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Latest & greatest articles for infants
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on infants or other clinical topics then use Trip today.
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Feasibility of Ultra-Rapid Exome Sequencing in Critically Ill Infants and Children With Suspected Monogenic Conditions in the Australian Public Health Care System. Widespread adoption of rapid genomic testing in pediatric critical care requires robust clinical and laboratory pathways that provide equitable and consistent service across health care systems.To prospectively evaluate the performance of a multicenter network for ultra-rapid genomic diagnosis in a public health care (...) system.Descriptive feasibility study of critically ill pediatric patients with suspected monogenic conditions treated at 12 Australian hospitals between March 2018 and February 2019, with data collected to May 2019. A formal implementation strategy emphasizing communication and feedback, standardized processes, coordination, distributed leadership, and collective learning was used to facilitate adoption.Ultra-rapid exome sequencing.The primary outcome was time from sample receipt to ultra-rapid exome sequencing
Effect of Intraoperative Dexamethasone on Major Complications and Mortality Among Infants Undergoing Cardiac Surgery: The DECISION Randomized Clinical Trial. Corticosteroids are widely used in pediatric cardiac surgery to blunt systemic inflammatory response and to reduce complications; nevertheless, their clinical efficacy is uncertain.To determine whether intraoperative administration of dexamethasone is more effective than placebo for reducing major complications and mortality during (...) pediatric cardiac surgery.The Intraoperative Dexamethasone in Pediatric Cardiac Surgery was an investigator-initiated, double-blind, multicenter randomized trial that involved 4 centers in China, Brazil, and Russia. A total of 394 infants younger than 12 months, undergoing cardiac surgery with cardiopulmonary bypass were enrolled from December 2015 to October 2018, with follow-up completed in November 2018.The dexamethasone group (n = 194) received 1 mg/kg of dexamethasone; the control group (n = 200
Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. In communities with high rates of coronavirus disease 2019, reports have emerged of children with an unusual syndrome of fever and inflammation.To describe the clinical and laboratory characteristics of hospitalized children who met criteria for the pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (...) (SARS-CoV-2) (PIMS-TS) and compare these characteristics with other pediatric inflammatory disorders.Case series of 58 children from 8 hospitals in England admitted between March 23 and May 16, 2020, with persistent fever and laboratory evidence of inflammation meeting published definitions for PIMS-TS. The final date of follow-up was May 22, 2020. Clinical and laboratory characteristics were abstracted by medical record review, and were compared with clinical characteristics of patients
Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: analysis for the Global Burden of Disease Study 2017. Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat (...) disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood diarrhoea.We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMICs, in combination with findings of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, to estimate posterior distributions of diarrhoea prevalence, incidence, and mortality from 2000
Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children. Rituximab added to chemotherapy prolongs survival among adults with B-cell cancer. Data on its efficacy and safety in children with high-grade, mature B-cell non-Hodgkin's lymphoma are limited.We conducted an open-label, international, randomized, phase 3 trial involving patients younger than 18 years of age with high-risk, mature B-cell non-Hodgkin's lymphoma (stage III with an elevated lactate dehydrogenase level (...) neutropenia and infection. Approximately twice as many patients in the rituximab-chemotherapy group as in the chemotherapy group had a low IgG level 1 year after trial inclusion.Rituximab added to standard LMB chemotherapy markedly prolonged event-free survival and overall survival among children and adolescents with high-grade, high-risk, mature B-cell non-Hodgkin's lymphoma and was associated with a higher incidence of hypogammaglobulinemia and, potentially, more episodes of infection. (Funded
Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. To describe the characteristics of children and adolescents affected by an outbreak of Kawasaki-like multisystem inflammatory syndrome and to evaluate a potential temporal association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Prospective observational study.General paediatric department of a university hospital in Paris (...) , France.21 children and adolescents (aged ≤18 years) with features of Kawasaki disease who were admitted to hospital between 27 April and 11 May 2020 and followed up until discharge by 15 May 2020.The primary outcomes were clinical and biological data, imaging and echocardiographic findings, treatment, and outcomes. Nasopharyngeal swabs were prospectively tested for SARS-CoV-2 using reverse transcription-polymerase chain reaction (RT-PCR) and blood samples were tested for IgG antibodies to the virus
