Latest & greatest articles for doxycycline

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Top results for doxycycline

1. Effect of Doxycycline on Aneurysm Growth Among Patients With Small Infrarenal Abdominal Aortic Aneurysms: A Randomized Clinical Trial. (Abstract)

Effect of Doxycycline on Aneurysm Growth Among Patients With Small Infrarenal Abdominal Aortic Aneurysms: A Randomized Clinical Trial. Abdominal aortic aneurysms affect more than 3% of US older adults.To test whether doxycycline reduces the growth of abdominal aortic aneurysm over 2 years as measured by maximum transverse diameter.Parallel, 2-group, randomized clinical trial that was conducted at 22 US clinical centers between May 2013 and January 2017, and enrolled patients 50 years or older (...) with small (3.5-5.0 cm for men, 3.5-4.5 cm for women) infrarenal aneurysms. The final date of follow-up was July 31, 2018.Patients were randomized to receive twice daily for 2 years doxycycline 100 mg orally (as capsules) (n = 133) or placebo (n = 128).The primary outcome was change in abdominal aortic aneurysm maximum transverse diameter measured from CT images at baseline and follow-up at 2 years. Patients were assigned ranks based on the maximum transverse diameter (measured or imputed) of the aorta

2020 JAMA

2. Bites - human and animal: Doxycycline

Bites - human and animal: Doxycycline Doxycycline | Prescribing information | Bites - human and animal | CKS | NICE Search CKS… Menu Doxycycline Bites - human and animal: Doxycycline Last revised in October 2018 Doxycycline What dosage of doxycycline should I prescribe? For prophylaxis or treatment of an infected bite wound, the dosage of oral doxycycline is: Adults: 100 mg twice daily for seven days [ ]. Child: doxycycline is contraindicated (and not licensed) in children less than 12 years (...) of age because of the risk of dental staining and hypoplasia [ ]. What are the contraindications and cautions when prescribing doxycycline? Do not prescribe doxycycline in: Women who are pregnant or breastfeeding, and children younger than 12 years of age. Tetracyclines are deposited in growing bone and teeth which can result in discolouration of teeth and occasionally dental hypoplasia. Prescribe doxycycline with caution in people with: Hepatic impairment and those receiving potentially hepatotoxic

2020 NICE Clinical Knowledge Summaries

3. One Dose of Doxycycline for the Prevention of Lyme Disease: A Review of Clinical Effectiveness and Guidelines

One Dose of Doxycycline for the Prevention of Lyme Disease: A Review of Clinical Effectiveness and Guidelines One Dose of Doxycycline for the Prevention of Lyme Disease: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need One Dose of Doxycycline for the Prevention of Lyme Disease: A Review of Clinical Effectiveness and Guidelines One Dose of Doxycycline for the Prevention of Lyme Disease: A Review of Clinical Effectiveness and Guidelines Last updated: May (...) 21, 2019 Project Number: RC1121-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of one dose of doxycycline for the prevention of Lyme disease in patients with tick attachment? Are the evidence-based guidelines associated with the use of one dose of doxycycline for the prevention of Lyme disease in patients with tick attachment? Key Message Based primarily on a very-low quality randomized controlled

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Doxycycline

Doxycycline Top results for doxycycline - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for doxycycline The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you

2018 Trip Latest and Greatest

5. Bronchiectasis: Doxycycline

Bronchiectasis: Doxycycline Doxycycline | Prescribing information | Bronchiectasis | CKS | NICE Search CKS… Menu Doxycycline Bronchiectasis: Doxycycline Last revised in December 2018 Doxycycline What contraindications and cautions are associated with doxycycline? Do not prescribe doxycycline to: Pregnant or breastfeeding women. Children under 12 years of age People with: Liver problems. Systemic lupus erythematosus. Myasthenia gravis. Porphyria. [ ; ] What are the adverse effects (...) of doxycycline? The common adverse effects of doxycycline include: Gastrointestinal effects, such as nausea, vomiting, and diarrhoea. Less frequently, doxycycline may cause photosensitivity. Advise the person to minimize exposure to direct sunlight. Severe adverse effects are unusual with a short course. However, benign intracranial hypertension has rarely been reported following treatment with a tetracycline. If a person taking doxycycline develops headache and visual disturbances, the drug should

