Latest & greatest articles for fluticasone

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Top results for fluticasone

81. Fluticasone versus beclomethasone or budesonide for chronic asthma. (Abstract)

Fluticasone versus beclomethasone or budesonide for chronic asthma. Beclomethasone dipropionate (BDP) and budesonide (BUD) are commonly prescribed inhaled corticosteroids for the treatment of asthma, Fluticasone propionate (FP) is newer agent with greater potency in in-vitro assays.To compare the efficacy and safety of Fluticasone to Beclomethasone or Budesonide in the treatment of chronic asthma.We searched the Cochrane Airways Group Trial Register (1999) and reference lists of articles. We (...) contacted trialists and pharmaceutical companies for additional studies and searched abstracts of major respiratory society meetings (1997-1999).Randomised trials in children and adults comparing Fluticasone to either Beclomethasone or Budesonide in the treatment of chronic asthma. Two reviewers independently assessed articles for inclusion and methodological quality.One reviewer extracted data. Quantitative analyses where undertaken using Review Manager 4.0.3 with Metaview 3.1.42 studies (>10,000

2002 Cochrane

82. Inhaled fluticasone at different doses for chronic asthma. (Abstract)

Inhaled fluticasone at different doses for chronic asthma. Inhaled fluticasone propionate (FP) is a high potency inhaled corticosteroid used in the treatment of asthma.1. To assess the efficacy and safety outcomes in studies that compared inhaled fluticasone at different nominal daily doses in the treatment of chronic asthma. 2. To test for the presence of a dose response effect.We searched the Cochrane Airways Group Trial Register (1999) and reference lists of articles. We contacted trialists (...) and pharmaceutical companies for additional studies and searched abstracts of major respiratory society meetings (1997-1999).Randomised trials in children and adults comparing fluticasone at different nominal daily doses in the treatment of chronic asthma. Two reviewers independently assessed articles for inclusion and methodological quality.One reviewer extracted data. Quantitative analyses where undertaken using Review Manager 4.0.3 with Metaview 3.1.20 studies (>6000 patients) met the inclusion criteria

2002 Cochrane

83. Cost-effectiveness comparison of salmeterol/fluticasone propionate versus montelukast in the treatment of adults with persistent asthma

Cost-effectiveness comparison of salmeterol/fluticasone propionate versus montelukast in the treatment of adults with persistent asthma Cost-effectiveness comparison of salmeterol/fluticasone propionate versus montelukast in the treatment of adults with persistent asthma Cost-effectiveness comparison of salmeterol/fluticasone propionate versus montelukast in the treatment of adults with persistent asthma Sheth K, Borker R, Emmett A, Rickard K, Dorinsky P Record Status This is a critical (...) abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Two initial maintenance treatments for patients with persistent asthma were examined. Salmeterol-fluticasone propionate (SF; salmeterol 50 microg and fluticasone propionate 100 microg) delivered twice daily via

2002 NHS Economic Evaluation Database.

84. Economic impact of asthma therapy with fluticasone propionate, montelukast, or zafirlukast in a managed care population

Economic impact of asthma therapy with fluticasone propionate, montelukast, or zafirlukast in a managed care population Economic impact of asthma therapy with fluticasone propionate, montelukast, or zafirlukast in a managed care population Economic impact of asthma therapy with fluticasone propionate, montelukast, or zafirlukast in a managed care population Pathak D S, Davis E A, Stanford R H Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The health technology was controller therapy for patients with asthma. The comparators were inhaled corticosteroids and leukotriene modifiers in real world clinical practice. The authors compared fluticasone propionate (44 or 110 microg) with oral zafirlukast (20 mg) and montelukast

