Latest & greatest articles for colorectal cancer

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Top results for colorectal cancer

21. Colorectal Cancer

of Colorectal Liver Metastases 111 7.4.3. Tumor Markers 113 7.4.4. Specific Diagnostics for Rectal Cancer 114 7.5. Surgical Therapy with Curative Intention 117 7.5.1. Intraoperative Staging 117 7.5.1.1. Intra-Operative Pathological Examination 117 7.5.2. Radical Surgical Therapy of Colon Cancer 118 7.5.2.1. Extent of Lymph Node Dissection: 118 7.5.2.2. Complete Mesocolic Excision (CME) 120 7.5.2.3. Local Ablative Therapies for Liver Metastases 121 7.5.2.3.1. Radio-Frequency Ablation (RFA) 121 7.5.2.3.2 (...) (Hereditary Non-Polyposis Colorectal Cancer) 135 7.7.8. Cancers in Familial Adenomatous Polyposis (FAP) 136 1.1 Editors © German Guideline Program in Oncology | Evidenced-based Guideline for Colorectal Cancer | Version 2.1 | Januar 2019 6 7.7.9. Cancers in Ulcerative Colitis 136 7.8. Postoperative Histopathological Examination 137 7.8.1. Cancer-Grading Based on MSI-H 137 7.8.2. Number of LN to be Removed 138 7.8.3. Relevance of Distance Between the Tumor Margin and Resection Area of the Mesocolon in Colon

2019 German Guideline Program in Oncology

22. Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer

Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Digestive Oncology (ESDO) Guideline – European Society of Gastrointestinal Endoscopy (ESGE) +49-89-9077936-11 Menu DOI https://doi.org/10.1055/a-0831-2522 Endoscopy 2019; 51: 266–277 © Georg Thieme Verlag KG Stuttgart· New York Explore the ESGE (...) website Menu Contact us +49-89-9077936-0 Follow us © 2004 - 2019 European Society of Gastrointestinal Endoscopy (ESGE). All Rights Reserved. |

2019 European Society of Gastrointestinal Endoscopy

23. Endoscopic management of Lynch syndrome and of familial risk of colorectal cancer

Endoscopic management of Lynch syndrome and of familial risk of colorectal cancer Endoscopic management of Lynch syndrome and of familial risk of colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – European Society of Gastrointestinal Endoscopy (ESGE) +49-89-9077936-11 Menu DOI https://doi.org/10.1055/a-1016-4977 | Endoscopy 2019; 51:1082–1093 Published online: 9.10.2019 © Georg Thieme Verlag KG Stuttgart · New York Explore the ESGE website Menu Contact us +49 (...) -89-9077936-0 Follow us © 2004 - 2019 European Society of Gastrointestinal Endoscopy (ESGE). All Rights Reserved. |

2019 European Society of Gastrointestinal Endoscopy

24. Advanced imaging for detection and differentiation of colorectal neoplasia

Advanced imaging for detection and differentiation of colorectal neoplasia Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2019 – European Society of Gastrointestinal Endoscopy (ESGE) +49-89-9077936-11 Menu DOI https://doi.org/10.1055/a-1031-7657 | Endoscopy 2019; 51: 1155–1179 Published online: 11.11.2019 © Georg Thieme Verlag KG Stuttgart · New York Explore the ESGE website Menu Contact us +49 (...) -89-9077936-0 Follow us © 2004 - 2019 European Society of Gastrointestinal Endoscopy (ESGE). All Rights Reserved. |

2019 European Society of Gastrointestinal Endoscopy

25. Bowel cancer screening: imaging use

screening: imaging use Information about imaging practice standards for bowel cancer screening of individuals unsuitable for a colonoscopy. Published 1 November 2012 Last updated 14 October 2019 — From: Documents Ref: PHE publications gateway number: GW-810 HTML Details This publication explains the use of whole colon imaging as an alternative to a colonoscopy as part of the NHS Bowel Cancer Screening Programme ( 14 October 2019 Added new guidelines on CTC imaging in NHS bowel cancer screening. 1 (...) Bowel cancer screening: imaging use Bowel cancer screening: imaging use - GOV.UK GOV.UK uses cookies which are essential for the site to work. We also use non-essential cookies to help us improve government digital services. Any data collected is anonymised. By continuing to use this site, you agree to our use of cookies. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Register by 26 November to vote in the General Election on 12 December. Guidance Bowel cancer

2019 Public Health England

26. Phase II randomized clinical trial of endosonography and PET/CT versus clinical assessment only for follow-up after surgery for upper gastrointestinal cancer (EUFURO study) (Abstract)

