Latest & greatest articles for ibuprofen

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Top results for ibuprofen

1. Relative Effectiveness of Naproxen vs. Ibuprofen for Postoperative Pain Following Non-surgical Root Canal Therapy Is Unknown

Relative Effectiveness of Naproxen vs. Ibuprofen for Postoperative Pain Following Non-surgical Root Canal Therapy Is Unknown UTCAT3455, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Relative Effectiveness of Naproxen vs. Ibuprofen for Postoperative Pain Following Non-surgical Root Canal Therapy Is Unknown Clinical Question In patients diagnosed with irreversible pulpitis, is naproxen more effective at reducing post (...) -operative pain levels following non-surgical root canal therapy compared to ibuprofen? Clinical Bottom Line There are no studies that directly compare naproxen and ibuprofen analgesic efficacy following non-surgical root canal therapy, i.e., their relative effectiveness. However, the effectiveness of NSAIDs is well-documented in several endodontic studies using ibuprofen as the prototypical drug. Given the similar mechanisms of action, these two drugs are expected to be similarly effective. Nonetheless

2020 UTHSCSA Dental School CAT Library

2. Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis Full Text available with Trip Pro

Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced (...) Open Actions . 2020 Oct 1;3(10):e2022398. doi: 10.1001/jamanetworkopen.2020.22398. Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis , , , Affiliations Expand Affiliations 1 Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. 2 Emergency Department, Middlemore Hospital, Auckland, New Zealand. 3 Medical Research Institute of New

2020 EvidenceUpdates

3. Comparison of ibuprofen and piroxicam gel in the treatment of trauma pain: A randomized double-blind trial of geriatric population

Comparison of ibuprofen and piroxicam gel in the treatment of trauma pain: A randomized double-blind trial of geriatric population Comparison of ibuprofen and piroxicam gel in the treatment of trauma pain: A randomized double-blind trial of geriatric population - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging (...) .2020.08.041. Online ahead of print. Comparison of ibuprofen and piroxicam gel in the treatment of trauma pain: A randomized double-blind trial of geriatric population , , , , , , Affiliations Expand Affiliations 1 Department of Emergency Medicine, Manisa Merkez Efendi State Hospital, Manisa, Turkey. 2 Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey. 3 Department of Emergency Medicine, Bingol State Hospital, Bingol, Turkey. Electronic address: akbasilker@gmail.com

2020 EvidenceUpdates

4. Effect of Nonintervention vs Oral Ibuprofen in Patent Ductus Arteriosus in Preterm Infants: A Randomized Clinical Trial Full Text available with Trip Pro

Effect of Nonintervention vs Oral Ibuprofen in Patent Ductus Arteriosus in Preterm Infants: A Randomized Clinical Trial Effect of Nonintervention vs Oral Ibuprofen in Patent Ductus Arteriosus in Preterm Infants: A Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National (...) of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation JAMA Pediatr Actions . 2020 Jun 15;e201447. doi: 10.1001/jamapediatrics.2020.1447. Online ahead of print. Effect of Nonintervention vs Oral Ibuprofen in Patent Ductus Arteriosus in Preterm Infants: A Randomized Clinical Trial , , , , Affiliations Expand Affiliations 1 Samsung Medical Center, Department of Pediatrics, Sungkyunkwan University School of Medicine, Seoul, Korea. 2 Statistics and Data Center

2020 EvidenceUpdates

5. Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial Full Text available with Trip Pro

Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine (...) RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Pediatr Actions . 2020 Jul;222:79-84.e2. doi: 10.1016/j.jpeds.2020.01.058. Epub 2020 Apr 24. Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial , , , , , , , , , , Affiliations Expand Affiliations 1 Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Department of Pediatrics, Research

