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181. Violence, abuse and discrimination: key factors militating against control of HIV/AIDS among the LGBTI sector Full Text available with Trip Pro

Violence, abuse and discrimination: key factors militating against control of HIV/AIDS among the LGBTI sector The Lesbian, Gay, Bisexual, Transgender and Intersex (LGBTI) South Africans continue to face considerable challenges, including societal stigma, homophobic violence (particularly corrective rape), and high rates of sexually transmitted diseases and infections (particularly Human Immunodeficiency Virus (HIV)/AIDS) even when discrimination based on sexual orientation was outlawed by South (...) African's post-apartheid constitution. This study was conducted to ascertain violence, abuse and discrimination against the LGBTI sector as key factors that hinder the smooth implementation of HIV/AIDS programme among sexually minority (LGBTI) group in Walter Sisulu University, South Africa. The self-structured questionnaire was used to collect data. The study involved 3048 purposively selected participants (1285 male and 1763 female) aged 17-38 years. About 70.5% of the participants witnessed physical

2018 SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliance

182. Rapid urine-based screening for tuberculosis in HIV-positive patients admitted to hospital in Africa (STAMP): a pragmatic, multicentre, parallel-group, double-blind, randomised controlled trial. Full Text available with Trip Pro

Rapid urine-based screening for tuberculosis in HIV-positive patients admitted to hospital in Africa (STAMP): a pragmatic, multicentre, parallel-group, double-blind, randomised controlled trial. Current diagnostics for HIV-associated tuberculosis are suboptimal, with missed diagnoses contributing to high hospital mortality and approximately 374 000 annual HIV-positive deaths globally. Urine-based assays have a good diagnostic yield; therefore, we aimed to assess whether urine-based screening (...) in HIV-positive inpatients for tuberculosis improved outcomes.We did a pragmatic, multicentre, double-blind, randomised controlled trial in two hospitals in Malawi and South Africa. We included HIV-positive medical inpatients aged 18 years or more who were not taking tuberculosis treatment. We randomly assigned patients (1:1), using a computer-generated list of random block size stratified by site, to either the standard-of-care or the intervention screening group, irrespective of symptoms

2018 Lancet Controlled trial quality: predicted high

183. Performance of verbal autopsy methods in estimating HIV-associated mortality among adults in South Africa Full Text available with Trip Pro

Performance of verbal autopsy methods in estimating HIV-associated mortality among adults in South Africa Verbal autopsy (VA) can be integrated into civil registration and vital statistics systems, but its accuracy in determining HIV-associated causes of death (CoD) is uncertain. We assessed the sensitivity and specificity of VA questions in determining HIV status and antiretroviral therapy (ART) initiation and compared HIV-associated mortality fractions assigned by different VA interpretation (...) methods.Using the WHO 2012 instrument with added ART questions, VA was conducted for deaths among adults with known HIV status (356 HIV positive and 103 HIV negative) in South Africa. CoD were assigned using physician-certified VA (PCVA) and computer-coded VA (CCVA) methods and compared with documented HIV status.The sensitivity of VA questions in detecting HIV status and ART initiation was 84.3% (95% CI 80 to 88) and 91.0% (95% CI 86 to 95); 283/356 (79.5%) HIV-positive individuals were assigned HIV

2018 BMJ global health

184. Dolutegravir (HIV infection) - Addendum to commission A17-11

Dolutegravir (HIV infection) - Addendum to commission A17-11 1 Translation of addendum A17-37 Dolutegravir (HIV-Infektion) – Addendum zum Auftrag A17-11 (Version 1.0; Status: 30 August 2017). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Addendum 30 August 2017 1.0 Commission: A17-37 Version: Status: IQWiG Reports – Commission No. A17-37 Dolutegravir (HIV (...) infection) – Addendum to Commission A17-11 1 Addendum A17-37 Version 1.0 Dolutegravir – Addendum to Commission A17-11 30 August 2017 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Dolutegravir (HIV infection) – Addendum to Commission A17-11 Commissioning agency: Federal Joint Committee Commission awarded on: 10 August 2017 Internal Commission No.: A17-37 Address of publisher: Institut für Qualität

