Latest & greatest articles for corticosteroids

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Top results for corticosteroids

161. Stopping long-acting beta2-agonists (LABA) for children with asthma well controlled on LABA and inhaled corticosteroids. Full Text available with Trip Pro

Stopping long-acting beta2-agonists (LABA) for children with asthma well controlled on LABA and inhaled corticosteroids. Asthma is the most common chronic medical condition among children and is one of the most common causes of hospitalisation and medical visits. Poorly controlled asthma often leads to preventable exacerbations that require additional medications, hospital stays, or treatment in the emergency department.Long-acting beta2-agonists (LABA) are the preferred add-on treatment (...) for children with asthma whose symptoms are not well controlled on inhaled corticosteroids (ICS). The US Food and Drug Administration has issued a 'black box' warning for LABA in asthma, and now recommends that they be used "for the shortest duration of time required to achieve control of asthma symptoms and discontinued, if possible, once asthma control is achieved".To compare the effect on asthma control and adverse effects of stepping down to inhaled corticosteroids (ICS)-only therapy versus continuing

2015 Cochrane

162. Treatment of systemic necrotizing vasculitides in patients aged sixty-five years or older: results of a multicenter, open-label, randomized controlled trial of corticosteroid and cyclophosphamide-based induction therapy (Abstract)

Treatment of systemic necrotizing vasculitides in patients aged sixty-five years or older: results of a multicenter, open-label, randomized controlled trial of corticosteroid and cyclophosphamide-based induction therapy To investigate a new therapeutic strategy, with rapid corticosteroid dose tapering and limited cyclophosphamide (CYC) exposure, for older patients with systemic necrotizing vasculitides (SNVs; polyarteritis nodosa [PAN], granulomatosis with polyangiitis [Wegnener's] [GPA (...) ], microscopic polyangiitis [MPA], or eosinophilic GPA [Churg-Strauss] [EGPA]).A multicenter, open-label, randomized controlled trial comprising patients ≥65 years old and newly diagnosed as having SNV was conducted. The experimental treatment consisted of corticosteroids for ∼9 months and a maximum of six 500-mg fixed-dose intravenous (IV) CYC pulses, every 2-3 weeks, then maintenance azathioprine or methotrexate. The control treatment included ∼26 months of corticosteroids for all patients, combined

2015 EvidenceUpdates Controlled trial quality: predicted high

163. Systemic corticosteroid therapy for acute sinusitis. Full Text available with Trip Pro

Systemic corticosteroid therapy for acute sinusitis. Are oral or parenteral corticosteroids associated with improved clinical outcomes in patients with acute sinusitis compared with placebo or nonsteroidal anti-inflammatory drugs (NSAIDs)?Oral corticosteroids combined with antibiotics may be associated with modest benefit for short-term relief of symptoms in adults with severe symptoms of acute sinusitis compared with antibiotics alone. Oral corticosteroids as monotherapy are not associated

2015 JAMA Controlled trial quality: uncertain

164. Low-Dose Corticosteroid Treatment in Septic Shock: A Propensity-Matching Study

Low-Dose Corticosteroid Treatment in Septic Shock: A Propensity-Matching Study PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2015 PedsCCM Evidence-Based Journal Club

165. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis

Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2015 PedsCCM Evidence-Based Journal Club

166. A population-based, multifaceted strategy to implement antenatal corticosteroid treatment versus standard care for the reduction of neonatal mortality due to preterm birth in low-income and middle-income countries: the ACT cluster-randomised trial. Full Text available with Trip Pro

A population-based, multifaceted strategy to implement antenatal corticosteroid treatment versus standard care for the reduction of neonatal mortality due to preterm birth in low-income and middle-income countries: the ACT cluster-randomised trial. Antenatal corticosteroids for pregnant women at risk of preterm birth are among the most effective hospital-based interventions to reduce neonatal mortality. We aimed to assess the feasibility, effectiveness, and safety of a multifaceted intervention (...) designed to increase the use of antenatal corticosteroids at all levels of health care in low-income and middle-income countries.In this 18-month, cluster-randomised trial, we randomly assigned (1:1) rural and semi-urban clusters within six countries (Argentina, Guatemala, India, Kenya, Pakistan, and Zambia) to standard care or a multifaceted intervention including components to improve identification of women at risk of preterm birth and to facilitate appropriate use of antenatal corticosteroids

2015 Lancet Controlled trial quality: predicted high

167. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. Full Text available with Trip Pro

Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. In patients with severe community-acquired pneumonia, treatment failure is associated with excessive inflammatory response and worse outcomes. Corticosteroids may modulate cytokine release in these patients, but the benefit of this adjunctive therapy remains controversial.To assess the effect of corticosteroids (...)  = .02), with a difference between groups of 18% (95% CI, 3% to 32%). Corticosteroid treatment reduced the risk of treatment failure (odds ratio, 0.34 [95% CI, 0.14 to 0.87]; P = .02). In-hospital mortality did not differ between the 2 groups (6 patients [10%] in the methylprednisolone group vs 9 patients [15%] in the placebo group; P = .37); the difference between groups was 5% (95% CI, -6% to 17%). Hyperglycemia occurred in 11 patients (18%) in the methylprednisolone group and in 7 patients (12

2015 JAMA Controlled trial quality: predicted high

168. Corticosteroids for parasitic eosinophilic meningitis. (Abstract)

Corticosteroids for parasitic eosinophilic meningitis. Angiostrongylus cantonensis (A. cantonensis) is the major cause of infectious eosinophilic meningitis. Dead larvae of this parasite cause inflammation and exacerbate symptoms of meningitis. Corticosteroids are drugs used to reduce the inflammation caused by this parasite.To assess the efficacy and safety of corticosteroids for the treatment of eosinophilic meningitis.We searched CENTRAL (2014, Issue 11), MEDLINE (1950 to November Week 3 (...) , 2014), EMBASE (1974 to December 2014), Scopus (1960 to December 2014), Web of Science (1955 to December 2014), LILACS (1982 to December 2014) and CINAHL (1981 to December 2014).Randomised controlled trials (RCTs) of corticosteroids versus placebo for eosinophilic meningitis.Two review authors (SiT, SaT) independently collected and extracted study data. We graded the methodological quality of the RCTs. We identified and analysed outcomes and adverse effects.We did not identifiy any new trials

2015 Cochrane

169. Sciatica and epidural corticosteroid injections

Sciatica and epidural corticosteroid injections Prescrire IN ENGLISH - Spotlight ''In the February issue of Prescrire International: Sciatica and epidural corticosteroid injections'', 1 February 2015 {1} {1} {1} | | > > > In the February issue of Prescrire International: Sciatica and epidural corticosteroid injections Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |  (...)  |  Spotlight In the February issue of Prescrire International: Sciatica and epidural corticosteroid injections FREE DOWNLOAD What is the analgesic efficacy of epidural corticosteroid injections in patients with sciatic pain? And what are their adverse effects? This sample page from the "Reviews" section explores the harm-benefit balance of this treatment option. Full text available for free download. Summary According to trials conducted in hundreds of patients with sciatica, epidural

2015 Prescrire

170. Randomised controlled trial: Similar clinical outcomes but more healthcare use in shoulder impingement patients following corticosteroid injection compared with physical therapy

Randomised controlled trial: Similar clinical outcomes but more healthcare use in shoulder impingement patients following corticosteroid injection compared with physical therapy Similar clinical outcomes but more healthcare use in shoulder impingement patients following corticosteroid injection compared with physical therapy | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser (...) impingement patients following corticosteroid injection compared with physical therapy Article Text Therapeutics/Prevention Randomised controlled trial Similar clinical outcomes but more healthcare use in shoulder impingement patients following corticosteroid injection compared with physical therapy Nadine E Foster Statistics from Altmetric.com Commentary on : Rhon DI , Boyles RB , Cleland JA . One-year outcome of subacromial corticosteroid injection compared with manual physical therapy

2015 Evidence-Based Medicine

171. Corticosteroid Injections Accelerate Pain Relief and Recovery of Function Compared With Oral NSAIDs in Patients With Adhesive Capsulitis: A Randomized Controlled Trial (Abstract)

Corticosteroid Injections Accelerate Pain Relief and Recovery of Function Compared With Oral NSAIDs in Patients With Adhesive Capsulitis: A Randomized Controlled Trial Intra-articular corticosteroid injection is a common therapy for adhesive capsulitis, but there is a lack of prospective randomized controlled studies analyzing the efficacy of single injections applied blindly to accelerate improvement in pain and function.In patients with adhesive capsulitis, a single intra-articular (...) corticosteroid injection without image control applied before the beginning of a physical therapy program will accelerate pain relief and recovery of function compared with oral nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy.Randomized controlled trial; Level of evidence, 1.A total of 74 patients with primary adhesive capsulitis in the freezing stage were randomized to receive either intra-articular injections with betamethasone or oral NSAIDs. Clinical outcome was documented at baseline

