Latest & greatest articles for elderly

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Top results for elderly

121. Non-pharmacological depression therapies for older Chinese adults: A systematic review & meta-analysis. (Abstract)

Non-pharmacological depression therapies for older Chinese adults: A systematic review & meta-analysis. To conduct a systematic review of randomized controlled trials to evaluate the evidence for the use of non-pharmacological depression therapies in older Chinese adults.The population was individuals of Chinese extraction over the age of 60 who meet the criteria for depression. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA

2020 Archives of gerontology and geriatrics

122. Docosahexaenoic acid supplementation in age-related cognitive decline: a systematic review and meta-analysis. (Abstract)

Docosahexaenoic acid supplementation in age-related cognitive decline: a systematic review and meta-analysis. To investigate the role of DHA supplementation in preventing age-related cognitive decline (ARCD) in individual cognitive domains by conducting systematic review and meta-analysis.Relevant clinical trials were systematically searched at Medline, PubMed, Scopus, Cochrane, ProQuest, and Embase databases since inception to June 2018. The PRISMA guidelines were adhered for data abstraction (...) , quality assessment, and validation of included studies. Study details such as participant characteristics, DHA supplementation, and cognitive function outcome measures, i.e., memory, attention, working memory, and executive function, were extracted to perform meta-analysis according to the Cochrane guidelines. Additional meta-regression and subgroup analyses were performed to detect confounding variables and sensitivity of results, respectively.Ten studies including 2327 elderly individuals were part

2020 European journal of clinical pharmacology

123. Tuberculosis infection in under-2-year-old refugees: Should we be screening? A systematic review and meta-regression analysis. (Abstract)

Tuberculosis infection in under-2-year-old refugees: Should we be screening? A systematic review and meta-regression analysis. Refugees are at increased risk of tuberculosis infection due to time spent in crowded camps, decreased nutrition and originating from countries whose own tuberculosis control systems may have been disturbed. In Australia, tuberculosis is screened for in for all refugees aged 11-34 years old and in those aged 2-10 years arriving from high-incidence countries. Our aims (...) were to determine if refugee children aged under 2 years of age should also be screened.A systematic literature review and meta-regression was carried out on studies in refugee children under 18 years old, involving screening for tuberculosis (active or latent tuberculosis infection (LTBI)). Studies were extracted from the last 10 years from a range of bibliographic databases using the search terms 'tuberculosis', 'children', 'screening' and 'refugee', which tested for tuberculosis using

2020 Journal of paediatrics and child health

124. Age at menarche and epithelial ovarian cancer risk: A meta-analysis and Mendelian randomization study. (Full text)

Age at menarche and epithelial ovarian cancer risk: A meta-analysis and Mendelian randomization study. Age at menarche (AAM) was found to be associated with ovarian cancer risk in previous observational studies. However, the causality of this association remains unclear. Here, after systematic meta-analyses, we performed two-sample Mendelian randomization (MR) analyses to evaluate the causal effect of AAM in epithelial ovarian cancer (EOC) etiology. We performed meta-analyses including 11 410 (...) of Modifiers of BRCA1/2 studies with 29 396 cases and 68 502 controls of European ancestry. In meta-analyses, we observed an inverse association (odds ratio [OR] = 0.96, 95% confidence interval [CI] = 0.93 to 1.00, P = 0.036) between per year older AAM and ovarian cancer risk in case-control studies, but no association was observed in cohort studies. In MR analyses, the OR of EOC risk per year increase in AAM was 0.81 (95% CI = 0.67 to 0.97, P = 0.026) in Chinese and 0.94 (95% CI = 0.90 to 0.98, P = 0.003

2020 Cancer medicine PubMed abstract

125. RETRACTED ARTICLE: Vasodilatory Properties of Sacubitril/Valsartan Explored in Hypertensives Aged Over 55 Years: A Meta-Analysis. (Abstract)

RETRACTED ARTICLE: Vasodilatory Properties of Sacubitril/Valsartan Explored in Hypertensives Aged Over 55 Years: A Meta-Analysis. 30937854 2020 04 20 1179-1985 27 1 2020 02 High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension High Blood Press Cardiovasc Prev RETRACTED ARTICLE: Vasodilatory Properties of Sacubitril/Valsartan Explored in Hypertensives Aged Over 55 Years: A Meta-Analysis. 103 10.1007/s40292-019-00313-9 De Vecchis Renato R

