Latest & greatest articles for colorectal cancer

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on colorectal cancer or other clinical topics then use Trip today.

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Top results for colorectal cancer

81. Efficacy and Tolerability of First-Line Cetuximab Plus Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX-4) Versus FOLFOX-4 in Patients With RAS Wild-Type Metastatic Colorectal Cancer: The Open-Label, Randomized, Phase III TAILOR Trial Full Text available with Trip Pro

Efficacy and Tolerability of First-Line Cetuximab Plus Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX-4) Versus FOLFOX-4 in Patients With RAS Wild-Type Metastatic Colorectal Cancer: The Open-Label, Randomized, Phase III TAILOR Trial Cetuximab in combination with chemotherapy is a standard-of-care first-line treatment regimen for patients with RAS wild-type (wt) metastatic colorectal cancer (mCRC); however, the efficacy of cetuximab plus leucovorin, fluorouracil, and oxaliplatin (FOLFOX) has

2018 EvidenceUpdates

82. Bevacizumab (Mvasi) - Metastatic Colorectal Cancer (mCRC) or Locally Advanced, Metastatic or Recurrent Non-small Cell Lung Cancer (NSCLC)

Bevacizumab (Mvasi) - Metastatic Colorectal Cancer (mCRC) or Locally Advanced, Metastatic or Recurrent Non-small Cell Lung Cancer (NSCLC) Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product

2018 Health Canada - Drug and Health Product Register

83. Gastrointestinal Stromal Tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

–170. 8. Novelli M, Rossi S, Rodriguez-Justo M et al. DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology 2010; 57: 259–270. 9. Gasparotto D, Rossi S, Polano M et al. Quadruple-negative GIST is a sen- tinel for unrecognized neuro?bromatosis type 1 syndrome. Clin Cancer Res 2017; 23: 273–282. 10. Brierley JD, Gospodarowicz MK, Wittekind C. (eds). TNM Classi?cation of Malignant Tumours, 8th edn. Oxford: John Wiley & Sons, Inc. 2016. 11 (...) imatinib for high- risk GI stromal tumor: analysis of a randomized trial. J Clin Oncol 2016; 34: 244–250. 17. Dematteo RP, Ballman KV, Antonescu CR et al. Adjuvant imatinib mesy- late after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet 2009; 373: 1097–1104. 18. Gronchi A, Judson I, Nishida T et al. Adjuvant treatment of GIST with imatinib: solid ground or still quicksand? A comment on behalf of the EORTC Soft Tissue

2018 European Society for Medical Oncology

84. Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer. Full Text available with Trip Pro

subtype of squamous-cell carcinoma, adenocarcinoma, or adenosquamous carcinoma, we randomly assigned patients to undergo minimally invasive surgery or open surgery. The primary outcome was the rate of disease-free survival at 4.5 years, with noninferiority claimed if the lower boundary of the two-sided 95% confidence interval of the between-group difference (minimally invasive surgery minus open surgery) was greater than -7.2 percentage points (i.e., closer to zero).A total of 319 patients were (...) , body-mass index, stage of disease, lymphovascular invasion, and lymph-node involvement; minimally invasive surgery was also associated with a lower rate of overall survival (3-year rate, 93.8% vs. 99.0%; hazard ratio for death from any cause, 6.00; 95% CI, 1.77 to 20.30).In this trial, minimally invasive radical hysterectomy was associated with lower rates of disease-free survival and overall survival than open abdominal radical hysterectomy among women with early-stage cervical cancer. (Funded

2018 NEJM Controlled trial quality: predicted high

85. Updated 5-year survival and exploratory T x N subset analyses of ACTS-CC trial: a randomised controlled trial of S-1 versus tegafur-uracil/leucovorin as adjuvant chemotherapy for stage III colon cancer Full Text available with Trip Pro