2018 Institute for Quality and Efficiency in Healthcare (IQWiG)

185. HIV and infant feeding in emergencies: operational guidance

contributions to the process.vi HIV AND INFANT FEEDING IN EMERGENCIES: OPERATIONAL GUIDANCE Abbreviations and acronyms AIDS acquired immunodeficiency syndrome ANC antenatal care ART antiretroviral therapy ARV antiretroviral drug AZT zidovudine BMS breast-milk substitute(s) ENN Emergency Nutrition Network HIV human immunodeficiency virus IFE infant and young child feeding in emergencies IYCF infant and young child feeding MTCT mother-to-child transmission of HIV NGO nongovernmental organization NVP (...) : the infant receives only breast milk without any other liquids or solids, not even water, except for oral rehydration solution or drops or syrups of vitamins, minerals or medicines. Generalized HIV epidemic: HIV is firmly established in the general population. Numerical proxy: HIV prevalence is consistently over 1% among pregnant women. Most generalized HIV epidemics are mixed in nature, where certain (key) subpopulations are disproportionately affected. HIV: the human immunodeficiency virus

2018 World Health Organisation Guidelines

186. Raltegravir (Isentress) - human immunodeficiency virus in neonates

Raltegravir (Isentress) - human immunodeficiency virus in neonates Published 9 July 2018 Statement of Advice: raltegravir 100mg granules for oral suspension (Isentress ® ) SMC2101 Merck Sharp & Dohme Limited 8 June 2018 ADVICE: in the absence of a submission from the holder of the marketing authorisation raltegravir (Isentress ® ) is not recommended for use within NHSScotland. Indication under review: in combination with other anti-retroviral medicinal products in the treatment of human (...) immunodeficiency virus in neonates. The holder of the marketing authorisation has not made a submission to SMC regarding this product in this setting. As a result we cannot recommend its use within NHSScotland. Advice context: No part of this advice may be used without the whole of the advice being quoted in full. This advice represents the view of the Scottish Medicines Consortium. It is provided to inform the considerations of Area Drug & Therapeutics Committees and NHS Boards in Scotland in determining

2018 Scottish Medicines Consortium

187. New study suggests risk of birth defects in babies born to women on HIV medicine dolutegravir

in the EU will be sent a dear healthcare professional letter concerning these recommendations. More about the medicine Dolutegravir is an integrase inhibitor. This means that it blocks an enzyme called integrase that is needed by the HIV virus to make new copies of itself in the body. When it is given with other medicines, it helps to prevent the spread of HIV and keep the amount of the virus in the blood at a low level. Dolutegravir does not cure HIV infection or AIDS, but it may hold off damage (...) New study suggests risk of birth defects in babies born to women on HIV medicine dolutegravir New study suggests risk of birth defects in babies born to women on HIV medicine dolutegravir | European Medicines Agency Search Search Menu New study suggests risk of birth defects in babies born to women on HIV medicine dolutegravir Press release 18/05/2018 While EMA review is ongoing, dolutegravir should not be used in women seeking to become pregnant The European Medicines Agency (EMA

2018 European Medicines Agency - EPARs

188. Depression and Suicidal Ideation Among HIV-Infected Adults Receiving Efavirenz Versus Nevirapine in Uganda: A Prospective Cohort Study. Full Text available with Trip Pro

Depression and Suicidal Ideation Among HIV-Infected Adults Receiving Efavirenz Versus Nevirapine in Uganda: A Prospective Cohort Study. Evidence regarding potential adverse neuropsychiatric effects of efavirenz is conflicting, and data from sub-Saharan Africa, where 70% of persons living with HIV (PLHIV) reside and efavirenz is used as first-line therapy, are limited.To estimate associations between efavirenz use and depression and suicidal ideation among PLHIV in Uganda.Prospective

