Latest & greatest articles for elderly

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Top results for elderly

61. Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial

Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable (...) : Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation JAMA Pediatr Actions . 2020 Feb 24;e196083. doi: 10.1001/jamapediatrics.2019.6083. Online ahead of print. Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years

2020 EvidenceUpdates

62. Continuation of Annual Screening Mammography and Breast Cancer Mortality in Women Older Than 70 Years. (Abstract)

Continuation of Annual Screening Mammography and Breast Cancer Mortality in Women Older Than 70 Years. Randomized trials have shown that initiating breast cancer screening between ages 50 and 69 years and continuing it for 10 years decreases breast cancer mortality. However, no trials have studied whether or when women can safely stop screening mammography. An estimated 52% of women aged 75 years or older undergo screening mammography in the United States.To estimate the effect of breast cancer (...) screening on breast cancer mortality in Medicare beneficiaries aged 70 to 84 years.Large-scale, population-based, observational study of 2 screening strategies: continuing annual mammography, and stopping screening.U.S. Medicare program, 2000 to 2008.1 058 013 beneficiaries aged 70 to 84 years who had a life expectancy of at least 10 years, had no previous breast cancer diagnosis, and underwent screening mammography.Eight-year breast cancer mortality, incidence, and treatments, plus the positive

2020 Annals of Internal Medicine

63. Mortality and Hospitalizations for Dually Enrolled and Nondually Enrolled Medicare Beneficiaries Aged 65 Years or Older, 2004 to 2017. (Abstract)

Mortality and Hospitalizations for Dually Enrolled and Nondually Enrolled Medicare Beneficiaries Aged 65 Years or Older, 2004 to 2017. Medicare beneficiaries who are also enrolled in Medicaid (dually enrolled beneficiaries) have drawn the attention of policy makers because they comprise the poorest subset of the Medicare population; however, it is unclear how their outcomes have changed over time compared with those only enrolled in Medicare (nondually enrolled beneficiaries).To evaluate annual (...) changes in all-cause mortality, hospitalization rates, and hospitalization-related mortality among dually enrolled beneficiaries and nondually enrolled beneficiaries.Serial cross-sectional study of Medicare fee-for-service beneficiaries aged 65 years or older between January 2004 and December 2017. The final date of follow-up was September 30, 2018.Dual vs nondual enrollment status.Annual all-cause mortality rates; all-cause hospitalization rates; and in-hospital, 30-day, 1-year hospitalization

2020 JAMA

64. Deprescribing for Older Veterans: A Systematic Review

& Development Management eBrief no. 170 » Issue 170 March 2020 The report is a product of the VA/HSR&D Evidence Synthesis Program. Deprescribing for Older Veterans: A Systematic Review More than 40% of people in the United States age ≥65 years take five or more prescription medications on a regular basis to control or prevent disease symptoms and complications. The number of medications a person is taking may be the single most important predictor of adverse drug effects. Efforts have been underway for more (...) medications, and medications known to pose risks in the elderly. The VA Center for Medication Safety in Aging was charged with the development and implementation of deprescribing approaches in VA settings. Commissioned by the National Center for Patient Safety and endorsed by VA Pharmacy Benefits Management and the Geriatrics and Extended Care Services, the purpose of this evidence review is to inform that work. Specific questions to be addressed included: What are the effectiveness, comparative

2020 Veterans Affairs - R&D

65. Preventive home visits to older people

" OR AB "Health promotion") 1236 4. 1 OR 2 OR 3 5690 Population: 5. DE "OLDER people" 7927 6. (TI (elderly OR aged OR old*) N2 (person* OR people* OR m#n OR wom#n OR patient*)) OR (AB (elderly OR aged OR old*) N2 (person* OR people* OR m#n OR wom#n OR patient*)) 29086 7. (TI (geriatric* OR "senior citizen*")) OR (AB (geriatric* OR "senior citizen*")) 4799 8. 5 OR 6 OR 7 36564 Study types: 9. DE "Systematic reviews (Medical research)" OR DE "Cochrane reviews" OR DE "Meta-analysis" 5181 10. (TI (...) Population: 5. exp Aged/ 3041480 6. ((elderly or aged or old$) adj2 (person$ or people$ or m?n or wom?n or patient$)).ti,ab. 714320 7. (geriatric$ or senior citizen$).ti,ab 46885 8. 5 OR 6 OR 7 3469976 Study types: 9. Exp systematic review/ OR cochrane library.mp OR exp meta analysis/ 191889 10. ((systematic* ADJ3 review) OR meta analy* OR metaanaly*).ab,ti,kw 255856 11. 9 OR 10 282791 Combined sets: 12. 4 AND 8 5311 Final 11 AND 12 102 Cochrane Library via Wiley 2020-01-14 Preventive home visits