2020 High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

126. Associations Between Potentially Inappropriate Medications and Adverse Health Outcomes in the Elderly: A Systematic Review and Meta-analysis. (Abstract)

Associations Between Potentially Inappropriate Medications and Adverse Health Outcomes in the Elderly: A Systematic Review and Meta-analysis. Background: Adverse drug outcomes in the elderly have led to the development of lists of potentially inappropriate medications (PIMs), such as the Beers criteria, and these PIMs have been studied widely; however, it is still unclear whether PIM use is predictive of adverse outcomes in older people. Objective: To qualitatively examine the associations (...) . Compared with the elderly individuals exposed to 1 PIM, the risk of adverse health outcomes was much higher for those who took ≥2 PIMs. Conclusion and Relevance: We recommend that clinicians avoid prescribing PIMs for older adults whenever feasible. In addition, the observed associations should be generalized to other countries with different PIM criteria with caution.

2020 The Annals of pharmacotherapy

127. Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age. (Abstract)

Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age. The development of clinical interventions that significantly improve human healthspan requires robust markers of biological age as well as thoughtful therapeutic targets. To promote these goals, we performed a systematic review and analysis of human aging and proteomics studies. The systematic review includes 36 different proteomics analyses (...) , each of which identified proteins that significantly changed with age. We discovered 1,128 proteins that had been reported by at least two or more analyses and 32 proteins that had been reported by five or more analyses. Each of these 32 proteins has known connections relevant to aging and age-related disease. GDF15, for example, extends both lifespan and healthspan when overexpressed in mice and is additionally required for the anti-diabetic drug metformin to exert beneficial effects on body

2020 Ageing research reviews

128. Effect of Wii Fit© Exercise on Balance of Older Adults with Neurocognitive Disorders: A Meta-Analysis. (Abstract)

Effect of Wii Fit© Exercise on Balance of Older Adults with Neurocognitive Disorders: A Meta-Analysis. Exercise is beneficial to maintain balance. Wii Fit©, a video game-based exercise, offers an enjoyable way to exercise and is feasible for older adults with neurocognitive disorders (NCD).To evaluate the effects of Wii Fit© exercise training on the balance of older adults with NCD.Systematic review and meta-analysis of randomized control trials using Cochrane collaboration tools (...) . The participants were older adults (60 years and over) with NCD. Balance was measured with Berg Balance Scale (BBS) and Timed Up and Go (TUG). Two reviewers independently searched, selected, extracted data, assessed risk of biases, and determined the quality of evidence. Outcomes were evaluated using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). A meta-analysis was performed.The literature search identified 522 source documents of which titles and abstracts were reviewed for 428

2020 Journal of Alzheimer's disease : JAD

129. Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain. (Full text)

Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain. Despite ongoing research efforts, mechanisms of brain aging are still enigmatic and need to be elucidated for a better understanding of age-associated cognitive decline. The aim of this study is to investigate aging in the prefrontal cortex region of human brain in a meta-analysis of transcriptome datasets. We analyzed 591 gene expression datasets pertaining to female (...) and male human prefrontal cortex biopsies of distinct ages. We used hierarchical clustering and principal component analysis (PCA) to determine the influence of sex and age on global transcriptome levels. In sex-specific analysis we identified genes correlating with age and differentially expressed between groups of young, middle-aged and aged. Pathways and gene ontologies (GOs) over-represented in the resulting gene sets were calculated. Potential causal relationships between genes and between GOs

2020 Acta neuropathologica communications PubMed abstract

130. Prevalence and determinants of anaemia in children aged (Full text)

Prevalence and determinants of anaemia in children aged Anaemia, especially in children aged <5 years, is a global health problem disproportionately affecting populations in low-income and middle-income countries. It is associated with high disability and death rates and has a negative effect on development. This study seeks to evaluate the prevalence and determinants of anaemia in children aged 6-59 months residing in Africa.This protocol was prepared using the 2015 Preferred Reporting Items

