Latest & greatest articles for corticosteroids

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on corticosteroids or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on corticosteroids and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for corticosteroids

21. Are corticosteroid injections needed after needling and lavage of calcific tendinitis? Randomised, double-blind, non-inferiority trial (Abstract)

Are corticosteroid injections needed after needling and lavage of calcific tendinitis? Randomised, double-blind, non-inferiority trial Steroid injections are common after an ultrasound-guided puncture and lavage (UGPL) of calcific tendonitis of the rotator cuff. However, steroids may prevent calcification resorption and negatively affect tendon healing. Our study was designed to determine whether saline solution was non-inferior to steroids in the prevention of acute pain reactions in the week

2019 EvidenceUpdates

22. Should HIV-uninfected patients with Pneumocystis pneumonia be treated with corticosteroids?

Should HIV-uninfected patients with Pneumocystis pneumonia be treated with corticosteroids? Chiefs’ Inquiry Corner – March 17th, 2019 – Clinical Correlations Search Chiefs’ Inquiry Corner – March 17th, 2019 March 18, 2019 3 min read Propofol is a short-acting, intravenous sedative-hypnotic that is metabolized by the liver and excreted in the urine as conjugates of 2,6-diisopropyl-1,4 quinol. The pharmacokinetics of propofol favor its use for the induction/maintenance of anesthesia (...) with HIV have a mortality of 20-50%, higher than in patients with HIV. A recent retrospective study of 323 patients with PCP concluded that the addition of early corticosteroids to anti-Pneumocystis therapy in patients without HIV was not associated with improved respiratory outcomes. Other, older studies have also shown no benefit, or even some evidence of harm in this population. References: Share: | | Sites We Follow: Useful Links: Questions? Comments? Contact us! © New York University. All rights

2019 Clinical Correlations

23. Tralokinumab did not demonstrate oral corticosteroid-sparing effects in severe asthma Full Text available with Trip Pro

Tralokinumab did not demonstrate oral corticosteroid-sparing effects in severe asthma Long-term oral corticosteroid (OCS) use in patients with severe asthma is associated with significant adverse effects.This 40-week, randomised, double-blind trial evaluated the OCS-sparing potential of tralokinumab in patients with severe, uncontrolled asthma requiring maintenance OCS treatment plus inhaled corticosteroids/long-acting β2-agonists. Overall, 140 patients were randomised to tralokinumab 300 mg

2019 EvidenceUpdates

24. Comparison Between Corticosteroid and Lidocaine Injection in the Treatment of Tennis Elbow: A Randomized, Double-Blinded, Controlled Trial. (Abstract)

Comparison Between Corticosteroid and Lidocaine Injection in the Treatment of Tennis Elbow: A Randomized, Double-Blinded, Controlled Trial. The aim of the study was to compare the effects of corticosteroid injection with lidocaine injection in treating tennis elbow.It is a prospective, double-blinded, randomized controlled trial. Patients with tennis elbow for more than 1 mo were recruited from a hospital-based rehabilitation outpatient clinic. A total of 70 patients were recruited, and 61 (...) patients completed the study. Patients received an injection of either 10 mg (1 ml) of triamcinolone (corticosteroid group, n = 30) or 1 ml of 1% lidocaine (lidocaine group, n = 31). All of the outcome measures were evaluated before the intervention and at 2 wks and 2 mos after treatment.No significant group differences were observed between the corticosteroid and lidocaine groups regarding Patient-Rated Tennis Elbow Evaluation, Disability of the Arm, Shoulder, and Hand, visual analog scale for pain

2019 American journal of physical medicine & rehabilitation Controlled trial quality: predicted high

25. Comparison of Infection Risk with Corticosteroid or Hyaluronic Acid Injection Prior to Total Knee Arthroplasty (Abstract)

Comparison of Infection Risk with Corticosteroid or Hyaluronic Acid Injection Prior to Total Knee Arthroplasty Recent studies have shown that intra-articular injections ≤3 months before total knee arthroplasty increase the risk of periprosthetic joint infection. We are aware of no previous study that has differentiated the risk of periprosthetic joint infection on the basis of the type of medication injected. In addition, we are aware of no prior study that has evaluated whether hyaluronic acid (...) injections increase the risk of infection after total knee arthroplasty. In this study, we utilized pharmaceutical data to compare patients who received preoperative corticosteroid or hyaluronic acid injections and to determine whether a specific injection type increased the risk of periprosthetic joint infection.Patients undergoing unilateral primary total knee arthroplasty were selected from a nationwide private insurer database. Ipsilateral preoperative injections were identified and were grouped

