Latest & greatest articles for epilepsy

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Top results for epilepsy

141. Neuropsychological outcome after subtemporal versus transsylvian approach for selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy: a randomised prospective clinical trial (Abstract)

Neuropsychological outcome after subtemporal versus transsylvian approach for selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy: a randomised prospective clinical trial To compare the effects of different surgical approaches for selective amygdalohippocampectomy in patients with pharmacoresistant mesial temporal lobe epilepsy with regard to the neuropsychological outcome and to replicate an earlier study employing a matched-pair design.47 patients were randomised (...) to subtemporal versus transsylvian approaches. Memory, language, attentional and executive functions were assessed before and 1 year after surgery. Multivariate analyses of variance (MANOVAs) with presurgical and postsurgical assessments as within-subject variables and approach and side of surgery as between-subject factors were calculated. Additionally, the frequencies of individual performance changes based on reliable change indices were analysed.Seizure freedom International League Against Epilepsy (ILAE

2018 EvidenceUpdates

142. Monarch external Trigeminal Nerve Stimulation System for drug-refractory epilepsy

Monarch external Trigeminal Nerve Stimulation System for drug-refractory epilepsy HealthPACT Health Policy Advisory Committee on Technology Australia and New Zealand Technology Brief 90Y Zevalin for the treatment of non-Hodgkin’s lymphoma (v1.0) August 2011 © State of Queensland (Queensland Health) 2011 This work is licensed under a Creative Commons Attribution Non-Commercial No Derivatives 2.5 Australia licence. In essence, you are free to copy and communicate the work in its current form

2018 COAG Health Council - Horizon Scanning Technology Briefs

143. Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial. (Abstract)

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial. Patients with Lennox-Gastaut syndrome, a rare, severe form of epileptic encephalopathy, are frequently treatment resistant to available medications. No controlled studies have investigated the use of cannabidiol for patients with seizures associated with Lennox-Gastaut syndrome. We therefore assessed the efficacy and safety of cannabidiol (...) as an add-on anticonvulsant therapy in this population of patients.In this randomised, double-blind, placebo-controlled trial done at 24 clinical sites in the USA, the Netherlands, and Poland, we investigated the efficacy of cannabidiol as add-on therapy for drop seizures in patients with treatment-resistant Lennox-Gastaut syndrome. Eligible patients (aged 2-55 years) had Lennox-Gastaut syndrome, including a history of slow (<3 Hz) spike-and-wave patterns on electroencephalogram, evidence of more than

2018 Lancet Controlled trial quality: predicted high

144. Clinical Commissioning Policy: Deep Brain Stimulation for Refractory Epilepsy

Clinical Commissioning Policy: Deep Brain Stimulation for Refractory Epilepsy NHS England » Clinical Commissioning Policy: Deep Brain Stimulation for Refractory Epilepsy (all ages) Search Search Menu Clinical Commissioning Policy: Deep Brain Stimulation for Refractory Epilepsy (all ages) Document first published: 2 March 2018 Page updated: 2 March 2018 Topic: , Publication type: This policy document outlines the arrangements for funding of Deep Brain Stimulation for Refractory Epilepsy

2018 NHS England

145. Clinical Commissioning Policy: Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above)

Clinical Commissioning Policy: Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above) NHS England » Clinical Commissioning Policy: Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above) Search Search Menu Clinical Commissioning Policy: Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above) Document first published: 6 (...) July 2018 Page updated: 6 July 2018 Topic: , Publication type: This policy document outlines the arrangements for funding of treatment for refractory focal onset seizures, associated with tuberous sclerosis complex, for ages 2 years and above. Document 21 pages

2018 NHS England

146. Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above)

Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above) NHS England » Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above) Search Search Menu Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above) Document first published: 21 December 2018 Page updated: 21 December 2018 Topic: Publication type: , NHS England (...) will commission everolimus as an add on treatment of people aged 2 and above who have tuberous sclerosis related seizures in accordance with the criteria outlined in this document. In creating this policy NHS England has reviewed this clinical condition and the options for its treatment. It has considered the place of this treatment in current clinical practice, whether scientific research has shown the treatment to be of benefit to patients, (including how any benefit is balanced against possible risks

