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Latest & greatest articles for dementia
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Association of ideal cardiovascular health at age 50 with incidence of dementia: 25 year follow-up of Whitehall II cohort study. To examine the association between the Life Simple 7 cardiovascular health score at age 50 and incidence of dementia.Prospective cohort study.Civil service departments in London (Whitehall II study; study inception 1985-88).7899 participants with data on the cardiovascular health score at age 50.The cardiovascular health score included four behavioural (smoking, diet (...) , physical activity, body mass index) and three biological (fasting glucose, blood cholesterol, blood pressure) metrics, coded on a three point scale (0, 1, 2). The cardiovascular health score was the sum of seven metrics (score range 0-14) and was categorised into poor (scores 0-6), intermediate (7-11), and optimal (12-14) cardiovascular health.Incident dementia, identified through linkage to hospital, mental health services, and mortality registers until 2017.347 incident cases of dementia were
Association of Lifestyle and Genetic Risk With Incidence of Dementia. Genetic factors increase risk of dementia, but the extent to which this can be offset by lifestyle factors is unknown.To investigate whether a healthy lifestyle is associated with lower risk of dementia regardless of genetic risk.A retrospective cohort study that included adults of European ancestry aged at least 60 years without cognitive impairment or dementia at baseline. Participants joined the UK Biobank study from 2006 (...) to 2010 and were followed up until 2016 or 2017.A polygenic risk score for dementia with low (lowest quintile), intermediate (quintiles 2 to 4), and high (highest quintile) risk categories and a weighted healthy lifestyle score, including no current smoking, regular physical activity, healthy diet, and moderate alcohol consumption, categorized into favorable, intermediate, and unfavorable lifestyles.Incident all-cause dementia, ascertained through hospital inpatient and death records.A total
Setting goals can help people with early stage dementia improve function. The studyClare L, Kudlicka A, Oyebode J R, et al. Goal-oriented cognitive rehabilitation for early-stage Alzheimer's and related dementias: the GREAT RCT. Health Technol Assess 2019;23:1-242.The trial was funded by the NIHR Health Technology Assessment Programme (project number11/15/04).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000767/goal-setting-in-early-stage-dementia-can
Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia. A National Institute on Aging and Alzheimer's Association workgroup proposed a research framework for Alzheimer disease in which biomarker classification of research participants is labeled AT(N) for amyloid, tau, and neurodegeneration biomarkers.To determine the associations between AT(N) biomarker profiles and memory decline in a population-based cohort (...) of individuals without dementia age 60 years or older, and to determine whether biomarkers provide incremental prognostic value beyond more readily available clinical and genetic information.Population-based cohort study of cognitive aging in Olmsted County, Minnesota, that included 480 nondemented Mayo Clinic Study of Aging participants who had a clinical evaluation and amyloid positron emission tomography (PET) (A), tau PET (T), and magnetic resonance imaging (MRI) cortical thickness (N) measures between
ACR–ASNR Practice Parameter for Brain PET/CT Imaging Dementia Res. 17 – 2015 - 2019 PRACTICE PARAMETER Brain Dementia PET/CT Imaging / 1 The American College of Radiology, with more than 30,000 members, is the principal organization of radiologists, radiation oncologists, and clinical medical physicists in the United States. The College is a nonprofit professional society whose primary purposes are to advance the science of radiology, improve radiologic services to the patient, study (...) in each document. Reproduction or modification of the published practice parameter and technical standard by those entities not providing these services is not authorized. 2015 (Resolution 21)* ACR–ASNR PRACTICE PARAMETER FOR BRAIN PET/CT IMAGING IN DEMENTIA PREAMBLE This document is an educational tool designed to assist practitioners in providing appropriate radiologic care for patients. Practice Parameters and Technical Standards are not inflexible rules or requirements of practice