2015 EvidenceUpdates Controlled trial quality: uncertain

172. High-dose inhaled corticosteroids in asthma

, including self-monitoring and a follow- up with a healthcare professional. Review and update the person's asthma action plan when decreasing maintenance therapy. Prolonged use of high doses of ICS (as with the use of oral corticosteroids) carries a risk of systemic side effects, including adrenal suppression, growth retardation in children and young people, decreased bone mineral density, cataracts, glaucoma, and psychological or behavioural effects. (See the following links for more details: MHRA 2006 (...) High-dose inhaled corticosteroids in asthma Asthma: medicines safety priorities Asthma: medicines safety priorities Key therapeutic topic Published: 15 January 2015 nice.org.uk/guidance/ktt5 pathways K Ke ey points y points Inhaled corticosteroids (ICS) are the first-choice regular preventer therapy for adults, young people and children with asthma. When long-acting beta agonists (LABAs) are prescribed for people with asthma, they should be prescribed with an ICS. LABAs should not be used

2015 National Institute for Health and Clinical Excellence - Advice

173. Corticosteroids - inhaled

Corticosteroids - inhaled Corticosteroids - inhaled - NICE CKS Share Corticosteroids - inhaled : Summary Corticosteroids are synthetic analogues of hormones produced by the adrenal cortex. Inhaled corticosteroids are glucocorticoids and have 4 main effects, which are: Anti-inflammatory. Immunosuppressive. Anti-proliferative (anti-mitotic). Vasoconstrictive. Inhaled corticosteroids exert these effects on the airways to reduce inflammation, oedema, and mucus secretion. Because they are delivered (...) of the natural hormones that are produced by the adrenal cortex. Like the natural hormones, synthetic corticosteroids can have glucocorticoid and/or mineralocorticoid properties. The glucocorticoid properties are anti-inflammatory, immunosuppressive, anti-proliferative, and vasoconstrictive. The glucocorticoid properties also support a variety of metabolic functions including carbohydrate and protein metabolism, whilst playing a vital role in helping the body adjust to physical stress. The mineralocorticoid

2015 NICE Clinical Knowledge Summaries

174. Treating tennis elbow (lateral epicondylalgia) with corticosteroid injections are beneficial in the short term but harmful in the long term

Treating tennis elbow (lateral epicondylalgia) with corticosteroid injections are beneficial in the short term but harmful in the long term 1 sbu – swedish council on health technology assessment What is tennis elbow? Tendon pain is referred to as tendinopathy when the pain is associated with a tendon, or enthesopathy when the pain is associated with the areas where liga- ments or tendons are attached to the bone. Tendons and their associated tissues can become painful and swollen in response (...) with local injec- tions of the anti-inflammatory agent corticosteroid. Treatment in Sweden Tennis elbow occurs in 0.3–1.1 percent of the Swedish population [1], meaning that between 29,000 and 105,000 Swedish people suffer from tennis elbow each year [2]. Tennis elbow most commonly effects people between the ages of 40 and 60. It is unclear to what extent corticosteroid injections are used to treat tennis elbow in Sweden, however direct communication with several health clinics revealed that the method

2014 Swedish Council on Technology Assessement

175. Pegylated interferon-alpha-2b reduces corticosteroid requirement in patients with Behcet's disease with upregulation of circulating regulatory T cells and reduction of Th17 Full Text available with Trip Pro

Pegylated interferon-alpha-2b reduces corticosteroid requirement in patients with Behcet's disease with upregulation of circulating regulatory T cells and reduction of Th17 To determine whether the addition of 26 weeks of subcutaneous peginterferon-α-2b could reduce the requirement for systemic corticosteroids and conventional immunosuppressive medication in patients with Behçet's disease (BD).We conducted a multicentre randomised trial in patients with BD requiring systemic therapy. Patients (...) were randomised to 26 weeks of peginterferon-α-2b in addition to their standard care or to standard care only and followed 6-monthly for 3 years with BD activity scores and quality of life questionnaires. Patients at one centre had blood taken to measure regulatory T cells (Tregs) and Th17 cells.72 patients were included. At months 10-12, while among the entire patient population there was no difference in the corticosteroid dose or immunosuppression use between the treatment groups (adjusted

2014 EvidenceUpdates Controlled trial quality: uncertain

176. Use of antenatal corticosteroids and tocolytic drugs in preterm births in 29 countries: an analysis of the WHO Multicountry Survey on Maternal and Newborn Health. (Abstract)