2019 EvidenceUpdates

26. A Randomized Control Trial of Comparing Ultrasound-Guided Ozone (O2-O3) vs Corticosteroid Injection in Patients With Shoulder Impingement. (Abstract)

A Randomized Control Trial of Comparing Ultrasound-Guided Ozone (O2-O3) vs Corticosteroid Injection in Patients With Shoulder Impingement. Ozone has been recently used as a safe alternative treatment in musculoskeletal disorders with fewer adverse effects than corticosteroids. The aim of this study was to compare the efficacy of a single injection of ozone with that of a corticosteroid in the treatment of shoulder impingement.Thirty patients with shoulder pain and clinical signs and symptoms (...) of impingement were randomly assigned into two groups: ultrasound-guided injection with ozone or corticosteroid. Patients' symptoms were evaluated by visual analog scale, constant score, shoulder pain and disability scale, shoulder range of motion, and ultrasonographic measures before treatment, 2 wks, and 2 mos after injections.Patients' visual analog scale, shoulder pain and disability scale and constant score improved significantly in both groups (P < 0.001), but the benefits were in favor

2019 American journal of physical medicine & rehabilitation Controlled trial quality: uncertain

27. Carpal Tunnel Release Surgery Plus Intraoperative Corticosteroid Injection versus Carpal Tunnel Release Surgery Alone: A Double Blinded Clinical Trial. (Abstract)

Carpal Tunnel Release Surgery Plus Intraoperative Corticosteroid Injection versus Carpal Tunnel Release Surgery Alone: A Double Blinded Clinical Trial. Background: Carpal tunnel syndrome is a prevalent disease with significant morbidity. The current treatments range from oral medication and local corticosteroid injection to surgical carpal tunnel release (CTR). In this study, we tried to assess the results of Carpal Tunnel Release surgery in combination with the anti-inflammatory effect (...) of local corticosteroid injection. Methods: 65 patients were enrolled by clinical and electrodiagnostic tests and randomly divided into two groups, 32 in group one which underwent surgery with Dexamethasone injection and 33 in group 2 which intervened with carpal tunnel release surgery alone. Data on Boston questionnaire of patients were conducted before and two weeks after surgery. Distal motor and sensory latencies of patients were recorded before and two months after surgery. Mean values were

2019 The journal of hand surgery Asian-Pacific volume Controlled trial quality: uncertain

28. A Randomized Trial of a Long-Acting Depot Corticosteroid Versus Dexamethasone to Prevent Headache Recurrence Among Patients With Acute Migraine Who Are Discharged From an Emergency Department (Abstract)

A Randomized Trial of a Long-Acting Depot Corticosteroid Versus Dexamethasone to Prevent Headache Recurrence Among Patients With Acute Migraine Who Are Discharged From an Emergency Department Migraine patients continue to report headache during the days and weeks after emergency department (ED) discharge. Dexamethasone is an evidence-based treatment of acute migraine that decreases the frequency of moderate or severe headache within 72 hours of ED discharge. We hypothesize that intramuscular

2019 EvidenceUpdates

29. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature (Abstract)

Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature This review provides an overview of the role of long-term treatment of severe asthma with oral corticosteroids (OCS) and its associated side-effects in adults. It is based on a systematic literature search conducted in MEDLINE, Embase and the Cochrane Library to identify relevant studies. After a short overview of severe asthma and its (...) , studies showed a significant increase in healthcare resource utilisation due to OCS treatment. Therefore, it is incumbent on every clinician to carefully weigh the potential benefit of preventing loss of asthma control against this risk before opting to prescribe long-term OCS therapy. Effective corticosteroid-sparing strategies must be used and should aim at short-term use with the lowest effective dose and start tapering as soon as possible until OCS therapy is terminated.Copyright ©ERS 2018.

2018 EvidenceUpdates

30. Corticosteroids Provide Better Postoperative Endodontic Pain Relief Compared to Placebo (CAT#3350)

Corticosteroids Provide Better Postoperative Endodontic Pain Relief Compared to Placebo (CAT#3350) UTCAT3350, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Corticosteroids Provide Better Postoperative Endodontic Pain Relief Compared to Placebo Clinical Question In patients receiving non-surgical endodontic therapy, do corticosteroids provide better postoperative endodontic pain relief compared to placebo? Clinical (...) Bottom Line Corticosteroids provide better postoperative endodontic pain relief compared to placebo. Different types and dosages of corticosteroids have different levels of analgesic efficacy. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Shamszadeh/2018 1088 patients in 18 Randomized clinical trials Systematic Review and Meta-Analysis Key results Patients who received corticosteroids had greater

2018 UTHSCSA Dental School CAT Library

31. The Effect of Local Versus Intravenous Corticosteroids on the Likelihood of Dysphagia and Dysphonia Following Anterior Cervical Discectomy and Fusion: A Single-Blinded, Prospective, Randomized Controlled Trial (Abstract)