2018 Annals of Internal Medicine

189. The rise and fall of mortality inequality in South Africa in the HIV era Full Text available with Trip Pro

The rise and fall of mortality inequality in South Africa in the HIV era Post-apartheid South Africa has seen an unprecedented rise and fall of mortality in less than two decades as a result of the HIV/AIDS epidemic and the subsequent rollout of free antiretroviral therapy (ART). Since the incidence of both was not equal for rich and poor, it is likely to also have affected disparities in health and survival chances by income. We use large nationwide surveys for 2001, 2007 and 2011 to obtain (...) the 2001-2011 period. The analysis of age-sex-specific mortality rates shows that it was in particular for adults aged 18-59 years that mortality and absolute inequality increased substantially between 2001 and 2006, followed by a rapid drop thereafter. These trends were far more pronounced for males than females. This means that the HIV/AIDS epidemic has taken a serious death toll, which was concentrated disproportionately among the poorest segments of the population and especially affected (older

2018 SSM - population health

190. NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation Full Text available with Trip Pro

NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation 29921650 2019 03 15 2473-9537 2 12 2018 06 26 Blood advances Blood Adv NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation. 1412-1416 10.1182/bloodadvances.2018016329 Hogan Louise E LE Division of Experimental Medicine, University of California, San Francisco, San Francisco, CA

2018 Blood advances

191. Association of Viral Suppression With Lower AIDS-Defining and Non-AIDS-Defining Cancer Incidence in HIV-Infected Veterans: A Prospective Cohort Study. Full Text available with Trip Pro

Association of Viral Suppression With Lower AIDS-Defining and Non-AIDS-Defining Cancer Incidence in HIV-Infected Veterans: A Prospective Cohort Study. Viral suppression is a primary marker of HIV treatment success. Persons with HIV are at increased risk for AIDS-defining cancer (ADC) and several types of non-AIDS-defining cancer (NADC), some of which are caused by oncogenic viruses.To determine whether viral suppression is associated with decreased cancer risk.Prospective cohort.Department (...) of Veterans Affairs.HIV-positive veterans (n = 42 441) and demographically matched uninfected veterans (n = 104 712) from 1999 to 2015.Standardized cancer incidence rates and Poisson regression rate ratios (RRs; HIV-positive vs. uninfected persons) by viral suppression status (unsuppressed: person-time with HIV RNA levels ≥500 copies/mL; early suppression: initial 2 years with HIV RNA levels <500 copies/mL; long-term suppression: person-time after early suppression with HIV RNA levels <500 copies/mL

2018 Annals of Internal Medicine

192. Autoimmune blistering disorders in the setting of human immunodeficiency virus infection Full Text available with Trip Pro

Autoimmune blistering disorders in the setting of human immunodeficiency virus infection The interplay between immune dysfunction and human immunodeficiency virus (HIV) is complex. Reports of autoimmune disorders including autoimmune bullous disorders (AIBDs) have been increasing in prevalence in the HIV population since the introduction of highly active antiretroviral therapy in 1995. We offer a literature review of clinical experiences in various AIBDs with particular emphasis on therapeutic (...) management as well as a brief overview of the mechanisms that explain the relationship between AIBD and HIV. Because immunosuppressants are first-line therapies for AIBD treatment, careful consideration is warranted when considering management in the HIV population.

2018 International journal of women's dermatology

193. Frequent HIV and Young Age Among Individuals With Diverse Cancers at a National Teaching Hospital in Malawi Full Text available with Trip Pro

Frequent HIV and Young Age Among Individuals With Diverse Cancers at a National Teaching Hospital in Malawi Purpose Cancer surveillance provides a critical evidence base to guide cancer control efforts, yet population-based coverage in Africa is sparse. Hospital-based registries may help fill this need by providing local epidemiologic data to guide policy and forecast local health care needs. We report the epidemiology of patients with cancer recorded by a de novo hospital-based cancer registry (...) at Kamuzu Central Hospital, Malawi, the sole provider of comprehensive oncology services for half the country and location of a high-volume pathology laboratory. Methods We conducted active case finding across all hospital departments and the pathology laboratory from June 2014 to March 2016. Patient demographics, tumor characteristics, treatment, and HIV status were collected. We describe epidemiology of the cancer caseload, registry design, and costs associated with registry operations. Results Among