2002 NHS Economic Evaluation Database.

85. Inhaled fluticasone propionate for chronic asthma. (Abstract)

Inhaled fluticasone propionate for chronic asthma. Inhaled fluticasone propionate (FP) is a relatively new inhaled corticosteroid for the treatment of asthma.1. To assess efficacy and safety outcomes in studies that compared FP to placebo for treatment of chronic asthma. 2. To explore the presence of a dose-response effect.We searched the Cochrane Airways Group Trial Register (1999), reference lists of articles, contacted trialists and searched abstracts of major respiratory society meetings

2001 Cochrane

86. Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial. (Abstract)

Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial. It is not known whether intranasal corticosteroids are beneficial to treat acute rhinosinusitis in patients with a history of chronic or recurrent sinus symptoms.To assess whether the addition of an intranasal corticosteroid to antibiotic therapy affects the speed and rate of recovery of such patients with acute rhinosinusitis.A double-blind (...) , randomized, placebo-controlled multicenter trial of 95 patients (median age, 39 years) with a history of recurrent sinusitis or chronic rhinitis and evidence of acute infection by sinus radiograph or nasal endoscopy, which was conducted from October 1998 through April 2000 at 22 sites (12 primary care and 10 otolaryngology).Two puffs (total dose, 200 microgram) of fluticasone propionate (n = 47) or placebo nasal spray (n = 48) in each nostril once daily for 21 days; all received 2 puffs of xylometazoline

2001 JAMA Controlled trial quality: predicted high

87. One-year claims analysis comparing inhaled fluticasone propionate with zafirlukast for the treatment of asthma Full Text available with Trip Pro

One-year claims analysis comparing inhaled fluticasone propionate with zafirlukast for the treatment of asthma One-year claims analysis comparing inhaled fluticasone propionate with zafirlukast for the treatment of asthma One-year claims analysis comparing inhaled fluticasone propionate with zafirlukast for the treatment of asthma Stempel D A, Meyer J W, Stanford R H, Yancey S W Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED (...) . Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The health technology under investigation was the use of inhaled corticosteroids (ICSs), specifically fluticasone propionate (FP), in the treatment of asthma. Type of intervention Treatment and secondary prevention. Economic study type Cost-effectiveness analysis. Study population The study

2001 NHS Economic Evaluation Database.

88. Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis

Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis Holt S, Suder A, Weatherall M, Cheng S, Shirtcliffe P, Beasley R Authors' objectives To examine the dose-response relation of inhaled fluticasone propionate (...) in adolescents and adults with asthma. Searching MEDLINE was searched from January 1 1966 to December 1999 with the keyword 'fluticasone'. This search was combined with a search using the MeSH terms 'asthma' and 'chemical and pharmacologic phenomena' or 'dose-response relationship, drug', or the keywords 'dose' or 'dosage'. EMBASE was searched from 1980 to December 1999 using the keywords 'fluticasone' and 'dose' or 'dosage'. Additional studies were identified by contacting the manufacturer of fluticasone

2001 DARE.

89. Cost-effectiveness of fluticasone propionate administered via metered-dose inhaler plus Babyhaler spacer in the treatment of asthma in preschool-aged children

Cost-effectiveness of fluticasone propionate administered via metered-dose inhaler plus Babyhaler spacer in the treatment of asthma in preschool-aged children Cost-effectiveness of fluticasone propionate administered via metered-dose inhaler plus Babyhaler spacer in the treatment of asthma in preschool-aged children Cost-effectiveness of fluticasone propionate administered via metered-dose inhaler plus Babyhaler spacer in the treatment of asthma in preschool-aged children Bisgaard H, Price M J (...) , Maden C, Olsen N A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined fluticasone propionate (FP), administered by a metered-dose inhaler and a Babyhaler spacer device. Type of intervention Secondary prevention