Phase II randomized clinical trial of endosonography and PET/CT versus clinical assessment only for follow-up after surgery for upper gastrointestinal cancer (EUFURO study) Upper gastrointestinal malignancies have a poor prognosis. There is no consensus on how patients should be followed after surgery. The authors hypothesized that a structured follow-up programme including endoscopic ultrasonography (EUS) and [18 F]fluorodeoxyglucose (FDG) PET/CT would detect cancer recurrences, leading (...) chemotherapy (P = 0·028). Although survival after detection of recurrence in asymptomatic patients was significantly longer than that for symptomatic patients (P < 0·001), overall survival from date of surgery in the two treatment groups was comparable.Follow-up after surgery for upper gastrointestinal cancer with EUS and PET/CT leads to detection of more asymptomatic cancer recurrences and patients referred for treatment without prolonging overall survival. Registration number: NCT02209415 ( http

2019 EvidenceUpdates

27. Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a microsimulation modelling study. Full Text available with Trip Pro

Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a microsimulation modelling study. To estimate benefits and harms of different colorectal cancer screening strategies, stratified by (baseline) 15-year colorectal cancer risk.Microsimulation modelling study using MIcrosimulation SCreening ANalysis-Colon (MISCAN-Colon).A parallel guideline committee (BMJ Rapid Recommendations) defined the time frame and screening interventions, including selection (...) of outcome measures.Norwegian men and women aged 50-79 years with varying 15-year colorectal cancer risk (1-7%).Four screening strategies were compared with no screening: biennial or annual faecal immunochemical test (FIT) or single sigmoidoscopy or colonoscopy at 100% adherence.Colorectal cancer mortality and incidence, burdens, and harms over 15 years of follow-up. The certainty of the evidence was assessed using the GRADE approach.Over 15 years of follow-up, screening individuals aged 50-79 at 3% risk

2019 BMJ

28. Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness

Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness | CADTH.ca Find the information you need Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness Last updated: April 15 (...) , 2019 Project Number: RA1026-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the clinical effectiveness of the fecal immunochemical test in detecting medical conditions other than colorectal cancer where occult blood detection is needed? What is the clinical effectiveness of the guaiac fecal blood occult test in detecting medical conditions other than colorectal cancer where occult blood detection is needed? Key Message

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

29. Trifluridine and Tipiracil (Lonsurf) for Metastatic Colorectal Cancer Resubmission – Details

Strength 15 mg & 20 mg Tumour Type Gastrointestinal Indication Metastatic Colorectal Cancer Funding Request Treatment of adult patients with mCRC who have been previously treated with, or are not candidates for, available therapies including fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies, anti-VEGF biological agents, and, if RAS wild-type, anti-EGFR agents Review Status Notification to Implement Issued Pre Noc Submission No NOC Date January 25, 2018 Manufacturer Taiho Pharma Canada (...) Trifluridine and Tipiracil (Lonsurf) for Metastatic Colorectal Cancer Resubmission – Details Trifluridine and Tipiracil (Lonsurf) for Metastatic Colorectal Cancer Resubmission – Details | CADTH.ca Find the information you need Trifluridine and Tipiracil (Lonsurf) for Metastatic Colorectal Cancer Resubmission – Details Trifluridine and Tipiracil (Lonsurf) for Metastatic Colorectal Cancer Resubmission – Details Project Number pCODR 10173 Brand Name Lonsurf Generic Name Trifluridine and Tipiracil

2019 CADTH - Pan Canadian Oncology Drug Review

30. Guidelines for the management of hereditary colorectal cancer

neoplasia. ATZ: anal transitional zone. BSG: British Society of Gastroenterology. BSGM: British society of genetic medicine. CHRPE: congenital hypertrophy retinal pigmentation epithelium. CI: confidence intervals. COX-2: Cyclooxygenase-2 . CRC: colorectal cancer. CSSC: Clinical Services and Standards Committee. EHTG: European Hereditary Tumour Group. EOCRC: Early onset CRC. ESGE: European Society of Gastrointestinal Endoscopy. FAP: Familial adenomatous polyposis. FDR: First-degree relative. FH: family (...) ; Strength of recommendation: strong) o We suggest that when abdominal-perineal excision can be avoided, a standard low anterior resection is a reasonable option to treat rectal cancers in LS patients, even though the residual colon is at high-risk of metachronous neoplasia. (GRADE of evidence: low; Strength of recommendation: weak) o We recommend that gastric, small bowel, or pancreatic surveillance in LS patients is only performed in the context of a clinical trial. (GRADE of evidence: low; Strength

