Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for fatigue
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on fatigue or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on fatigue and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via firstname.lastname@example.org
Chronic fatigue syndrome - exercise and cognitive behaviour therapies Chronic fatigue syndrome - exercise and cognitive behaviour therapies Chronic fatigue syndrome - exercise and cognitive behaviour therapies Bernath V Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Bernath V. Chronic fatigue syndrome - exercise and cognitive behaviour therapies. Clayton (...) , Victoria: Centre for Clinical Effectiveness (CCE) 2001: 11 Authors' objectives This aim of this critical appraisal was to assess whether exercise or cognitive behaviour therapies are effective in reducing symptoms of chronic fatigue syndrome in hospitalised patients or patients visiting outpatient clinics. Project page URL Indexing Status Subject indexing assigned by CRD MeSH Cognitive Therapy; Exercise Therapy; Fatigue Syndrome, Chronic Language Published English Country of organisation Australia
Defining and managing chronic fatigue syndrome Defining and managing chronic fatigue syndrome Defining and managing chronic fatigue syndrome Mulrow C D, Ramirez G, Cornell J E, Allsup K Authors' objectives The review covered four research objectives: (1) to find the existing case definitions of chronic fatigue syndrome (CFS) in adults; (2) what case definitions have been substantiated and/or validated in adults; (3) the prevalence and natural history of CFS in adults; and (4) whether (...) there is evidence to show that particular treatments improve clinical symptoms of CFS when compared to placebo, no therapy, or each other. Only the fourth objective is addressed in this abstract of the review. Searching MEDLINE, the Cochrane Library, PsycINFO (from 1980 to July 2000), EMBASE (from 1988 to 1993 and 1998 to 2000) and the Journal of Chronic Fatigue Syndrome (from 1996 to 2000) were searched using an extensive list of search terms, which were listed in full in the report. In addition, Internet
Cognitive behaviour therapy for adults with chronic fatigue syndrome. 1. To systematically review all randomised controlled trials of cognitive-behaviour therapy (CBT) for adults with chronic fatigue syndrome (CFS); 2. To test the hypothesis that CBT is more effective than orthodox medical management or other interventions in adults with CFS.1. Electronic searching of bibliographic databases, including Medline, PsycLIT, Biological Abstracts, Embase, SIGLE, Index to Theses, Index to Scientific (...) appears to be an effective and acceptable treatment for adult out-patients with chronic fatigue syndrome. CFS is a common and disabling disorder. Its sufferers deserve the medical profession to be more aware of the potential of this therapy to bring lasting functional benefit, and health service managers to increase its availability. Further research is needed in this important area. Trials should conform to accepted standards of reporting and methodology. The effectiveness of CBT in more and less
Treatments for fatigue in multiple sclerosis: a rapid and systematic review Treatments for fatigue in multiple sclerosis: a rapid and systematic review Treatments for fatigue in multiple sclerosis: a rapid and systematic review Branas P, Jordan R, Fry-Smith A, Burls A, Hyde C Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Branas P (...) , Jordan R, Fry-Smith A, Burls A, Hyde C. Treatments for fatigue in multiple sclerosis: a rapid and systematic review. Health Technology Assessment 2000; 4(27): 1-61 Authors' objectives - To identify current treatments for fatigue in MS and their evidence-base. - To systematically review the evidence for those treatments that have been investigated in more than one rigorous study, in order to determine their effectiveness and cost-effectiveness. Authors' conclusions There is insufficient evidence
Treatments for fatigue in multiple sclerosis: a rapid and systematic review Treatments for fatigue in multiple sclerosis: a rapid and systematic review Treatments for fatigue in multiple sclerosis: a rapid and systematic review Branas P, Jordan R, Fry-Smith A, Burls A, Hyde C Authors' objectives To review evidence of the effects and overall effectiveness of promising interventions in the treatment of fatigue in multiple sclerosis (MS). Searching The authors searched MEDLINE (1966 to December (...) or an alternative intervention were included in the review. Specific interventions included in the review Amantadine and pemoline. Participants included in the review Patients diagnosed with clinically definite multiple sclerosis (MS) without restriction by age, sex, or category of MS. Presence of fatigue at baseline was not a necessary criterion. Clinically definite MS was defined as: two attacks and clinical evidence of two lesions (or paraclinical evidence of the second). Outcomes assessed in the review
Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial. Reports of mild hypocortisolism in chronic fatigue syndrome led us to postulate that low-dose hydrocortisone therapy may be an effective treatment.In a randomised crossover trial, we screened 218 patients with chronic fatigue. 32 patients met our strict criteria for chronic fatigue syndrome without co-morbid psychiatric disorder. The eligible patients received consecutive treatment with low-dose hydrocortisone (5 (...) mg or 10 mg daily) for 1 month and placebo for 1 month; the order of treatment was randomly assigned. Analysis was by intention to treat.None of the patients dropped out. Compared with the baseline self-reported fatigue scores (mean 25.1 points), the score fell by 7.2 points for patients on hydrocortisone and by 3.3 points for those on placebo (paired difference in mean scores 4.5 points [95% CI 1.2-7.7], p=0.009). In nine (28%) of the 32 patients on hydrocortisone, fatigue scores reached
1999LancetControlled trial quality: predicted high
Relief from profound fatigue associated with chronic liver disease by long-term ondansetron therapy. A woman with chronic hepatitis C and profound fatigue became symptomfree when treated long-term with ondansetron 4 mg twice daily. Altered central serotoninergic neurotransmission may contribute to fatigue complicating chronic liver disease.
Iron therapy in chronically fatigued, nonanemic women: a double-blind study. 13800263 1998 11 01 2018 12 01 0003-4819 52 1960 Feb Annals of internal medicine Ann. Intern. Med. Iron therapy in chronically fatigued, nonanemic women: a double-blind study. 378-94 BEUTLER E E LARSH S E SE GURNEY C W CW eng Journal Article United States Ann Intern Med 0372351 0003-4819 E1UOL152H7 Iron OM Double-Blind Method Fatigue therapy Female Humans Iron therapy FATIGUE/therapy IRON/therapy 1960 2 1 1960 2 1 0 1
Low-dose hydrocortisone for treatment of chronic fatigue syndrome: a randomized controlled trial. Chronic fatigue syndrome (CFS) is associated with a dysregulated hypothalamic-pituitary adrenal axis and hypocortisolemia.To evaluate the efficacy and safety of low-dose oral hydrocortisone as a treatment for CFS.A randomized, placebo-controlled, double-blind therapeutic trial, conducted between 1992 and 1996.A single-center study in a tertiary care research institution.A total of 56 women and 14
Randomised controlled trial of graded exercise in patients with the chronic fatigue syndrome. To test the efficacy of a graded aerobic exercise programme in the chronic fatigue syndrome.Randomised controlled trial with control treatment crossover after the first follow up examination.Chronic fatigue clinic in a general hospital department of psychiatry.66 patients with the chronic fatigue syndrome who had neither a psychiatric disorder nor appreciable sleep disturbance.Random allocation to 12 (...) exercise treatment compared with eight of 30 patients who completed flexibility treatment. Analysis by intention to treat gave similar results (17/33 v 9/33 patients better). Fatigue, functional capacity, and fitness were significantly better after exercise than after flexibility treatment. 12 of 22 patients who crossed over to exercise after flexibility treatment rated themselves as better after completing exercise treatment 32 of 47 patients rated themselves as better three months after completing
Cognitive behaviour therapy for the chronic fatigue syndrome: a randomized controlled trial. To evaluate the acceptability and efficacy of adding cognitive behaviour therapy to the medical care of patients presenting with the chronic fatigue syndrome.Randomised controlled trial with final assessment at 12 months.An infectious diseases outpatient clinic.60 consecutively referred patients meeting consensus criteria for the chronic fatigue syndrome.Medical care comprised assessment, advice (...) associated with a poor outcome changed more with cognitive behaviour therapy than with medical care alone.Adding cognitive behaviour therapy to the medical care of patients with the chronic fatigue syndrome is acceptable to patients and leads to a sustained reduction in functional impairment.