Use of antenatal corticosteroids and tocolytic drugs in preterm births in 29 countries: an analysis of the WHO Multicountry Survey on Maternal and Newborn Health. Despite the global burden of morbidity and mortality associated with preterm birth, little evidence is available for use of antenatal corticosteroids and tocolytic drugs in preterm births in low-income and middle-income countries. We analysed data from the WHO Multicountry Survey on Maternal and Newborn Health (WHOMCS) to assess (...) coverage for these interventions in preterm deliveries.WHOMCS is a facility-based, cross-sectional survey database of birth outcomes in 359 facilities in 29 countries, with data collected prospectively from May 1, 2010, to Dec 31, 2011. For this analysis, we included deliveries after 22 weeks' gestation and we excluded births that occurred outside a facility or quicker than 3 h after arrival. We calculated use of antenatal corticosteroids in women who gave birth between 26 and 34 weeks' gestation, when

2014 Lancet

177. What are the benefits and risks of inhaled corticosteroids for COPD?

What are the benefits and risks of inhaled corticosteroids for COPD? What are the benefits and risks of inhaled corticosteroids for COPD? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics What are the benefits and risks of inhaled corticosteroids for COPD? View/ Open Date 2014-05 Format Metadata Abstract Q: What (...) are the benefits and risks of inhaled corticosteroids for COPD? A: Inhaled corticosteroids (ICS), either alone or with a long-acting [beta] agonist (LABA), reduce the frequency of exacerbations of chronic obstructive pulmonary disease (COPD) and statistically, but not clinically, improve quality of life (QOL) (strength of recommendation [SOR]: B, meta-analyses of heterogeneous studies). However, ICS have no mortality benefit and don’t consistently improve forced expiratory volume in 1 second (FEV1) (SOR: B

2014 Clinical Inquiries

178. Psychiatric Adverse Effects of Pediatric Corticosteroid Use Full Text available with Trip Pro

included corticosteroids, adrenal cortex hormones, steroid psychosis, substance-induced psychoses, glucocorticoids, dexamethasone, hydrocortisone, prednisone, adverse effects, mood disorders, mental disorders, psychosis, psychotic, psychoses, side effect, chemically induced, emotions, affective symptoms, toxicity, behavior, behavioral symptoms, infant, child, adolescent, pediatric, paediatric, neonatal, children, teen, and teenager. Following guidelines for systematic reviews from the Potsdam (...) Psychiatric Adverse Effects of Pediatric Corticosteroid Use Corticosteroids, highly effective drugs for myriad disease states, have considerable neuropsychiatric adverse effects that can manifest in cognitive disorders, behavioral changes, and frank psychiatric disease. Recent reviews have summarized these effects in adults, but a comprehensive review on corticosteroid effects in children has not been published since 2005. Here, we systematically review articles published since then that, we

2014 EvidenceUpdates

179. Long-acting beta-agonists and inhaled corticosteroids for treatment of chronic obstructive pulmonary disease: a review of the clinical efficacy and cost-effectiveness

Long-acting beta-agonists and inhaled corticosteroids for treatment of chronic obstructive pulmonary disease: a review of the clinical efficacy and cost-effectiveness Long-acting beta-agonists and inhaled corticosteroids for treatment of chronic obstructive pulmonary disease: a review of the clinical efficacy and cost-effectiveness Long-acting beta-agonists and inhaled corticosteroids for treatment of chronic obstructive pulmonary disease: a review of the clinical efficacy and cost (...) -effectiveness CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Long-acting beta-agonists and inhaled corticosteroids for treatment of chronic obstructive pulmonary disease: a review of the clinical efficacy and cost-effectiveness. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response - Summary with Critical

2014 Health Technology Assessment (HTA) Database.

180. Corticosteroids

Corticosteroids USE OF SYSTEMIC CORTICOSTEROIDS IN PREGNANCY 0344 892 0909 USE OF SYSTEMIC CORTICOSTEROIDS IN PREGNANCY (Date of issue: December 2016 , Version: 1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . Summary Corticosteroids are a class of hormones produced in the adrenal cortex which are involved (...) in a range of physiological functions. Exogenous corticosteroids are commonly used to reduce inflammation, suppress the immune system, and to replace hormones in the body where a deficiency exists. During pregnancy, where premature delivery is anticipated, corticosteroids may be administered to the mother to reduce the risk of respiratory distress syndrome in the neonate. Systemic corticosteroids available in the UK include: prednisolone, prednisone, hydrocortisone, betamethasone, dexamethasone

2014 UK Teratology Information Service