2020 BMJ open PubMed abstract

131. Engaging older adults in self-management talk in healthcare encounters: a systematic review protocol. (Full text)

Engaging older adults in self-management talk in healthcare encounters: a systematic review protocol. Clinical practice guidelines for the management of complex chronic conditions in older adults encourage healthcare providers to engage patients in shared decision-making about self-management goals and actions. Yet, healthcare decision-making and communication for this population can pose significant challenges. As a result, healthcare professionals may struggle to help patients define (...) and prioritise their values, goals, and preferences in ways that are clinically and personally meaningful, incorporating physical functioning and quality of life, when faced with numerous diagnostic and treatment alternatives. The aim of this systematic review is to locate and synthesise a body of fine-grained observational research on communication between professionals, older adults, and carers regarding self-management in audio/audio-visually recorded naturalistic interactions.The paper describes

2020 Systematic reviews PubMed abstract

132. Gut microbiota differences between healthy older adults and individuals with Parkinson's disease: A systematic review. (Abstract)

Gut microbiota differences between healthy older adults and individuals with Parkinson's disease: A systematic review. The 'Dual Hit' hypothesis, stating that Parkinson's disease (PD) begins via olfactory pathways and the gut, and the gastrointestinal symptoms PD individuals face, have largely driven the interest of the gut's involvement in PD. Studies have since observed gut microbiota differences between PD groups and controls, with these alterations potentially relating to PD pathophysiology

2020 Neuroscience and biobehavioral reviews

133. Age-related differences in flashbulb memories: A meta-analysis. (Abstract)

, emotional, or personally important (the reception event). The existing literature on aging and flashbulb memories includes inconsistent findings. The present meta-analyses included 16 studies (N = 1898) that examined flashbulb memory in nonclinical samples of younger adults (below age 40 years) and older adults (above age 60 years). Findings, after exclusion of an outlier, suggest a small-to-moderate age-related impairment in flashbulb memory scores (k = 14, Hedges' g = -0.30, 95% CI [-0.45, -0.15], p (...) < .001) that was not moderated by study characteristics. After exclusion of an outlier, older adults' flashbulb memories were also significantly less consistent across time than younger adults' (k = 7, Hedges' g = -0.29, 95% CI [-0.47, -0.11], p = .002). Secondary analyses investigated age-related differences in the presence and consistency of canonical categories of flashbulb memories and encoding and rehearsal variables associated with flashbulb memory formation and retention. Age-related

2020 Psychology and aging

134. Computer-mediated communication and social support among community-dwelling older adults: A systematic review of cross-sectional data. (Abstract)

Computer-mediated communication and social support among community-dwelling older adults: A systematic review of cross-sectional data. To systematically assess the relationship between computer-mediated communication and social function in older adults aged 55 or older.Embase, PsycINFO and PubMed were searched (database inception to December 2018). Where available, effect sizes (correlation r) with 95% confidence intervals and P values were calculated for individual studies. Of 4,139 eligible (...) articles retrieved, 17 studies involving a pooled sample of 17,640 participants were included.Frequent computer-mediated communication was significantly, albeit weakly, associated with higher levels of social support and connectedness (r range = 0.08 to 0.33, P < 0.05). One discrepant negative relationship was noted (r = -0.16, 95% CI [-0.30, -0.02], P = 0.03), involving a distinct sample of gamers.Computer-mediated communication is related to amount of social functioning in older adults, although

2020 Australasian journal on ageing

135. Clinical medication review type III of polypharmacy reduced unplanned hospitalizations in older adults: A meta-analysis of randomized clinical trials. (Abstract)

identified randomized controlled trials focusing on CMR that evaluated unplanned hospitalization and re-hospitalization among older adults as a primary outcome. The keywords used were "CMR" or "medication review" in their titles, and the phrases "elderly" or "older adults" or "geriatric" and "polypharmacy." The randomized controlled trials selected were divided according to the three types of CMR to analyze the characteristics of each review.We included nine randomized controlled trials that examined (...) , particularly for type III in older adults with polypharmacy, to decrease hospitalizations. Geriatr Gerontol Int 2019; 19: 1275-1281.© 2019 Japan Geriatrics Society.