2019 British Society of Gastroenterology

31. New eUpdate featuring treatment algorithm for Early Colon Cancer

Breast/Ovarian Hereditary Cancer Syndromes Cancers of Unknown Primary Site Cancers of Unknown Primary Site Endocrine and Neuroendocrine Cancers Neuroendocrine Bronchial and Thymic Tumours • Neuroendocrine Gastroenteropancreatic Tumours • Adrenal Cancer • Thyroid Cancer Gastrointestinal Cancers Rectal Cancer • Biliary cancer • Gastric cancer • Oesophageal cancerCancer of the pancreas • Metastatic colorectal cancer • Anal cancer • Early colon cancer • Familial risk colorectal cancer • Hepatocellular (...) carcinoma Genitourinary Cancers Testicular Germ Cell CancerCancer of the Prostate • Bladder Cancer • Renal Cell Carcinoma • Penile Carcinoma • Testicular Seminoma and Non-Seminoma Gynaecological Cancers Cervical cancer • Endometrial cancer • Gestational trophoblastic disease • Newly diagnosed and relapsed epithelial ovarian carcinoma • Non-epithelial ovarian cancer • Ovarian Cancer Haematological Malignancies Waldenstrom's macroglobulinaemia • Chronic myeloid leukaemia • Newly diagnosed and relapsed

2019 European Society for Medical Oncology

32. Updated treatment recommendations for Early Colon Cancer

Hereditary Cancer Syndromes Cancers of Unknown Primary Site Cancers of Unknown Primary Site Endocrine and Neuroendocrine Cancers Neuroendocrine Bronchial and Thymic Tumours • Neuroendocrine Gastroenteropancreatic Tumours • Adrenal Cancer • Thyroid Cancer Gastrointestinal Cancers Rectal Cancer • Biliary cancer • Gastric cancer • Oesophageal cancerCancer of the pancreas • Metastatic colorectal cancer • Anal cancer • Early colon cancer • Familial risk colorectal cancer • Hepatocellular carcinoma (...) Genitourinary Cancers Testicular Germ Cell CancerCancer of the Prostate • Bladder Cancer • Renal Cell Carcinoma • Penile Carcinoma • Testicular Seminoma and Non-Seminoma Gynaecological Cancers Cervical cancer • Endometrial cancer • Gestational trophoblastic disease • Newly diagnosed and relapsed epithelial ovarian carcinoma • Non-epithelial ovarian cancer • Ovarian Cancer Haematological Malignancies Waldenstrom's macroglobulinaemia • Chronic myeloid leukaemia • Newly diagnosed and relapsed mantle cell

2019 European Society for Medical Oncology

33. Colorectal Cancer Screening Evidence Brief

fruits and vegetables, fiber, and calcium). Awareness Given the data that colorectal cancer is increasing in younger individuals we must be more vigilant for signs and symptoms that could indicate a problem. I want to know if you develop blood in your stools, anemia, abdominal pain, or changes in bowel habits. However, it is also important to realize that early colon cancers and precancerous polyps do not commonly cause symptoms. 5 References American Academy of Family Physicians Statement: https (...) with a personal or family history of colorectal cancer or adenomatous polyps, persons with inflammatory bowel disease, and those with symptoms that may be attributable to colorectal. Background Recently, the American Cancer Society (ACS) released their updated 2018 Colorectal Cancer (CRC) Screening Guidelines. These guidelines added the qualified recommendation* that screening for average risk patients start at 45 years of age regardless of race. Screening all adults aged 50 years and older, which

2019 Institute for Clinical Systems Improvement

34. Mvasi for Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar – Details

Type Gastrointestinal / Lung Indication Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar Funding Request For first-line treatment of patients with metastatic carcinoma of the colon or rectum, in combination with fluoropyrimidine based chemotherapy / For treatment of patients with unresectable advanced, metastatic or recurrent non-squamous non-small cell lung cancer, in combination with carboplatin/paclitaxel chemotherapy regimen Review Status Final Biosimilar Dossier Issued Pre (...) Mvasi for Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar – Details Mvasi for Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar – Details | CADTH.ca Find the information you need Mvasi for Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar – Details Mvasi for Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar – Details Project Number pCODR 10158 Brand Name Mvasi Generic Name Bevacizumab Strength 100 mg and 400 mg Tumour

2019 CADTH - Pan Canadian Oncology Drug Review

35. Adjuvant Systemic Chemotherapy for Stage II and III Colon Cancer Following Complete Resection

, there is tumour penetration through the bowel wall beyond the submucosa, but there is no involvement of the regional lymph nodes or distant sites. Stage III disease involves metastases to regional lymph nodes. The overall survival (OS) of patients with stage II disease is 70% to 80% five years after surgery [19]. More than one-third of patients with colon carcinoma present with lymph node metastases (stage III), and more than one-half of those patients, initially treated for cure, relapse and later die (...) stage III colon cancer [20]. Many questions remained about other therapies. In 2008, the Gastrointestinal Disease Site Group (GI DSG) developed a systematic review (SR) and clinical practice guideline on adjuvant systemic chemotherapy for stage II and III colon cancer following complete resection. The guideline recommended adjuvant chemotherapy for stage III patients [21]. For those with stage II disease, adjuvant chemotherapy was to be an option considered for the subset of patients with high-risk

