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Latest & greatest articles for elderly
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on elderly or other clinical topics then use Trip today.
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Legacy effect of delayed blood pressure lowering drug treatment in middle-aged adults with mildly elevated blood pressure: systematic review and meta-analysis. To investigate if there is evidence for a 'legacy effect' for blood pressure (BP) lowering treatment, that is, worse health outcomes from not initiating drug treatment at a systolic BP threshold of 140 mmHg in middle-age adults. We systematically reviewed studies comparing the effects of delayed BP treatment (placebo/untreated during (...) no significant difference in all-cause mortality between 'delayed BP' and 'early treatment' in the short-term OR 0.95 (95% CI 0.68-1.32) or long-term OR 0.90 (95% CI 0.78-1.04), with similar results for mortality from cardiovascular disease (CVD). The effects of delayed BP lowering treatment on long-term all-cause and CVD mortality did not vary with baseline risk of CVD. The review showed no clinically adverse 'legacy effect' on mortality or major CVD event from not treating middle-aged adults at a systolic
Rapid point of care test for detecting urogenital Chlamydia trachomatis infection in nonpregnant women and men at reproductive age. Chlamydia trachomatis (C trachomatis) is one of the most frequent sexually transmitted infections and a source of deleterious effects on the reproductive health of men and women. Because this infection is likely asymptomatic and is associated with subfertility, ectopic pregnancy, and chronic pain, its presence needs to be confirmed. Technologies available (...) . The principal advantage of this technology is the immediate presentation of results with the subsequent possibility to start the treatment of infected patients immediately.To determine the diagnostic accuracy of rapid point-of-care (POC) testing for detecting urogenital C trachomatis infection in nonpregnant women and men of reproductive age, as verified with nucleic acid amplification tests (NAATs) as the reference standard.In November 2019 we searched CENTRAL, MEDLINE, Embase and LILACS. We also searched
Partial river flow recovery with forest age is rare in the decades following establishment. Forest regeneration and expansion are occurring in many countries, with 80 million ha established from 2000 to 2012 under the Bonn accord and 17.5 million ha established from 1990 to 2005 according to the Food and Agriculture Organisation. Multiple reviews have linked increasing forest cover with reduced river flow and potentially detrimental effects downstream. Previous reviews have investigated trends (...) in river flow response over time, but the influence of forest age remains uncertain. Partial river flow recovery (towards non-forested conditions) has been reported in decades following forest establishment, but the role of climate in driving these trends has not been explored. Here, we evaluate river flow trends in 43 studies following forest establishment, which provide sufficient information to distinguish the effects of ageing forests from variable climate. Our meta-analysis supports previous
The Impact of Nutrition and Intestinal Microbiome on Elderly Depression-A Systematic Review. The aim of this review is to systematically review the evidence whether proper nutrition has a positive impact on the prevention or decline of depressive symptoms among elderlypeople. In addition, possible connections between nutrition, microbiome, and serotonin molecules and its tryptophan precursor are discussed. The methodology follows the PRISMA guidelines, including the PRISMA flow chart (...) . The authors systematically reviewed peer-review, English-written articles published in Web of Science and PubMed between 2013 and 2018. The findings of six original articles, detected on the set inclusion and exclusion criteria, indicate that there is an association between nutrition and depressive symptoms in the target group, i.e., that proper nutrition has a positive impact on the prevention or reduction of depressive symptoms among elderlypeople. The findings also reveal that there is a considerable
Epidemiology of intestinal parasitic infections in preschool and school-aged Ethiopian children: a systematic review and meta-analysis. Numerous studies have been carried out on assessing the prevalence of intestinal parasites infections (IPIs) amongpreschool and school-age children in Ethiopia, but there is lack of study systematically gathered and analyzedinformation for policymakers. Therefore, the aim of this systematic review and meta-analysis was to provide a summary on prevalence (...) , geographical distribution and trends of IPIs among preschool and school-age childrenin Ethiopia.The search were carried out in Medline via PubMed, Scopus, Science Direct, Web of Science, and Google Scholar from 1996to July2019 for studies describing prevalence of IPIs among preschooland school-age children. We conducted meta-regression to understand the trends and the source of heterogeneity and pooled the prevalence using 'metaprop' command using STATA software version 14.Eighty-three(83) studies