The Effect of Local Versus Intravenous Corticosteroids on the Likelihood of Dysphagia and Dysphonia Following Anterior Cervical Discectomy and Fusion: A Single-Blinded, Prospective, Randomized Controlled Trial Dysphagia and dysphonia are the most common postoperative complications following anterior cervical discectomy and fusion (ACDF). Although most postoperative dysphagia is mild and transient, severe dysphagia can have profound effects on overall patient health and on surgical outcomes

2018 EvidenceUpdates

32. Are Corticosteroids Beneficial in the Treatment of Community-Acquired Pneumonia? (SRS Therapy)

Are Corticosteroids Beneficial in the Treatment of Community-Acquired Pneumonia? (SRS Therapy) TAKE-HOME MESSAGE For adult patients with severe community-acquired pneumonia, corticosteroids reduce morbidity and mortality. For pediatric patients and adults with nonsevere community-acquired pneumonia, corticosteroids appear to reduce morbidity, but not mortality. Are Corticosteroids Bene?cial in the Treatment of Community-Acquired Pneumonia? EBEM Commentators Thomas Seagraves, MD Michael Gottlieb (...) , MD Department of Emergency Medicine Rush University Medical Center Chicago, IL Results Comparison of corticosteroids with control for community-acquired pneumonia. Outcome No. of Studies (No. of Participants) Relative Risk (95% CI) I 2 ,% Mortality (adults with severe CAP) 9 (995) 0.58 (0.40–0.84) 12 Mortality (adults with nonsevere CAP) 4 (868) 0.95 (0.45–2.00) 0 Early clinical failure (adults with severe CAP) 5 (419) 0.32 (0.15–0.70) 74 Early clinical failure (adults with nonsevere CAP) 2 (905

2018 Annals of Emergency Medicine Systematic Review Snapshots

33. Do Corticosteroids Improve Mortality or Shock Reversal in Patients With Septic Shock? (SRS therapy)

is a potentially deadly con- dition. Primary treatments include sourcecontrol,antimicrobials,and resuscitation with hemodynamic support (intravenous?uids and va- sopressors).Inaddition,thereexist several accepted indications for corticosteroid therapy in patients with sepsis including immunosup- pression and adrenal insuf?- ciency. 8-11 One of the most common steroid regimens used is hydrocortisone at less than 400 Results of included trials. Study Intervention Mean OR for Shock Reversal (95% CI) Mean (...) Do Corticosteroids Improve Mortality or Shock Reversal in Patients With Septic Shock? (SRS therapy) TAKE-HOME MESSAGE No studied corticosteroid regimen is superior to placebo or any other regimen in patient-centered outcomes including mortality; however, hydrocortisone infusion improves shock reversal compared with placebo or methylprednisolone. Do Corticosteroids Improve Mortality or Shock Reversal in Patients With Septic Shock? EBEM Commentators Brit Long, MD Michael D. April, MD, DPhil

2018 Annals of Emergency Medicine Systematic Review Snapshots

34. Are Corticosteroids Superior to Nonsteroidal Anti-inflammatory Drugs in the Treatment of Acute Gout? (SRS Therapy)

?ciency, liver dysfunction, and bleeding disorders, and discouraged in the elderly and patients with a history of peptic ulcer disease. 7 Adverse effects of corticosteroids such as immunosuppression, adrenal suppression, glaucoma, myopathy, osteoporosis, or psychiatric disturbances are generally thought to be dose and duration dependent; prescribing for patients with underlying diabetes mellitus, active infections, or psychiatric conditions must be carefully considered. 8 Several studies, including (...) Are Corticosteroids Superior to Nonsteroidal Anti-inflammatory Drugs in the Treatment of Acute Gout? (SRS Therapy) TAKE-HOME MESSAGE Corticosteroids provide pain relief similar to that of nonsteroidal anti- in?ammatory drugs for acute gout, with fewer adverse effects. Are Corticosteroids Superior to Nonsteroidal Anti-in?ammatory Drugs in the Treatment of Acute Gout? EBEM Commentators Joseph W. Watkins IV, MD Rawle A. Seupaul, MD Department of Emergency Medicine University of Arkansas

