Latest & greatest articles for elderly

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Top results for elderly

41. Comparison of the Effect of Age (< 75 Versus >/= 75) on the Efficacy and Safety of Dual Therapy (Dabigatran+Clopidogrel or Ticagrelor) Versus Triple Therapy (Warfarin+Aspirin+Clopidogrel or Ticagrelor) in Patients With Atrial Fibrillation After Percutaneo Full Text available with Trip Pro

to treatment, 1,026 (37.7%) were categorized into older and 1,699 (62.3%) into younger age groups. Dabigatran 110 mg dual therapy lowered bleeding risk versus warfarin triple therapy in older (hazard ratio [HR] 0.67; 95% confidence interval [CI] 0.51 to 0.89) and younger patients (HR 0.40; 95% CI 0.30 to 0.54); interaction p value: 0.0125. Dabigatran 150 mg dual therapy lowered bleeding risk versus warfarin triple therapy in younger patients (HR 0.57; 95% CI 0.44 to 0.74), whereas no benefit could (...) Comparison of the Effect of Age (< 75 Versus >/= 75) on the Efficacy and Safety of Dual Therapy (Dabigatran+Clopidogrel or Ticagrelor) Versus Triple Therapy (Warfarin+Aspirin+Clopidogrel or Ticagrelor) in Patients With Atrial Fibrillation After Percutaneo Comparison of the Effect of Age ( - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History

2020 EvidenceUpdates

42. Older adults: cost-effective commissioning

and implementing services to support older people's healthy ageing. Published 28 January 2020 From: Documents Ref: PHE publications gateway reference GW-1008 If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you say what assistive technology you use. Ref: PHE publications gateway reference GW-1008 If you use assistive technology (such as a screen reader) and need (...) on identified interventions to support older people, generated through a literature review. The return on investment (ROI) tool: can be adapted to local conditions presents results showing the economic benefits of each intervention has a built-in user guide Local authorities and clinical commissioning groups can use these resources to improve the provision of services for older people. Published 28 January 2020 Related content Explore the topic Is this page useful? Thank you for your feedback Help us

2020 Public Health England

43. Plerixafor (Mozobil) - children aged 1 year to <18 years with lymphoma or solid malignant tumours

Plerixafor (Mozobil) - children aged 1 year to <18 years with lymphoma or solid malignant tumours Published 10 February 2020 1 Product update SMC2249 plerixafor 20mg/mL solution for injection (Mozobil®) Sanofi Aventis 10 January 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated (...) submission plerixafor (Mozobil®) is accepted for use within NHSScotland. Indication under review: in combination with granulocyte-colony stimulating factor (G-CSF) to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in children aged 1 year to <18 years with lymphoma or solid malignant tumours, either: - pre-emptively, when circulating stem cell count on the predicted day of collection after adequate mobilisation with G-CSF

2020 Scottish Medicines Consortium

44. Testosterone Treatment in Adult Men with Age-Related Low Testosterone Full Text available with Trip Pro

, Nankin HR , Spark RF , et al American Association of Clinical Endocrinologists American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients—2002 update. Endocr Pract 2002 Nov-Dec 8 440 56 Wu FC , Tajar A , Beynon JM , et al EMAS Group Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010 363 123 35 Bassil N , Morley JE . Late-life onset hypogonadism: a review (...) . Clin Geriatr Med 2010 26 197 222 Nguyen CP , Hirsch MS , Moeny D , et al Testosterone and “Age-related hypogonadism”—FDA concerns. N Engl J Med 2015 373 689 91 Diem SJ , Greer NL , MacDonald R , et al Efficacy and safety of testosterone treatment in men: an evidence report for a clinical practice guideline by the American College of Physicians. Ann Intern Med 7 January 2020 [Epub ahead of print] Qaseem A , Kansagara D , Lin JS , et al Clinical Guidelines Committee of the American College

2020 American College of Physicians

45. Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery Full Text available with Trip Pro

in elderly patients after surgery and is associated with poor outcomes. This study aimed to investigate the impact of intraoperative dexmedetomidine on the incidence of delirium in elderly patients undergoing major surgery. Methods: This was a randomized double-blind placebo-controlled trial. Elderly patients (aged 60 years or more) scheduled to undergo major non-cardiac surgery were randomized into two groups. Patients in the intervention group received a loading dose of dexmedetomidine 0·6 μg/kg 10 min (...) Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery Randomized Clinical Trial of Intraoperative Dexmedetomidine to Prevent Delirium in the Elderly Undergoing Major Non-Cardiac Surgery - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced

2020 EvidenceUpdates

46. Validation of the Elderly Risk Assessment Index in the Emergency Department (Abstract)

Validation of the Elderly Risk Assessment Index in the Emergency Department The Elderly Risk Assessment (ERA) score is a validated index for primary care patients that predict hospitalizations, mortality, and Emergency Department (ED) visits. The score incorporates age, prior hospital days, marital status, and comorbidities. Our aim was to validate the ERA score in ED patients.Observational cohort study of patients age ≥ 60 presenting to an academic ED over a 1-year period. Regression analyses (...) were performed for associations with outcomes (hospitalization, return visits and death). Medians, interquartile range (IQR), odds ratios (OR) and 95% confidence intervals (CI) were calculated.The cohort included 27,397 visits among 18,607 patients. Median age 74 years (66-82), 48% were female and 59% were married. Patients from 54% of visits were admitted to the hospital, 16% returned to the ED within 30 days, and 18% died within one year. Higher ERA scores were associated with: hospital admission

2020 EvidenceUpdates

47. Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial

Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features (...) a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation J Clin Oncol Actions , 38 (3), 248-256 2020 Jan 20 Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial , , , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 University Medical Center Groningen

2020 EvidenceUpdates

48. Developing an all-age response to meet the age-specific needs of service users

Developing an all-age response to meet the age-specific needs of service users NHS England » Developing an all-age response to meet the age-specific needs of service users Search Search Menu Developing an all-age response to meet the age-specific needs of service users Document first published: 22 January 2020 Page updated: 22 January 2020 Topic: Publication type: Document PDF 476 KB 14 pages

2020 NHS England

49. Incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children: prospective population-based study

Incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children: prospective population-based study Incident Psychiatric Comorbidity Following Stress Disorder Diagnoses in Danish School-Aged Children: Prospective Population-Based Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other (...) characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Br J Psychiatry Actions , 1-6 2019 Nov 22 [Online ahead of print] Incident Psychiatric Comorbidity Following Stress Disorder Diagnoses in Danish School-Aged Children: Prospective Population-Based Study , , , , , , Affiliations Expand Affiliations 1 Research Associate

2020 EvidenceUpdates

50. Physical Activity: Digital Health Interventions for Adults 55 Years and Older

Studies The number of studies and publications do not always correspond (e.g., a publication may include several studies or one study may be explained in several publications). . Bickmore TW, Silliman RA, Nelson K, Cheng DM, Winter M, et al.. A randomized controlled trial of an automated exercise coach for older adults. J Am Geriatr Soc 2013;61:1676–83. Freene N. Physiotherapist-led home-based physical activity program versus community group exercise for middle-aged adults: quasi-experimental (...) , Castro CM, et al. Promoting physical activity through hand-held computer technology. Am J Prev Med 2008;34:138–42. King AC, Bickmore TW, Campero MI, Pruitt LA, Yin JL. Employing virtual advisors in preventive care for underserved communities: results from the COMPASS study. J Health Commun 2013b;18:1449–64. Kolt GS, Schofield GM, Kerse N, Garrett N, Oliver M. Effect of telephone counseling on physical activity for low-active older people in primary care: a randomized, controlled trial. J Am Geriatr

2020 Community Preventive Services Task Force

51. Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 x 2, Phase II Trial (Abstract)

inhibitor valproate and all-trans retinoic acid (ATRA) in treatment-naive elderly patients with acute myeloid leukemia (AML).Two hundred patients (median age, 76 years; range, 61-92 years) ineligible for induction chemotherapy received decitabine (20 mg/m2 intravenously, days 1 to 5) alone (n = 47) or in combination with valproate (n = 57), ATRA (n = 46), or valproate + ATRA (n = 50). The primary endpoint was objective response, defined as complete and partial remission, tested at a one-sided (...) Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 x 2, Phase II Trial DNA-hypomethylating agents are studied in combination with other epigenetic drugs, such as histone deacetylase inhibitors or differentiation inducers (eg, retinoids), in myeloid neoplasias. A randomized, phase II trial with a 2 × 2 factorial design was conducted to investigate the effects of the histone deacetylase

