Latest & greatest articles for fibromyalgia

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on fibromyalgia or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on fibromyalgia and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for fibromyalgia

21. Combination pharmacotherapy for the treatment of fibromyalgia in adults. Full Text available with Trip Pro

Combination pharmacotherapy for the treatment of fibromyalgia in adults. Fibromyalgia is a chronic widespread pain condition affecting millions of people worldwide. Current pharmacotherapies are often ineffective and poorly tolerated. Combining different agents could provide superior pain relief and possibly also fewer side effects.To assess the efficacy, safety, and tolerability of combination pharmacotherapy compared to monotherapy or placebo, or both, for the treatment of fibromyalgia pain (...) in adults.We searched CENTRAL, MEDLINE, and Embase to September 2017. We also searched reference lists of other reviews and trials registries.Double-blind, randomised controlled trials comparing combinations of two or more drugs to placebo or other comparators, or both, for the treatment of fibromyalgia pain.From all studies, we extracted data on: participant-reported pain relief of 30% or 50% or greater; patient global impression of clinical change (PGIC) much or very much improved or very much improved

2018 Cochrane

22. Interdisciplinary assessment-oriented treatment of fibromyalgia: a case report Full Text available with Trip Pro

Interdisciplinary assessment-oriented treatment of fibromyalgia: a case report Patients with fibromyalgia (FM) have often tried many outpatient treatments, and breakthrough pain frequently stops them from performing everyday tasks and participating in society. FM-pain that has become chronic, therefore, affects quality of life. This case study describes the administration of interdisciplinary inpatient pain therapy due to a primary diagnosis of fibromyalgia with integrated complementary

2018 Integrative medicine research

23. Evidence of peripheral large nerve involvement in fibromyalgia: a retrospective review of EMG and nerve conduction findings in 55 FM subjects Full Text available with Trip Pro

Evidence of peripheral large nerve involvement in fibromyalgia: a retrospective review of EMG and nerve conduction findings in 55 FM subjects Whereas small fiber neuropathy (SFN) is now a recognized part of fibromyalgia (FM), surprisingly little attention has been paid to any findings of large fiber neuropathy (LFN) in this disorder. Since 90% to 95% of FM subjects seen in our outpatient facility routinely undergo EMG and nerve conduction studies (NCS) we elected to retrospectively review

2018 European journal of rheumatology

24. Fibromyalgia

Fibromyalgia Fibromyalgia - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Fibromyalgia Last reviewed: February 2019 Last updated: May 2018 Summary Patients typically present with chronic, widespread body pain and almost always have accompanying comorbid symptoms such as fatigue, memory difficulties, and sleep and mood difficulties Physical examination is typically normal but there is often diffuse tenderness, which (...) have a problem recognising fibromyalgia as a discrete disorder, they should understand the diagnostic and therapeutic importance of 'centralisation' of pain as exemplified by a typical fibromyalgia patient. When a patient with any chronic pain state develops evidence of centralisation of pain, it is likely that treatments that work well for acute pain or pain primarily due to nociceptive input (NSAIDs, opioids, anti-inflammatories, immunosuppressives, injections, surgical procedures) will be less

2018 BMJ Best Practice

25. A Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with Fibromyalgia Full Text available with Trip Pro

A Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with Fibromyalgia This study sought to compare efficacy and safety of ferric carboxymaltose vs. placebo in iron-deficient patients with fibromyalgia.This blinded, placebo-controlled, phase 2 study randomized adults with fibromyalgia and Revised Fibromyalgia Impact Questionnaire (FIQR) scores ≥ 60, ferritin levels < 0.05 µg/ml, and transferrin saturation < 20 (...) indices. Mean changes in MOS Sleep scale scores were similar between groups. Ferric carboxymaltose was safe and well tolerated.Compared with placebo, ferric carboxymaltose improved measures of fibromyalgia severity and was well tolerated. The current results suggest that ferric carboxymaltose shows benefit in iron-deficient patients with concurrent fibromyalgia.Luitpold Pharmaceuticals, Inc.ClinicalTrials.gov identifier, NCT02409459.