2001 NHS Economic Evaluation Database.

90. Cost-efficacy analysis of fluticasone propionate versus zafirlukast in patients with persistent asthma

Cost-efficacy analysis of fluticasone propionate versus zafirlukast in patients with persistent asthma Cost-efficacy analysis of fluticasone propionate versus zafirlukast in patients with persistent asthma Cost-efficacy analysis of fluticasone propionate versus zafirlukast in patients with persistent asthma Menendez R, Stanford R H, Edwards L, Kalberg C, Rickard K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Two drug therapies were compared for the treatment of patients suffering from persistent asthma. The first was an inhaled glucocorticoid, fluticasone propionate (FP), at a dose of 88 microg twice daily. The second was a leukotriene receptor antagonist, zafirlukast (ZA), at a dose of 20 mg twice daily. Salbutamol

2001 NHS Economic Evaluation Database.

91. Comparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: a randomised crossover study. (Abstract)

Comparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: a randomised crossover study. Inhaled corticosteroids are currently the cornerstone of asthma treatment. Some studies of high-dose fluticasone propionate in patients with no or mild asthma have, however, suggested substantial systemic absorption. We investigated the pharmacokinetics of fluticasone propionate in patients with asthma receiving appropriate doses (...) for severity.We did a double-blind, randomised, crossover study in 11 patients with asthma and 13 matched healthy controls (age 20-65 years; asthma patients forced expiratory volume in 1 s <75% and stable on high-dose inhaled corticosteroids). Patients received one 1000 microg intravenous dose or 1000 microg daily for 7 days inhaled (via spacer device) fluticasone propionate. In the 12 h after dosing, we monitored plasma fluticasone propionate and cortisol concentrations by mass spectrometry and competitive

2000 Lancet Controlled trial quality: predicted high

92. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. Full Text available with Trip Pro

Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. To determine the effect of long term inhaled corticosteroids on lung function, exacerbations, and health status in patients with moderate to severe chronic obstructive pulmonary disease.Double blind, placebo controlled study.Eighteen UK hospitals.751 men and women aged between 40 and 75 years with mean forced expiratory volume (...) in one second (FEV(1)) 50% of predicted normal.Inhaled fluticasone propionate 500 microgram twice daily from a metered dose inhaler or identical placebo.Efficacy measures: rate of decline in FEV(1) after the bronchodilator and in health status, frequency of exacerbations, respiratory withdrawals. Safety measures: morning serum cortisol concentration, incidence of adverse events.There was no significant difference in the annual rate of decline in FEV(1 )(P=0.16). Mean FEV(1) after bronchodilator

2000 BMJ Controlled trial quality: predicted high

93. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. (Abstract)

A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. Inhaled corticosteroids are effective in the treatment of children with asthma. It is uncertain how inhaled corticosteroids compare with oral corticosteroids in the management of severe acute disease.We performed a double-blind, randomized trial involving 100 children five years of age or older who had severe acute asthma (indicated by a forced expiratory volume in one second [FEV1] that was less than (...) 60 percent of the predicted value) and in whom the results could be evaluated. All were treated with an aggressive bronchodilator regimen and received one dose of either 2 mg of inhaled fluticasone through a metered-dose inhaler with a spacer or 2 mg of oral prednisone per kilogram of body weight. They were assessed hourly for up to four hours.The mean (+/-SD) base-line FEV1 as a percentage of the predicted value was 46.3+/-12.5 in the fluticasone group (51 subjects) and 43.9+/-9.9

2000 NEJM Controlled trial quality: uncertain

94. Cost-effectiveness analysis of budesonide aqueous nasal spray and fluticasone propionate nasal spray in the treatment of perennial allergic rhinitis

Cost-effectiveness analysis of budesonide aqueous nasal spray and fluticasone propionate nasal spray in the treatment of perennial allergic rhinitis Cost-effectiveness analysis of budesonide aqueous nasal spray and fluticasone propionate nasal spray in the treatment of perennial allergic rhinitis Cost-effectiveness analysis of budesonide aqueous nasal spray and fluticasone propionate nasal spray in the treatment of perennial allergic rhinitis Stahl E, van Rompay W, Wang E C, Thomson D M Record (...) Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Budesonide aqueous nasal spray and fluticasone propionate allergic spray in the treatment of perennial allergic rhinitis (PAR). Type of intervention Treatment. Economic study type Cost