Updated 5-year survival and exploratory T x N subset analyses of ACTS-CC trial: a randomised controlled trial of S-1 versus tegafur-uracil/leucovorin as adjuvant chemotherapy for stage III colon cancer Adjuvant Chemotherapy Trial of TS-1 for Colon Cancer (ACTS-CC), a randomised phase III trial, demonstrated that adjuvant therapy with S-1 for stage III colon cancer was non-inferior in 3-year disease-free survival (DFS) to that of tegafur-uracil plus leucovorin (UFT/LV). We updated DFS (...) and overall survival (OS) and performed T x N subset analysis.A total of 1518 patients with curatively resected stage III colon cancer were randomly assigned to receive S-1 (80-120  mg/day on days 1-28 every 42 days, four courses) or UFT/LV (UFT: 300-600  mg/day and LV: 75  mg/day on days 1-28 every 35 days, five courses).The 5-year DFS rates of the S-1 and UFT/LV group were 70.2 % and 66.9 %, respectively (HR 0.88; 95%  CI 0.74 to 1.06; p=0.177), and non-inferiority of DFS was reconfirmed with a median

2018 ESMO open Controlled trial quality: uncertain

86. Can nut consumption improve colon cancer survival? Full Text available with Trip Pro

Can nut consumption improve colon cancer survival? 30363796 2018 11 14 2415-1289 3 2018 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol Can nut consumption improve colon cancer survival? 73 10.21037/tgh.2018.09.14 Aune Dagfinn D Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Department of Nutrition, Bjørknes University College, Oslo, Norway. Department of Endocrinology, Morbid Obesity and Preventive Medicine

2018 Translational gastroenterology and hepatology

87. Surgical treatment of gastrointestinal stromal tumors of the duodenum: a literature review Full Text available with Trip Pro

Surgical treatment of gastrointestinal stromal tumors of the duodenum: a literature review Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumours in the digestive tract. The duodenal GIST (dGIST) is the rarest subtype, representing only 4-5% of all GIST, but up to 21% of the resected ones. The diagnostic and therapeutic management of dGIST may be difficult due to the rarity of this tumor, its anatomical location, and the clinical behavior that often mimic a variety (...) patients with dGIST: twenty-seven patients were treated with pancreatoduodenectomy and ninety-six with only local resection (segmental/wedge resections); in four hundred twenty-six patients it is not possible identify the type of treatment performed (pancreatoduodenectomy or segmental/wedge resections).dGISTs are a very rare subset of GISTs. They may be asymptomatic or may involve symptoms of upper GI bleeding and abdominal pain at presentation. Because of the misleading clinical presentation

2018 Translational gastroenterology and hepatology

88. Influence of Varying Quantitative Fecal Immunochemical Test Positivity Thresholds on Colorectal Cancer Detection: A Community-Based Cohort Study. Full Text available with Trip Pro

Influence of Varying Quantitative Fecal Immunochemical Test Positivity Thresholds on Colorectal Cancer Detection: A Community-Based Cohort Study. The fecal immunochemical test (FIT) is commonly used for colorectal cancer (CRC) screening. Despite demographic variations in stool hemoglobin concentrations, few data exist regarding optimal positivity thresholds by age and sex.To identify programmatic (multitest) FIT performance characteristics and optimal FIT quantitative hemoglobin positivity (...) thresholds in a large, population-based, screening program.Retrospective cohort study.Kaiser Permanente Northern and Southern California.Adults aged 50 to 75 years who were eligible for screening and had baseline quantitative FIT results (2013 to 2014) and 2 years of follow-up. Nearly two thirds (411 241) had FIT screening in the previous 2 years.FIT programmatic sensitivity for CRC and number of positive test results per cancer case detected, overall and by age and sex.Of 640 859 persons who completed