2018 Journal of global oncology

194. Nutrition and HIV

Food & the Nutrition Care Process. 14 ed. St. Louis, Missouri: Elsevier; 2017. p. 757–74. van Graan AE. Nutritional management in HIV/AIDS infection. World Review of Nutrition & Dietetics. 2015;111:130–5. Willig A, Wright L, Galvin TA. Practice paper of the Academy of Nutrition and Dietetics: Nutrition intervention and human immunodeficiency virus infection. Journal of the Academy of Nutrition and Dietetics. 2018;118(3):486–98. Pribham V. Introduction to Nutrition and HIV. In: Pribham V, editor (...) . Nutrition and HIV. Chichester: Wiley-Blackwell; 2011. p. 18–29. Somarriba G, Neri D, Schaefer N, Miller TL. The effect of aging, nutrition, and exercise during HIV infection. HIV/AIDS — Research and Palliative Care. 2010;2:191–201. Clark WA, Cress EM. Nutritional issues and positive living in human immunodeficiency virus/AIDS. Nursing Clinics of North America. 2018;53(1):13–24. Batterham MJ. Investigating heterogeneity in studies of resting energy expenditure in persons with HIV/AIDS: A meta-analysis

2018 Ontario HIV Treatment Network

195. Cardiovascular Risk Prediction Functions Underestimate Risk in HIV Infection Full Text available with Trip Pro

Cardiovascular Risk Prediction Functions Underestimate Risk in HIV Infection Cardiovascular disease (CVD) risk is elevated in HIV-infected individuals, with contributions from both traditional and nontraditional risk factors. The accuracy of established CVD risk prediction functions in HIV is uncertain. We sought to assess the performance of 3 established CVD risk prediction functions in a longitudinal cohort of HIV-infected men.The FHS (Framingham Heart Study) functions for hard coronary heart (...) disease (FHS CHD) and atherosclerotic CVD (FHS ASCVD) and the American College of Cardiology/American Heart Association ASCVD function were applied to the Partners HIV cohort. Risk scores were calculated between January 1, 2006, and December 31, 2008. Outcomes included CHD (myocardial infarction or coronary death) for the FHS CHD function and ASCVD (myocardial infarction, stroke, or coronary death) for the FHS ASCVD and American College of Cardiology/American Heart Association ASCVD functions. We

2018 EvidenceUpdates

196. Dolutegravir sodium rilpivirine hydrochloride (Juluca) - HIV Infections

and Drug Administration FDC Fixed-dose combination FI Fluctuation index FMEA Failure mode effects analysis FPV Fosamprenavir FTC Emtricitabine GC Gas chromatography GFR Glomerular filtration rate GLS Geometric Least-Squares GSK GlaxoSmithKline h or hr Hour(s) HBV Hepatitis B virus HCV Hepatitis C virus HDL High-density lipoprotein HDPE High density polyethylene HIV Human immunodeficiency virus HPLC High performance liquid chromatography HSA Human serum albumin IB Investigator’s Brochure IC 50 (...) Dolutegravir sodium rilpivirine hydrochloride (Juluca) - HIV Infections 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 22 March 2018 EMA/243517/2018 Committee for Medicinal Products for Human Use (CHMP) Assessment report Juluca