Exposure to ultrafine particles in children until 18 years of age: A systematic review. Airborne ultrafine particles (UFP) have been related to adverse health effects, but exposure in vulnerable population groups such as children is still not well understood. We aim to review the scientific literature regarding personal exposure to UFP in different microenvironments in populations until 18 years of age. The bibliographical search was carried out in July 2019 using the online database PubMed
The relationship between pressure injury complication and mortality risk of older patients in follow-up: A systematic review and meta-analysis. Pressure injuries (PIs) have now become a common complication of the elderly patients. Some studies have observed that pressure injuries may increase mortality, but this area of evidence has not been evaluated and summarised. The aim of this study was to compare the mortality of patients with pressure injuries and those without pressure injuries. A meta (...) -analysis of observational studies was performed. PubMed, Cochrane Library, Embase, and Web of Science were searched up to April 2019. Studies about mortality among the elderly patients with and without pressure injuries were included. Methodological quality was assessed by the Newcastle-Ottawa Scale (NOS). The fixed effect or random effect model was determined by the test of heterogeneity. The subgroup analysis was performed based on the pressure injuries stages, the region, and the type of study
Factors associated with medication adherence in older patients: A systematic review. Medication adherence is a major challenge in the treatment of older patients; however, they are under-represented in research. We undertook a systematic review focused on older patients to assess the reasons underlying non-adherence in this population.We searched multiple electronic databases for studies reporting reasons for non-adherence to medication regimens in patients aged 75 years and over. Our results
Toll-like receptor 4 gene polymorphisms rs4986790 and rs4986791 and age-related macular degeneration susceptibility: a meta-analysis. Background: Several studies have investigated two single nucleotide polymorphisms (SNPs) (rs4986790 and rs4986791) of toll-like receptor 4 (TLR4) and age-related macular degeneration (AMD) susceptibility. However, their results varied. Here, we performed a systematic review and meta-analysis to investigate the association between these two SNPs and AMD
Dexmedetomidine in the prevention of postoperative delirium in elderly patients following non-cardiac surgery: A systematic review and meta-analysis. The efficacy of dexmedetomidine in the prevention of postoperative delirium (POD) remains ambiguous, however, it has been used to reduce the incidence of delirium in elderly patients. Here, we conducted a meta-analysis study for assessing the effects of dexmedetomidine on POD among elderly patients following non-cardiac surgery. A systematic (...) literature search was performed against the PubMed, EMBASE, Cochrane Library, and Web of Science databases, and all relevant literature published till November 30, 2019, were considered. Our analysis included 16 randomised controlled trials conducted with 4534 patients for exploring the effects of dexmedetomidine on POD in elderly patients following non-cardiac surgery. It was observed that the overall incidence of POD was significantly lower in the dexmedetomidine group than in the control group (risk
Protocol for the SAFEST review: the Shock-Absorbing Flooring Effectiveness SysTematic review including older adults and staff in hospitals and care homes. Falls in hospitals and care homes are a major issue of international concern. Inpatient falls are the most commonly reported safety incident in the UK's National Health Service (NHS), costing the NHS £630 million a year. Injurious falls are particularly life-limiting and costly. There is a growing body of evidence on shock-absorbing flooring
Comment on: "Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis" by Yeung et al. 31898861 2020 04 21 2190-6009 11 1 2020 Feb Journal of cachexia, sarcopenia and muscle J Cachexia Sarcopenia Muscle Comment on: "Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis" by Yeung et al. 330-331 10.1002/jcsm.12467 Zhang Xiao-Ming XM https://orcid.org/0000-0001-9741-133X Department (...) of Emergency Medicine, People's Hospital of Bao'an District of Shenzhen, Shenzhen, Guangdong Province, China. Cheng Andy S K ASK Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong. Dou Qingli Q Department of Emergency Medicine, People's Hospital of Bao'an District of Shenzhen, Shenzhen, Guangdong Province, China. Zhang Wenwu W Department of Emergency Medicine, People's Hospital of Bao'an District of Shenzhen, Shenzhen, Guangdong Province, China. Zeng Yingchun Y Research
