Latest & greatest articles for heart failure

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Top results for heart failure

181. Measurement and monitoring of pulmonary artery pressure via an implanted sensor for treatment optimization in heart failure

”. The application was transferred to IQWiG on 27 November 2015. According to the applicant, the method applied – hereinafter referred to as “PA pressure monitoring” – aims to detect early haemodynamic changes in the pulmonary circulation of heart failure patients to help optimize drug treatment and avoid symptoms, cardiac decompensation and hospitalization. Results from a randomized controlled trial (RCT) were available for the method “measurement and monitoring of pulmonary artery pressure via an implanted (...) Measurement and monitoring of pulmonary artery pressure via an implanted sensor for treatment optimization in heart failure 1 Translation of the executive summary of the assessment of potential Messung und Monitoring des pulmonalarteriellen Druckes mittels implantiertem Sensor zur Therapieoptimierung bei Herzinsuffizienz (Version 1.0; Status: 8 January 2016). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text

2018 Institute for Quality and Efficiency in Healthcare (IQWiG)

182. Measurement and monitoring of pulmonary artery pressure via an implanted sensor for treatment optimization in heart failure ? Addendum to Commission E15-04

Measurement and monitoring of pulmonary artery pressure via an implanted sensor for treatment optimization in heart failure ? Addendum to Commission E15-04 1 Translation of the executive summary of the addendum Messung und Monitoring des pulmonalarteriellen Druckes mittels implantiertem Sensor zur Therapieoptimierung bei Herzinsuffizienz – Addendum zum Auftrag E15-04 (Version 1.0; Status: 20 April 2016). Please note: This translation is provided as a service by IQWiG to English-language readers (...) . However, solely the German original text is absolutely authoritative and legally binding. Executive Summary IQWiG Reports – Commission No. E16-02 Measurement and monitoring of pulmonary artery pressure via an implanted sensor for treatment optimization in heart failure – Addendum to Commission E15-04 1 Executive summary of Addendum E16-02 Version 1.0 PA pressure monitoring in heart failure 20 April 2016 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher

2018 Institute for Quality and Efficiency in Healthcare (IQWiG)

183. Mitral valve interventions in heart failure Full Text available with Trip Pro

. Percutaneous edge-to-edge mitral valve repair (MitraClip) has emerged as an alternative to surgical valve repair to improve symptoms, functional capacity, heart failure hospitalizations, and cardiac haemodynamics. Further new transcatheter strategies addressing MR are evolving. The Carillion, Cardioband, and Mitralign devices were designed to reduce the annulus dilatation, which is a frequent and important determinant of secondary MR. Several transcatheter mitral valve replacement systems (Tendyne, CardiAQ (...) Mitral valve interventions in heart failure Secondary mitral regurgitation (MR) results from left ventricular dilatation and dysfunction. Quantification of secondary MR is challenging because of the underlying myocardial disease. Clinical and echocardiographic evaluation requires a multi-parametric approach. Severe secondary MR occurs in up to one-fourth of patients with heart failure with reduced ejection fraction, which is associated with a mortality rate of 40% to 50% in 3 years

2018 ESC heart failure

184. Early identification of acute heart failure at the time of presentation: do natriuretic peptides make the difference? Full Text available with Trip Pro

Early identification of acute heart failure at the time of presentation: do natriuretic peptides make the difference? The early identification of patients with acute heart failure (AHF) is challenging as many other diseases lead to a clinical presentation with dyspnea.The aim of the study was to evaluate the impact of natriuretic peptides at common HF study cut-offs on the diagnosis of patients with dyspnea at admission.For this post hoc analysis, we analysed n = 726 European Union (EU (...) ) patients from the prospective BACH (Biomarkers in Acute Heart Failure) study. Cut-offs were 350 ng/L (BNP), 300 pmol/L [pro-atrial natriuretic peptide (proANP)], and 1800 ng/L (NT-proBNP). These cut-offs had equivalent 90 days' mortality in the EU cohort of BACH. We analysed the effect of selection using these cut-offs on the prevalence of the gold standard diagnoses made in the BACH study and the respective mortality. The prevalence of AHF is increased from 47.5 to 75.6% (NT-proBNP criteria) up

