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Latest & greatest articles for fenofibrate
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Effects of fenofibrate and gemfibrozil on plasma homocysteine. Fenofibrate increases plasma homocysteine. Because the concentration of plasma homocysteine depends on renal function, we postulate that increases in plasma homocysteine are a result of the known impairment of renal function caused by fenofibrate. Gemfibrozil, another fibrate, does not affect renal function. In a crossover study we tested whether gemfibrozil would raise homocysteine. 22 patients who had hypertriglyceridaemia were (...) given 900 mg gemfibrozil or 200 mg fenofibrate daily for 6 weeks. Lipids were altered similarly, but homocysteine, creatinine, and cystatin C were raised by fenofibrate but not by gemfibrozil (p for differences between treatment effects: 0.007, 0.006, and 0.040, respectively). We propose gemfibrozil should be the fibrate of choice.
Serum homocysteine increases after therapy with fenofibrate or bezafibrate. A 44% and 17.5% increase of homocysteine occurred in patients treated either with fenofibrate or bezafibrate. The increase was not explained by changes in vitamin concentrations but may be related to renal function.
Micronized fenofibrate: a new fibric acid hypolipidemic agent Micronized fenofibrate: a new fibric acid hypolipidemic agent Micronized fenofibrate: a new fibric acid hypolipidemic agent Guay D R Authors' objectives To assess the efficacy and safety of fenofibrate in the management of hyperlipidaemias. Searching MEDLINE (from 1974 to October 1998) and Currents Contents were searched, and the bibliographies from identified studies were examined. In addition, the package inserts from (...) the manufacturers were used to identify data. Study selection Study designs of evaluations included in the review The inclusion criteria were not defined in terms of study design. The studies included were randomised controlled trials (RCTs) of parallel or crossover design, including double-blinded RCTs, and observational studies. The duration of the comparative studies ranged from 4 weeks to 1 year. Specific interventions included in the review Studies evaluating fenofibrate were eligible. Fenofibrate (regular
Cost effectiveness of micronised fenofibrate and simvastatin in the short term treatment of type IIa and type IIb hyperlipidaemia Cost effectiveness of micronised fenofibrate and simvastatin in the short term treatment of type IIa and type IIb hyperlipidaemia Cost effectiveness of micronised fenofibrate and simvastatin in the short term treatment of type IIa and type IIb hyperlipidaemia Kirchgassler K U, Schiffner-Rohe J, Stahlheber U Record Status This is a critical abstract of an economic (...) evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Micronised Fenofibrate and Simvastatin in the treatment of type IIa and IIb hyperlipidaemia. Type of intervention Treatment; Secondary prevention. Economic study type Cost-effectiveness analysis. Study population Patients (median age 51 years