been updated based on current evidence and information available at the time of publishing. Guidance will be regularly reviewed with regards to the evolving nature of the pandemic and emerging evidence. All interim guidance will be presumed to expire in December 2020 unless otherwise specified. Last Updated 05/21/2020 Source American Academy of Pediatrics We're 67,000 pediatricians committed to the optimal physical, mental, and social health and well-being for all infants, children, adolescents (...) Management of Infants Born to Mothers with Suspected or Confirmed COVID-19 FAQs: Management of Infants Born to Mothers with Suspected or Confirmed COVID-19 Internet Explorer Alert It appears you are using Internet Explorer as your web browser. Please note, Internet Explorer is no longer up-to-date and can cause problems in how this website functions This site functions best using the latest versions of any of the following browsers: Edge, Firefox, Chrome, Opera, or Safari . You can find
Pediatric Hyperinflammatory Syndrome and COVID-19: Statement and Recommendations From a Pediatric Intensive Care International Collaborative Conference Call Pediatric Hyperinflammatory Syndrome and COVID-19: Statement and Recommendations From a Pediatric Intensive Care International Collaborative Conference Call - American College of Cardiology ') Search All Types Search or Menu put forth by the Royal College of Pediatrics and Child Health (see sidebar on right). Children with SARS-CoV-2 (...) benefit from care by a multidisciplinary team of specialists, including those with expertise in intensive care, cardiology, rheumatology, immunology and infectious diseases. Royal College of Pediatrics and Child Health Case Definition for Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 A child presenting with persistent fever, inflammation (neutrophilia, elevated CRP and lymphopenia) and evidence of single or multiorgan dysfunction (shock, cardiac, respiratory, renal
Haycraft , on behalf of Originally published 11 May 2020 Journal of the American Heart Association. 2020;9 Abstract Abstract A substantial body of research suggests that efforts to prevent pediatric obesity may benefit from targeting not just what a child eats, but how they eat. Specifically, child obesity prevention should include a component that addresses reasons why children have differing abilities to start and stop eating in response to internal cues of hunger and satiety, a construct known (...) as eating self‐regulation . This review summarizes current knowledge regarding how caregivers can be an important influence on children's eating self‐regulation during early childhood. First, we discuss the evidence supporting an association between caregiver feeding and child eating self‐regulation. Second, we discuss what implications the current evidence has for actions caregivers may be able to take to support children's eating self‐regulation. Finally, we consider the broader social, economic
( 70 decibels hearing level (dB HL) without acoustic hearing aids (HA), ? A hearing aid trial of 3 to 6 months, unless contraindicated or inappropriate, and ? Parental support in the form of motivation and commitment to rehabilitation. ? Simultaneous BCI should be provided to the eligible child as early as clinically suitable. ? For children who have received unilateral cochlear implant (CI), the second CI in the contralateral ear should be provided only if this is judged to provide sufficient (...) benefit by the clinician. ? The second CI should be provided by 6 years of age unless there are special conditions to consider (e.g. large vestibular aqueduct syndrome (LVAS), meningitis, irradiated ears). ? Children will be eligible for subsidy for the replacement of CI sound processors, which include replacement with or without upgrade where an upgrade refers to a change to a later model than currently used by the individual, if all of the following criteria are met: ? The child is deemed
through agreed national centres in the UK for all paediatric age groups (London, Liverpool and Birmingham). Psoriatic arthritis – adalimumab is licensed for psoriatic arthritis in adults but not in children. It has also been used in other rheumatological conditions which may require formal financial approval. Contraindications: • Moderate or severe heart failure. • Severe infection (including but not limited to active TB and other opportunistic infections). • Hypersensitivity to the active substance (...) by the child. The manufacturers consider it safe to use adalimumab while breastfeeding. Screening and recommendations before starting: Clearly documented decision to start adalimumab treatment with the indication noted. Documented adherence to concomitant medication plan (e.g. DMARDs, steroids, other immunosuppression, prophylactic antibiotics/antivirals etc.). Paediatric and adolescent rheumatology nurse specialist has delivered appropriate education regarding the medication with documentation
be revisited once the child matures. These issues must be discussed prior to starting methotrexate treatment. Health professionals should be aware that methotrexate can cause embryotoxicity and teratogenicity, and they should avoid handling of it if they are concerned. Vaccinations: The Department of Health publication ‘Immunisation against Infectious disease’ (the Green Book) is regularly updated and should be considered as the definitive source of information about vaccination. • Live vaccines – children (...) • Improving compliance with oral methotrexate guidelines. National Patient Safety Alert (NPSA). June 2006 updated June 2018. https://www.sps.nhs.uk/articles/npsa-alert- improving-compliance-with-oral-methotrexate-guidelines-2006/ • NHS Improvements Never Event List 2018 https://improvement.nhs.uk/documents/2899/Never_Events_list_2018_FINAL_v6.pdf • Paediatric Formulary Committee. BNF for Children (online) London: BMJ Group, Pharmaceutical Press, and RCPCH Publications http://www.medicinescomplete.com