2018 ESC heart failure

185. ASB1 differential methylation in ischaemic cardiomyopathy: relationship with left ventricular performance in end‐stage heart failure patients Full Text available with Trip Pro

ASB1 differential methylation in ischaemic cardiomyopathy: relationship with left ventricular performance in end‐stage heart failure patients Ischaemic cardiomyopathy (ICM) leads to impaired contraction and ventricular dysfunction, causing high rates of morbidity and mortality. Epigenomics allows the identification of epigenetic signatures in human diseases. We analyse the differential epigenetic patterns of the ASB gene family in ICM patients and relate these alterations (...) to their haemodynamic and functional status.Epigenomic analysis was carried out using 16 left ventricular (LV) tissue samples, eight from ICM patients undergoing heart transplantation and eight from control (CNT) subjects without cardiac disease. We increased the sample size up to 13 ICM and 10 CNT for RNA sequencing and to 14 ICM for pyrosequencing analyses. We found a hypermethylated profile (cg11189868) in the ASB1 gene that showed a differential methylation of 0.26Δβ (P = 0.016). This result was validated

2018 ESC heart failure

186. Homozygous missense MYBPC3 Pro873His mutation associated with increased risk for heart failure development in hypertrophic cardiomyopathy Full Text available with Trip Pro

Homozygous missense MYBPC3 Pro873His mutation associated with increased risk for heart failure development in hypertrophic cardiomyopathy Hypertrophic cardiomyopathy (HCM) is a primary autosomal-dominant disorder of the myocardium with variable expressivity and penetrance. Occasionally, homozygous sarcomere genetic variants emerge while genotyping HCM patients. In these cases, a more severe HCM phenotype is generally seen. Here, we report a case of HCM that was diagnosed clinically at 39 years (...) of age. Initial symptoms were shortness of breath during exertion. Successively, he developed a wide array of severe clinical manifestations, which progressed to an ominous end-stage heart failure that resulted in heart transplantation. Genotype analysis revealed a missense MYBPC3 variant NM_000256.3:c.2618C>A,p.(Pro873His) that presented in the homozygous form. Conflicting interpretations of pathogenicity have been reported for the Pro873His MYBPC3 variant described here. Our patient, presenting

2018 ESC heart failure

187. Canagliflozin and Heart Failure in Type 2 Diabetes Mellitus: Results From the CANVAS Program (Canagliflozin Cardiovascular Assessment Study) Full Text available with Trip Pro

Canagliflozin and Heart Failure in Type 2 Diabetes Mellitus: Results From the CANVAS Program (Canagliflozin Cardiovascular Assessment Study) Canagliflozin is a sodium glucose cotransporter 2 inhibitor that reduces the risk of cardiovascular events. We report the effects on heart failure (HF) and cardiovascular death overall, in those with and without a baseline history of HF, and in other participant subgroups.The CANVAS Program (Canagliflozin Cardiovascular Assessment Study) enrolled 10 142

2018 EvidenceUpdates

188. A Multivariable Prediction Model for Mortality in Individuals Admitted for Heart Failure (Abstract)

A Multivariable Prediction Model for Mortality in Individuals Admitted for Heart Failure To derive and validate a 30-day mortality clinical prediction rule for heart failure based on admission data and prior healthcare usage. A secondary objective was to determine the discriminatory function for mortality at 1 and 2 years.Observational cohort.Veterans Affairs inpatient medical centers (n=124).The derivation (2010-12; n=36,021) and validation (2013-15; n=30,364) cohorts included randomly

2018 EvidenceUpdates

189. Cardiac Resynchronization Therapy in Patients With Heart Failure and Narrow QRS Complexes Full Text available with Trip Pro