2018 Annals of Internal Medicine

89. Recent advances in colorectal cancer screening Full Text available with Trip Pro

Recent advances in colorectal cancer screening 30276360 2018 11 14 2589-0514 4 3 2018 Sep Chronic diseases and translational medicine Chronic Dis Transl Med Recent advances in colorectal cancer screening. 139-147 10.1016/j.cdtm.2018.08.004 Li Dan D Department of Gastroenterology, Kaiser Permanente Medical Center, Santa Clara, CA 95051, USA. Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA. eng Editorial 2018 09 17 China Chronic Dis Transl Med 101679934 2095 (...) -882X Colonoscopy Colorectal cancer Screening 2018 06 26 2018 10 3 6 0 2018 10 3 6 0 2018 10 3 6 1 epublish 30276360 10.1016/j.cdtm.2018.08.004 S2095-882X(18)30060-4 PMC6160607 Lancet. 2013 Apr 6;381(9873):1185-93 23414648 Am J Surg Pathol. 2004 Nov;28(11):1452-9 15489648 Gastroenterology. 2016 Nov;151(5):870-878.e3 27443823 CA Cancer J Clin. 2017 May 6;67(3):177-193 28248415 Gastroenterology. 2015 Sep;149(3):777-82; quiz e16-7 26226577 Am J Gastroenterol. 2012 Sep;107(9):1315-29; quiz 1314, 1330

2018 Chronic diseases and translational medicine

90. Effectiveness of a Mailed Colorectal Cancer Screening Outreach Program in Community Health Clinics: The STOP CRC Cluster Randomized Clinical Trial Full Text available with Trip Pro

percentage points; 95% CI, 0.1%-6.8%) and any colorectal cancer screening (18.3% vs 14.5%; difference, 3.8 percentage points; 95% CI, 0.6%-7.0%). We observed large variation across health centers in effectiveness (FIT completion differences range, -7.4 percentage points to 17.6 percentage points) and implementation (proportion who were mailed a FIT range, 6.5% to 68.2%). The number needed to mail to achieve a completed FIT was 4.8 overall, and 4.0 in clinics that mailed a FIT reminder.An EHR-embedded (...) Effectiveness of a Mailed Colorectal Cancer Screening Outreach Program in Community Health Clinics: The STOP CRC Cluster Randomized Clinical Trial Approximately 24 million US individuals receive care at federally qualified health centers, which historically have low rates of colorectal cancer screening. The US Preventive Services Task Force recommends routine colorectal cancer screening for individuals aged 50 to 75 years.To determine the effectiveness of an electronic health record (EHR

2018 EvidenceUpdates

91. Revisiting the prognostic relevance of muscle mass among non-metastatic colorectal cancer Full Text available with Trip Pro

Revisiting the prognostic relevance of muscle mass among non-metastatic colorectal cancer 30225389 2018 11 14 2415-1289 3 2018 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol Revisiting the prognostic relevance of muscle mass among non-metastatic colorectal cancer. 55 10.21037/tgh.2018.07.11 Abdel-Rahman Omar O Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Department of Oncology, University of Calgary, Tom Baker Cancer Centre (...) Cancer. 2013 Sep 15;119(18):3377-84 23801109 Clin Transl Oncol. 2018 Jun;20(6):794-800 29086248 Cancer. 2018 Jul 15;124(14):3008-3015 29797673 J Gastrointest Cancer. 2013 Jun;44(2):203-10 23264206 Gastrointest Cancer Res. 2007 Nov;1(6):248-53 19262903 J Cachexia Sarcopenia Muscle. 2018 Aug;9(4):664-672 29766660 Clin Colorectal Cancer. 2016 Mar;15(1):16-23 26281943 Ann Oncol. 2013 Oct;24 Suppl 6:vi64-72 24078664 J Nutr. 1994 Jun;124(6):906-10 7515956 J Cancer Surviv. 2012 Dec;6(4):398-406 23054848 Dig

2018 Translational gastroenterology and hepatology

92. New Development of Biomarkers for Gastrointestinal Cancers: From Neoplastic Cells to Tumor Microenvironment Full Text available with Trip Pro