Incident Atrial Fibrillation, Dementia and the Role of Anticoagulation: A Population-Based Cohort Study Atrial fibrillation (AF) is associated with dementia. Anticoagulation may modify this relationship, but it is unclear if this is due to stroke reduction alone. Age- and sex-matched individuals from the U.K. Clinical Practice Research Datalink (2008-2016) with and without an incident diagnosis of AF were followed for a new dementia diagnosis. We estimated adjusted hazard ratios (aHRs (...) ) for incident dementia diagnosis in the AF cohort, overall and stratified by anticoagulation status, using the matched non-AF cohorts as reference. We performed a sensitivity analysis excluding individuals with stroke/transient ischaemic attack (TIA) before the observation period. Over 193,082 person-years (mean follow-up 25.7 ± 0.1 months), 347/15,276 AF (2.3%) and 1,085/76,096 non-AF (1.4%) were newly diagnosed with dementia (aHR, 1.31, 95% confidence interval, 1.15-1.49). The AF group had more co
Effects of a modified mindfulness-based cognitive therapy for family caregivers of people with dementia: A pilot randomized controlled trial Caregivers of people with dementia experience high stress levels. Mindfulness-based cognitive therapy has been found to be effective in reducing stress and improving the psychological well-being of several populations.To explore the feasibility and preliminary effects of a modified mindfulness-based cognitive therapy for family caregivers of people (...) with dementia.In a single-blinded, parallel-group, randomized controlled trial, 36 caregivers of people with dementia were randomized to either the intervention group, receiving the 7-session modified mindfulness-based cognitive therapy in 10 weeks; or the control group, receiving the usual family care and brief education on dementia care. The brief education sessions were similar in frequency and duration to the intervention group. Various psychological outcomes of caregivers were assessed and compared
Scam Awareness Related to Incident Alzheimer Dementia and Mild Cognitive Impairment: A Prospective Cohort Study. Decreased scam awareness may be an early indicator of impending Alzheimer dementia and its precursor, mild cognitive impairment, but prior studies have not systematically examined the associations between scam awareness and adverse cognitive outcomes.To test the hypothesis that low scam awareness is associated with increased risk for incident Alzheimer dementia, mild cognitive (...) impairment, and Alzheimer disease pathology in the brain.Prospective cohort study of aging.Community-based study in the greater Chicago metropolitan area.935 older persons initially free of dementia.Scam awareness was measured via questionnaire, incident Alzheimer dementia and mild cognitive impairment were documented in detailed annual cognitive and clinical evaluations, and Alzheimer disease neuropathology was quantified after death among a subset of persons who died (n = 264). Proportional hazards
Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia. Amyloid positron emission tomography (PET) detects amyloid plaques in the brain, a core neuropathological feature of Alzheimer disease.To determine if amyloid PET is associated with subsequent changes in the management of patients with mild cognitive impairment (MCI) or dementia of uncertain etiology.The Imaging Dementia (...) -Evidence for Amyloid Scanning (IDEAS) study was a single-group, multisite longitudinal study that assessed the association between amyloid PET and subsequent changes in clinical management for Medicare beneficiaries with MCI or dementia. Participants were required to meet published appropriate use criteria stating that etiology of cognitive impairment was unknown, Alzheimer disease was a diagnostic consideration, and knowledge of PET results was expected to change diagnosis and management. A total
Evidence Brief: Traumatic Brain Injury and Dementia Management Briefs eBrief-no150 -- Traumatic Brain Injury and Dementia Enter search terms Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Management Briefs eBrief-no150 -- Traumatic Brain Injury and Dementia Health Services Research & Development Management eBrief no. 150 » Issue 150 March 2019 The report is a product of the VA/HSR&D Evidence Synthesis Program. Evidence (...) Brief: Traumatic Brain Injury and Dementia Traumatic brain injury (TBI) is a common condition among both civilian and military populations. While some TBIs cause acute symptoms that resolve over several weeks or months, evidence accumulated over nearly three decades suggests that TBI may lead to chronic neurodegenerative diseases such as dementia. More public awareness about TBI in active-duty service members as a risk factor for earlier onset of dementia and/or of Chronic Traumatic Encephalopathy