2017 Rheumatology and therapy Controlled trial quality: predicted high

26. Fibromyalgia has a high prevalence and impact in cardiac failure patients Full Text available with Trip Pro

Fibromyalgia has a high prevalence and impact in cardiac failure patients Chronic cardiac failure (CCF) shares several clinical features with fibromyalgia (FM), a syndrome of increased central sensitivity and musculoskeletal pain. FM frequently coexists with other chronic illness. Musculoskeletal pain is reported in patients with CCF; however, the prevalence and impact of FM in patients with CCF is not known. This research aims to assess the prevalence and effects of concurrent FM in patients

2017 European journal of rheumatology

27. The reliability and validity of the Turkish version of the Fibromyalgia Participation Questionnaire Full Text available with Trip Pro

The reliability and validity of the Turkish version of the Fibromyalgia Participation Questionnaire The objective of this study was to test the reliability and validity of the Turkish version of the Fibromyalgia Participation Questionnaire (FPQ).One hundred and eighty-four female patients with fibromyalgia syndrome were included in the study. All patients filled out the Turkish FPQ (FPQ-T) questionnaire, which was obtained by translation from German according to the guideline for the process (...) of cross-cultural adaptation The patients filled out the revised Fibromyalgia Impact Questionnaire (FIQ) and reevaluated the FPQ-T two hours later. Internal consistency reliability of the FPQ-T was assessed by calculating the "if item deleted" using Cronbach's alpha and the "item-total correction" coefficient for each item of the questionnaire. The consistency of the subscales and the correlation of the test-retest values were assessed. The test-retest values were compared using the Wilcoxon test

2017 European journal of rheumatology

28. A qualitative exploration of the experiences of living with and being treated for fibromyalgia Full Text available with Trip Pro

A qualitative exploration of the experiences of living with and being treated for fibromyalgia This study explores the life and treatment experience of people in the United Kingdom with fibromyalgia in order to inform the development of treatments which are both effective and acceptable to users. Qualitative interviews were conducted with 14 participants with interpretative phenomenological analysis used as the theoretical framework and analytical method. The themes identified were as follows (...) : Inauthenticity of fibromyalgia, An Unconventional healthcare experience, Re-creating support networks, Challenging the working identity, Threatening the family dynamic and Fighting, accepting or accommodating? The biopsychosocial impacts of fibromyalgia disrupted the identity, lifestyle, roles and relationships of our participants with such challenges further exacerbated by the contested nature of the illness.

2017 Health psychology open

29. Emotional awareness and expression therapy, cognitive behavioral therapy, and education for fibromyalgia: a cluster-randomized controlled trial Full Text available with Trip Pro

Emotional awareness and expression therapy, cognitive behavioral therapy, and education for fibromyalgia: a cluster-randomized controlled trial Patients with fibromyalgia (FM) experience increased lifetime levels of psychosocial adversity, trauma, and emotional conflict. To address these risk factors, we developed emotion awareness and expression therapy (EAET) and tested its benefits against an active control condition, FM education, and the field's gold standard intervention for FM, cognitive

2017 EvidenceUpdates

30. Exercise for the Management of Fibromyalgia: Clinical Effectiveness

is the clinical effectiveness of exercise for the management of fibromyalgia? Key Message Twenty-two systematic reviews (11 with meta-analysis) were identified regarding the clinical benefits and harms of exercise for adults with fibromyalgia. Tags exercise, exercise movement techniques, exercise therapy, fibromyalgia, hydrotherapy, musculoskeletal, exercise therapies, muscular rheumatism, Myofascial Pain, fibrositis, physical activity, physical activities, water therapy, water therapies, vibration therapy (...) Exercise for the Management of Fibromyalgia: Clinical Effectiveness Exercise for the Management of Fibromyalgia: Clinical Effectiveness | CADTH.ca Find the information you need Exercise for the Management of Fibromyalgia: Clinical Effectiveness Exercise for the Management of Fibromyalgia: Clinical Effectiveness Published on: July 20, 2017 Project Number: RB1116-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