2020 Geriatrics & gerontology international

136. Older driver training programs: A systematic review of evidence aimed at improving behind-the-wheel performance. (Abstract)

Older driver training programs: A systematic review of evidence aimed at improving behind-the-wheel performance. Age- and health-related changes, alongside declines in driving confidence and on-road exposure, have been implicated in crashes involving older drivers. Interventions aimed at improving behind-the-wheel behavior are diverse and their associated impact remains unclear. This systematic review examined evidence on older driver training with respect to (1) road safety knowledge; (2) self (...) -perceived changes in driving abilities; and (3) behind-the-wheel performance. Method Nine databases were searched for English-language articles describing randomized controlled trials (RCTs) and non-RCTs of driver training interventions aimed at those aged 55+ who did not have medical or other impairments that precluded licensure. Quality appraisals were conducted using Cochrane's Risk of Bias Tool (RoB) and Risk Of Bias In Non-randomized Studies - of Interventions tool (ROBINS - I). [PROSPERO

2020 Journal of safety research

137. Does Obesity Increase the Risk and Severity of Falls in People Aged 60 Years and Older? A Systematic Review and Meta-analysis of Observational Studies. (Abstract)

reported in only one study, which demonstrated a lower risk of hip fracture with obesity (odds ratio: 0.65; 95% CI: 0.63-0.68).Obesity increases the risk of falls and multiple falls in people aged 60 years and older; however, there is insufficient evidence of an association with fall-related injuries or fractures. Prevention and treatment of obesity may play a role in preventing falls in older age.© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society (...) Does Obesity Increase the Risk and Severity of Falls in People Aged 60 Years and Older? A Systematic Review and Meta-analysis of Observational Studies. Recent investigations suggest that obesity may be associated with an increased risk of falls; however, this theory has yet to be definitively confirmed. This systematic review and meta-analysis examined the strength of the association between obesity and falls, multiple falls, fall-related injuries, and fall-related fractures among older

2020 The journals of gerontology. Series A, Biological sciences and medical sciences

138. The (cost-)effectiveness of preventive, integrated care for community-dwelling frail older people: A systematic review. (Full text)

The (cost-)effectiveness of preventive, integrated care for community-dwelling frail older people: A systematic review. Integrated care is increasingly promoted as an effective and cost-effective way to organise care for community-dwelling frail older people with complex problems but the question remains whether high expectations are justified. Our study aims to systematically review the empirical evidence for the effectiveness and cost-effectiveness of preventive, integrated care for community (...) -dwelling frail older people and close attention is paid to the elements and levels of integration of the interventions. We searched nine databases for eligible studies until May 2016 with a comparison group and reporting at least one outcome regarding effectiveness or cost-effectiveness. We identified 2,998 unique records and, after exclusions, selected 46 studies on 29 interventions. We assessed the quality of the included studies with the Effective Practice and Organization of Care risk-of-bias tool

2020 Health & social care in the community PubMed abstract

139. Advance care plans and hospitalized frail older adults: a systematic review. (Full text)

Advance care plans and hospitalized frail older adults: a systematic review. Frail older people are known to have low rates of advance care planning (ACP). Many frail patients prefer less aggressive treatment, but these preferences are often not known or respected. Frail patients often have multiple hospital admissions, potentially providing opportunities for ACP.To systematically review the literature concerning ACP with frail older people in the acute hospital, with particular reference (...) to: (1) Does ACP improve outcomes? (2) What are the views of patients, relatives and healthcare professionals regarding ACP? (3) Does ACP currently occur? (4) What are the facilitators and barriers to ACP?Systematic literature review and narrative synthesis. Electronic search of MEDLINE, CINAHL, ASSIA, PsycINFO and Embase databases from January 1990 to May 2019 inclusive. Studies in the acute setting of populations with a mean age >75 years, not focused on a disease-specific terminal condition were

2020 BMJ supportive & palliative care PubMed abstract

140. Physical therapy interventions for cervicogenic dizziness in a military-aged population: protocol for a systematic review. (Full text)

Physical therapy interventions for cervicogenic dizziness in a military-aged population: protocol for a systematic review. Traumatic cervicogenic dizziness is dizziness that is temporally associated with neck pain and injury after other causes of dizziness have been excluded. It can lead to activity limitations and participation restrictions that may include lost duty or work days. The objective of this systematic review is to determine which interventions are most effective in decreasing (...) dizziness or vertigo and neck pain in military-aged adults with traumatic cervicogenic dizziness.The literature will be systematically searched using the following online databases: MEDLINE, EMBASE, The Cochrane Library (Cochrane Database of Systematic Reviews, CENTRAL, Cochrane Methodology Register), CINAHL, SCOPUS, Web of Science, and J-STAGE. The review will include randomized controlled trials (RCTs), including cluster RCTs and controlled (non-randomized) clinical trials or cluster trials

2020 Systematic reviews PubMed abstract