2020 EvidenceUpdates

6. Should Ibuprofen be Used for COVID-19?

Should Ibuprofen be Used for COVID-19? MOH-ACE COVID-19 RAPID REVIEW Updated 3 June 2020. First published 21 March 2020. Page 1 of 3 Clinical evidence Background Should ibuprofen be used for COVID-19? This write-up summarises a rapid evidence review of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly ibuprofen, to manage symptoms of COVID-19. The information may be revised as new evidence emerges. A news article titled “COVID-19: ibuprofen should not be used for managing symptoms (...) , say doctors and scientists” was published in BMJ on 17 March 2020. 1 It claims that anti-inflammatory drugs (e.g. ibuprofen and cortisone) could exacerbate symptoms of COVID-19 infection, and paracetamol should be used instead; however different views were expressed. No clinical trials were identified assessing the safety of nonsteroidal anti-inflammatory drugs (NSAIDs) in managing symptoms of COVID-19. However, there are some studies on the potential mechanisms of inflammatory responses available

2020 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

7. Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. (Abstract)

Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be as effective as indomethacin with fewer adverse effects.To determine the effectiveness and safety of ibuprofen compared with indomethacin, other cyclo-oxygenase inhibitor(s), placebo (...) controlled trials and quasi-randomised trials.Randomised or quasi-randomised controlled trials of ibuprofen for the treatment of a PDA in preterm, low birth weight, or both preterm and low-birth-weight newborn infants.Data collection and analysis conformed to the methods of the Cochrane Neonatal Review Group. We used the GRADE approach to assess the quality of evidence.We included 39 studies enrolling 2843 infants. Ibuprofen (IV) versus placebo: IV Ibuprofen (3 doses) reduced the failure to close a PDA

2020 Cochrane

8. Ibuprofen Plus Acetaminophen Versus Ibuprofen Alone for Acute Low Back Pain: An Emergency Department-based Randomized Study (Abstract)

Ibuprofen Plus Acetaminophen Versus Ibuprofen Alone for Acute Low Back Pain: An Emergency Department-based Randomized Study Patients with low back pain (LBP) are often treated with nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs are modestly effective for LBP, but many patients with LBP continue to suffer despite treatment with these medications. We compared pain and functional outcomes 1 week after emergency department (ED) discharge among patients randomized to a 1-week course (...) of ibuprofen plus acetaminophen versus ibuprofen plus placebo.This was a randomized, double-blind study conducted in two urban EDs. Patients presenting with acute, nontraumatic, nonradicular LBP of no more than 2 weeks' duration were eligible for enrollment immediately prior to discharge from an ED if they had a score > 5 on the Roland Morris Disability Questionnaire (RMDQ), a 24-item validated instrument, indicating more than minimal functional impairment. All patients were given a standardized 10-minute

2020 EvidenceUpdates

9. Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. (Abstract)

Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants and increases the risk of adverse outcomes. Indomethacin has been the standard treatment to close a PDA but is associated with renal, gastrointestinal, and cerebral side effects. Ibuprofen has less effect on blood flow velocity to important organs.Primary objectives To determine the effectiveness and safety (...) of ibuprofen compared to placebo/no intervention, or other cyclo-oxygenase inhibitor drugs in the prevention of PDA in preterm infants.We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 10), MEDLINE via PubMed (1966 to 17 October 2018), Embase (1980 to 17 October 2018), and CINAHL; 1982 to 17 October 2018). We searched clinical trials databases, conference proceedings, and the reference lists of retrieved articles

2020 Cochrane

10. Should Ibuprofen be Used for COVID-19?

Should Ibuprofen be Used for COVID-19? MOH-ACE COVID-19 RAPID REVIEW 21 March 2020 Page 1 of 2 Clinical evidence Recommendations from professional bodies Background Should ibuprofen be used for COVID-19? This write-up summarises a rapid evidence review of NSAIDs, particularly ibuprofen, to manage symptoms of patients with COVID-19. The information may be revised as new evidence emerges. A news article titled “COVID-19: ibuprofen should not be used for managing symptoms, say doctors (...) and scientists” was published in BMJ on 17 Mar 2020. 1 It claims that anti-inflammatory drugs (eg. ibuprofen, cortisone) could aggravate infection in patients with suspected COVID-19 and paracetamol should be used in these patients; however different views were expressed. No clinical trials were identified assessing the safety of nonsteroidal anti-inflammatory drugs (NSAIDs) in managing symptoms of COVID-19. Instead, there are studies on the potential mechanisms of inflammatory responses and some proposes