Randomised, double-blind, placebo-controlled study of fluoxetine in chronic fatigue syndrome. No somatic treatment has been found to be effective for chronic fatigue syndrome (CFS). Antidepressant therapy is commonly used. Fluoxetine is recommended in preference to tricyclic agents because it has fewer sedative and autonomic nervous system effects. However, there have been no randomised, placebo-controlled, double-blind studies showing the effectiveness of antidepressant therapy in CFS. We have (...) (Actometer), which were applied on the day treatment started and on the last day.The two groups were well matched in terms of age, sex distribution, employment and marital status, and duration of CFS. There were no significant differences between the placebo and fluoxetine-treated groups in the change during the 8-week treatment period for any dimension of CFS. There was no change in subjective assessments of fatigue, severity of depression, functional impairment, sleep disturbances, neuropsychological
Cognitive behavioural therapy in the treatment of chronic fatigue syndrome Cognitive behavioural therapy in the treatment of chronic fatigue syndrome Cognitive behavioural therapy in the treatment of chronic fatigue syndrome Best L, Stevens A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Best L, Stevens A. Cognitive behavioural therapy (...) in the treatment of chronic fatigue syndrome. Southampton: Wessex Institute for Health Research and Development (WIHRD) 1996 Authors' objectives The author aims to determine whether the proposal for cognitive behavioural therapy to be available in the management of CFS, in order to supplement existing programmes of care, is justified. Authors' conclusions The authors recommend CBT as out-patient treatment for a certain group of people, but say that the criteria for the selection of those who would gain most
Empirical parenteral antibiotic treatment of patients with fibromyalgia and fatigue and a positive serologic result for Lyme disease Empirical parenteral antibiotic treatment of patients with fibromyalgia and fatigue and a positive serologic result for Lyme disease Empirical parenteral antibiotic treatment of patients with fibromyalgia and fatigue and a positive serologic result for Lyme disease Lightfoot R W, Luft B J, Rahn D W, Steere A C, Sigal L H, Zoschke D C, Gardner P, Britton M C (...) Patients in endemic areas with chronic fatigue and myalgia and a positive serologic result for Lyme disease. Setting Primary care. The study was conducted in the USA. Dates to which data relate Not reported. Source of effectiveness data Review of previous studies. Outcomes assessed in the review False positive rates and toxicity rates due to treatment. Study designs and other criteria for inclusion in the review Decisions on the relevance of the studies were based on the methods followed for patient
Red blood cell magnesium and chronic fatigue syndrome. The hypotheses that patients with chronic fatigue syndrome (CFS) have low red blood cell magnesium and that magnesium treatment would improve the wellbeing of such patients were tested in a case-control study and a randomised, double-blind, placebo-controlled trial, respectively. In the case-control study, 20 patients with CFS had lower red cell magnesium concentrations than did 20 healthy control subjects matched for age, sex, and social
1991LancetControlled trial quality: predicted high
Acyclovir treatment of the chronic fatigue syndrome. Lack of efficacy in a placebo-controlled trial. Twenty-seven adults with a diagnosis of the chronic fatigue syndrome were enrolled in a double-blind, placebo-controlled study of acyclovir therapy. The patients had had debilitating fatigue for an average of 6.8 years, accompanied by persisting antibodies to Epstein-Barr virus early antigens (titers greater than or equal to 1:40) or undetectable levels of antibodies to Epstein-Barr virus (...) the trial, similar numbers improved with acyclovir therapy and with placebo (11 and 10, respectively). Neither acyclovir treatment nor clinical improvement correlated with alterations in laboratory findings, including titers of antibody to Epstein-Barr virus or levels of circulating immune complexes or of leukocyte 2',5'-oligoadenylate synthetase. Subjective improvement correlated with various measures of mood. We conclude that acyclovir, as used in this study, does not ameliorate the chronic fatigue