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Latest & greatest articles for elderly
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on elderly or other clinical topics then use Trip today.
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Antiepileptic drug monotherapy for epilepsy in the elderly: A systematic review and network meta-analysis. To estimate the comparative efficacy and safety of antiepileptic drugs (AEDs) in the elderly with new-onset epilepsy.We searched electronic databases for randomized controlled trials (RCTs) of monotherapy AEDs to treat epilepsy in elderly. The following outcomes were analyzed: seizure freedom and withdrawal from the study for any cause at 6 and 12 months; withdrawal from the study for any
exercise on depression and brain-derived neurotrophic factor for this group of people. In conclusion, this meta-analysis indicated that group exercises improve cognition, attention and executive function in community-dwelling older adults with mild cognitive impairment or Alzheimer's disease. (...) The neurocognitive and BDNF changes of multicomponent exercise for community-dwelling older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis. Our goal was to examine whether multicomponent exercise performed by older adults with mild cognitive impairment or dementia as group-based exercise in community have beneficial effects on cognition and brain-derived neurotrophic factor. Eight studies were identified through Emabase, Medline, PubMed. Searches
A meta-analysis of genome-wide association studies identifies multiple longevity genes. Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age (...) corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA
A meta-analysis of pro-inflammatory cytokines in autism spectrum disorders: Effects of age, gender, and latitude. Autism spectrum disorders (ASD) occur in 1.5% of the general population worldwide. Studies suggest that ASD might have more costs than diabetes and attention deficit and hyperactivity disorder by 2025. Dysregulation of the cytokine system is well-documented in ASD. We conducted a meta-analysis of studies providing data on circulating concentrations of pro-inflammatory cytokines (...) in people with ASD compared with control subjects without ASD.We identified potentially eligible studies by systematically searching electronic databases from inception to February 2018.Thirty-eight studies with total of 2487 participants (1393 patients with ASD and 1094 control subjects) were included in the meta-analysis; 13 for interferon (IFN)-γ, 17 for interleukin (IL)-1β, 22 for IL-6, 19 for tumor necrosis factor (TNF)-α, 4 for IL-1α, 6 for IL-2, 4 for IL-7, 8 for IL-8, 14 for IL-12, 3 for IL-15
. To provide an overview of MCoW in OA and YA and to investigate the quantitative effect of age on MCoW, we have conducted a literature review and performed two meta-analyses. We extracted data on MCoW in healthy YA (18-41 years old) and healthy OA (≥59 years old) and calculated, if not already reported, the Gross (GCoW) and Net MCoW (NCoW) in J/kg/m. If studies reported MCoW measured at multiple speeds, we selected those values for YA and OA at which MCoW was minimal. All studies directly comparing YA (...) The Metabolic Cost of Walking in healthy young and older adults - A Systematic Review and Meta Analysis. The Metabolic Cost of Walking (MCoW) is an important variable of daily life that has been studied extensively. Several studies suggest that MCoW is higher in Older Adults (OA) than in Young Adults (YA). However, it is difficult to compare values across studies due to differences in the way MCoW was expressed, the units in which it was reported and the walking speed at which it was measured
Systematic review with meta-analysis: biologics and risk of infection or cancer in elderly patients with inflammatory bowel disease. Uncertainty exists concerning the risk of infection and cancer associated with biologic therapies in elderly patients with inflammatory bowel disease (IBD).To identify, synthesise and critically appraise the available evidence on the topic.We systematically searched Medline/PubMed, Embase and Scopus, through October 2019, and recent conference proceedings (...) , to identify studies investigating the risk of serious infections, opportunistic infections, any infection and cancer in elderly IBD patients (>60 years) exposed to biologics as compared to those unexposed to biologics. Two reviewers independently extracted study data and assessed each study's risk of bias. We examined heterogeneity, and calculated summary effect estimates using fixed- and random effects models. Quality of evidence was determined with GRADE.We included 15 studies (one post hoc analysis
Phenobarbital rheumatism-A fresh look at an old malady: Case report and systematic review of literature. 32100469 2020 04 14 1756-185X 23 4 2020 Apr International journal of rheumatic diseases Int J Rheum Dis Phenobarbital rheumatism-A fresh look at an old malady: Case report and systematic review of literature. 589-594 10.1111/1756-185X.13813 Jha Saket S https://orcid.org/0000-0001-9011-464X Clinical Immunology & Rheumatology Unit, Department of Internal Medicine, PGIMER, Chandigarh, India
