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Comparative safety of biologic versus conventional synthetic DMARDs in rheumatoid arthritis with COPD: a real-world population study Abatacept, a biologic DMARD, was associated with respiratory adverse events in a small subgroup of RA patients with chronicobstructivepulmonarydisease (COPD) in a trial. Whether this potential risk is specific to abatacept or extends to all biologics and targeted synthetic DMARDs (tsDMARDs) is unclear. We assessed the risk of adverse respiratory events (...) associated with biologic and tsDMARDs compared with conventional synthetic DMARDs (csDMARDs) among RA patients with concomitant COPD in a large, real-world cohort.We used a prevalent new-user design to study RA patients with COPD in the US-based MarketScan databases. New users of biologic DMARDs and/or tsDMARDs were matched on time-conditional propensity scores to new users of csDMARDs. Adverse respiratory events were estimated using Cox models comparing current use of biologic/tsDMARDs with csDMARDs.The
Abstract purpose : The aim of the study was to analyze the correlation between quantitative computed tomography (CT) parameters and airflowobstruction in patients with chronicobstructionpulmonarydisease (COPD). Methods: PubMed, Embase, Cochrane and Web of Knowledge were searched by two investigators from inception to 2018, using a combination of pertinent items to discover articles that investigated the relationship between CT measurements and lung function parameters in patients with COPD. Five (...) Jing Wu Qinghai University Dong Han Shaanxi Provincial People's Hospital Wei Guan Corresponding Author ORCiD: https://orcid.org/0000-0002-1080-0509 DOI: License: This work is licensed under a CC BY 4.0 License. Abstract Abstract purpose : The aim of the study was to analyze the correlation between quantitative computed tomography (CT) parameters and airflowobstruction in patients with chronicobstructionpulmonarydisease (COPD). Methods: PubMed, Embase, Cochrane and Web of Knowledge were searched
(on dyspnea), resistance training (on dyspnea and quality of life), early pulmonary rehabilitation commenced before hospital discharge during the initial most acute phase of exacerbation rather than the convalescence period (on dyspnea) and whole body vibration training (on quality of life). Vitamin D supplementation may improve quality of life (low SOE). Conclusions. Although chronicobstructivepulmonarydisease is a common condition, the evidence base for most interventions in ECOPD remains limited (...) Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD Systematic Review October 11, 2019 3.1 MB Related Files This report is available in PDF only ( [3.05 MB]; [211.1 KB]; [298.6 KB]). People using assistive technology may not be able to fully access information in these files. For additional assistance, please . Purpose of Review To evaluate the effectiveness and harms of pharmacologic and nonpharmacologic treatments for exacerbations of chronicobstructivepulmonary
Effect of a Hospital-Initiated Program Combining Transitional Care and Long-term Self-management Support on Outcomes of Patients Hospitalized With ChronicObstructivePulmonaryDisease: A Randomized Clinical Trial. Patients hospitalized for chronicobstructivepulmonarydisease (COPD) exacerbations have high rehospitalization rates and reduced quality of life.To evaluate whether a hospital-initiated program that combined transition and long-term self-management support for patients hospitalized (...) quality of life measured by the St George's Respiratory Questionnaire (SGRQ) at 6 months after discharge (score, 0 [best] to 100 [worst]; 4-point difference is clinically meaningful).Among 240 patients who were randomized (mean [SD] age, 64.9 [9.8] years; 61.7% women), 203 (85%) completed the study. The mean (SD) baseline SGRQ score was 62.3 (18.8) in the intervention group and 63.6 (17.4) in the usual care group. The mean number of COPD-related acute care events per participant at 6 months was 1.40