New Development of Biomarkers for Gastrointestinal Cancers: From Neoplastic Cells to Tumor Microenvironment Biomarkers refer to a plethora of biological characteristics that can be quantified to facilitate cancer diagnosis, forecast the prognosis of disease, and predict a response to treatment. The identification of objective biomarkers is among the most crucial steps in the realization of individualized cancer care. Several tumor biomarkers for gastrointestinal malignancies have been applied (...) in the clinical setting to help differentiate between cancer and other conditions, facilitate patient selection for targeted therapies, and to monitor treatment response and recurrence. With the coming of the immunotherapy age, the need for a new development of biomarkers that are indicative of the immune response to tumors are unprecedentedly urgent. Biomarkers from the tumor microenvironment, tumor genome, and signatures from liquid biopsies have been explored, but the majority have shown a limited

2018 Biomedicines

93. Current treatment strategies in pediatric gastrointestinal stromal cell tumor Full Text available with Trip Pro

Current treatment strategies in pediatric gastrointestinal stromal cell tumor Gastrointestinal stromal tumors (GIST) are exceedingly rare tumors in the pediatric population. As a result, many clinicians either may never see this diagnosis or will encounter it only a few times throughout their careers. Additionally, the more we discover about this disease, it becomes evident that it represents a distinct clinical entity from adult GIST. Many of the treatments and strategies used to combat (...) the adult tumor are either ineffective or may be harmful to the pediatric population with this disease. The unique tumor biology found in pediatric GIST necessitates unique approaches and treatment strategies in order to achieve the best clinical outcome. This review aims to discuss the most recent data available on the different therapeutic modalities utilized in cases of Pediatric GIST.

2018 Translational gastroenterology and hepatology

94. Red and processed meat and risk of colorectal cancer: an update Full Text available with Trip Pro

Red and processed meat and risk of colorectal cancer: an update 30190669 2018 11 14 1611-2156 17 2018 EXCLI journal EXCLI J Red and processed meat and risk of colorectal cancer: an update. 792-797 10.17179/excli2018-1554 Benarba Bachir B Laboratory Research on Biological Systems and Geomatics, Faculty of Nature and Life,University of Mascara, Algeria. eng Journal Article 2018 08 08 Germany EXCLI J 101299402 1611-2156 2018 07 22 2018 08 06 2018 9 8 6 0 2018 9 8 6 0 2018 9 8 6 1 epublish 30190669 (...) 10.17179/excli2018-1554 2018-1554 Doc792 PMC6123610 Nutrition. 2018 May;49:17-23 29571606 Eur J Epidemiol. 2017 May;32(5):409-418 28646407 Eur J Cancer. 2018 Feb;90:73-82 29274927 Cancer Epidemiol. 2018 Aug;55:1-7 29753206 J Clin Med. 2018 Jan 30;7(2):null 29385768 Am J Clin Nutr. 2018 Mar 1;107(3):465-479 29566186 Meat Sci. 2014 Aug;97(4):583-96 24769880 PLoS One. 2015 Aug 25;10(8):e0135959 26305323 Clin Nutr. 2017 Jun;36(3):848-852 27206698 Clin Nutr. 2018 Jun;37(3):1019-1026 28526274 Curr Colorectal

2018 EXCLI journal

95. Macrophage repolarisation therapy in colorectal cancer Full Text available with Trip Pro

Macrophage repolarisation therapy in colorectal cancer 30116595 2018 08 17 2059-7029 3 5 2018 ESMO open ESMO Open Macrophage repolarisation therapy in colorectal cancer. e000426 10.1136/esmoopen-2018-000426 Halama Niels N Department of Medical Oncology and Internal Medicine VI, National Center for Tumor Diseases, UniversitatsKlinikum Heidelberg, Heidelberg, Germany. eng Journal Article 2018 08 03 England ESMO Open 101690685 2059-7029 Podcast Competing interests: None declared. 2018 8 18 6 0