2000 NHS Economic Evaluation Database.

95. Cost effectiveness of inhaled fluticasone propionate vs inhaled triamcinolone acetonide in the treatment of persistent asthma

Cost effectiveness of inhaled fluticasone propionate vs inhaled triamcinolone acetonide in the treatment of persistent asthma Cost effectiveness of inhaled fluticasone propionate vs inhaled triamcinolone acetonide in the treatment of persistent asthma Cost effectiveness of inhaled fluticasone propionate vs inhaled triamcinolone acetonide in the treatment of persistent asthma Stanford R H, Edwards L D, Rickard K A Record Status This is a critical abstract of an economic evaluation that meets (...) the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Two inhaled corticosteroids, fluticasone propionate (FP) and triamcinolone acetonide (TA), were compared. The patients were treated with FP (250 microg twice daily) and placebo TA (two puffs four times daily) or TA (200 microg four times daily) and placebo FP (twice

2000 NHS Economic Evaluation Database.

96. Cost-effectiveness of salmeterol/fluticasone propionate combination product 50/250 micro g twice daily and budesonide 800 micro g twice daily in the treatment of adults and adolescents with asthma

Cost-effectiveness of salmeterol/fluticasone propionate combination product 50/250 micro g twice daily and budesonide 800 micro g twice daily in the treatment of adults and adolescents with asthma Cost-effectiveness of salmeterol/fluticasone propionate combination product 50/250 micro g twice daily and budesonide 800 micro g twice daily in the treatment of adults and adolescents with asthma Cost-effectiveness of salmeterol/fluticasone propionate combination product 50/250 micro g twice daily (...) and budesonide 800 micro g twice daily in the treatment of adults and adolescents with asthma Lundback B, Jenkins C, Price M J, Thwaites R M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Salmeterol/fluticasone propionate combination

2000 NHS Economic Evaluation Database.

97. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma.

A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2000 PedsCCM Evidence-Based Journal Club

98. Differences in lung bioavailability between different propellants for fluticasone propionate. (Abstract)

Differences in lung bioavailability between different propellants for fluticasone propionate. The lung bioavailability (as adrenal suppression) of fluticasone propionate was about twofold greater with chlorofluorocarbons than hydrofluoroalkane as propellant. Direct switching between formulations on a microg equivalent may therefore be inadvisable.

1999 Lancet Controlled trial quality: uncertain

99. The cost-effectiveness of inhaled fluticasone propionate and budesonide in the treatment of asthma in adults and children Full Text available with Trip Pro

The cost-effectiveness of inhaled fluticasone propionate and budesonide in the treatment of asthma in adults and children The cost-effectiveness of inhaled fluticasone propionate and budesonide in the treatment of asthma in adults and children The cost-effectiveness of inhaled fluticasone propionate and budesonide in the treatment of asthma in adults and children Barnes N C, Thwaites R M, Price M J Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The health technologies were the use of fluticasone propionate (FP) and budesonide (Bud) in the treatment of patients suffering from asthma. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population consisted of adult

1999 NHS Economic Evaluation Database.

100. Cost effectiveness of fluticasone propionate and flunisolide in the treatment of corticosteroid-naive patients with moderate asthma

Cost effectiveness of fluticasone propionate and flunisolide in the treatment of corticosteroid-naive patients with moderate asthma Cost effectiveness of fluticasone propionate and flunisolide in the treatment of corticosteroid-naive patients with moderate asthma Cost effectiveness of fluticasone propionate and flunisolide in the treatment of corticosteroid-naive patients with moderate asthma Volmer T, Kielhorn A, Weber H H, Wiessmann K J Record Status This is a critical abstract of an economic (...) evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Use of Fluticasone propionate (FP) or flunisolide (FL) in corticosteroid-naive patients with asthma of moderate severity. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Corticosteroid-naive

1999 NHS Economic Evaluation Database.