Cardiac Resynchronization Therapy in Patients With Heart Failure and Narrow QRS Complexes Cross correlation analysis (CCA) using tissue Doppler imaging has been shown to be associated with outcome after cardiac resynchronization therapy (CRT) in patients with heart failure (HF) with wide QRS. However, its significance in patients with narrow QRS treated with CRT is unknown.The aim of the current study was to investigate the association of mechanical activation delay by CCA with study outcome (...) -On group showed a significant increase in unfavorable events (hazard ratio: 3.73; 95% confidence interval: 1.15 to 12.14; p = 0.03).In the EchoCRT population, absence of delayed mechanical activation by CCA was significantly associated with poor outcomes, possibly due to the onset of new delayed mechanical activation with CRT pacing. (Echocardiography Guided Cardiac Resynchronization Therapy [EchoCRT] Trial; NCT00683696).Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier

2018 EvidenceUpdates

190. Prevalence, clinical correlates, and outcomes of anaemia in multi‐ethnic Asian patients with heart failure with reduced ejection fraction Full Text available with Trip Pro

studied 3886 Asian patients (60 ± 13 years, 21% women) with HF (ejection fraction ≤40%) from 11 regions in the Asian Sudden Cardiac Death in Heart Failure study. Anaemia was defined as haemoglobin <13 g/dL (men) and <12 g/dL (women). Ethnic groups included Chinese (33.0%), Indian (26.2%), Malay (15.1%), Japanese/Korean (20.2%), and others (5.6%). Overall, anaemia was present in 41%, with a wide range across ethnicities (33-54%). Indian ethnicity, older age, diabetes, and chronic kidney disease were (...) Prevalence, clinical correlates, and outcomes of anaemia in multi‐ethnic Asian patients with heart failure with reduced ejection fraction Recent international heart failure (HF) guidelines recognize anaemia as an important comorbidity contributing to poor outcomes in HF, based on data mainly from Western populations. We sought to determine the prevalence, clinical correlates, and prognostic impact of anaemia in patients with HF with reduced ejection fraction across Asia.We prospectively

2018 ESC heart failure

191. Management of Chemotherapy-Induced Left Ventricular Dysfunction and Heart Failure in Patients With Cancer While Undergoing Cancer Treatment: The MD Anderson Practice Full Text available with Trip Pro

Management of Chemotherapy-Induced Left Ventricular Dysfunction and Heart Failure in Patients With Cancer While Undergoing Cancer Treatment: The MD Anderson Practice Chemotherapy-induced cardiotoxicity resulting in heart failure (HF) is one of the most dreaded complications of cancer therapy that can significantly impact morbidity and mortality. With a high prevalence of cardiovascular disease in cancer patients, the risk of developing HF is significantly increased. A new discipline of Onco (...) -Cardiology has evolved to address the cardiovascular needs of patients with cancer, however, there is limited evidence-based data to guide clinical decision-making in the management of the cardiovascular complications of cancer therapy. The department of cardiology at MD Anderson Cancer Center initiated the MD Anderson Practice (MAP) project and developed algorithms to guide the management of the cardiovascular complications of cancer therapy. For chemotherapy-induced HF, we initiated the Heart Success

2018 Frontiers in cardiovascular medicine

192. Diuretic dosing in heart failure: more data are needed Full Text available with Trip Pro

Diuretic dosing in heart failure: more data are needed 29575802 2018 11 14 2018 11 14 2055-5822 5 4 2018 08 ESC heart failure ESC Heart Fail Diuretic dosing in heart failure: more data are needed. 649-650 10.1002/ehf2.12229 De Vecchis Renato R Cardiology Unit, Presidio Sanitario Intermedio "Elena d'Aosta", via Cagnazzi 29, c.a.p, 80137, Napoli, Italy. Rigopoulos Angelos A Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle (...) England ESC Heart Fail 101669191 2055-5822 0 Diuretics 7LXU5N7ZO5 Furosemide IM ESC Heart Fail. 2018 Feb;5(1):87-94 28967699 Diuretics Furosemide Heart Failure Humans 2017 08 10 2017 09 25 2018 3 27 6 0 2018 11 15 6 0 2018 3 26 6 0 ppublish 29575802 10.1002/ehf2.12229 PMC6073013 ESC Heart Fail. 2018 Feb;5(1):87-94 28967699 Clin Drug Investig. 2017 Apr;37(4):327-342 27766511 ESC Heart Fail. 2018 Mar 25;:null 29575802 Am J Med. 2016 Dec;129(12):1299-1306 27542612 J Card Fail. 2010 Dec;16(12):922-30