2020 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

11. A randomized, placebo- and active-controlled, multi-country, multi-center parallel group trial to evaluate the efficacy and safety of a fixed-dose combination of 400 mg ibuprofen and 100 mg caffeine compared with ibuprofen 400 mg and placebo in patients w Full Text available with Trip Pro

A randomized, placebo- and active-controlled, multi-country, multi-center parallel group trial to evaluate the efficacy and safety of a fixed-dose combination of 400 mg ibuprofen and 100 mg caffeine compared with ibuprofen 400 mg and placebo in patients w Ibuprofen is a well-established analgesic for acute pain symptoms. In several acute pain models, caffeine has demonstrated an analgesic adjuvant effect. This randomized trial (NCT03003000) was designed to compare the efficacy of a fixed-dose (...) combination of ibuprofen and caffeine with ibuprofen or placebo for the treatment of acute lower back/neck pain.Patients with acute lower back/neck pain resulting in pain on movement (POM) ≥5 on a 10-point numerical rating scale were randomized 2:2:1 to receive orally, three times daily for 6 days, 400 mg ibuprofen+100 mg caffeine, 400 mg ibuprofen or placebo, respectively. The primary endpoint was change in POMWP (POM triggering highest pain score at baseline [worst procedure]) between baseline

2019 EvidenceUpdates

12. Comparison of Oral Ibuprofen at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial (Abstract)

Comparison of Oral Ibuprofen at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial Nonsteroidal anti-inflammatory drugs (NSAIDs) are used extensively for the management of acute pain, with ibuprofen being one of the most frequently used oral analgesics in the emergency department (ED). We compare the analgesic efficacy of oral ibuprofen at 3 different doses for adult ED patients with acute pain.This was a randomized, double-blind trial (...) comparing analgesic efficacy of 3 doses of oral ibuprofen (400, 600, and 800 mg) in adult ED patients with acute painful conditions. Primary outcome included difference in pain scores between the 3 groups at 60 minutes.We enrolled 225 subjects (75 per group). The difference in mean pain scores at 60 minutes between the 400- and 600-mg groups was -0.14 (95% confidence interval [CI] -0.67 to 0.39); between the 400- and 800-mg groups, 0.14 (95% CI -0.65 to 0.37); and between the 600- and 800-mg groups

2019 EvidenceUpdates

13. Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. Full Text available with Trip Pro

Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants and increases the risk of adverse outcomes. Indomethacin has been the standard treatment to close a PDA but is associated with renal, gastrointestinal, and cerebral side effects. Ibuprofen has less effect on blood flow velocity to important organs.Primary objectivesTo determine the effectiveness and safety (...) of ibuprofen compared to placebo/no intervention, or other cyclo-oxygenase inhibitor drugs in the prevention of PDA in preterm infants.We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 10), MEDLINE via PubMed (1966 to 17 October 2018), Embase (1980 to 17 October 2018), and CINAHL; 1982 to 17 October 2018). We searched clinical trials databases, conference proceedings, and the reference lists of retrieved articles

2019 Cochrane

14. An integrated safety analysis of combined acetaminophen and ibuprofen (Maxigesic ((R)) /Combogesic((R))) in adults Full Text available with Trip Pro

An integrated safety analysis of combined acetaminophen and ibuprofen (Maxigesic ((R)) /Combogesic((R))) in adults Acetaminophen (APAP) and ibuprofen (IBP) are two analgesic compounds with a long history of use. Both are considered safe at recommended over-the-counter daily doses. Chronic use, high doses, or concomitant medication can produce safety risks for both drugs. APAP is associated with increased risk of hepatic injury, while IBP can produce gastric bleeding and thromboembolic events