2018 European Medicines Agency - EPARs

197. Social capital and HIV/AIDS in the United States: Knowledge, gaps, and future directions Full Text available with Trip Pro

of Science, and Sociological Abstracts with no restriction on publication date, for articles in English language. Sample search terms included: HIV infections OR HIV OR AIDS OR acquired immunodeficiency syndrome OR human immunodeficiency virus AND social capital OR social control, informal OR social participation OR social cohesion OR generalized trust OR social trust OR collective efficacy OR community mob* OR civic participation.We identified 1581 unique manuscripts and reviewed 13 based on eligibility (...) Social capital and HIV/AIDS in the United States: Knowledge, gaps, and future directions Social capital is a well-established predictor of several behavioral health outcomes. However, we know less about the relationship with prevention, transmission, and treatment of HIV/AIDS outcomes in the United States (US).In 2017, we conducted a scoping review of empirical studies investigating the relationships between social capital and HIV/AIDS in the US by searching PubMed, Embase, PsycINFO, Web

2018 SSM - population health

198. Effects of an ActRIIB.Fc Ligand Trap on Cardiac Function in Simian Immunodeficiency Virus-Infected Male Rhesus Macaques Full Text available with Trip Pro

Effects of an ActRIIB.Fc Ligand Trap on Cardiac Function in Simian Immunodeficiency Virus-Infected Male Rhesus Macaques An important safety consideration in the use of antagonists of myostatin and activins is whether these drugs induce myocardial hypertrophy and impair cardiac function. The current study evaluated the effects of a soluble ActRIIB receptor Fc fusion protein (ActRIIB.Fc), a ligand trap for TGF-β/activin family members including myostatin, on myocardial mass and function in simian (...) immunodeficiency virus (SIV)-infected juvenile rhesus macaques (Macaca mulatta). Fourteen pair-housed, juvenile male rhesus macaques were inoculated with SIVmac239; 4 weeks postinoculation, they were treated with weekly injections of 10 mg/kg ActRIIB.Fc or saline for 12 weeks. Myocardial mass and function were evaluated using two-dimensional echocardiography at baseline and after 12 weeks. The administration of ActRIIB.Fc was associated with a significantly greater increase in thickness of left ventricular

2018 Journal of the Endocrine Society

199. Impact of the US Food and Drug Administration registration of antiretroviral drugs on global access to HIV treatment Full Text available with Trip Pro

Impact of the US Food and Drug Administration registration of antiretroviral drugs on global access to HIV treatment Since 2004, the US Food and Drug Administration's (USFDA) dedicated drug review process in support of President's Emergency Plan for AIDS Relief (PEPFAR) has made safe, effective and quality antiretrovirals (ARVs) available for millions of patients. Furthermore, the WHO and Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund) can add the USFDA-reviewed products (...) to their respective formularies, through a novel process of 'one-way reliance'. We assessed the number of ARVs made available through WHO and Global Fund based on the USFDA review.We conducted a cross-sectional study of all the USFDA-reviewed PEPFAR drugs between 1 December 2014 and 20 March 2017 to determine 1) the percentage that are included on the WHO and Global Fund formularies; 2) the number of the USFDA ARVs supporting the WHO HIV treatment guidelines, and their uptake by WHO and Global Fund and 3) time

2018 BMJ global health

200. Lipodystrophy Increases the Risk of CKD Development in HIV-Positive Patients in Switzerland: The LIPOKID Study Full Text available with Trip Pro

Lipodystrophy Increases the Risk of CKD Development in HIV-Positive Patients in Switzerland: The LIPOKID Study Antiretroviral therapy has improved the life expectancy of patients living with HIV. However, lipodystrophy syndrome (LD) remains prevalent, affecting mostly patients treated with first-generation antiretroviral drugs. This syndrome is characterized by changes in body fat distribution with or without associated metabolic changes. Here, we studied whether clinically evaluated LD (...) is independently associated with chronic kidney disease (CKD) development (sustained estimated glomerular filtration rate [eGFR] < 60 ml/min per 1.73 m2) in HIV-positive patients.We conducted a prospective cohort study (the LIPOKID Study) among all the patients from the Swiss HIV Cohort Study (SHCS) with an eGFR >60 ml/min per 1.73 m2 upon their entry into the cohort with more than 3 months of follow-up from January 2002 to August 2016. Cox regression models were used to estimate the association between LD

2018 Kidney international reports