2018 ESC heart failure

193. The impact of aerobic exercise training with vascular occlusion in patients with chronic heart failure Full Text available with Trip Pro

The impact of aerobic exercise training with vascular occlusion in patients with chronic heart failure This study aimed to evaluate the impact of aerobic exercise training with vascular occlusion in patients with chronic heart failure.Thirty patients with post-infarction heart failure were randomized to an interventional exercise group (IG; n = 15) or a control exercise group (CG; n = 15). Exercise was performed at an intensity of 40-70% of the peak VO2 /W for 6 months. Patients in the IG (...) characteristics at study entry. Peak VO2 /W in the IG significantly increased compared with that in the CG; the change in the serum BNP levels was significantly larger in the IG than in the CG.These results suggest that aerobic exercise training with vascular occlusion can improve exercise capacity and serum BNP levels in patients with chronic heart failure.© 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

2018 ESC heart failure Controlled trial quality: uncertain

194. Heart rate response and functional capacity in patients with chronic heart failure with preserved ejection fraction Full Text available with Trip Pro

Heart rate response and functional capacity in patients with chronic heart failure with preserved ejection fraction The mechanisms of exercise intolerance in heart failure with preserved ejection fraction (HFpEF) are not yet elucidated. Chronotropic incompetence has emerged as a potential mechanism. We aimed to evaluate whether heart rate (HR) response to exercise is associated to functional capacity in patients with symptomatic HFpEF.We prospectively studied 74 HFpEF patients [35.1% New York (...) positively associated with peak VO2 . We found a linear relationship between Delta-HR and peak VO2 (β coefficient of 0.03; 95% confidence interval: 0.004-0.05; P = 0.030); conversely, the association among CIs and peak VO2 was exponentially shaped.In patients with chronic HFpEF, the HR response to exercise was positively associated to patient's functional capacity.© 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

2018 ESC heart failure

195. Comparison of continuous‐flow ventricular assist device therapy with intensive medical therapy in fixed pulmonary hypertension secondary to advanced left heart failure Full Text available with Trip Pro

to intensive medical therapy.Ninety-five patients listed for heart transplantation with sequential right heart catheters were studied, 24 patients having fixed Group 2 PH (as defined by cardiac index < 2.8 L/min/m2 , pulmonary capillary wedge pressure > 15 mmHg, and transpulmonary gradient ≥ 15 mmHg or pulmonary vascular resistance > 3.0 WU, unresponsive to vasodilator challenge). Ten patients received VAD therapy, and 14 patients received standard heart failure therapy with or without sildenafil, nitrates (...) Comparison of continuous‐flow ventricular assist device therapy with intensive medical therapy in fixed pulmonary hypertension secondary to advanced left heart failure Both ventricular assist device (VAD) and pulmonary vasodilator therapy have been shown in uncontrolled studies to improve pulmonary hypertension secondary to advanced left heart failure (Group 2 PH). This study aimed to compare haemodynamic benefits and survival in patients with fixed Group 2 PH treated with continuous-flow VAD

2018 ESC heart failure

196. Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure. Full Text available with Trip Pro

Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure. In an early analysis of this trial, use of a magnetically levitated centrifugal continuous-flow circulatory pump was found to improve clinical outcomes, as compared with a mechanical-bearing axial continuous-flow pump, at 6 months in patients with advanced heart failure.In a randomized noninferiority and superiority trial, we compared the centrifugal-flow pump with the axial-flow pump in patients with advanced heart (...) to 0.84, P=0.02).In patients with advanced heart failure, a fully magnetically levitated centrifugal-flow pump was superior to a mechanical-bearing axial-flow pump with regard to survival free of disabling stroke or reoperation to replace or remove a malfunctioning device. (Funded by Abbott; MOMENTUM 3 ClinicalTrials.gov number, NCT02224755 .).