2018 ESMO open

96. Colon cancer screening

for Disease Control and Prevention (CDC's) Screen for Life materials. Some participants also will be asked to read a personal narrative about colon cancer screening . This study will determine whether participant's perceptions about 2015 16. Colon Capsule to Screen for Colorectal Neoplasia in Subjects with a Family History of Colorectal Cancer . BACKGROUND AND AIMS: Colon capsule endoscopy (CCE) has been recognized as an alternative for colorectal cancer (CRC) screening in average risk subjects (...) administration is a key factor in the tolerability and efficacy of colon preparation in colorectal cancer screening ]. 236-42 10.1016/j.gastrohep.2012.01.012 The quality and tolerability of antegrade (...) gut lavage bowel preparation are key elements in the success of population-based colorectal cancer screening . To evaluate cleansing quality and tolerability according to the timing of polyethylene glycol administration in persons undergoing colorectal cancer screening . Participants in colorectal cancer

2018 Trip Latest and Greatest

97. Colorectal cancer

cancer (CRC) but also increases the risk for gastrointestinal (GI) and cerebral hemorrhages. OBJECTIVE: To assess the net balance of benefits and harms from routine aspirin use across clinically relevant age, sex 2016 7. The clinical effectiveness and cost-effectiveness of cetuximab (review of technology appraisal no. 176) and panitumumab (partial review of technology appraisal no. 240) for previously untreated metastatic colorectal cancer : a systematic review and economi The clinical effectiveness (...) (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for colorectal cancer The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many

2018 Trip Latest and Greatest

98. The Use of CT-Guided Marking for the Laparoscopic Resection of a Solitary Retroperitoneal Metastasis of Colon Cancer Full Text available with Trip Pro

to the tumor by the radiologist. During the surgery, the marker was clearly identified and the cutting line was determined to ensure a sufficient surgical margin. The tumor was laparoscopically resected as planned. The histopathologic diagnosis was adenocarcinoma, compatible with metastasis of colon cancer. The postoperative course was uneventful and the patient remained free of disease at 10 months after surgery. Conclusion: When resecting small tumors or tumors with an irregular margin, a marking (...) The Use of CT-Guided Marking for the Laparoscopic Resection of a Solitary Retroperitoneal Metastasis of Colon Cancer Background: CT-guided marking technique is rarely used in abdominal or urologic surgery. We developed and performed a marking technique for a small tumor, undetectable by ultrasound, using CT guidance before laparoscopic resection of the tumor. Case Presentation: A 73-year-old woman with a history of breast cancer underwent right colectomy with D3 lymph node dissection

2018 Journal of endourology case reports

99. Review gastrointestinal stromal tumors: to prospect the next decade Full Text available with Trip Pro

Review gastrointestinal stromal tumors: to prospect the next decade 30148231 2018 11 14 2415-1289 3 2018 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol Review gastrointestinal stromal tumors: to prospect the next decade. 46 10.21037/tgh.2018.07.07 Kanda Tatsuo T Sanjo General Hospital, Niigata, Japan. (Email: kandat@herb.ocn.ne.jp). eng Journal Article 2018 07 23 China Transl Gastroenterol Hepatol 101683450 2415-1289 Conflicts of Interest: The author has no conflicts

2018 Translational gastroenterology and hepatology

100. Colorectal sarcoma: more than a gastrointestinal stromal tumor Full Text available with Trip Pro

Colorectal sarcoma: more than a gastrointestinal stromal tumor Primary colorectal sarcomas have been defined as a rare and diverse group of mesenchymal cancers distinct from gastrointestinal stromal tumors (GISTs). Primary colorectal sarcomas have been recognized as a distinct entity from GISTs due to the dramatically worse prognosis these sarcomas carry. Also, primary colorectal sarcomas when compared to the more common colorectal adenocarcinoma, demonstrate more aggressive biology, present (...) at a younger age and carry worse outcomes. At this time, surgery remains the mainstay of treatment and adjuvant chemotherapy has an unclear role in treatment of primary colorectal sarcoma. This paper attempts to review the available data regarding primary colorectal sarcomas.

2018 Translational gastroenterology and hepatology