2019 EvidenceUpdates

15. Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial. Multimodal postoperative analgesia is widely used but lacks evidence of benefit.Investigate beneficial and harmful effects of 4 nonopioid analgesics regimens.Randomized, blinded, placebo-controlled, 4-group trial in 6 Danish hospitals with 90-day follow-up that included 556 (...) patients undergoing total hip arthroplasty (THA) from December 2015 to October 2017. Final date of follow-up was January 1, 2018.Participants were randomized to receive paracetamol (acetaminophen) 1000 mg plus ibuprofen 400 mg (n = 136; PCM + IBU), paracetamol 1000 mg plus matched placebo (n = 142; PCM), ibuprofen 400 mg plus matched placebo (n = 141; IBU), or half-strength paracetamol 500 mg plus ibuprofen 200 mg (n = 140; HS-PCM + IBU) orally every 6 hours for 24 hours postoperatively, starting 1

2019 JAMA Controlled trial quality: predicted high

16. Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide (Abstract)

Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide Acute mountain sickness is a common occurrence for travel to high altitudes. Although previous studies of ibuprofen have shown efficacy for the prevention of acute mountain sickness, recommendations have been limited, as ibuprofen has not been compared directly with acetazolamide until this study.Before their ascent to 3810 m on White Mountain in California, adult volunteers were randomized to ibuprofen (600 mg, 3 times daily (...) , started 4 hours before the ascent), or to acetazolamide (125 mg, twice daily, started the night before the ascent). The main outcome measure was acute mountain sickness incidence, using the Lake Louise Questionnaire (LLQ), with a score of >3 with headache. Sleep quality and headache severity were measured with the Groningen Sleep Quality Survey (GSQS). This trial was registered at ClinicalTrials.gov: NCT03154645 RESULTS: Ninety-two participants completed the study: 45 (49%) on ibuprofen and 47 (51

2019 EvidenceUpdates

17. Common cold: Ibuprofen

Common cold: Ibuprofen Ibuprofen | Prescribing information | Common cold | CKS | NICE Search CKS… Menu Ibuprofen Common cold: Ibuprofen Last revised in August 2016 Ibuprofen For detailed prescribing information on ibuprofen, see the CKS topic on . © .

2019 NICE Clinical Knowledge Summaries

18. Bites - human and animal: What should I consider before prescribing paracetamol or ibuprofen?

Bites - human and animal: What should I consider before prescribing paracetamol or ibuprofen? Paracetamol and ibuprofen | Prescribing information | Bites - human and animal | CKS | NICE Search CKS… Menu Paracetamol and ibuprofen Bites - human and animal: What should I consider before prescribing paracetamol or ibuprofen? Last revised in October 2018 What should I consider before prescribing paracetamol or ibuprofen? For more information on prescribing paracetamol and ibuprofen, see the CKS

2019 NICE Clinical Knowledge Summaries

19. Ibuprofen

Ibuprofen Top results for ibuprofen - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for ibuprofen The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

20. Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women-A double-blind, randomized non-inferiority trial Full Text available with Trip Pro

Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women-A double-blind, randomized non-inferiority trial Although uncomplicated urinary tract infections (UTIs) are often self-limiting, most patients will be prescribed antibiotic treatment. We assessed whether treatment with ibuprofen was non-inferior to pivmecillinam in achieving symptomatic resolution by day 4, with a non-inferiority margin of 10%.This was a randomized, controlled, double-blind non-inferiority trial (...) . We recruited patients from 16 sites in a general practice setting in Norway, Sweden, and Denmark. Non-pregnant women aged 18-60 years presenting with symptoms of uncomplicated UTI were screened for eligibility from 11 April 2013 to 22 April 2016. Patients with informed consent were randomized (1:1 ratio) to treatment with either 600 mg ibuprofen or 200 mg pivmecillinam 3 times a day for 3 days. The patient, treating physician, and study personnel were blinded to treatment allocation. The primary

2018 EvidenceUpdates Controlled trial quality: predicted high