2018 NEJM Controlled trial quality: predicted high

197. Semaphorin 4D levels in heart failure patients: a potential novel biomarker of acute heart failure? Full Text available with Trip Pro

Semaphorin 4D levels in heart failure patients: a potential novel biomarker of acute heart failure? Semaphorin 4D (Sema4D) is expressed on platelets and T-cells and known to be involved in inflammation. The aims of this study include comparing Sema4D and N terminal pro brain natriuretic peptide (NT-proBNP) serum levels in heart failure (HF) patients to a control group, evaluating the correlation between Sema4D and NT-proBNP levels, and assessing Sema4D serum levels in HF patients during acute (...) (3534.94 ± 1650.55 vs. 2455.67 ± 1424, P = 0.03), while mean NT-proBNP levels did not change significantly.Sema4D levels in HF patients' serum are significantly higher than in healthy controls. Clinical improvement caused rapid reduction in Sema4D levels, possibly reflecting the inflammatory aspect of HF. These findings might suggest that Sema4D can be used as a diagnostic biomarker of acute HF. Further studies of Sema4D and HF are warranted.© 2018 The Authors. ESC Heart Failure published by John Wiley

2018 ESC heart failure

198. Performance of the MAGGIC heart failure risk score and its modification with the addition of discharge natriuretic peptides Full Text available with Trip Pro

Performance of the MAGGIC heart failure risk score and its modification with the addition of discharge natriuretic peptides Predictive models for heart failure patients are widely used in the clinical practice to stratify patients' mortality and enable clinicians to tailor and intensify their approach. However, such models have not been validated internationally. In addition, biomarkers are now frequently measured to obtain prognostic information, and the implications of this practice (...) are not known. In this study, we aimed to validate the model performance of the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) score in a Japanese acute heart failure registry and further explore the incremental prognostic value of discharge B-type natriuretic peptide (BNP) level.In this study, we evaluated the registered data of 2215 consecutive acute HF patients (with 694 119 person-years follow-up) from a prospective multicentre registry (the West Tokyo Heart Failure) conducted in Japan

2018 ESC heart failure

199. Current perspectives on the role of the pharmacist in heart failure management Full Text available with Trip Pro

Current perspectives on the role of the pharmacist in heart failure management Pharmacists play an important role within a multidisciplinary health care team in the care of patients with heart failure (HF). It has been evaluated and documented that pharmacists providing medication reconciliation especially during transition of care, educating patients on their medications, and providing collaborative medication management lead to positive changes in the patient outcomes, including

2018 Integrated pharmacy research & practice

200. Baseline diastolic pressure gradient and pressure reduction in chronic heart failure patients implanted with the CardioMEMSâ„¢ HF sensor Full Text available with Trip Pro

Baseline diastolic pressure gradient and pressure reduction in chronic heart failure patients implanted with the CardioMEMSâ„¢ HF sensor Remote haemodynamic monitoring (RHM) decreases hospitalization rates in patients with chronic heart failure (HF). Many patients with chronic HF develop pulmonary hypertension (PH) secondary to left heart disease with some acquiring combined pre-capillary and post-capillary PH (Cpc-PH). The efficacy of RHM in achieving pulmonary pressure reductions in patients (...) ΔPADP was seen in Cpc-PH vs. Ipc-PH patients (15.2 vs. 9.88 mmHg; P = 0.12). There was a moderate positive correlation between baseline PADP and ΔPADP [ρ = 0.55 (0.26-0.76); P < 0.001].Decreased PADP reduction was not seen in Cpc-PH vs. Ipc-PH patients. Higher PADPbaseline was associated with greater ΔPADP. Larger studies are needed to elaborate our findings.© 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

2018 ESC heart failure