Efficacy of continuous positive airway pressure (CPAP) for improvements in sleepiness, cognition, mood and quality of life in elderly patients with obstructive sleep apnea: Systematic review and meta-analysis of randomized controlled trials. Obstructive sleep apnea (OSA) is commonly found in the elderly population (≥ 65 years old), and continuous positive airway pressure (CPAP) improves sleepiness, health-related quality of life (HRQoL) in the middle-aged population; however, data about its (...) efficacy in elderly patients are unclear.To evaluate the efficacy of CPAP for sleepiness, HRQoL, mood, and cognition in elderly patients with OSA.We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), including trials performed in elderly patients with OSA. As an intervention, we compared CPAP versus a control. Two independent reviewers explored several databases; risk of bias (RoB) was evaluated using the Cochrane tool. Changes in sleepiness (Epworth Sleepiness
MALONDIALDEHYDE LEVELS IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION: A Systematic Review and Meta-analysis. The role of blood malondialdehyde (MDA) in age-related macular degeneration (AMD), the leading cause of new blindness in industrialized countries, is still matter of debate. We performed a systematic review and meta-analysis of the published data on the MDA levels in AMD patients.PubMed, ISI Web of Sciences, and Scopus searches were performed according to MOOSE guidelines. Case (...) -control studies were eligible for inclusion. Participants and controls were AMD patients and subjects without AMD, respectively. The main outcome measures were wet AMD and dry AMD. MDA level was the main exposure variable. Data were pooled using a random-effects model.Twelve case-control studies were identified. A total of 634 AMD patients (mean age 66.7 years) and 656 controls without AMD (mean age 67.8 years) were evaluated. Extreme between-study heterogeneity was observed (I = 96.8%, P < 0.001
The effect of transcranial direct current stimulation on balance in healthy young and older adults: A systematic review of the literature. Various studies have investigated the effect of noninvasive brain stimulation methods such as transcranial direct stimulation (tDCS) on postural control in healthy young and older adults. However, the use of different treatment protocols and outcome measures makes it difficult to interpret the research results. This systematic review provides a comprehensive (...) overview of the current literature on the effect of tDCS on postural control. Nine databases were searched for papers assessing the effect of tDCS on postural control in young healthy and/or older adults. The data of included studies were extracted and methodological quality examined using PEDro. Sixteen studies met the inclusion criteria. The results showed that anodal tDCS (a-tDCS) of primary motor cortex may improve dynamic balance in young healthy individuals. In older adults, a-tDCS
Consequences of physical inactivity in older adults: A systematic review of reviews and meta-analyses. Globally, populations are ageing. Typically, physical activity levels decline and health worsens as we age; however, estimates of the impact of physical inactivity for population health often fail to specifically focus on older adults.Multiple databases were searched for systematic reviews and/or meta-analyses of longitudinal observational studies, investigating the relationship between (...) physical activity and any physical or mental health outcome in adults aged ≥60 years. Quality of included reviews was assessed using AMSTAR.Twenty-four systematic reviews and meta-analyses were included. The majority of reviews were of moderate or high methodological quality. Physically active older adults (≥60 years) are at a reduced risk of all-cause and cardiovascular mortality, breast and prostate cancer, fractures, recurrent falls, ADL disability and functional limitation and cognitive decline
Determinants of Ageism against Older Adults: A Systematic Review. Ageism is a widespread phenomenon and constitutes a significant threat to olderpeople's well-being. Identifying the factors contributing to ageism is critical to inform policies that minimise its societal impact. In this systematic review, we gathered and summarised empirical studies exploring the key determinants of ageism against olderpeople for a period of over forty years (1970-2017). A comprehensive search using fourteen (...) on other-directed ageism, and one on self-directed ageism. The quality of contact with olderpeople and the positive or negative presentation of olderpeople to others emerged as the most robust determinants of other-directed ageism; self-directed ageism is mostly determined by older adults' health status. Given the correlational nature of most studies included in this review, inferences on causality should be made cautiously.