of Bias Appendix F. Results From Included Studies Appendix G. Results by Severity Appendix H. Adverse Events Appendix I. Inclusion and Exclusion Criteria of Included Studies Appendix J. Sensitivity Analysis Appendix K. Appendix References ES-1 Evidence Summary Background and Objectives Chronicobstructivepulmonarydisease (COPD) is a common respiratorydisease characterized by airflowlimitation and chronicrespiratory symptoms. The global prevalence is estimated to be greater than 10 percent (...) : MeiLan K. Han, M.D., M.S. University of Michigan Ann Arbor, MI Clare Hawkins, M.D. Aspire Health Care Houston, TX Cara Pasquale, M.P.H. COPD Patient Powered Research Network Washington, DC Antonello Punturieri, M.D., Ph.D. National Heart, Lung, and Blood Institute for ChronicObstructivePulmonaryDisease (COPD)/Environment Bethesda, MD Mark Steffen, M.D., M.P.H. Blue Cross and Blue Shield of Minnesota Eagan, MN James J. Stevermer, M.D., M.S.P.H. Department of Family and Community Medicine University
Current and future direct healthcare cost burden of chronicobstructivepulmonarydisease in Alberta, Canada Current and future direct healthcare cost burden of chronicobstructivepulmonarydisease in Alberta, Canada: Canadian Journal of Respiratory, Critical Care, and Sleep Medicine: Vol 0, No 0 | Search in: Journal Revue canadienne des soins respiratoires et critiques et de la médecine du sommeil 25 Views 0 CrossRef citations to date Altmetric Original Research Current and future direct (...) healthcare cost burden of chronicobstructivepulmonarydisease in Alberta, Canada , , , & Published online: 02 Jul 2019 Abstract OBJECTIVES: To examine the resource use and healthcare costs for chronicobstructivepulmonarydisease (COPD) in Alberta, Canada between 2008 and 2016 and model the future costs to 2030. METHODS: Interlinked hospitalization, ambulatory care, practitioner claims and drug databases in Alberta were used to identify COPD healthcare encounters and medications. Canadian Institution
in the medium term (over 5 years ) due to reduced all-cause mortality as well as proof of harm due to a short- term (up to 1 year postoperatively) increase in all-cause mortality. In terms of other outcomes, there were hints of benefit regarding dyspnea (as the only reported symptom of chronicobstructivepulmonarydisease [COPD]) and exacerbations as well as indications of benefit regarding improved exercise capacity and health-related quality of life. When compared to pulmonary rehabilitation (...) ? Dawid Pieper, Institute for Research in Operative Medicine, University Witten/Herdecke, Cologne, Germany ? Erich Stoelben, Lung Hospital Cologne-Merheim, Hospitals of Cologne City, Germany IQWiG thanks the external experts for their collaboration in the project. IQWiG employees ? Ulrike Paschen ? Christoph Mosch ? Stefan Sauerland ? Sibylle Sturtz ? Siw Waffenschmidt Keywords: Pneumonectomy, Bronchoscopy, PulmonaryEmphysema, Benefit Assessment Extract of final report N14-04 Version 1.0 LVR
the German original text is absolutely authoritative and legally binding. Extract IQWiG Reports – Commission No. H18-02 Targeted lung denervation using catheter ablation for chronicobstructivepulmonarydisease – Addendum to Commission H16-01 1 Extract of addendum H18-02 Version 1.0 Targeted lung denervation for COPD 27 April 2018 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Targeted lung (...) for COPD 27 April 2018 Institute for Quality and Efficiency in Health Care (IQWiG) - ii - IQWiG employees involved in the addendum: ? Martina Lietz ? Julia Kreis ? Fabian Lotz ? Stefan Sauerland Keywords: Catheter Ablation, PulmonaryDisease – ChronicObstructive, Assessment of Potential, Benefit Assessment Extract of addendum H18-02 Version 1.0 Targeted lung denervation for COPD 27 April 2018 Institute for Quality and Efficiency in Health Care (IQWiG) - iii - Executive summary On 22 March 2018
status”, “geographical region”, “visit”, “baseline” and the interaction terms for “baseline” and “visit” as well as for “treatment group” and “visit”. c: Institute’s calculation. CAT: COPD Assessment Test; COPD: chronicobstructivepulmonarydisease; CI: confidence interval; FF: fluticasone furoate; MD: mean difference; MMRM: mixed-effects model repeated measures; N: number of analysed patients; RCT: randomized controlled trial; SD: standard deviation; SGRQ: St. George`s Respiratory Questionnaire; SE (...) -responders. c: Patients with a reduction in SGRQ total score by = 4 points (a reduction in score indicates improvement). Patients with missing values at baseline or at the date of analysis were rated as non-responders. CAT: COPD Assessment Test; CI: confidence interval; COPD: chronicobstructivepulmonarydisease; FF: fluticasone furoate; n: number of patients with (at least one) event; N: number of analysed patients; RCT: randomized controlled trial; RR: relative risk; SGRQ: St. George`s Respiratory