24;348:f7450 24464277 J Gerontol A Biol Sci Med Sci. 2018 Aug 10;73(9):1199-1204 29300839 J Am Geriatr Soc. 2015 Nov;63(11):2247-59 26502831 J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):1081-1083 29098794 J Bone Miner Res. 2012 Sep;27(9):1907-15 22550021 Gerontology. 2002 May-Jun;48(3):147-50 11961367 Geriatr Nurs. 2017 Sep - Oct;38(5):406-411 28291562 J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):485-500 30993881 (...) The authors reply: Letter on: " Sarcopenia and its association with falls and fracturesin older adults: A systematic review andmeta-analysis" by Zhang et al. 31903717 2020 04 21 2190-6009 11 1 2020 Feb Journal of cachexia, sarcopenia and muscle J Cachexia Sarcopenia Muscle The authors reply: Letter on: " Sarcopenia and its association with falls and fracturesin older adults: A systematic review andmeta-analysis" by Zhang et al. 332-335 10.1002/jcsm.12521 Yeung Suey S Y SSY Department of Human
Hearing loss is a risk factor of disability in older adults: A systematic review. Hearing loss (HL) is a public health problem affecting older adults. HL is not only a health condition but also a complex, dynamic phenomenon related to disability. Previous studies identified associations between HL and undesirable outcomes; however, their correlation remains inconclusive. Hearing loss can have profound impact on daily life in the elderly, and an understanding of how HL contributes to disability (...) is needed. A systematic review was conducted to comprehensively examine current evidence and determine the association between HL and disability regarding impairment, activity and participation in older adults.The Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines were applied in this systematic review. Quality assessment was conducted using the Newcastle-Ottawa Scale for longitudinal studies and the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for cross-sectional
Multidisciplinary interventions for reducing the avoidable displacement from home of frail olderpeople: a systematic review. To synthesise existing literature on interventions addressing a new concept of avoidable displacement from home for olderpeople with multimorbidity or frailty. The review focused on home-based interventions by any type of multidisciplinary team aimed at reducing avoidable displacement from home to hospital settings. A second objective was to characterise (...) these interventions to inform policy.A systematic search of the main bibliographic databases was conducted to identify studies relating to interventions addressing avoidable displacement from home for olderpeople. Studies focusing on one specific condition or interventions without multidisciplinary teams were excluded. A narrative synthesis of data was conducted, and themes were identified by using an adapted thematic framework analysis approach.The search strategy was performed using the following electronic
Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis. Senescent cells in tissues and organs are considered to be pivotal to not only the aging process but also the onset of chronic disease. Accumulating evidence from animal experiments indicates that the magnitude of senescence can vary within and between aged tissue samples from the same animal. However, whether this variation in senescence translates across to human tissue samples (...) is unknown. To address this fundamental question, we have conducted a systematic review and meta-analysis of all available literature investigating the magnitude of senescence and its association with chronological age in human tissue samples. While senescence is higher in aged tissue samples, the magnitude of senescence varies considerably depending upon tissue type, tissue section, and marker used to detect senescence. These findings echo animal experiments demonstrating that senescence levels may vary
The Effects of High- Versus Low-Intensity Power Training on Muscle Power Outcomes in Healthy, Older Adults: A Systematic Review. Power training (PT) improves muscle power in older adults; however, intensity recommendations are less clear. A narrative approach was used to compare high- versus low-intensity PT on muscle power (and function) in healthy, older adults. Searches were performed using Medline, Embase, CINAHL, SPORTDiscus, AgeLine, and Scopus. Interventions in which older subjects (60 (...) + years) were instructed to perform the concentric phase "as fast as possible" were included. After searches were performed, a third category of PT (moderate intensity) was included. Evidence from 27 studies (32 PT groups) showed changes in muscle power that averaged 26.8%, 33.4%, and 21.5% for high-, moderate-, and low-intensity PT, respectively, with greater changes with longer training duration and in mildly mobility-limited older adults. Function improved similarly across categories. In conclusion