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Latest & greatest articles for elderly
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Emerging Cognitive Intervention Technologies to Meet the Needs of an Aging Population: A Systematic Review. Background: Cognitive training helps to promote healthy aging and ease activities of daily living for older adults. Recently, experiments have been conducted using robots to perform this cognitive training. Methods: A review was conducted to examine the effects of computer-based cognitive interventions for older adults who were either healthy or experiencing mild cognitive impairment (MCI (...) ). A second study also examined the evolution of socially assistive robots (SAR) and their effectiveness at administering cognitive training for older adults. Results: Eighty-one studies published between 2009 and 2019 were identified for review, 56 of which focused on computerized cognitive training (CCT) while 25 examined the use of robotics. Twenty-four of the 56 CCT studies met the inclusion criteria. These were further classified into two groups: studies which used self-designed programs, and studies
Symphysis-fundal height to identify large-for-gestational-age and macrosomia: a meta-analysis. Bivariate diagnostic meta-analysis was performed to evaluate the diagnostic value of symphysis-fundal height (SFH) for identifying large-for-gestational- age (LGA) (i.e. birth weight >90th centile according to gestational age) and macrosomia (i.e. birth weight >4000 g). Ten databases, e.g. PubMed (MEDLINE), were searched to include English-language studies providing true- and false-positive and true (...) likelihood ratios <10 and >0.1, respectively). In conclusion, there is no evidence that SFH is useful to identify LGA or macrosomia.Impact StatementWhat is already known on this subject? Synthetic evidence has shown that symphysis-fundal height (SFH) is not useful for the detection of low birth weight and small-for-gestational-age babies mainly in developing countries. In the present study bivariate diagnostic meta-analysis was carried out to evaluate the diagnostic value of SFH for identifying large
Somerset & South Gloucestershire CCG, UK. Purdy Sarah S Pro Vice-Chancellor, Centre of Academic Primary Care, School of Population Science, University of Bristol, UK. Baxter Helen H Senior Research Associate, Centre of Academic Primary Care, School of Population Science, University of Bristol, UK. eng Journal Article 2019 12 05 England J Health Serv Res Policy 9604936 1355-8196 H hospital admission olderpeople systematic review 2019 12 7 6 0 2019 12 7 6 0 2019 12 7 6 0 aheadofprint 31805793 10.1177 (...) Determining when a hospital admission of an older person can be avoided in a subacute setting: a systematic review and concept analysis. 31805793 2019 12 06 1758-1060 2019 Dec 05 Journal of health services research & policy J Health Serv Res Policy Determining when a hospital admission of an older person can be avoided in a subacute setting: a systematic review and concept analysis. 1355819619886885 10.1177/1355819619886885 Huntley Alyson L AL https://orcid.org/0000-0001-9409-7891 Senior
Associations Between Handgrip Strength and Disease-Specific Mortality Including Cancer, Cardiovascular, and Respiratory Diseases in Older Adults: A Meta-Analysis. Several controversial studies linking handgrip strength and health have suggested that low handgrip strength in older adults may be related to health problems and have investigated whether there is a minimum handgrip strength level associated with reduced mortality. Thus, by meta-analysis, the authors identified an association between (...) handgrip strength in older adults and disease-specific mortality and all-cause mortality. Thirty studies with a total of 194,767 older adult participants were included in this meta-analysis. Higher handgrip strength was associated with an 18% decrease in all-cause mortality. Lower handgrip strength was associated with increased all-cause mortality. The minimum handgrip strength in older women that did not increase all-cause mortality was 18.21 kg. Increased handgrip strength showed a decreased all
The effects of mindfulness-based stress reduction on depression, anxiety, and stress in older adults: A systematic review and meta-analysis. Mindfulness-based stress reduction (MBSR) has been widely used to improve various physical and mental conditions. Studies show the intervention is particularly effective in alleviating depression, anxiety, and stress in working-aged adults. No recent systematic review has focused on the use of MBSR in older adults. This study aims to examine the effects (...) of MBSR intervention on depression, anxiety, and stress symptoms of older adults. Five electronic databases were searched for relevant randomized controlled trials (RCTs) published between 1990 and 2017. Six eligible studies were included and computed for meta-analysis. The methodological quality and risk of biases across the included RCTs were assessed using the Cochrane risk of bias assessment tool. Overall, the amount of evidence is limited and of relatively low quality. The results of this review