2018 NHS England

147. Study suggests that pre-existing maternal epilepsy increases the risk of adverse perinatal outcomes

nuances of the individual patient and take into account disease severity, antiepileptic drug (AED) type and dose and type and other adverse events (eg, miscarriage and malformations) that are not accounted for by administrative data. Context Epilepsy is one of the most common neurological conditions in pregnancy. Up to 1% of all pregnant women may be epileptic 1 and both seizures and the treatment for seizures, antiepileptic drugs (AEDs), have the potential … Request Permissions If you wish to reuse (...) Study suggests that pre-existing maternal epilepsy increases the risk of adverse perinatal outcomes Study suggests that pre-existing maternal epilepsy increases the risk of adverse perinatal outcomes | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts

2018 Evidence-Based Nursing

148. Generalised seizures in children

) of epilepsy and the epilepsy syndrome by recognising a pattern of seizure types, clinical features, and EEG characteristics. Detailed history is of paramount importance in the diagnosis, as key diagnostic factors lie in the history as opposed to ancillary investigations. Main treatment options will depend on the epilepsy syndrome and include anticonvulsants, a ketogenic diet, vagus nerve stimulation, and surgery as well as consideration of lifestyle factors. Definition With the revised and updated (...) and Terminology. Epilepsia. 2017 Apr;58(4):512-21. http://www.ncbi.nlm.nih.gov/pubmed/28276062?tool=bestpractice.com Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017 Apr;58(4):522-30. http://onlinelibrary.wiley.com/doi/10.1111/epi.13670/full http://www.ncbi.nlm.nih.gov/pubmed/28276060?tool=bestpractice.com The new ILAE classification presents

2018 BMJ Best Practice

149. Focal seizures

syndromes. Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85. http://www.ncbi.nlm.nih.gov/pubmed/20196795?tool=bestpractice.com The clinical definition of epilepsy was revised in 2014 to include any of the following conditions: 1) at least two unprovoked seizures occurring >24 hours apart; 2) one unprovoked seizure (...) and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; 3) diagnosis of an epilepsy syndrome. Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017 Apr;58(4):522-30. https://onlinelibrary.wiley.com/doi/full/10.1111/epi.13670 http

2018 BMJ Best Practice

150. Generalised seizures

diagnosis, most seizure disorders respond to treatment. The primary treatment complications include lack of efficacy and medication side effects or idiosyncratic reactions. Definition A generalised tonic-clonic seizure is a seizure type as identified by specific clinical and electroencephalographic criteria. International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia. 1981 Aug;22(4):489-501. http://www.ncbi.nlm.nih.gov (...) generalised-onset epilepsy or focal epilepsy that has secondarily generalised. Magnetic resonance imaging and an electroencephalogram (EEG) are essential tests for properly diagnosing an epilepsy syndrome after a generalised tonic-clonic seizure (GTCS). During a GTCS, the EEG will demonstrate bilateral synchrony in the epileptiform activity. After a GTCS, treatment depends on the type of epilepsy syndrome identified. Generalised-onset epilepsy is treated differently to focal epilepsy. With proper

2018 BMJ Best Practice

151. Febrile seizure

?tool=bestpractice.com The 2006 report by the International League Against Epilepsy Task Force on Classification and Terminology of Epilepsy and Epileptic Syndromes proposed a change in terminology and the omission of the words 'convulsion' and 'convulsive'. They suggested that the term 'febrile convulsions' be replaced by 'febrile seizures'. Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE (...) Febrile seizure Febrile seizure - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Febrile seizure Last reviewed: February 2019 Last updated: January 2019 Summary Febrile seizures are usually self-limiting; an increased risk of developing epilepsy is low except in a small number of cases. Most febrile seizures resolve spontaneously and quickly, and do not require acute or long-term anticonvulsant treatment. Definition