31. Exercise for the Management of Fibromyalgia: Clinical Effectiveness

is the clinical effectiveness of exercise for the management of fibromyalgia? Key Message Twenty-two systematic reviews (11 with meta-analysis) were identified regarding the clinical benefits and harms of exercise for adults with fibromyalgia. Tags exercise, exercise movement techniques, exercise therapy, fibromyalgia, hydrotherapy, musculoskeletal, exercise therapies, muscular rheumatism, Myofascial Pain, fibrositis, physical activity, physical activities, water therapy, water therapies, vibration therapy (...) Exercise for the Management of Fibromyalgia: Clinical Effectiveness Exercise for the Management of Fibromyalgia: Clinical Effectiveness | CADTH.ca Find the information you need Exercise for the Management of Fibromyalgia: Clinical Effectiveness Exercise for the Management of Fibromyalgia: Clinical Effectiveness Published on: July 20, 2017 Project Number: RB1116-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

32. The Effect Size of Fibromyalgia on PG-VAS in Rheumatoid Arthritis Patients. Adjustment Proposal in DAS28-ESR: Letter to the Editor regarding Challa, D.N.V., Crowson, C.S. & Davis, J.M. Rheumatol Ther (2017) 4: 201. doi:10.1007/s40744-017-0063-5 Full Text available with Trip Pro

The Effect Size of Fibromyalgia on PG-VAS in Rheumatoid Arthritis Patients. Adjustment Proposal in DAS28-ESR: Letter to the Editor regarding Challa, D.N.V., Crowson, C.S. & Davis, J.M. Rheumatol Ther (2017) 4: 201. doi:10.1007/s40744-017-0063-5 28685293 2018 11 13 2198-6576 4 2 2017 Dec Rheumatology and therapy Rheumatol Ther The Effect Size of Fibromyalgia on PG-VAS in Rheumatoid Arthritis Patients. Adjustment Proposal in DAS28-ESR: Letter to the Editor regarding Challa, D.N.V., Crowson, C.S (...) Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Avenida Gonzalitos 235 Norte, Monterrey, Nuevo León, México. Esquivel-Valerio Jorge Antonio JA Servicio de Reumatología, Departamento de Medicina Interna, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Avenida Gonzalitos 235 Norte, Monterrey, Nuevo León, México. eng Letter 2017 07 06 England Rheumatol Ther 101674543 2198-6576 Fibromyalgia Rheumatoid arthritis 2017 05 28 2017 7 8 6 0

2017 Rheumatology and therapy

33. Aerobic exercise training for adults with fibromyalgia. Full Text available with Trip Pro

Aerobic exercise training for adults with fibromyalgia. Exercise training is commonly recommended for individuals with fibromyalgia. This review is one of a series of reviews about exercise training for people with fibromyalgia that will replace the "Exercise for treating fibromyalgia syndrome" review first published in 2002.• To evaluate the benefits and harms of aerobic exercise training for adults with fibromyalgia• To assess the following specific comparisons ० Aerobic versus control (...) potentially relevant trials.We included randomized controlled trials (RCTs) in adults with a diagnosis of fibromyalgia that compared aerobic training interventions (dynamic physical activity that increases breathing and heart rate to submaximal levels for a prolonged period) versus no exercise or another intervention. Major outcomes were health-related quality of life (HRQL), pain intensity, stiffness, fatigue, physical function, withdrawals, and adverse events.Two review authors independently selected

2017 Cochrane

34. Physiotherapy Interventions for the Management of Fibromyalgia: Clinical and Cost Effectiveness

for fibromyalgia in adults. Tags acupuncture, fibromyalgia, hydrotherapy, massage, physical therapy modalities, transcutaneous electric nerve stimulation, ultrasonography, musculoskeletal, water therapy, water therapies, TENS, fibrositis, physical therapy, muscular rheumatism Files Rapid Response Summary of Abstracts Published : June 12, 2017 Related Content Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter: (...) Physiotherapy Interventions for the Management of Fibromyalgia: Clinical and Cost Effectiveness Physiotherapy Interventions for the Management of Fibromyalgia: Clinical and Cost Effectiveness | CADTH.ca Find the information you need Physiotherapy Interventions for the Management of Fibromyalgia: Clinical and Cost Effectiveness Physiotherapy Interventions for the Management of Fibromyalgia: Clinical and Cost Effectiveness Published on: June 12, 2017 Project Number: RB1101-000 Product Line