Exercise for preventing falls in olderpeople living in the community: an abridged Cochrane systematic Review. To assess the effects of exercise interventions for preventing falls in olderpeople living in the community.We included randomised controlled trials evaluating the effects of any form of exercise as a single intervention on falls in peopleaged 60+years living in the community.Exercise reduces the rate of falls by 23% (rate ratio (RaR) 0.77, 95% CI 0.71 to 0.83; 12 981 participants (...) , 59 studies; high-certainty evidence). Subgroup analyses showed no evidence of a difference in effect on falls on the basis of risk of falling as a trial inclusion criterion, participant age 75 years+ or group versus individual exercise but revealed a larger effect of exercise in trials where interventions were delivered by a health professional (usually a physiotherapist). Different forms of exercise had different impacts on falls. Compared with control, balance and functional exercises reduce
Frailty syndrome and cognitive impairment in older adults: systematic review of the literature. to synthesize the knowledge about the association of frailty syndrome and cognitive impairment in older adults.the Joanna Briggs Institute's systematic review of etiology and risk factors was adopted. The search for the studies was conducted by two independent reviewers in the databases MEDLINE, Embase, CINAHL and LILACS and by manual search was performed by tow reviewers independently. The measures (...) of association Odds Ratio and Relative Risk were used in the meta-analysis. The software R version 3.4.3 and the meta-analysis package Metafor 2.0 were used for figure analysis.three studies identified the association of frailty syndrome and cognitive impairment through Odds Ratio values show that frail older adults are 1.4 times more likely to present cognitive impairment than non-frail older adults. Four studies analyzed the association through the measure of Relative Risk and found no statistical
Cognitive and Behavioral Interventions to Improve Sleep in School-Age Children and Adolescents: A Systematic Review and Meta-Analysis. Sleep problems are common in children and adolescents and can aggravate comorbid disorders. This meta-analysis examined the effect of cognitive and behavioral sleep interventions (with four or more treatment sessions) from randomized controlled trials on school-age children and adolescents.In a systematic literature search, six randomized controlled trials were (...) identified (n = 528; mean age = 14.6 years; female = 63%) that reported total sleep time (TST), sleep onset latency (SOL), wake after sleep onset, and daytime sleepiness from ratings and actigraphy.After intervention, no effect was seen on self-reported TST, but when measured with actigraphy, an effect favoring the intervention group was observed (+11.47 minutes, P = .05). SOL decreased in the intervention group compared to the control group after intervention as measured by both sleep diaries (-9.31
Preventing Progression in Nonexudative Age-Related Macular Degeneration With Subthreshold Laser Therapy: A Systematic Review. Age-related macular degeneration (AMD) is the leading cause of irreversible blindness among the elderly in developed countries. Subthreshold retinal laser therapy is a new technique that targets drusen - a marker of nonexudative AMD - without causing incidental retinal damage associated with conventional laser photocoagulation. This review summarizes published literature
Comparative assessment of early versus delayed surgery to treat proximal femoral fractures in elderly patients: A systematic review and meta-analysis. Recently, many studies have suggested that timely surgery to treat proximal femoral fractures can benefit patients in many respects. However, both the short- and long-term outcomes, and the perioperative complications, of early surgery remain controversial. In addition, the optimal cut-off time for early surgery remains unclear. Thus, we