Association of Midlife Diet With Subsequent Risk for Dementia. Observational studies suggest that diet is linked to cognitive health. However, the duration of follow-up in many studies is not sufficient to take into account the long preclinical phase of dementia, and the evidence from interventional studies is not conclusive.To examine whether midlife diet is associated with subsequent risk for dementia.Population-based cohort study established in 1985-1988 that had dietary intake assessed (...) in 1991-1993, 1997-1999, and 2002-2004 and follow-up for incident dementia until March 31, 2017.Food frequency questionnaire to derive the Alternate Healthy Eating Index (AHEI), an 11-component diet quality score (score range, 0-110), with higher scores indicating a healthier diet.Incident dementia ascertained through linkage to electronic health records.Among 8225 participants without dementia in 1991-1993 (mean age, 50.2 years [SD, 6.1 years]; 5686 [69.1%] were men), a total of 344 cases of incident
Peri-operative care of people with dementia. Online Supporting Information Online Supporting Information S1 Sources of further information S2 Quality assessment/quality improvement (QA/QI) toolkit S4 Abbey pain scale  S1 Sources of further information • Alzheimer’s Society, Royal College of Nursing. This is me. A support tool to enable person-centred care. This proforma can be completed pre- operatively by a person with cognitive impairment or their carers, to provide information (...) for hospital staff about how to care for that person when they are admitted for surgery. https://www.alzheimers.org.uk/download/downloads/id/3423/this_is_me.pdf (accessed 20/02/2018). • Alzheimer’s Society. Fix Dementia Care: Hospitals. January, 2016. This document describes the experiences of people with dementia admitted to hospital, and recommends care improvements that should be made. https://www.alzheimers.org.uk/download/downloads/id/2907/fix_dementia_care_- _hospitals.pdf (accessed 20/02/2018
Traumatic Brain Injury and Dementia 4 February 2019 Prepared for: Department of Veterans Affairs Veterans Health Administration Health Services Research & Development Service Washington, DC 20420 Prepared by: Evidence Synthesis Program (ESP) Coordinating Center Portland VA Health Care System Portland, OR Mark Helfand, MD, MPH, MS, Director Evidence Brief: Traumatic Brain Injury and Dementia Authors: Kim Peterson, MS Stephanie Veazie, MPH Donald Bourne, MPH Johanna Anderson, MPH Evidence (...) Synthesis Program 4 Evidence Brief: TBI and Dementia Evidence Synthesis Program i PREFACE The VA Evidence Synthesis Program (ESP) was established in 2007 to provide timely and accurate syntheses of targeted healthcare topics of importance to clinicians, managers, and policymakers as they work to improve the health and healthcare of Veterans. These reports help: · Develop clinical policies informed by evidence; · Implement effective services to improve patient outcomes and to support VA clinical practice
Development and Validation of a Dementia Risk Prediction Model in the General Population: An Analysis of Three Longitudinal Studies Identification of individuals at high risk of dementia is essential for development of prevention strategies, but reliable tools are lacking for risk stratification in the population. The authors developed and validated a prediction model to calculate the 10-year absolute risk of developing dementia in an aging population.In a large, prospective population-based (...) cohort, data were collected on demographic, clinical, neuropsychological, genetic, and neuroimaging parameters from 2,710 nondemented individuals age 60 or older, examined between 1995 and 2011. A basic and an extended model were derived to predict 10-year risk of dementia while taking into account competing risks from death due to other causes. Model performance was assessed using optimism-corrected C-statistics and calibration plots, and the models were externally validated in the Dutch population
Peri-operative care of people with dementia Guidelines Peri-operative care of people with dementia February 2019Guidelines Guidelinesfortheperi-operativecareofpeoplewithdementia GuidelinesfromtheAssociationofAnaesthetists S.White, 1 R.Grif?ths, 2 M.Baxter, 3 T.Beanland, 4 J.Cross, 5 J.Dhesi, 6 A.B.Docherty, 7 I.Foo, 8 G.Jolly, 9 J.Jones, 10 I.K.Moppett, 11 E.Plunkett 12 andK.Sachdev 13 1ConsultantAnaesthetist,RoyalSussexCountyHospital,Brighton,UKandco-Chair,AssociationofAnaesthetists (...) 13ConsultantinOlderAdultPsychiatry,HomertonUniversityHospitalNHSFoundationTrust,London,UK Summary Ageing populations have greater incidences of dementia. People with dementia present for emergency and, increasingly, elective surgery, but are poorly served by the lack of available guidance on their peri-operative management, particularly relating to pharmacological, medico-legal, environmental and attitudinal considerations. These guidelines seek to deliver such guidance, by providing information for peri-operative care