provide them with the discounts agreed in the patient access schemes for these technologies. NB 2. At the time of production of this document the manufacturer has not sought a paediatric and adolescent licence for the S/C pen device and so only the prefilled syringe is licenced for use in children. Use – licenced/not licenced/NHSE pathway: Licensed for indications listed above and present on NHS England pathway within document: Biologic Therapies for the use in Juvenile Idiopathic Arthritis (2015 (...) medication who are exposed to varicella and do not have immunity require prophylactic aciclovir and selected patients may require passive immunisation using VZIG. See Public Health England Guidelines for details. Patients developing chickenpox or shingles should be treated with aciclovir and have their immunosuppressive medication withheld until they have recovered. Authors: Dr Peter Bale, Consultant Paediatric Rheumatologist (Addenbrookes Hospital) Clare Nash, BSPAR pharmacy lead (Sheffield Children’s
The role of dietary fibre and prebiotics in the paediatric diet Dietary fibres are resistant to digestion and absorption. Prebiotics are fermentable dietary fibres that confer health benefits through their effects on microbiome composition and activity. The range of physiological benefits from consuming dietary fibres is broad. Encouraging children to eat fibre-rich foods promotes a nutrient-dense diet. Introducing a variety of dietary fibre sources to young children helps establish future (...) dietary choices and a more diverse intestinal microbiota. Low fibre intake is associated with a higher prevalence of constipation and obesity. Keywords : Children; Dietary fibre; Microbiome; Prebiotics
of Technology, Brisbane, Australia. 7 Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia. 8 University Children's Hospital, Vienna, Austria. 9 Breathing Institute, Children's Hospital Colorado, Dept of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA. 10 National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. 11 Pediatric Dept, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium. 12 Dept (...) of Paediatrics, Antwerp University Hospital, Antwerp, Belgium. 13 Child Health, University of Aberdeen, Aberdeen, UK email@example.com. PMID: 32165403 DOI: Item in Clipboard Does Treatment Guided by Exhaled Nitric Oxide Fraction Improve Outcomes in Subgroups of Children With Asthma? Shona S Fielding et al. Eur Respir J . 2020 . Show details Eur Respir J Actions . 2020 May 21;55(5):1901879. doi: 10.1183/13993003.01879-2019. Print 2020 May. Authors , , , , , , , , , , , , , Affiliations 1 Medical
Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Diabetes Care Actions . 2020 Jul;43(7):1553-1556. doi: 10.2337/dc19-1944. Epub 2020 Apr 28. Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Division of Endocrinology, Department of Pediatrics, The Hospital (...) for Sick Children, University of Toronto, Toronto, Ontario, Canada firstname.lastname@example.org. 2 Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. 3 Division of Endocrinology and Metabolism, St. Joseph's Health Care, London Health Sciences Centre, Western University, London, Ontario, Canada. 4 Division of Gastroenterology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. 5 Department
and maternal health data and intelligence. Published 14 June 2017 Last updated 12 March 2019 — From: Contents Public Health England (PHE) collects and analyses available child and maternal health data and produces intelligence resources to help with improving services and outcomes. This guidance supports commissioners, service planners and other healthcare professionals with using these resources to make or influence decisions about services that improve the health of children, young people and pregnant (...) women. Child and maternal health statistics PHE publishes several collections of . You can use these to help improve decision making when planning services for mothers, children and young people. Overview of child health and child health profiles The on the Fingertips data website provide a snapshot of child health in upper-tier local authority areas. These are part of an overview of child health that brings together indicators for local government and CCG areas across several different themes
COVID-19: paediatric surveillance COVID-19: paediatric surveillance - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Coronavirus guidance is being updated. Read Stay alert. Control the virus. Save lives. Guidance COVID-19: paediatric surveillance Description and contact details of PHE (...) paediatric surveillance programmes for COVID-19. Published 27 April 2020 From: Paediatric surveillance for . If you would like more information about the surveillance, please contact Dr Shamez Ladhani at . 2. Clinical follow up of laboratory-confirmed cases in neonates up to 28 days of age . Paediatricians across the UK and Ireland will receive weekly emails from the . For more information about the . At the end of the surveillance, cases will be linked to a similar surveillance of . For more information
of Pediatrics recommends that all adolescents be screened for alcohol and drug use and that, based on the results, clinicians conduct further assessment, provide guidance and brief counseling interventions, and, if appropriate, refer for treatment . The American Academy of Family Physicians' recommendation on interventions to address drug use in children and adolescents is currently under review. Members of the U.S. Preventive Services Task Force at the time this recommendation was finalized are Virginia (...) Illicit Drug Use in Children, Adolescents, and Young Adults: Primary Care-Based Interventions Recommendation | United States Preventive Services Taskforce Toggle navigation Main navigation Main navigation Recommendation to see the latest documents available. Recommendation Summary Population Recommendation Children and Adolescents without a Substance Use Disorder The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of primary care-based