2020 EvidenceUpdates

52. The CHIRPY DRAGON intervention in preventing obesity in Chinese primary-school--aged children: A cluster-randomised controlled trial Full Text available with Trip Pro

The CHIRPY DRAGON intervention in preventing obesity in Chinese primary-school--aged children: A cluster-randomised controlled trial The CHIRPY DRAGON Intervention in Preventing Obesity in Chinese Primary-School--Aged Children: A Cluster-Randomised Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced (...) characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Randomized Controlled Trial PLoS Med Actions , 16 (11), e1002971 2019 Nov 26 eCollection Nov 2019 The CHIRPY DRAGON Intervention in Preventing Obesity in Chinese Primary-School--Aged Children: A Cluster-Randomised Controlled Trial , , , , , , , , , , , Affiliations Expand

2020 EvidenceUpdates

53. Examining the relationship between triage acuity and frailty to inform the care of older emergency department patients: Findings from a large Canadian multisite cohort study (Abstract)

Examining the relationship between triage acuity and frailty to inform the care of older emergency department patients: Findings from a large Canadian multisite cohort study The 2016 Canadian Triage and Acuity Scale (CTAS) updates introduced frailty screening within triage to more accurately code frail patients who may deteriorate waiting for care. The relationship between triage acuity and frailty is not well understood, but may help inform which supplemental geriatric assessments (...) are beneficial to support care in the emergency department (ED). Our objectives were to investigate the relationship between triage acuity and frailty, and to compare their associations with a series of patient outcomes.We conducted a secondary analysis of the Canadian cohort from a multinational prospective study. Data were collected on ED patients 75 years of age and older from eight ED sites across Canada between November 2009 and April 2012. Triage acuity was assigned using the CTAS, whereas frailty

2020 EvidenceUpdates

54. Guidance for Providers Caring for Women and Men Of Reproductive Age with Possible Zika Virus Exposure

Guidance for Providers Caring for Women and Men Of Reproductive Age with Possible Zika Virus Exposure -1- Guidance for Providers Caring for Women and Men Of Reproductive Age with Possible Zika Virus Exposure (Modified from CDC a- i FDA j-l and WHO k Published Guidance) Updated July 2019 Planning Pregnancy for Infected, Exposed, or Possibly Exposed Individuals This is an update of the ASRM Zika virus guidance for providers that addresses the care of non-pregnant patients desiring pregnancy (...) taking into account any new available data and such variables as age of the female patient and other infertility factors with documentation of the conversation and decision. 4. Symptomatic women and men attempting pregnancy through ART with possible Zika virus exposure should have testing that includes the Zika virus nucleic acid test (NAT) to rule out active Zika infection, and serologic testing, as outlined in section #8 below, to identify Zika immunity, before proceeding on with infertility

2020 Society for Assisted Reproductive Technology

55. Best-practice prevention alone or with conventional or biological caries management for 3- to 7-year-olds: the FiCTION three-arm RCT

Best-practice prevention alone or with conventional or biological caries management for 3- to 7-year-olds: the FiCTION three-arm RCT Best-practice prevention alone or with conventional or biological caries management for 3- to 7-year-olds: the FiCTION three-arm RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try

2020 NIHR HTA programme

56. Combination non-pharmacologic intervention for orthostatic hypotension in older people: a phase 2 study Full Text available with Trip Pro

to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Age Ageing Actions 2019 Dec 23 [Online ahead of print] Combination Non-Pharmacologic Intervention for Orthostatic Hypotension in Older People: A Phase 2 Study , Affiliations Expand Affiliations 1 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. 2 The Falls and Syncope Service, Newcastle upon Tyne (...) Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK. 3 NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Trust and Newcastle University, Newcastle upon Tyne, UK. PMID: 31868889 DOI: Item in Clipboard Combination Non-Pharmacologic Intervention for Orthostatic Hypotension in Older People: A Phase 2 Study James Frith et al. Age Ageing . 2019 Show details Age Ageing Actions Authors , Affiliations 1 Institute of Cellular Medicine, Newcastle University, Newcastle upon