2018 NICE Clinical Knowledge Summaries

6. Cellulitis - acute: Doxycycline

Cellulitis - acute: Doxycycline Doxycycline | Prescribing information | Cellulitis - acute | CKS | NICE Search CKS… Menu Doxycycline Cellulitis - acute: Doxycycline Last revised in December 2019 Doxycycline What are the contraindications and cautions for doxycyline? Do not prescribe doxycycline to: Women who are pregnant or breastfeeding, and children younger than 12 years of age — tetracyclines are deposited in growing bone and teeth which can result in discolouration of teeth (...) and occasionally dental hypoplasia. Prescribe doxycycline with caution to people with: Hepatic impairment and those receiving potentially hepatotoxic drugs. Myasthenia gravis — tetracyclines may increase muscle weakness in people with myasthenia gravis. Systemic lupus erythematosus (SLE) — tetracyclines may exacerbate SLE symptoms. Renal impairment — avoid excessive doses. [ ; ] What are the possible adverse effects of doxycycline? Common adverse effects of doxycycline include dyspnoea, hypotension, peripheral

2018 NICE Clinical Knowledge Summaries

7. Chlamydia - uncomplicated genital: Doxycycline

Chlamydia - uncomplicated genital: Doxycycline Doxycycline | Prescribing information | Chlamydia - uncomplicated genital | CKS | NICE Search CKS… Menu Doxycycline Chlamydia - uncomplicated genital: Doxycycline Last revised in June 2019 Doxycycline What contraindications and cautions are important with doxycycline? Do not prescribe doxycycline to: Pregnant or breastfeeding women. People with: Liver disease. Systemic lupus erythematosus. Myasthenia gravis. Porphyria. [ ; ] What are the adverse (...) effects of doxycycline? The adverse effects of doxycycline include: Gastrointestinal adverse effects, such as nausea, vomiting, and diarrhoea. Less frequently, doxycycline may cause photosensitivity. Advise the person to minimize exposure to direct sunlight. Severe adverse effects are unusual with a short course. However, benign intracranial hypertension has rarely been reported following treatment with a tetracycline. If a person taking doxycyline develops headache and visual disturbance, the drug

2018 NICE Clinical Knowledge Summaries

8. Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial. Full Text available with Trip Pro

Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial. Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline gives acceptable short-term blister control while conferring long-term safety advantages over starting treatment with oral corticosteroids.We did a pragmatic, multicentre, parallel-group randomised controlled (...) trial of adults with bullous pemphigoid (three or more blisters at two or more sites and linear basement membrane IgG or C3). Participants were randomly assigned to doxycycline (200 mg per day) or prednisolone (0·5 mg/kg per day) using random permuted blocks of randomly varying size, and stratified by baseline severity (3-9, 10-30, and >30 blisters for mild, moderate, and severe disease, respectively). Localised adjuvant potent topical corticosteroids (<30 g per week) were permitted during weeks 1-3

2017 Lancet Controlled trial quality: predicted high

9. Chest infections - adult: Doxycycline

Chest infections - adult: Doxycycline Doxycycline | Prescribing information | Chest infections - adult | CKS | NICE Search CKS… Menu Doxycycline Chest infections - adult: Doxycycline Last revised in May 2020 Doxycycline What contraindications and cautions are important with doxycyline? Do not prescribe doxycycline in: Women who are pregnant or breastfeeding. Tetracyclines are deposited in growing bone and teeth which can result in discolouration of teeth and occasionally dental hypoplasia (...) . Prescribe doxycycline with caution in people with: Hepatic impairment and those receiving potentially hepatotoxic drugs. Myasthenia gravis — tetracyclines may increase muscle weakness in people with myasthenia gravis. Systemic lupus erythematosus (SLE) — tetracyclines may exacerbate SLE symptoms. Renal impairment — avoid excessive doses. [ ; ] What are the adverse effects of doxycyline? Blood disorders — haemolytic anaemia, thrombocytopenia, neutropenia, eosinophilia, porphyria. Gastrointestinal

2017 NICE Clinical Knowledge Summaries

10. Azithromycin versus Doxycycline for Chlamydia. (Abstract)

Azithromycin versus Doxycycline for Chlamydia. 27144856 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Azithromycin versus Doxycycline for Chlamydia. 1787 10.1056/NEJMc1600830 Geisler William M WM Perry Raymond C W RC Kerndt Peter R PR eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents 83905-01-5 Azithromycin N12000U13O Doxycycline AIM IM N Engl J Med. 2015 Dec 24;373(26):2512-21 26699167 N Engl J Med (...) . 2016 May 5;374(18):1786 27144857 N Engl J Med. 2016 May 5;374(18):1786-7 27144858 Anti-Bacterial Agents therapeutic use Azithromycin therapeutic use Chlamydia Infections drug therapy Chlamydia trachomatis Doxycycline therapeutic use Female Humans Male 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144856 10.1056/NEJMc1600830 10.1056/NEJMc1600830#SA3