2020 Swedish Council on Technology Assessement

66. Similar Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins

Similar Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins Similar Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes (...) to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Diabetes Care Actions 2020 Feb 19 [Online ahead of print] Similar Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins , , , , , , , , , , Affiliations Expand Affiliations 1 Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver

2020 EvidenceUpdates

67. Reverse Shoulder Arthroplasty Is Superior to Plate Fixation at 2 Years for Displaced Proximal Humeral Fractures in the Elderly: A Multicenter Randomized Controlled Trial Full Text available with Trip Pro

results compared with open reduction and internal fixation (ORIF) using an angular stable plate. Methods: The DelPhi trial is a randomized controlled trial comparing reverse TSA with ORIF for displaced proximal humeral fractures (OTA/AO types 11-B2 and 11-C2) in elderly patients (65 to 85 years of age). The primary outcome measure was the Constant score at a 2-year follow-up. The secondary outcome measures included the Oxford Shoulder Score and radiographic evaluation. Results were reported (...) Reverse Shoulder Arthroplasty Is Superior to Plate Fixation at 2 Years for Displaced Proximal Humeral Fractures in the Elderly: A Multicenter Randomized Controlled Trial Reverse Shoulder Arthroplasty Is Superior to Plate Fixation at 2 Years for Displaced Proximal Humeral Fractures in the Elderly: A Multicenter Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy

2020 EvidenceUpdates

68. Association between preadmission frailty and care level at discharge in older adults undergoing emergency laparotomy (Abstract)

with increased dependence at the time of discharge.The ELF study was a UK-wide multicentre prospective cohort study of older patients (65 years or more) undergoing emergency laparotomy during March and June 2017. The objective was to establish whether preoperative frailty was associated with increased care level at discharge compared with preoperative care level. The analysis used a multilevel logistic regression adjusted for preadmission frailty, patient age, sex and care level.A total of 934 patients were (...) included from 49 hospitals. Mean(s.d.) age was 76·2(6·8) years, with 57·6 per cent women; 20·2 per cent were frail. Some 37·4 per cent of older adults had an increased care level at discharge. Increasing frailty was associated with increased discharge care level, with greater predictive power than age. The adjusted odds ratio for an increase in care level was 4·48 (95 per cent c.i. 2·03 to 9·91) for apparently vulnerable patients (Clinical Frailty Score (CFS) 4), 5·94 (2·54 to 13·90) for those mildly

2020 EvidenceUpdates

69. Happiness or hopelessness in late life: A cluster RCT of the 3L-Mind-Training programme among the institutionalized older people (Abstract)

Happiness or hopelessness in late life: A cluster RCT of the 3L-Mind-Training programme among the institutionalized older people To explore the effectiveness of a new mental health promotion activities programme by including the criterion variables of happiness and depressive mood.A single-blinded, clustered, randomized and controlled trial.A list consisting of the names of elderly residents was provided by the senior social worker at a geriatric institution. The participants recruited (...) to measure happiness. The Geriatric Depression Scale short-form was used to measure depression in older people. A generalized estimating equation was used to analyse the short-term and durative effects.The 126 residents included in the study were 65-97 years old, and 90% of the residents relied on wheelchairs. The intervention activities give significant immediate and durative effects both on subjective well-being enhancement and depressive mood relief. When evaluating the overall intervention activity

2020 EvidenceUpdates

70. Acupuncture vs Noninsertive Sham Acupuncture in Aging Patients with Degenerative Lumbar Spinal Stenosis: A Randomized Controlled Trial Full Text available with Trip Pro

Acupuncture vs Noninsertive Sham Acupuncture in Aging Patients with Degenerative Lumbar Spinal Stenosis: A Randomized Controlled Trial Acupuncture is commonly used to treat degenerative lumbar spinal stenosis in Asian countries. However, rigorous data regarding the efficacy and safety of acupuncture for aging patients are currently lacking.Eighty patients older than 50 years were assigned randomly to the acupuncture group or the noninsertive sham acupuncture for 24 treatments over an 8-week