more_vert close Download article Export article Sciwheel Download citation BibTeX RIS Share Email Prophylactic use of macrolide antibiotics for the prevention of chronicobstructivepulmonarydisease exacerbation: a meta-analysis. ARTICLE PUBLISHED: 2015 CITE AS: PLoS ONE. 2015 ; 10 ( 3 ): e0121257 Recommendations Abstract Comments You have reached your article limit. Register for 30-day free trial Registration is free and only takes a moment, or subscribe for unlimited access. Already registered (...) F1000Prime recommendation of Prophylactic use of macrolide antibiotics for the prevention of chronicobstructivepulmonarydisease exacerbation: a meta-analysis. Prophylactic use of macrolide antibiotics for the... | Faculty Opinions On April 12th, 2020, F1000Prime became Faculty Opinions. See our to learn more. Welcome Guest 1 Recommendations info_outline Systematic Review / Meta-analysis New Finding close Classified As New Finding 1 Article Type Systematic Review / Meta-analysis More
Association Between Long-term Exposure to Ambient Air Pollution and Change in Quantitatively Assessed Emphysema and Lung Function. While air pollutants at historical levels have been associated with cardiovascular and respiratorydiseases, it is not known whether exposure to contemporary air pollutant concentrations is associated with progression of emphysema.To assess the longitudinal association of ambient ozone (O3), fine particulate matter (PM2.5), oxides of nitrogen (NOx), and black carbon (...) exposure with change in percent emphysema assessed via computed tomographic (CT) imaging and lung function.This cohort study included participants from the Multi-Ethnic Study of Atherosclerosis (MESA) Air and Lung Studies conducted in 6 metropolitan regions of the United States, which included 6814 adults aged 45 to 84 years recruited between July 2000 and August 2002, and an additional 257 participants recruited from February 2005 to May 2007, with follow-up through November 2018.Residence-specific
(2006) Heart failure and chronicobstructivepulmonarydisease: An ignored combination? Eur J Heart Fail 8: 706-711. Link: Iversen KK, Kjaergaard J, Akkan D, Kober L, Torp-Pedersen C, et al. (2010) The prognostic importance of lung function in patients admitted with heart failure. Eur J Heart Fail 2: 685-691. Link: Brenner S, Guder G, Berliner D, Deubner N, Fröhlich K, et al. (2013) Airwayobstruction in systolic heart failure–COPD or congestion? Int J Cardiol. 168: 1910-1916. Link: Salpeter SR (...) Khafaji HA, Cheema A (2019) Heart failure and chronicobstructiveairwaydisease as combined comorbidities. Meta-analysis and Review. Arch Pulmonol Respir Care 5(1): 015-022. DOI: Background: The existence of COPD and heart failure in elderly population adds additional morbidity and mortality risk than if those with only one of the two comorbidities. The aim of the current meta-analysis was to explore the effect of COPD on heart failure patient in terms of all-cause mortality, cardiac mortality
Statins versus placebo for people with chronicobstructivepulmonarydisease. Chronicobstructivepulmonarydisease (COPD) is a common, preventable, and treatable respiratorydisease. COPD exacerbations are associated with worse quality of life, increased hospitalisations, and increased mortality. Currently available pharmacological interventions have variable impact on exacerbation frequency. The anti-inflammatory effects of statins may lead to decreased pulmonary and systemic inflammation (...) , resulting in fewer exacerbations of COPD. Several observational studies have shown potential benefits of statins for patients with COPD.This review aims to evaluate available evidence on benefits and harms associated with statin therapy compared with placebo as adjunct therapy for patients with COPD. Primary objectives include the following.• To determine whether statins reduce mortality rates in COPD.• To determine whether statins reduce exacerbation frequency, improve quality of life, or improve lung
2019CochraneControlled trial quality: predicted high
