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Latest & greatest articles for corticosteroids
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on corticosteroids or other clinical topics then use Trip today.
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/therapeutic use; Administration, Inhalation; Adolescent; AdrenalCortexHormones /economics /therapeutic use; Adult; Albuterol /analogs & Asthma /drug therapy /economics; Bronchodilator Agents /economics /therapeutic use; Child; Drug Therapy, Combination; Female; Health Care Costs; Health Maintenance Organizations; Humans; Male; Quinolines /economics /therapeutic use; Salmeterol Xinafoate; derivatives /economics /therapeutic use AccessionNumber 22002000664 Date bibliographic record published 31/05/2004 (...) Inhaled corticosteroids plus salmeterol or montelukast: effects on resource utilization and costs Inhaled corticosteroids plus salmeterol or montelukast: effects on resource utilization and costs Inhaled corticosteroids plus salmeterol or montelukast: effects on resource utilization and costs Stempel D A, O'Donnell J C, Meyer J W Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary
review. Pain 2002; 96(1-2): 23-40 PubMedID Indexing Status Subject indexing assigned by NLM MeSH AdrenalCortexHormones /administration & Humans; Randomized Controlled Trials as Topic; Tennis Elbow /drug therapy; dosage AccessionNumber 12002001316 Date bibliographic record published 30/06/2004 Date abstract record published 30/06/2004 Record Status This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each critical abstract contains a brief summary (...) Corticosteroid injections for lateral epicondylitis: a systematic review Corticosteroid injections for lateral epicondylitis: a systematic review Corticosteroid injections for lateral epicondylitis: a systematic review Smidt N, Assendelft W J, van der Windt D A, Hay E M, Buchbinder R, Bouter L M Authors' objectives To evaluate the effectiveness of corticosteroid injections for lateral epicondylitis. Searching MEDLINE, EMBASE and CINAHL were searched from inception to July 1999
Corticosteroids for the Prevention of Reintubation and Postextubation Stridor in Pediatric Patients: A Meta-Analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. Long-acting beta(2)-agonists are prescribed for patients with persistent asthma and are sometimes used without inhaled corticosteroids (ICSs). No evidence exists, however, to support their use as monotherapy in adults with persistent asthma.To examine the effectiveness of salmeterol xinafoate, a long-acting beta(2)-agonist, as replacement
Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. Inhaled long-acting beta(2)-agonists improve asthma control when added to inhaled corticosteroid (ICS) therapy.To determine whether ICS therapy can be reduced or eliminated in patients with persistent asthma after adding a long-acting beta(2)-agonist to their treatment regimen.A 24-week randomized, controlled, blinded, double-dummy, parallel-group trial
Corticosteroids for induction of labour. The role of corticosteroids in the process of labour is not well understood. Animal studies have shown the importance of cortisol secretion by the fetal adrenal gland in initiating labour in sheep. Infusion of glucocorticosteroids into the fetus has also shown to induce premature labour in sheep. Some assumptions have been proposed regarding the mode of action of corticosteroids, including both a paracrine and autocrine action, following (...) the identification of glucocorticoid receptors on human amnion. Given these studies it has been postulated that corticosteroids given intraamniotically will promote the induction of labour. This is one of a series of reviews of methods of cervical ripening and labour induction using standardised methodology.To determine the effects of corticosteroids for third trimester cervical ripening or induction of labour in comparison with other methods of cervical priming or induction of labour.The Cochrane Pregnancy