2016 NEJM

11. Azithromycin versus Doxycycline for Chlamydia. Full Text available with Trip Pro

Azithromycin versus Doxycycline for Chlamydia. 27144857 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Azithromycin versus Doxycycline for Chlamydia. 1786 10.1056/NEJMc1600830 Schachter Julius J University of California, San Francisco, San Francisco, CA julius.schachter@ucsf.edu. eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents 83905-01-5 Azithromycin N12000U13O Doxycycline AIM IM N Engl J Med. 2015 (...) Dec 24;373(26):2512-21 26699167 N Engl J Med. 2016 May 5;374(18):1787 27144856 Anti-Bacterial Agents therapeutic use Azithromycin therapeutic use Chlamydia Infections drug therapy Chlamydia trachomatis Doxycycline therapeutic use Female Humans Male 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144857 10.1056/NEJMc1600830 10.1056/NEJMc1600830#SA1

2016 NEJM

12. Azithromycin versus Doxycycline for Chlamydia. Full Text available with Trip Pro

Azithromycin versus Doxycycline for Chlamydia. 27144858 2016 05 05 2018 12 02 1533-4406 374 18 2016 05 05 The New England journal of medicine N. Engl. J. Med. Azithromycin versus Doxycycline for Chlamydia. 1786-7 10.1056/NEJMc1600830 Kreuter Alexander A Helios St. Elisabeth Hospital, Oberhausen, Germany alexander.kreuter@helios-kliniken.de. Wieland Ulrike U University of Cologne, Cologne, Germany. eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents 83905-01-5 (...) Azithromycin N12000U13O Doxycycline AIM IM N Engl J Med. 2015 Dec 24;373(26):2512-21 26699167 N Engl J Med. 2016 May 5;374(18):1787 27144856 Anti-Bacterial Agents therapeutic use Azithromycin therapeutic use Chlamydia Infections drug therapy Chlamydia trachomatis Doxycycline therapeutic use Female Humans Male 2016 5 5 6 0 2016 5 6 6 0 2016 5 6 6 1 ppublish 27144858 10.1056/NEJMc1600830 10.1056/NEJMc1600830#SA2

2016 NEJM

13. Acticlate Tablets (Doxycycline hyclate)

Acticlate Tablets (Doxycycline hyclate) Drug Approval Package: Brand Omtryg capsules NDA 204977 Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Acticlate Tablets (Doxycycline hyclate) Company: Aqua Pharmaceuticals Application No.: 205931 Approval Date: 7/25/2014 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF

2014 FDA - Drug Approval Package

14. Doxycycline

Doxycycline USE OF DOXYCYCLINE IN PREGNANCY 0344 892 0909 USE OF DOXYCYCLINE IN PREGNANCY (Date of issue: June 2012 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . Summary Doxycycline is a broad spectrum tetracycline antibiotic which is also used in the prophylaxis of malaria and as an adjunct to quinine (...) in the treatment of falciparum malaria. Exposure to doxycycline in early pregnancy has not been firmly associated with any specific malformations but its use in the second or third trimester can cause discolouration of the teeth. During pregnancy, travel to areas where malaria is endemic should be avoided wherever possible. If travel to such areas is unavoidable, chloroquine and proguanil are the preferred antimalarials to use during pregnancy. Doxycycline is best avoided for antimalarial prophylaxis during

2014 UK Teratology Information Service

15. Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial. Full Text available with Trip Pro

Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial. Doxycycline inhibits formation and progression of abdominal aortic aneurysms (AAAs) in preclinical models of the disease, but it is unclear whether and how this observation translates to humans.To test whether doxycycline inhibits AAA progression in humans.Randomized, placebo-controlled, double-blind trial. (Dutch Trial Registry: NTR 1345) SETTING: 14 Dutch hospitals.286 patients with small AAAs between October (...) 2008 and June 2011.Daily dose of 100 mg of doxycycline (n = 144) or placebo (n = 142) for 18 months.The primary outcome measure was aneurysm growth at 18 months, as estimated by repeated single-observer ultrasonography. Secondary outcomes included growth at 6 and 12 months and the need for elective surgery.Mean aneurysm diameter (approximately 43 mm) and other baseline characteristics were similar in both groups. Doxycycline treatment was associated with increased aneurysm growth (4.1 mm

2013 Annals of Internal Medicine Controlled trial quality: predicted high

16. Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial. Full Text available with Trip Pro

Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial. Melioidosis, an infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, is difficult to cure. Antimicrobial treatment comprises intravenous drugs for at least 10 days, followed by oral drugs for at least 12 weeks. The standard oral regimen based on trial (...) evidence is trimethoprim-sulfamethoxaxole (TMP-SMX) plus doxycycline. This regimen is used in Thailand but is associated with side-effects and poor adherence by patients, and TMP-SMX alone is recommended in Australia. We compared the efficacy and side-effects of TMP-SMX with TMP-SMX plus doxycycline for the oral phase of melioidosis treatment.For this multi-centre, double-blind, non-inferiority, randomised placebo-controlled trial, we enrolled patients (aged ≥15 years) from five centres in northeast

2013 Lancet Controlled trial quality: predicted high

17. Doxycycline monohydrate - Rosacea treatment

Doxycycline monohydrate - Rosacea treatment Common Drug Review CDEC Meeting — January 16, 2013; CDEC Reconsideration — March 20, 2013 Notice of CDEC Final Recommendation — March 27, 2013 Page 1 of 4 © 2013 CADTH FINAL CDEC RECOMMENDATION DOXYCYCLINE MONOHYDRATE (Apprilon – Galderma Canada Inc.) Indication: Inflammatory Rosacea Recommendation: The Canadian Drug Expert Committee (CDEC) recommends that 40 mg doxycycline modified- release capsules not be listed. Reason for the Recommendation (...) : The Committee considered the comparative clinical benefit of 40 mg doxycycline modified- release (MR) capsules to be uncertain due to limitations in the design and analysis of the single randomized controlled trial (RCT) (ROSE-401) that compared 40 mg doxycycline MR capsules with 100 mg doxycycline immediate-release (IR) capsules. Background: Doxycycline monohydrate has a Health Canada indication for the treatment of inflammatory lesions (papules and pustules) of rosacea in adult patients. Doxycycline has

2013 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

18. Ciprofloxacin or Doxycycline for the Treatment of Anthrax: A Review of the Clinical and Cost-Effectiveness

Ciprofloxacin or Doxycycline for the Treatment of Anthrax: A Review of the Clinical and Cost-Effectiveness Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources and a summary of the best evidence on the topic that CADTH could identify using all reasonable efforts within (...) is given to CADTH. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: Ciprofloxacin or Doxycycline for the Treatment of Anthrax: A Review of the Clinical and Cost-Effectiveness DATE: 27 November 2012 CONTEXT AND POLICY ISSUES The potential use of anthrax as a biological terrorist attack has

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

19. Doxycycline ineffective for osteoarthritis of the knee or hip

Doxycycline ineffective for osteoarthritis of the knee or hip PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Doxycycline ineffective for osteoarthritis of the knee or hip Clinical question How effective is doxycycline for osteoarthritis (OA) of the knee or hip? Bottom line Compared to placebo, there is minimal or no symptomatic benefit (pain reduction and improved physical function (...) ) with doxycycline treatment. The small benefit observed in joint space narrowing is of questionable clinical relevance and outweighed by safety issues. Doxycycline should therefore not be recommended for the treatment of osteoarthritis of the knee or hip. Caveat The trial was designed to detect differences in joint space narrowing rather than differences in clinical outcomes. No threshold for the level of knee pain was used for inclusion and the average level of knee pain was low at baseline, leaving little

2011 Cochrane PEARLS

20. Subantimicrobial-Dose Doxycycline (SDD) Periodontal therapy reduces serum biomarkers of systemic inflammation and can increase high-density lipoprotein

Subantimicrobial-Dose Doxycycline (SDD) Periodontal therapy reduces serum biomarkers of systemic inflammation and can increase high-density lipoprotein UTCAT856, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Subantimicrobial-Dose Doxycycline (SDD) Periodontal Therapy Reduces Serum Biomarkers Of Systemic Inflammation And Can Increase High-Density Lipoprotein Clinical Question In post-menopausal women with chronic (...) periodontitis does a systemic dose of Doxycycline in comparison to placebo increase high-density lipoprotein (HDL) levels? Clinical Bottom Line In post-menopausal women with chronic periodontitis Subantimicrobial-Dose Doxycycline Periodontal therapy reduces serum biomarkers of systemic inflammation and among women more than five years post-menopausal, the SDD regimen elevated their level of high-density lipoprotein (HDL) cholesterol. (See Comments on the CAT below) Best Evidence (you may view more info

2011 UTHSCSA Dental School CAT Library