2020 EvidenceUpdates

57. Ageing and mobility: A grand challenge

as a barrier to use and improvement. This results in difficulties for individuals to navigate the systems and weakens system-wide incentives for integration and innovation. On average at least one-third of older people report unmet travel needs. It worsens with age, and women were reported to be more affected than men. (Luiu et al 2016). Mobility challenges faced in later life6 © Centre for Ageing Better 20197 © Centre for Ageing Better 2019 As we grow older, we are more likely to have health conditions (...) % of older people cannot reach a hospital within 30 minutes by public transport. (Future of Mobility: Evidence Review). Accessible and inclusive new technologies, services and business models Opportunities for innovation8 © Centre for Ageing Better 2019 Specific issues to address in their development include: - New vehicles, including Autonomous Vehicles, need to be designed to be accessible for people with limited mobility. - Addressing the door to vehicle portion of the journey, which can

2020 The Centre for Ageing Better

58. The State of Ageing in 2019: Adding life to our years

occupations. Pessimism about getting older is also linked to poorer health. People who worry about their health getting worse and those who expect to get lonely are around 30% more likely to have a negative experience of ageing than people who don’t. 31 8% 6% 5% 3% 3% 25 to 34 year olds 50 to 64 year olds 35 to 49 year olds 65 to 74 year olds 75 and over professional occupations routine occupations 7% 20% Later lives todayHow will future generations experience later life? In less than 20 years, the number (...) at risk. HealthHousing The majority of people continue to live in mainstream houses as they grow older, rather than moving into specialist accommodation, and increasing numbers of over 50s are renting. Yet UK housing stock is by and large unsuitable for people to grow old in.The State of Ageing in 2019 Adding life to our years 27 Housing With 38% of our homes dating from before 1946 (21% from before 1919), and just 7% from after 2000, the UK has the oldest housing stock in the EU. 69 Unsurprisingly

2020 The Centre for Ageing Better

59. Efficacy, safety, and tolerability of mirabegron in patients aged >/=65yr with overactive bladder wet: a phase IV, double-blind, randomised, placebo-controlled study (PILLAR)

. Safety and tolerability were consistent with the known mirabegron safety profile. Conclusions: Mirabegron efficacy, safety, and tolerability over 12 wk were confirmed in patients aged ≥65yr with OAB and incontinence. Patient summary: We examined the effect of mirabegron compared with placebo in people aged 65yr or older with overactive bladder and incontinence. Mirabegron improved the symptoms of overactive bladder compared with placebo. Side effects were similar to those already known for mirabegron (...) of Mirabegron in Patients Aged ≥65yr With Overactive Bladder Wet: A Phase IV, Double-Blind, Randomised, Placebo-Controlled Study (PILLAR) Adrian Wagg et al. Eur Urol . Feb 2020 Show details Eur Urol Actions , 77 (2), 211-220 Authors , , , , , Affiliations 1 Geriatric Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address: adrian.wagg@ualberta.ca. 2 Division of Urology, St Elizabeth's Medical Center, Boston, MA, USA. 3 Bayview Research Group, LLC, Valley Village, CA, USA. 4 Sunnybrook

2020 EvidenceUpdates

60. Mortality Implications of Prediabetes and Diabetes in Older Adults

delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Diabetes Care Actions , 43 (2), 382-388 Feb 2020 Mortality Implications of Prediabetes and Diabetes in Older Adults , , , , , , , Affiliations Expand Affiliations 1 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 2 Division of Cardiology and National Institute for Prevention and Cardiovascular Health, National University of Ireland, Galway, Ireland. 3 Department of Geriatric (...) @jhu.edu. PMID: 31776141 PMCID: (available on 2021-02-01 ) DOI: Item in Clipboard Full-text links Cite Abstract Objective: Diabetes in older age is heterogeneous, and the treatment approach varies by patient characteristics. We characterized the short-term all-cause and cardiovascular mortality risk associated with hyperglycemia in older age. Research design and methods: We included 5,791 older adults in the Atherosclerosis Risk in Communities Study who attended visit 5 (2011-2013; ages 66-90 years

2020 EvidenceUpdates