trials of corticosteroids treatment for chronic inflammatory demyelinating polyradiculoneuropathy and enquiry from subject experts.Types of studies: All randomised or quasi-randomised trials Types of participants: All patients with chronic inflammatory demyelinating polyradiculoneuropathy who were diagnosed by an internationally accepted definition. Types of interventions: Treatment with any form of corticosteroid or adrenocorticotropic hormone. Types of outcome measures:Change in disability 12 weeks (...) Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy. Chronic inflammatory demyelinating polyradiculoneuropathy is an autoimmune peripheral neuropathy and would be expected to benefit from corticosteroids. Non-randomised studies suggest that corticosteroids are often beneficial.To evaluate the efficacy of corticosteroids for treating chronic inflammatory demyelinating polyradiculoneuropathy.Search of the Cochrane Neuromuscular Disease Group register for randomised
Addition of anti-leukotriene agents to inhaled corticosteroids for chronic asthma. Anti-leukotriene (AL) agents are being considered as "add-on" therapy to inhaled corticosteroids (ICS), in chronic asthma.To examine the safety and efficacy of daily AL plus ICS compared to ICS alone, and determine the corticosteroid-sparing effect of AL when added to ICS in chronic asthma.We searched Medline, Embase, Cinahl (all up to 2001), reference lists of review articles and trials, contacted international (...) of ICS was 300-2000 mcg beclomethasone-equivalent. In symptomatic adults, AL (at 2-4 times licensed dose) combined with ICS reduced the number of patients with exacerbations that required systemic corticosteroids, compared to ICS alone [Relative Risk (RR) = 0.34; 95% Confidence Interval (CI) 0.13, 0.88]. This equates to 20 patients (95% CI 1,100 patients) treated to prevent one needing systemic corticosteroids. There was no difference in side effects. No trials tested the efficacy of licensed doses
Non-corticosteroid treatment for nephrotic syndrome in children. Eighty to ninety per cent children with steroid sensitive nephrotic syndrome (SSNS) have one or more relapses. About half of these children relapse frequently and are at risk of the adverse effects of corticosteroids. Non-corticosteroid immunosuppressive agents are used to prolong periods of remission in children, who relapse frequently. However these non-corticosteroid agents also have significant potential adverse effects (...) . Currently there is no consensus as to the most appropriate second line agent in children who are steroid sensitive, but who continue to relapse. In this systematic review of randomised controlled trials (RCTs), the benefits and harms of these immunosuppressive agents are evaluated.To evaluate the benefits and harms of non-corticosteroid immunosuppressive agents in relapsing SSNS in children.Published and unpublished randomised controlled trials were identified from the Cochrane Controlled Trials
Gold as an oral corticosteroid sparing agent in stable asthma. Patients with chronic severe asthma are often dependent on the long term prescription of oral corticosteroids. The use of steroids is associated with serious side effects. Physicians treating such patients continue to search for alternative therapies that reduce the need for chronic dosing with oral steroids. Gold compounds are immunosuppressive agents and have benefits in the treatment of a number of inflammatory disorders
Troleandomycin as an oral corticosteroid steroid sparing agent in stable asthma. Patients with chronic severe asthma are often dependent on the long term prescription of oral corticosteroids. The use of steroids is associated with serious side effects. Physicians treating such patients continue to search for alternative therapies that reduce the need for chronic dosing with oral steroids. troleandomycin is a compound that is established as an effective antibiotic but may also have non
Cyclosporin as an oral corticosteroid sparing agent in stable asthma. Patients with chronic severe asthma are often dependent on the long term prescription of oral corticosteroids. The use of steroids is associated with serious side effects. Physicians treating such patients continue to search for alternative therapies that reduce the need for chronic dosing with oral steroids. Cyclosporin is an immunosuppressive agent and has benefits in the treatment of a number of inflammatory disorders (...) could be performed for measures of lung function although one study showed small, but significant improvements in lung spirometry.The changes with cyclosporin are small and of questionable clinical significance. Given the side effects of cyclosporin, the evidence available does not recommend routine use of this drug in the treatment of oral corticosteroid dependent asthma.
Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: A randomized controlled trial. The practice of administering weekly courses of antenatal corticosteroids to pregnant women at risk of preterm delivery is widespread, but no randomized trial has established the efficacy or safety of this practice.To evaluate the efficacy of weekly administration of antenatal corticosteroids compared with a single course in reducing the incidence of neonatal morbidity (...) and to evaluate potential complications of weekly treatment.Randomized, double-blind, placebo-controlled intention-to-treat trial conducted in 13 academic centers in the United States from February 1996 through April 2000.A total of 502 pregnant women between 24 and 32 completed weeks' gestation who were at high risk of preterm delivery.All patients received a complete single course of antenatal corticosteroids (either betamethasone, 12 mg intramuscularly repeated once in 24 hours for 2 doses
Multiple courses of antenatal corticosteroids: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Should children with Bell's palsy be treated with corticosteroids: a systematic review Should children with Bell's palsy be treated with corticosteroids: a systematic review Should children with Bell's palsy be treated with corticosteroids: a systematic review Salman M S, MacGregor D L Authors' objectives To evaluate the effect of corticosteroids in the treatment of paediatric Bell's palsy. Searching MEDLINE (from 1966 to January 2000), EMBASE (from 1980 to March 1999) and the Cochrane (...) , although case series were excluded. The review included randomised controlled trials (RCTs) and non-randomised controlled trials (described as a parallel or historical control study design). Specific interventions included in the review Corticosteroids (prednisone) or corticotropin compared with a control group (not described). The drug dosages used were tabulated. Participants included in the review Children up to 16 years of age who had been diagnosed with acute idiopathic unilateral Bell's palsy
regimens. Bibliographic details Bennett M L, Fleischer A B, Chamlin S L, Frieden I J. Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation. Archives of Dermatology 2001; 137(9): 1208-1213 PubMedID Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH AdrenalCortexHormones /adverse effects /therapeutic use; Evidence-Based Medicine; Hemangioma /drug therapy; Humans; Treatment Outcome AccessionNumber 12001002209 Date bibliographic record (...) Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation Bennett M L, Fleischer A B, Chamlin S L, Frieden I J Authors' objectives To determine the efficacy of systemic corticosteroids in treating enlarging problematic cutaneous haemangiomas. Searching MEDLINE and PubMed were
of Obstetrics and Gynecology 2001; 184(2): 131-139 PubMedID Other publications of related interest Bracken MB. Statistical methods for analysis of effects of treatment in overviews of randomised trials. In: Sinclair JC, Bracken MB, editors. Effective care of the newborn infant. Oxford: Oxford University Press; 1992. Indexing Status Subject indexing assigned by NLM MeSH AdrenalCortexHormones /adverse effects /therapeutic use; Cerebral Hemorrhage /prevention & Enterocolitis, Necrotizing /prevention & Female (...) Do antenatal corticosteroids help in the setting of preterm rupture of membranes? Do antenatal corticosteroids help in the setting of preterm rupture of membranes? Do antenatal corticosteroids help in the setting of preterm rupture of membranes? Harding J E, Pang J, Knight D B, Liggins G C Authors' objectives To conduct a meta-analysis of studies investigating the use of corticosteroids before pre-term delivery in mothers with ruptured membranes. Searching The authors did not report how
Status Subject indexing assigned by NLM MeSH Administration, Inhalation; AdrenalCortexHormones /administration & Adult; Asthma /diagnosis /economics /prevention & Cost of Illness; Cost-Benefit Analysis; Decision Support Techniques; Forced Expiratory Volume; Hospitalization /economics; Humans; Markov Chains; Models, Theoretical; Quality of Life; Quality-Adjusted Life Years; Sensitivity and Specificity; control; dosage /economics /therapeutic use AccessionNumber 22001001553 Date bibliographic record (...) Cost-effectiveness of inhaled corticosteroids in adults with mild-to-moderate asthma: results from the Asthma Policy Model Cost-effectiveness of inhaled corticosteroids in adults with mild-to-moderate asthma: results from the Asthma Policy Model Cost-effectiveness of inhaled corticosteroids in adults with mild-to-moderate asthma: results from the Asthma Policy Model Paltiel A D, Fuhlbrigge A L, Kitch B T, Liljas B, Weiss S T, Neumann P J, Kuntz K M Record Status This is a critical abstract
, cerebral myeli nation, the function of the hypothalamic-pituitary-adrenal axis, and retinal development. In addition, there is evidence for a dose dependent effect on fetal growth and persistence of immature lung architecture. Evidence from human studies on both the short and long- term adverse effects of repeat doses of corticosteroids is contradictory and therefore inconclusive. The available human data come from inadequately controlled observational and retrospective studies, some of which suggest (...) and safety are needed. • In light of the possible risks, the design of randomized clinical trials should minimize the exposure of mothers and fetuses while protecting the integrity of the research design. These trials should assess: • Clinically important neonatal morbidities, such as respiratory distress syndrome, chronic lung disease, and brain injury. • Clinically important maternal morbidities, such as infection and adrenal suppression. • The effects of repeat courses of corticosteroids on patterns