2020 EvidenceUpdates

71. Epilepsy in older people. (Abstract)

Epilepsy in older people. Globally, as populations age there will be challenges and opportunities to deliver optimal health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent seizures, is common in older adults (aged >65 years) and yet has received comparatively little attention in this age group. In this Review, we evaluate the underlying causes of epilepsy in older people, explore difficulties in establishing a diagnosis of epilepsy in this population (...) , discuss appropriate antiseizure medications, and evaluate potential surgical treatment options. We consider cognitive, psychological, and psychosocial comorbidities and the effect that epilepsy might have on an older person's broader social or care network in high-income versus middle-income and low-income countries. We emphasise the need for clinical trials to be more inclusive of older people with epilepsy to help inform therapeutic decision making and discuss whether measures to improve vascular

2020 Lancet

72. Screening for Cognitive Impairment in Older Adults: US Preventive Services Task Force Recommendation Statement. Full Text available with Trip Pro

Screening for Cognitive Impairment in Older Adults: US Preventive Services Task Force Recommendation Statement. Dementia (also known as major neurocognitive disorder) is defined by a significant decline in 1 or more cognitive domains that interferes with a person's independence in daily activities. Dementia affects an estimated 2.4 to 5.5 million individuals in the United States, and its prevalence increases with age.To update its 2014 recommendation, the US Preventive Services Task Force (...) (USPSTF) commissioned a review of the evidence on screening for cognitive impairment, including mild cognitive impairment and mild to moderate dementia, in community-dwelling adults, including those 65 years or older residing in independent living facilities.This recommendation applies to community-dwelling older adults 65 years or older, without recognized signs or symptoms of cognitive impairment.The USPSTF concludes that the evidence is lacking, and the balance of benefits and harms of screening

2020 JAMA

73. Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial. (Abstract)

mortality at 90 days in ICU patients aged 65 years or older with vasodilatory hypotension.A multicenter, pragmatic, randomized clinical trial was conducted in 65 ICUs in the United Kingdom and included 2600 randomized patients aged 65 years or older with vasodilatory hypotension (assessed by treating clinician). The study was conducted from July 2017 to March 2019, and follow-up was completed in August 2019.Patients were randomized 1:1 to vasopressors guided either by MAP target (60-65 mm Hg, permissive (...) Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial. Vasopressors are commonly administered to intensive care unit (ICU) patients to raise blood pressure. Balancing risks and benefits of vasopressors is a challenge, particularly in older patients.To determine whether reducing exposure to vasopressors through permissive hypotension (mean arterial pressure [MAP] target, 60-65 mm Hg) reduces

2020 JAMA

74. Failure of Traditional Risk Factors to Adequately Predict Cardiovascular Events in Older Populations

patients. Among those aged 85 years and older, some traditional risk factors were not associated with ASCVD events. Better risk models are needed to appropriately inform treatment decision making for the growing population of older adults. Keywords: model validation; older adults; risk heterogeneity; risk prediction. © 2020 The American Geriatrics Society. Similar articles MG Nanna et al. J Gen Intern Med. 2019. PMID 31667745. The performance of the PCE for ASCVD risk estimation in older adults (...) to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation J Am Geriatr Soc Actions 2020 Jan 20 [Online ahead of print] Failure of Traditional Risk Factors to Adequately Predict Cardiovascular Events in Older Populations , , , , , Affiliations Expand Affiliations 1 Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio. 2 Department of Quantitative Health

2020 EvidenceUpdates

75. Comparison of the Effect of Age (< 75 Versus >/= 75) on the Efficacy and Safety of Dual Therapy (Dabigatran+Clopidogrel or Ticagrelor) Versus Triple Therapy (Warfarin+Aspirin+Clopidogrel or Ticagrelor) in Patients With Atrial Fibrillation After Percutaneo Full Text available with Trip Pro

to treatment, 1,026 (37.7%) were categorized into older and 1,699 (62.3%) into younger age groups. Dabigatran 110 mg dual therapy lowered bleeding risk versus warfarin triple therapy in older (hazard ratio [HR] 0.67; 95% confidence interval [CI] 0.51 to 0.89) and younger patients (HR 0.40; 95% CI 0.30 to 0.54); interaction p value: 0.0125. Dabigatran 150 mg dual therapy lowered bleeding risk versus warfarin triple therapy in younger patients (HR 0.57; 95% CI 0.44 to 0.74), whereas no benefit could (...) Comparison of the Effect of Age (< 75 Versus >/= 75) on the Efficacy and Safety of Dual Therapy (Dabigatran+Clopidogrel or Ticagrelor) Versus Triple Therapy (Warfarin+Aspirin+Clopidogrel or Ticagrelor) in Patients With Atrial Fibrillation After Percutaneo Comparison of the Effect of Age ( - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History