of TCM Cheng-xiang Wang Beijing University of TCM Mei Han Corresponding Author DOI: License: This work is licensed under a CC BY 4.0 License. View the published version . Abstract Abstract Objective: To investigate the clinical characteristics between the frequent exacerbator with chronic bronchitis (FE-CB) phenotype and the non-exacerbator (NE) phenotype among patients with chronicobstructivepulmonarydisease (COPD). Methods: We searched CNKI, Wan fang, Chongqing VIP, China Biology Medicine disc (...) : To investigate the clinical characteristics between the frequent exacerbator with chronic bronchitis (FE-CB) phenotype and the non-exacerbator (NE) phenotype among patients with chronicobstructivepulmonarydisease (COPD). Methods: We searched CNKI, Wan fang, Chongqing VIP, China Biology Medicine disc, PubMed, Cochrane Library, and EMBASE databases for relevant studies published as of April 30, 2019. All studies that investigated COPD patients with the FE-CB and NE phenotypes and which qualified
C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations. Point-of-care testing of C-reactive protein (CRP) may be a way to reduce unnecessary use of antibiotics without harming patients who have acute exacerbations of chronicobstructivepulmonarydisease (COPD).We performed a multicenter, open-label, randomized, controlled trial involving patients with a diagnosis of COPD in their primary care clinical record who consulted a clinician at 1 of 86 general medical (...) practices in England and Wales for an acute exacerbation of COPD. The patients were assigned to receive usual care guided by CRP point-of-care testing (CRP-guided group) or usual care alone (usual-care group). The primary outcomes were patient-reported use of antibiotics for acute exacerbations of COPD within 4 weeks after randomization (to show superiority) and COPD-related health status at 2 weeks after randomization, as measured by the Clinical COPD Questionnaire, a 10-item scale with scores ranging
Oxygen compared to air during exercise training in COPD with exercise-induced desaturation Almost half the patients referred to pulmonary rehabilitation with chronicobstructivepulmonarydisease (COPD) desaturate during exercise. Although oxygen supplementation may ameliorate oxygen desaturation, the effects on outcomes of exercise training have not been rigorously evaluated. This study aimed to determine whether supplemental oxygen during exercise training was more effective than medical air (...) at 5 L·min-1 during exercise training consisting of treadmill and cycle exercise, three times per week for 8 weeks. Primary outcomes were the endurance shuttle walk test (ESWT) time and ChronicRespiratoryDisease Questionnaire (CRQ)-Total score.111 participants (60 males), mean±sd age 69±7 years, with moderate to severe COPD were recruited and 97 completed (Oxygen group n=52; Air group n=45). At the end of the 8-week training programme there were no between-group differences in change in ESWT
puffers, does three-of-kind beat a pair? Clinical Question: In ChronicObstructivePulmonaryDisease (COPD) patients on Long-Acting Muscarinic Antagonist (LAMA) and Long-Acting Beta-Agonist (LABA) dual therapy, does adding inhaled corticosteroids (ICS) improve outcomes? Bottom Line: In COPD patients with =1 exacerbation per year, triple therapy reduces the risk of future exacerbations compared to LAMA/LABA dual therapy (one less in 36 patients/year) but increases the risk of pneumonia (one more in 34 (...) . 4. Cazzola M, Rogliani P, Calzetta L, et al. Eur Respir J. 2018; 52:1801586. 5. Ferguson GT, Rabe KF, Martinez FJ, et al. Lancet Respir. 2018; 6(10):747-58. 6. Global Initiative for ChronicObstructiveLungDisease. (2019). Global strategy for the diagnosis, management, and prevention of chronicobstructivepulmonarydisease. Available at https://goldcopd.org/gold-reports/ Accessed: May 11, 2019. 7. Magnussen H, Disse B, Rodriguez-Roisin R, et al. N Engl J Med. 2014; 371: 1285- 94. 8. Chapman KR
with chronicobstructivepulmonarydisease (COPD) has been limited by an absence of rigorous evidence-based studies supporting use. Our objective were to report and summarise the current evidence supporting use of nutritional supplementation to improve outcomes during pulmonary rehabilitation in stable COPD patients. Methods A systematic search was conducted up to May 7 th , 2019 (registration number CRD42018089142). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (...) Nutritional Supplementation during Pulmonary Rehabilitation in COPD: A Systematic Review Nutritional Supplementation during Pulmonary Rehabilitation in COPD: A Systematic Review | medRxiv Search for this keyword Nutritional Supplementation during Pulmonary Rehabilitation in COPD: A Systematic Review Abdulelah M Aldhahir , Ahmed M Al Rajah , Yousef S Aldabayan , Salifu Drammeh , Vanitha Subbu , Jaber S Alqahtani , John R Hurst , Swapna Mandal doi: https://doi.org/10.1101/19000786 Abdulelah M