2018 BMJ Best Practice

152. Absence seizures

and associated with mental retardation. Atypical absence seizures in Lennox-Gastaut syndrome and epilepsy with myoclonic absences are treated with valproate or lamotrigine as first-line therapies. Definition An epileptic seizure is defined as "a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain". Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014 Apr;55(4):475-82 (...) , have minimal, if any, postictal confusion, and are usually precipitated by hyperventilation and sometimes by photic stimulation. They have a classic ictal EEG pattern of bilateral symmetric 3 Hz spike-and-wave with normal interictal background. Epilepsy syndromes with typical absence seizures include childhood absence epilepsy (CAE; characterised by brief absence seizures, usually without convulsions), juvenile absence epilepsy (JAE; characterised by absence seizures with tonic-clonic and, less

2018 BMJ Best Practice

153. Overview of seizure disorder

) seizures occurring more than 24 hours apart One unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after 2 unprovoked seizures, occurring over the next 10 years Diagnosis of an epilepsy syndrome. Epileptic seizures may be classified as focal, generalised, or unknown onset, with subcategories of motor, non-motor (absence), with retained or impaired awareness for focal seizures. Fisher RS, Cross JH, French JA, et al. Operational (...) intervention. EEG shows bisynchronous epileptiform activity in both cerebral hemispheres. Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51:676-685. http://www.ncbi.nlm.nih.gov/pubmed/20196795?tool=bestpractice.com GTCS occur in many different types of epilepsy. Anti-epileptic agents are the primary treatment for all types. Bergey GK. Evidence

2018 BMJ Best Practice

154. Management of epilepsy in adults with intellectual disability

International members Special Interest Groups Your monthly eNewsletter Specialty doctors President's lectures Events Conferences and training events In house training International Congress Improving care CCQI Campaigning for better mental health policy Planning the psychiatric workforce National Collaborating Centre for Mental Health Working sustainably Mental health Problems and disorders Support, care and treatment Translations Management of epilepsy in adults with intellectual disability (CR203 May 2017 (...) Management of epilepsy in adults with intellectual disability Management of epilepsy in adults with intellectual disability (CR203 May 2017) This site uses cookies: Search Search Become a psychiatrist Choose psychiatry Medical students Foundation doctors Help us promote psychiatry Training Curricula and guidance Your training Exams Neuroscience in training International Medical Graduates Members Supporting you Submitting your CPD Membership Your Faculties Devolved Nations English Divisions

2018 Royal College of Psychiatrists

155. Prescribing anti-epileptic drugs for people with epilepsy and intellectual disability

Prescribing anti-epileptic drugs for people with epilepsy and intellectual disability Prescribing anti-epileptic drugs for people with epilepsy and intellectual disability (CR206 Oct 2017) This site uses cookies: Search Search Become a psychiatrist Choose psychiatry Medical students Foundation doctors Help us promote psychiatry Training Curricula and guidance Your training Exams Neuroscience in training International Medical Graduates Members Supporting you Submitting your CPD Membership Your (...) Faculties Devolved Nations English Divisions International members Special Interest Groups Your monthly eNewsletter Specialty doctors President's lectures Events Conferences and training events In house training International Congress Improving care CCQI Campaigning for better mental health policy Planning the psychiatric workforce National Collaborating Centre for Mental Health Working sustainably Mental health Problems and disorders Support, care and treatment Translations Prescribing anti-epileptic