Frailty as a Predictor of Emergency Department Utilization among Community-Dwelling OlderPeople: A Systematic Review and Meta-Analysis. 30470576 2020 04 13 2020 04 13 1538-9375 20 1 2019 01 Journal of the American Medical Directors Association J Am Med Dir Assoc Frailty as a Predictor of Emergency Department Utilization among Community-Dwelling OlderPeople: A Systematic Review and Meta-Analysis. 103-105 S1525-8610(18)30577-2 10.1016/j.jamda.2018.10.004 Kojima Gotaro G Department of Primary (...) Care and Population Health, University College London, London, United Kingdom. eng Letter Meta-Analysis Systematic Review 2018 11 20 United States J Am Med Dir Assoc 100893243 1525-8610 IM Aged Emergency Service, Hospital statistics & numerical data Frail Elderly Humans Independent Living 2018 10 01 2018 10 05 2018 11 25 6 0 2020 4 14 6 0 2018 11 25 6 0 ppublish 30470576 S1525-8610(18)30577-2 10.1016/j.jamda.2018.10.004
Liver transplantation in elderly patients: a systematic review and first meta-analysis. Elderly recipients are frequently discussed by the scientific community but objective indication for this parameter has been provided. The aim of this study was to synthesize the available evidence on liver transplantation for elderly patients to assess graft and patient survival.A literature search of the Medline, EMBASE, and Scopus databases was carried out from January 2000 to August 2018. Clinical (...) studies comparing the outcomes of liver transplantation in adult younger (<65 years) and elderly (>65 years) populations were analyzed. The primary outcomes were patient mortality and graft loss rates. This review was registered (Number CRD42017058261) as required in the international prospective register for systematic review protocols (PROSPERO).Twenty-two studies were included involving a total of 242,487 patients (elderly: 23,660 and young: 218,827) were included in this study. In the meta
social cognition and oral health.This systematic review provides evidence of an association between learning and memory, complex attention, and executive function with oral health in oldage. Gaining a detailed picture of how specific types of cognitive decline relate to oral health has potential implications for earlier identification of older adults who experience oral health problems, and may also inform the development of more effective interventions focused on enhancing oral health outcomes (...) Oral Health and Cognitive Function in Older Adults: A Systematic Review. It has often been argued that there is a relationship between oral health and cognitive decline in late adulthood, but a recent systematic review concluded that it was unclear "how or whether" any relationship exists. However, most of the studies that contributed to this review operationalised cognitive function using a brief cognitive screen and/or dementia status.An updated systematic review was conducted that focused
Dietary Fat Intake and Cognitive Function among Older Populations: A Systematic Review and Meta-Analysis. The associations between dietary fat intake and cognitive function are inconsistent and inconclusive. This study aimed to provide a quantitative synthesis of prospective cohort studies on the relationship between dietary fat intake and cognitive function among older adults.PubMed, EMBASE, PsycINFO and Web of Science databases were searched for prospective cohort studies published in English
Gestational age and maternal status of DHA and other polyunsaturated fatty acids in pregnancy: A systematic review. Maternal diet is important in determining omega-3 DHA status however there is limited knowledge of other factors influencing maternal omega-3 concentrations during pregnancy. The primary objective of this systematic review and meta-analysis was to evaluate whether maternal DHA status changed across gestation. Changes in levels of other key polyunsaturated fatty acids were also
of this meta-analytical review is to examine the effects of different exercise training on handgrip strength in healthy community-dwelling older adults of 60 years or older.The literature search was conducted in three databases (PubMed, Web of Science, SPORTDiscus) using the following search terms with Boolean conjunctions: (hand grip* OR grip strength OR grip power) AND (sport* OR train* OR exercis* OR strength OR intervention OR endurance OR resistance OR balance OR aerob*) AND (old* OR elder* OR senior (...) Effects of Exercise Training on Handgrip Strength in Older Adults: A Meta-Analytical Review. Handgrip strength measurements are feasible with older adults and a reliable indicator for vitality, physical function, and several risk factors in the ageing process. Interventions with exercise training induce a variety of strength, balance, and endurance improvements. The pooled transfer effects of exercise training on handgrip strength has not been investigated to date. Thus, the objective
Clinical outcomes of oesophagectomy in elderly versus relatively younger patients: a meta-analysis. The surgical efficacy of oesophagectomy for elderly patients (>80 years old) is still unclear. The aim of this meta-analysis was to compare the clinical outcomes of oesophagectomy between elderly and relatively younger patients.PubMed, EMBASE and the Cochrane Library were searched for relevant studies comparing the clinical outcomes of oesophagectomy for elderly and relatively younger patients (...) . Odds ratios were extracted to obtain pooled estimates of the perioperative effect, and hazard ratios were extracted to compare survival outcomes between the 2 cohorts.Nine studies involving 4946 patients were included in this meta-analysis. For patients older than 80 years of age, in-hospital mortality [odds ratio (OR) 2.00, 95% confidence interval (CI) 1.28-3.13; P = 0.002] and the incidence rates of cardiac (OR 1.55, 95% CI 1.10-2.20; P = 0.01) and pulmonary (OR 1.57, 95% CI 1.11-2.22; P = 0.01
Breastfeeding in children born small for gestational age and future nutritional and metabolic outcomes: a systematic review. To systematically review evidence related to nutritional and cardiometabolic outcomes in children born at term and small for gestational age and the association with breastfeeding.Two independent reviewers searched the MEDLINE, LILACS, SciELO, and Embase databases without time or language restrictions. The PRISMA tool was used, and studies that evaluated infants born (...) at term and small for gestational age, breastfed, and with an evaluation of cardiometabolic outcomes were included. Studies with preterm infants, those that did not have information on breastfeeding, and those with lack of evaluation of the outcome variables were excluded. Also excluded were review articles, editorials, and series of cases.Only seven articles were found that met the abovementioned criteria. There was a great variability in the type of evaluation, as well as in the age