated signal pathways plays an important role in CRC. The biology of cancer, intestinal disorders caused by carcinogens, and the morphological patterns of tumors have been found to be highly similar between zebrafish and humans. Therefore, the zebrafish has become an important animal model
in the life expectancy of patients with colorectalcancer has been achieved with different diagnostic and treatment programs. Despite these improvements, the presence of metastasis, disease recurrence, and advanced local tumors continue to remain poor prognostic factors. Median survival without treatment is <8 months from the moment of its presentation, and a survival rate at 5 years of 11% is the best prognosis for those who present with local metastasis. Even in patients with limited metastatic disease (...) , 5-year survival is exceptional. Patients with hepatic metastasis of colorectalcancer have a median survival of 5 to 20 months with no treatment. Approximately 20 to 30% of patients with colorectal metastasis have disease confined to the liver, and this can be managed with surgery. Modern surgical strategies at the main hepatobiliary centers have proved that hepatectomy of 70% of the liver can be performed, with a mortality rate of <5%. It is very important to have knowledge of predisposing
Functional Changes in the Gut Microbiome Contribute to Transforming Growth Factor Î²-Deficient ColonCancerColorectalcancer (CRC) is one of the most treatable cancers, with a 5-year survival rate of ~64%, yet over 50,000 deaths occur yearly in the United States. In 15% of cases, deficiency in mismatch repair leads to null mutations in transforming growth factor β (TGF-β) type II receptor, yet genotype alone is not responsible for tumorigenesis. Previous work in mice shows that disruptions (...) , which could promote tumor formation. H. hepaticus causes an increase in OXPHOS that may increase DNA-damaging free radicals. Finally, multiple bacterial species increase polyamines that are associated with coloncancer, implicating not just diet but also the microbiome in polyamine levels. These insights into cross talk between the microbiome, host genotype, and inflammation could promote the development of diagnostics and therapies for CRC. IMPORTANCE Most research on the gut microbiome in colon
Clinical outcome of patients with chemorefractory metastatic colorectalcancer treated with trifluridine/tipiracil (TAS-102): a single Italian institution compassionate use programme TAS-102 improves overall survival (OS) in patients with metastatic colorectalcancer (mCRC) refractory to standard treatments. However, predictive biomarkers of efficacy are currently lacking.We treated a cohort of 43 chemorefractory mCRC patients treated with TAS-102, in a single institution expanded access (...) , compassionate use programme. We stratified patients in two groups according to number of cycles received (<6 cycles and ≥6 cycles). OS, progression-free survival (PFS) and safety were evaluated.Thirteen out of 43 patients (30%) obtained a clinically relevant disease control with TAS-102 therapy. Eleven of them were treated for ≥6 cycles with TAS-102, reaching a median PFS of 7.5 months (95% CI 5.8 to 9.2 months) and a median OS of 11.2 months (95% CI range not reached yet). A trend towards significance (p
Association between oral leukoplakia and risk of upper gastrointestinalcancer death: A followâ€up study of the Linxian General Population Trial This study was conducted to explore the association between oral leukoplakia (OL) and the risk of upper gastrointestinalcancer death in the Linxian General Population Trial Cohort.A prospective cohort study of the Linxian General Population Trial Cohort was performed. Participants with OL were treated as an exposed group, and the remainder (...) was selected as a control group. All subjects were followed monthly by village health workers and reviewed quarterly by the Linxian Cancer Registry. Hazard ratios (HRs) and 95% confidence interval (CIs) were evaluated using proportional hazard and proportional subdistribution hazard models, respectively.Over a median of 27 years of observation, 29 476 subjects were followed-up. A total of 17 473 deaths occurred, including 2345 esophageal squamous cell carcinoma (ESCC), 1139 gastric cardia carcinoma
of 18.0 (14.4 to 22.7) corresponding to 202 cancers in patients with inflammatory boweldisease. The increased risk of cancer (before 25th birthday) was similar over time (1964-1989: 1.6, 1.0 to 2.4; 1990-2001: 2.3, 1.5 to 3.3); 2002-06: 2.9, 1.9 to 4.2; 2007-14: 2.2, 1.1 to 4.2).Conclusion Childhood onset inflammatory boweldisease is associated with an increased risk of any cancer, especially gastrointestinalcancers, both in childhood and later in life. The higher risk of cancer has not fallen over (...) Childhood onset inflammatory boweldisease and risk of cancer: a Swedish nationwide cohort study 1964-2014. Objective To assess risk of cancer in patients with childhood onset inflammatory boweldisease in childhood and adulthood.Design Cohort study with matched general population reference individuals using multivariable Cox regression to estimate hazard ratios.Setting Swedish national patient register (both inpatient and non-primary outpatient care) 1964-2014.Participants Incident cases
Medical Therapy of Gastrointestinal Neuroendocrine TumorsIntestinal neuroendocrine tumors (NETs) constitute a heterogeneous group with duodenal, small intestinal, colonic and rectal NETs. They constitute more than half of all NETs, with the highest frequencies in the rectum, small intestine, and colon. The tumor biology varies with the location of the primary tumor as well as with the grade and staging of the tumor. Small intestinal NETs usually present low proliferation and are treated (...) than the rest of intestinal NETs and will be treated with everolimus, sometimes in combination with somatostatin analogs based on positive scintigraphy. Another option is a cytotoxic agent such as streptozotocin plus 5-fluorouracil (5-FU) or temozolomide plus capecitabine. The most aggressive tumors, i.e. neuroendocrine carcinoma G3, are treated with a platin-based therapy plus etoposide; if they present with a lower proliferation, i.e. <50%, temozolomide plus capecitabine plus bevacizumab can also