Determining Which Prosthetic to Use During Aortic Valve Replacement in Patients Aged Younger than 70 Years: A Systematic Review of the Literature. The choice of bioprosthesis versus mechanical prosthesis in patients aged less than 70 years undergoing aortic valve replacement (AVR) remains controversial, with guidelines disparate in their recommendations. The objective of this study was to explore outcomes after AVR for various age ranges based on type of prosthesis.A systematic review (...) was undertaken according to the Preferred Reporting Instructions for Systematic Reviews and Meta-Analyses (PRISMA) guidelines by using Medline (PubMed), Cochrane, Web of Science, Embase, and Scopus databases. Rates of long-term survival (primary outcome), reoperation, major bleeding, thromboembolism, stroke, structural valve deterioration, and endocarditis were compared between subjects receiving biologic and mechanical prostheses. Findings were grouped into patients aged <60 years, aged ≤65 years
The association between polypharmacy and adverse health consequences in elderly type 2 diabetes mellitus patients; a systematic review and meta-analysis. To summarize the existing literature concerning the association between polypharmacy and adverse health consequences in elderly patients with type 2 diabetes mellitus.We searched four literature databases (PubMed/Medline, ScienceDirect and Web of Science) through April 2019. We included all studies that addressed the association between
Decitabine Compared With Conventional Regimens in Older Patients With Acute Myeloid Leukemia: A Meta-Analysis. The incidence of acute myeloid leukemia (AML) increases with age. The overall prognosis remains poor for older patients. Studies on the efficacy of decitabine, an epigenetic agent, in older patients with AML have reported conflicting results.For this meta-analysis, we performed a literature search and collected 38 studies (including 3298 patients with AML) to evaluate the role (...) of decitabine in elderly patients with AML. We used complete response (CR) or overall response (OR) rate as indicators of effectiveness.Patients treated with decitabine have a higher CR/OR rate than those treated with low-dose cytarabine (CR, 2.60; 95% confidence interval [CI], 1.64-4.14; OR, 4.88; 95% CI, 1.98-12.04) or CAG/HAG (low-dose epirubicin and cytarabine with granulocyte stimulating factor/low-dose homoharringtonine and cytarabine with granulocyte stimulating factor) regimens (CR, 2.53; 95% CI
Third-trimester uterine-artery Doppler for prediction of adverse outcome in late small-for-gestational-age fetuses: systematic review and meta-analysis. To investigate the prediction capacity for adverse perinatal outcome of abnormal uterine artery Doppler in small-for-gestational age (SGA) fetuses.A systematic search was performed to identify relevant observational studies and randomized controlled trials evaluating the performance of antenatal third trimester abnormal uterine artery Doppler (...) for the prediction of adverse perinatal outcomes among small-for-gestational-age fetuses and neonates (SGA). Hierarchical summary receiver-operating characteristic curves (hSROC) were constructed using random effects modeling.Seventeen observational studies and no randomized trials (including 7,552 fetuses and 4,091 neonates with SGA) met the inclusion criteria. Summary ROC curves showed that, among SGA-suspected fetuses, the best predictive accuracy of uterine Doppler was for perinatal mortality and the worst
Elexacaftor/ivacaftor/tezacaftor (Trikafta) - To treat patients 12 years of age and older with the most common gene mutation that causes cystic fibrosis Drug Approval Package: TRIKAFTA TRIKAFTA " /> U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: TRIKAFTA Company: Vertex Pharmaceuticals Inc. Application Number: 212273 Approval Date: 10/18/2019 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 (...) for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created: November 25, 2019 Vision impaired people having problems accessing certain pages of a PDF file may call (301) 796-3634 for assistance. Note: Documents in PDF format require the . Note: If you need help accessing information in different file formats, see . Language Assistance Available: | | | | | | | | | | | | | | | FDA Popular Content Product Areas
to in- crease somewhere between the ages 55 and 65 years, 6 and the American College of Surgeons Committee on Trauma recom- mends consideration for triage to TCs for patients 55 years or older.However,muchofthefocusedgeriatrictraumaliterature usesage65yearsorevenolderwhenexamininginterventions. For this reason, we chose to focus on interventions targeting adults 65 years or older. OBJECTIVES Thepurposeofthisreviewwastoprovideasystematicre- viewof 2 key issues in care of the geriatric trauma patient: TC (...) in the definition of elderly, which hampers studyinclusiondefinitions;ouruseoftheage65yearswasmost common,butthismayhaveimpactedourfindings.However,de- spite these limitations, most studies supported similar conclu- sions with at least a modest effect size, allowing us to make somerecommendations for clinicalpractice. UsingTheseGuidelinesinClinicalPractice As our older adult population increases, injured geriatric patientswillcontinuetoposechallengesforcare,suchascomor