2019 Cancer Care Ontario

36. Post-polypectomy and post-colorectal cancer resection surveillance guidelines

words 3 | P a g e Abstract These consensus guidelines were jointly commissioned by the British Society of Gastroenterology, the Association of Coloproctology of Great Britain and Ireland and Public Health England. They provide an evidence-based framework for the use of surveillance colonoscopy and non-colonoscopic colorectal imaging in people aged 18 and over. They are the first guidelines that take into account the introduction of national bowel cancer screening. For the first time, they also (...) ); OR ? 5 or more premalignant polyps This cohort should undergo a one-off surveillance colonoscopy at 3 years. Post-CRC-resection patients should undergo a 1-year clearance colonoscopy, then a surveillance colonoscopy after 3 more years. Introduction Colorectal cancer (CRC) is a major cause of morbidity and mortality in the United Kingdom: more than 40,000 people are diagnosed and more than 16,000 people die from the disease each year.(1) The vast majority of CRCs arise from premalignant polyps

2019 British Society of Gastroenterology

37. Palpable Abdominal Mass-Suspected Neoplasm.

may help differentiate or further characterize the lesion. ???? X-ray abdomen 5 This procedure is a simple and inexpensive way to evaluate bowel for obstruction or constipation as the cause of the mass. ?? X-ray contrast enema 4 ??? X-ray upper GI series 4 ??? X-ray upper GI series with small bowel follow-through 4 ??? Rating Scale: 1,2,3 Usually not appropriate; 4,5,6 May be appropriate; 7,8,9 Usually appropriate *Relative Radiation Level ACR Appropriateness Criteria ® 2 Palpable Abdominal Mass (...) Palpable Abdominal Mass-Suspected Neoplasm. Date of origin: 1998 Last review date: 2014 ACR Appropriateness Criteria ® 1 Palpable Abdominal Mass American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Palpable Abdominal Mass Radiologic Procedure Rating Comments RRL* CT abdomen with IV contrast 9 Use of intravenous contrast may help better delineate the mass. ??? MRI abdomen without and with IV contrast 9 Use of intravenous contrast may help better delineate the mass. O

2019 American College of Radiology

38. Encorafenib, Binimetinib, and Cetuximab in <i>BRAF</i> V600E-Mutated Colorectal Cancer. (Abstract)

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer. Patients with metastatic colorectal cancer with the BRAF V600E mutation have a poor prognosis, with a median overall survival of 4 to 6 months after failure of initial therapy. Inhibition of BRAF alone has limited activity because of pathway reactivation through epidermal growth factor receptor signaling.In this open-label, phase 3 trial, we enrolled 665 patients with BRAF V600E-mutated metastatic colorectal (...) cancer who had had disease progression after one or two previous regimens. Patients were randomly assigned in a 1:1:1 ratio to receive encorafenib, binimetinib, and cetuximab (triplet-therapy group); encorafenib and cetuximab (doublet-therapy group); or the investigators' choice of either cetuximab and irinotecan or cetuximab and FOLFIRI (folinic acid, fluorouracil, and irinotecan) (control group). The primary end points were overall survival and objective response rate in the triplet-therapy group

2019 NEJM

39. Whole body MRI is effective for identifying metastatic disease in colorectal cancer patients. (Abstract)

Whole body MRI is effective for identifying metastatic disease in colorectal cancer patients. The studyTaylor S, Mallett S, Beare S et al. Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer: the prospective Streamline C trial. Lancet Gastroenterol Hepatol 2019;4:529-37.This project was funded by the NIHR Health Technology Assessment Programme (project number 10/68/01).To read the full NIHR Signal, go to https (...) ://discover.dc.nihr.ac.uk/content/signal-000797/identifying-metastatic-disease-in-colorectal-cancer-with-whole-body-mri.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

2019 BMJ

40. Follow-up strategies for patients treated for non-metastatic colorectal cancer. (Abstract)

Follow-up strategies for patients treated for non-metastatic colorectal cancer. This is the fourth update of a Cochrane Review first published in 2002 and last updated in 2016.It is common clinical practice to follow patients with colorectal cancer for several years following their curative surgery or adjuvant therapy, or both. Despite this widespread practice, there is considerable controversy about how often patients should be seen, what tests should be performed, and whether these varying (...) strategies have any significant impact on patient outcomes.To assess the effect of follow-up programmes (follow-up versus no follow-up, follow-up strategies of varying intensity, and follow-up in different healthcare settings) on overall survival for patients with colorectal cancer treated with curative intent. Secondary objectives are to assess relapse-free survival, salvage surgery, interval recurrences, quality of life, and the harms and costs of surveillance and investigations.For this update, on 5

2019 Cochrane