2018 Royal College of Psychiatrists

156. Potential clinical benefits of CBD-rich Cannabis extracts over purified CBD in treatment-resistant epilepsy: observational data meta-analysis Full Text available with Trip Pro

disorders such as the Dravet Syndrome, which has received a lot of attention in Brazil. Our country has been giving visibility for this issue after the public discussion regarding the patient Anne Fischer, who benefited from a treatment with hemp based products, imported from the United States of America as a nutritional supplement, and still unregistered in Brazil. To this moment there is no cannabinoid based product registered for clinical indication for epilepsy, so patients have at their disposal (...) on the extracts was 7,1 mg/kg/day, while the purified CBD was 22,9 mg/kg/day, suggesting that CBD is about 3x more potent in the extract than in its purified form. Looking only at the data relative to genetic originated disorders, there is evidence of a superior efficacy on Dravet Syndrome patients (37/72, p=0,01), but not for Lennox-Gastaut Syndrome (78/188, p=0,18), compared to the number of refractory epilepsy respondents in general (107/305). There is also an advantage of the CBD enriched extracts related

2017 Cold Spring Harbor Laboratory

157. Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. Full Text available with Trip Pro

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy.We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination (...) of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%).The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most

2017 NEJM

158. Surgery for Drug-Resistant Epilepsy in Children. Full Text available with Trip Pro

Surgery for Drug-Resistant Epilepsy in Children. Neurosurgical treatment may improve seizures in children and adolescents with drug-resistant epilepsy, but additional data are needed from randomized trials.In this single-center trial, we randomly assigned 116 patients who were 18 years of age or younger with drug-resistant epilepsy to undergo brain surgery appropriate to the underlying cause of epilepsy along with appropriate medical therapy (surgery group, 57 patients) or to receive medical (...) ), and on the Vineland Social Maturity Scale (difference, 4.7; 95% CI, 0.4 to 9.1; P=0.03), but not on the Binet-Kamat intelligence quotient (difference, 2.5; 95% CI, -0.1 to 5.1; P=0.06). Serious adverse events occurred in 19 patients (33%) in the surgery group, including hemiparesis in 15 (26%).In this single-center trial, children and adolescents with drug-resistant epilepsy who had undergone epilepsy surgery had a significantly higher rate of freedom from seizures and better scores with respect to behavior

2017 NEJM Controlled trial quality: predicted high

159. EEG for children with complex febrile seizures. Full Text available with Trip Pro

complex febrile seizures among children.To assess the use of EEG and its timing after complex febrile seizures in children younger than five years of age.For the latest update of this review, we searched the Cochrane Epilepsy Group Specialized Register (23 January 2017), the Cochrane Central Register of Controlled Trials (CENTRAL) via the Cochrane Register of Studies Online (CRSO, 23 January 2017), MEDLINE (Ovid, 23 January 2017), and ClinicalTrials.gov (23 January 2017). We applied no language (...) restrictions.All randomised controlled trials (RCTs) that examined the utility of an EEG and its timing after complex febrile seizures in children.The review authors selected and retrieved the articles and independently assessed which articles should be included. Any disagreements were resolved by discussion and by consultation with the Cochrane Epilepsy Group. We applied standard methodological procedures expected by Cochrane.Of 41 potentially eligible studies, no RCTs met the inclusion criteria.We found

2017 Cochrane

160. Yoga for epilepsy. Full Text available with Trip Pro

Yoga for epilepsy. This is an updated version of the original Cochrane Review published in the Cochrane Library, Issue 5, 2015.Yoga may induce relaxation and stress reduction, and influence the electroencephalogram and the autonomic nervous system, thereby controlling seizures. Yoga would be an attractive therapeutic option for epilepsy if proved effective.To assess whether people with epilepsy treated with yoga:(a) have a greater probability of becoming seizure free;(b) have a significant (...) reduction in the frequency or duration of seizures, or both; and(c) have a better quality of life.For this update, we searched the Cochrane Epilepsy Group Specialized Register (3 January 2017), the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 12) in the Cochrane Library (searched 3 January 2017), MEDLINE (Ovid, 1946 to 3 January 2017), SCOPUS (1823 to 3 January 2017), ClinicalTrials.gov (searched 3 January 2017), the World Health Organization (WHO) International Clinical Trials

2017 Cochrane