2020 EvidenceUpdates

76. Older adults: cost-effective commissioning

and implementing services to support older people's healthy ageing. Published 28 January 2020 From: Documents Ref: PHE publications gateway reference GW-1008 If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you say what assistive technology you use. Ref: PHE publications gateway reference GW-1008 If you use assistive technology (such as a screen reader) and need (...) on identified interventions to support older people, generated through a literature review. The return on investment (ROI) tool: can be adapted to local conditions presents results showing the economic benefits of each intervention has a built-in user guide Local authorities and clinical commissioning groups can use these resources to improve the provision of services for older people. Published 28 January 2020 Related content Explore the topic Is this page useful? Thank you for your feedback Help us

2020 Public Health England

77. Plerixafor (Mozobil) - children aged 1 year to <18 years with lymphoma or solid malignant tumours

Plerixafor (Mozobil) - children aged 1 year to <18 years with lymphoma or solid malignant tumours Published 10 February 2020 1 Product update SMC2249 plerixafor 20mg/mL solution for injection (Mozobil®) Sanofi Aventis 10 January 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated (...) submission plerixafor (Mozobil®) is accepted for use within NHSScotland. Indication under review: in combination with granulocyte-colony stimulating factor (G-CSF) to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in children aged 1 year to <18 years with lymphoma or solid malignant tumours, either: - pre-emptively, when circulating stem cell count on the predicted day of collection after adequate mobilisation with G-CSF

2020 Scottish Medicines Consortium

78. Testosterone Treatment in Adult Men with Age-Related Low Testosterone Full Text available with Trip Pro

, Nankin HR , Spark RF , et al American Association of Clinical Endocrinologists American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients—2002 update. Endocr Pract 2002 Nov-Dec 8 440 56 Wu FC , Tajar A , Beynon JM , et al EMAS Group Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010 363 123 35 Bassil N , Morley JE . Late-life onset hypogonadism: a review (...) . Clin Geriatr Med 2010 26 197 222 Nguyen CP , Hirsch MS , Moeny D , et al Testosterone and “Age-related hypogonadism”—FDA concerns. N Engl J Med 2015 373 689 91 Diem SJ , Greer NL , MacDonald R , et al Efficacy and safety of testosterone treatment in men: an evidence report for a clinical practice guideline by the American College of Physicians. Ann Intern Med 7 January 2020 [Epub ahead of print] Qaseem A , Kansagara D , Lin JS , et al Clinical Guidelines Committee of the American College

2020 American College of Physicians

79. Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery Full Text available with Trip Pro

in elderly patients after surgery and is associated with poor outcomes. This study aimed to investigate the impact of intraoperative dexmedetomidine on the incidence of delirium in elderly patients undergoing major surgery. Methods: This was a randomized double-blind placebo-controlled trial. Elderly patients (aged 60 years or more) scheduled to undergo major non-cardiac surgery were randomized into two groups. Patients in the intervention group received a loading dose of dexmedetomidine 0·6 μg/kg 10 min (...) Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery Randomized Clinical Trial of Intraoperative Dexmedetomidine to Prevent Delirium in the Elderly Undergoing Major Non-Cardiac Surgery - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced

2020 EvidenceUpdates

80. Validation of the Elderly Risk Assessment Index in the Emergency Department (Abstract)

Validation of the Elderly Risk Assessment Index in the Emergency Department The Elderly Risk Assessment (ERA) score is a validated index for primary care patients that predict hospitalizations, mortality, and Emergency Department (ED) visits. The score incorporates age, prior hospital days, marital status, and comorbidities. Our aim was to validate the ERA score in ED patients.Observational cohort study of patients age ≥ 60 presenting to an academic ED over a 1-year period. Regression analyses (...) were performed for associations with outcomes (hospitalization, return visits and death). Medians, interquartile range (IQR), odds ratios (OR) and 95% confidence intervals (CI) were calculated.The cohort included 27,397 visits among 18,607 patients. Median age 74 years (66-82), 48% were female and 59% were married. Patients from 54% of visits were admitted to the hospital, 16% returned to the ED within 30 days, and 18% died within one year. Higher ERA scores were associated with: hospital admission

2020 EvidenceUpdates