2018 Annals of Emergency Medicine Systematic Review Snapshots

35. The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial. Full Text available with Trip Pro

The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial. To our knowledge, the comparative effectiveness of commonly used conservative treatments for carpal tunnel syndrome has not been evaluated previously in primary care. We aimed to compare the clinical and cost-effectiveness of night splints with a corticosteroid injection with regards to reducing symptoms (...) with the European Clinical Trials Database, number 2013-001435-48, and ClinicalTrial.gov, number NCT02038452.Between April 17, 2014, and Dec 31, 2016, 234 participants were randomly assigned (118 to the night splint group and 116 to the corticosteroid injection group), of whom 212 (91%) completed the BCTQ at 6 weeks. The BCTQ score was significantly better at 6 weeks in the corticosteroid injection group (mean 2·02 [SD 0·81]) than the night splint group (2·29 [0·75]; adjusted mean difference -0·32; 95% CI -0·48

2018 Lancet Controlled trial quality: predicted high

36. Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial. Chronic obstructive pulmonary disease (COPD) is a major global health issue and theophylline is used extensively. Preclinical investigations have demonstrated that low plasma concentrations (1-5 mg/L) of theophylline enhance antiinflammatory effects of corticosteroids in COPD.To investigate the effectiveness of adding low-dose theophylline to inhaled corticosteroids (...) in COPD.The TWICS (theophylline with inhaled corticosteroids) trial was a pragmatic, double-blind, placebo-controlled, randomized clinical trial that enrolled patients with COPD between February 6, 2014, and August 31, 2016. Final follow-up ended on August 31, 2017. Participants had a ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) of less than 0.7 with at least 2 exacerbations (treated with antibiotics, oral corticosteroids, or both) in the previous year and were

2018 JAMA Controlled trial quality: predicted high

37. School-supervised use of a once-daily inhaled corticosteroid regimen: A cluster randomized trial Full Text available with Trip Pro

School-supervised use of a once-daily inhaled corticosteroid regimen: A cluster randomized trial School-supervised use of a once-daily inhaled corticosteroid regimen (supervised therapy) can improve medication adherence and asthma control.We sought to evaluate the effectiveness of supervised therapy in a unique setting and population.We conducted a cluster randomized trial of supervised therapy in 20 elementary schools with a disproportionate enrollment of low-income Latino students. Schools

2018 EvidenceUpdates

38. Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes

and adrenal suppression. Intended Users Maternity care providers including midwives, family physicians, and obstetricians. Target Population Pregnant women. Evidence Medline, PubMed, Embase, and the Cochrane Library were searched from inception to September 2017. Medical Subject Heading (MeSH) terms and key words related to pregnancy, prematurity, corticosteroids, and perinatal and neonatal mortality and morbidity were used. Statements from professional organizations including that of the National (...) Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes No. 364-Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 40, Issue 9, Pages 1219–1239 No. 364-Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes x Amanda Skoll , MD * Vancouver, BC x Amélie Boutin , PhD * Québec City, QC x Emmanuel Bujold , MD, MSc Québec City, QC x Jason

2018 Society of Obstetricians and Gynaecologists of Canada

39. Efficacy of Rituximab vs Tacrolimus in Pediatric Corticosteroid-Dependent Nephrotic Syndrome: A Randomized Clinical Trial Full Text available with Trip Pro

Efficacy of Rituximab vs Tacrolimus in Pediatric Corticosteroid-Dependent Nephrotic Syndrome: A Randomized Clinical Trial Calcineurin inhibitors are an established first-line corticosteroid-sparing therapy for patients with corticosteroid-dependent nephrotic syndrome (CDNS), whereas B-lymphocyte-depleting therapy is mostly used as a rescue for calcineurin inhibitor-resistant cases. The positive efficacy and safety profile of rituximab raises the question of whether it could be used as a first (...) -line alternative to calcineurin inhibitor therapy.To compare the efficacy of rituximab and tacrolimus in maintaining relapse-free survival among children with CDNS.A parallel-arm, open-label, randomized clinical trial was performed from May 8, 2015, to September 20, 2016, with 1-year follow-up in a single-center, tertiary care unit. A total of 176 consecutive children aged 3 to 16 years with CDNS not previously treated with corticosteroid-sparing agents were screened for eligibility.The children

2018 EvidenceUpdates

40. Low back pain: no corticosteroids

Low back pain: no corticosteroids Prescrire IN ENGLISH - Spotlight ''Low back pain: no corticosteroids '', 1 September 2018 {1} {1} {1} | | > > > Low back pain: no corticosteroids Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Low back pain: no corticosteroids There is no evidence that systemic corticosteroids have any efficacy on low back pain (...) , beyond a placebo effect. Furthermore, they expose patients to numerous adverse effects. Low back pain is common in adults. It is sometimes accompanied by pain spreading into the lower limbs (radiculalgia). In most cases, it improves spontaneously, within a few days or weeks. When low back pain persists for more than three months, it is termed chronic. In most cases, there is no identifiable cause. Several trials have compared systemic corticosteroid therapy with a placebo. Their results converge

2018 Prescrire