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

35. A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia Full Text available with Trip Pro

A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia Fibromyalgia is a complex chronic condition characterized by pain, physical fatigue, sleep disorder and cognitive impairment. Evidence-based guidelines recommend antidepressants as treatments of fibromyalgia where tricyclics are often considered to have the greatest efficacy, with amitriptyline often being a first-line treatment. Amitriptyline evokes a preferential reduction in pain and fatigue (...) of fibromyalgia, and in the Fibromyalgia Impact Questionnaire (FIQ) score, which is a quality of life assessment. The multimodal profile of the mechanisms of action of amitriptyline include monoamine reuptake inhibition, receptor modulation and ion channel modulation. Several of the actions of amitriptyline on multiple nociceptive and sensory processes at central and peripheral locations have the potential to act cumulatively to suppress the characteristic symptoms of fibromyalgia. Greater understanding

2017 Biomedicines

36. New Insights into the Pathophysiology and Treatment of Fibromyalgia Full Text available with Trip Pro

New Insights into the Pathophysiology and Treatment of Fibromyalgia Fibromyalgia is characterized by chronic widespread pain and several additional symptoms such as fatigue, cognitive dysfunction, depressive episodes, and anxiety. The underlying pathophysiology of fibromyalgia is still poorly understood, and treatment is often unsatisfactory. Current research provides evidence for altered pain processing in chronic pain patients, and specifically in fibromyalgia patients, possibly based

2017 Biomedicines

37. Update on Treatment Guideline in Fibromyalgia Syndrome with Focus on Pharmacology Full Text available with Trip Pro

Update on Treatment Guideline in Fibromyalgia Syndrome with Focus on Pharmacology Fibromyalgia syndrome (FMS) is a chronic condition with unknown aetiology. The pathophysiology of the disease is incompletely understood; despite advances in our knowledge with regards to abnormal central and peripheral pain processing, and hypothalamo-pituitary-adrenal dysfunction, there is no clear specific pathophysiological therapeutic target. The management of this complex condition has thus perplexed

2017 Biomedicines

38. Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia Full Text available with Trip Pro

Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia Fibromyalgia (FM) is a complex, multi-symptom condition that predominantly affects women. The majority of those affected are unlikely to gain significant symptomatic control from the few treatments that are approved for FM. In this 10-week, single-blind, crossover trial we tested the immune effects of eight weeks of oral administration of low-dose naltrexone (LDN). We enrolled eight women (...) . The findings of this pilot trial suggest that LDN treatment in fibromyalgia is associated with a reduction of several key pro-inflammatory cytokines and symptoms. The potential role of LDN as an atypical anti-inflammatory medication should be explored further.

2017 Biomedicines Controlled trial quality: uncertain

39. Modulation of NMDA Receptor Activity in Fibromyalgia Full Text available with Trip Pro

Modulation of NMDA Receptor Activity in Fibromyalgia Activation of the N-methyl-d-aspartate receptor (NMDAR) results in increased sensitivity of spinal cord and brain pathways that process sensory information, particularly those which relate to pain. The NMDAR shows increased activity in fibromyalgia and hence modulation of the NMDAR is a target for therapeutic intervention. A literature review of interventions impacting on the NMDAR shows a number of drugs to be active on the NMDAR mechanism (...) in fibromyalgia patients, with variable clinical effects. Low-dose intravenous ketamine and oral memantine both show clinically useful benefit in fibromyalgia. However, consideration of side-effects, logistics and cost need to be factored into management decisions regarding use of these drugs in this clinical setting. Overall benefits with current NMDAR antagonists appear modest and there is a need for better strategy trials to clarify optimal dose schedules and to delineate potential longer-term adverse

2017 Biomedicines

40. The effects of acupuncture versus sham acupuncture in the treatment of fibromyalgia: a randomized controlled clinical trial. (Abstract)

The effects of acupuncture versus sham acupuncture in the treatment of fibromyalgia: a randomized controlled clinical trial. The aim of this manuscript is to determine and to compare the efficacy of real acupuncture with sham acupuncture on fibromyalgia (FM) treatment.50 women with FM were randomized into 2 groups to receive either true acupuncture or sham acupuncture. Subjects were evaluated with VAS (at night, at rest, during activity), SF-36, Fibromyalgia Impact Questionnaire (FIQ), Beck

2017 Acta reumatologica portuguesa Controlled trial quality: uncertain