Appropriate prescribing of psychotropic medication for non-cognitive symptoms in people with dementia Appropriate prescribing of psychotropic medication for non-cognitive symptoms in people with dementia National Clinical Guideline No. 21 National Patient Safety Office Oi?g Náisiúnta um Shábháilteacht Othar December 2019This National Clinical Guideline has been developed by a guideline development group convened by the National Dementia Office, to fulfil priority action point 2.3 (...) of the National Dementia Strategy Implementation plan, namely “The Health Service Executive will develop guidance material on the appropriate management of medication for people with dementia, and in particular on psychotropic medication management, and make arrangements for this material to be made available in all relevant settings, including nursing homes”. Using this National Clinical Guideline This National Clinical Guideline applies to people with dementia of any age, and of any type, and in any setting
Promising results from a pilot study to reduce distress in Vietnamese American dementia and memory loss caregivers. This study developed and examined the feasibility of a culturally tailored, evidence-based skill-building program to reduce stress and depression of Vietnamese American dementia caregivers.This pilot randomized controlled trial included pretest and posttest measures using the Center for Epidemiologic Studies-Depression Scale and the Revised Memory and Behavior Problems Checklist (...) . The intervention (n = 30) group participated in a culturally tailored, 4-week Vietnamese-language cognitive-behavioral skills evidenced-based program (Our Family Journey); caregivers in the control condition (n = 30) received dementia-related educational materials (education control condition).Our Family Journey caregivers showed significantly lower somatic scores on the Center for Epidemiologic Studies-Depression Scale and reported lower frequency of care recipients' disruptive behaviors. However, they also
Study protocol of the self-monitoring activity program: Effects of activity on incident dementia. Numerous studies have focused on nonpharmacological interventions on cognitive function and the effects of cognitive function on daily living. However, effects of behavior change techniques that promote physical, cognitive, and social activities on cognitive function and incident dementia in the elderly are yet to be elucidated. In this study, we aimed to design a single-blind, randomized (...) controlled trial to study dementia prevention effects of behavior change techniques, using an accelerometer and a newly developed daily activity booklet in community-living older adults.The study cohort comprised 5390 individuals aged 65 years and older who were randomized into one of the following three groups: accelerometer group (n = 1508), accelerometer and daily activity booklet group (n = 1180), or a control group (n = 2702; vs. accelerometer group [n = 1509] vs. accelerometer and daily activity
Outcomes: Electroconvulsive therapy does not increase the risk of dementia in patients with affective disorders Electroconvulsive therapy does not increase the risk of dementia in patients with affective disorders | Evidence-Based Mental Health Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Electroconvulsive therapy does not increase the risk of dementia in patients with affective disorders Article Text Commentary Outcomes Electroconvulsive therapy does not increase the risk of dementia in patients with affective disorders Pascal Sienaert Correspondence to Professor Pascal Sienaert, Academic Center for ECT and Neuromodulation (AcCENT), University Psychiatric Center KU
Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial. There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia.To evaluate the effect of intensive blood pressure control on risk of dementia.Randomized clinical trial conducted at 102 sites in the United States and Puerto Rico among adults aged 50 years or older with hypertension but without diabetes or history of stroke. Randomization began (...) on November 8, 2010. The trial was stopped early for benefit on its primary outcome (a composite of cardiovascular events) and all-cause mortality on August 20, 2015. The final date for follow-up of cognitive outcomes was July 22, 2018.Participants were randomized to a systolic blood pressure goal of either less than 120 mm Hg (intensive treatment group; n = 4678) or less than 140 mm Hg (standard treatment group; n = 4683).The primary cognitive outcome was occurrence of adjudicated probable dementia