Latest & greatest articles for irritable bowel syndrome

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Top results for irritable bowel syndrome

61. Hydrogen breath test for irritable bowel syndrome

obtaining breath samples before and at timed intervals after ingesting a carbohydrate substrate and analyzing these samples for hydrogen (H2) content. Intestinal bacteria ferment the carbohydrate, producing the only source of bodily H2, which is expelled in the breath. The pattern and degree of expelled H2 may indicate the presence of particular gastrointestinal (GI) disorders. Irritable bowel syndrome (IBS) is a chronic GI disorder that is diagnosed only by symptoms but shares symptoms with other GI (...) conditions. In patients with IBS, the HBT is performed to identify GI conditions that may be responsible for symptoms and may be treatable, potentially providing symptom relief. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Breath Tests; Hydrogen; Irritable Bowel Syndromes Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S

2012 Health Technology Assessment (HTA) Database.

62. Should I Consider Antibiotics in My Patient with Irritable Bowel Syndrome?

in the United States. Gastroenterology. 2002;122(5):1500-1511. 3. Galatola G, Grosso M, Barlotta A, et al. [Diagnosis of bacterial contamination of the small intestine using the 1 g [14C] xylose breath test in various gastrointestinal diseases]. Minerva gastroenterol dietol. 1991;37(3):169-175. 4. Pimentel M, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol. 2000;95(12):3503-3506. 5. Pimentel M, Chow EJ, Lin HC (...) and gastroenterologists. The workup is often extensive and rules out many etiologies. After discovering no metabolic, inflammatory, or anatomic pathology, physicians use the Rome III criteria to diagnose irritable bowel syndrome (IBS). IBS is a functional bowel disorder that is diagnosed by symptoms of recurrent abdominal pain or discomfort for at least 3 days per month in the last 3 months and associated with 2 or more of the following: 1) improvement with defecation, 2) onset associated with a change in frequency

2012 Clinical Correlations

63. Systematic review with meta-analysis: In irritable bowel syndrome, antispasmodics and antidepressants improve abdominal pain and global assessment and symptom scores, but there is no evidence for the effectiveness of bulking agents

Systematic review with meta-analysis: In irritable bowel syndrome, antispasmodics and antidepressants improve abdominal pain and global assessment and symptom scores, but there is no evidence for the effectiveness of bulking agents In irritable bowel syndrome, antispasmodics and antidepressants improve abdominal pain and global assessment and symptom scores, but there is no evidence for the effectiveness of bulking agents | BMJ Evidence-Based Medicine We use cookies to improve our service (...) name or password? You are here In irritable bowel syndrome, antispasmodics and antidepressants improve abdominal pain and global assessment and symptom scores, but there is no evidence for the effectiveness of bulking agents Article Text This article has a correction. Please see: Therapeutics Systematic review with meta-analysis In irritable bowel syndrome, antispasmodics and antidepressants improve abdominal pain and global assessment and symptom scores, but there is no evidence

2012 Evidence-Based Medicine

64. Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation (Abstract)

Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation Linaclotide, a minimally absorbed, 14-amino acid peptide agonist of guanylate cyclase-C, has shown benefit in a proof-of-concept study for the treatment of patients with irritable bowel syndrome (IBS) with constipation (IBS-C). We assessed the efficacy and safety of linaclotide at a daily dose range of 75-600 μg in IBS-C.We performed a randomized, double-blind (...) , multicenter, placebo-controlled study of 420 patients with IBS-C given oral linaclotide at doses of 75, 150, 300, or 600 μg or placebo once daily for 12 weeks. End points included change from baseline in daily bowel habits, daily abdominal symptoms, and weekly global assessments, in addition to responder criteria.All doses of linaclotide significantly improved bowel habits, including frequency of spontaneous bowel movements and complete spontaneous bowel movements (primary end point), severity

2011 EvidenceUpdates Controlled trial quality: predicted high

65. Rifaximin therapy for patients with irritable bowel syndrome without constipation. Full Text available with Trip Pro

Rifaximin therapy for patients with irritable bowel syndrome without constipation. Evidence suggests that gut flora may play an important role in the pathophysiology of the irritable bowel syndrome (IBS). We evaluated rifaximin, a minimally absorbed antibiotic, as treatment for IBS.In two identically designed, phase 3, double-blind, placebo-controlled trials (TARGET 1 and TARGET 2), patients who had IBS without constipation were randomly assigned to either rifaximin at a dose of 550 mg (...) a response to treatment as assessed by daily self-ratings of global IBS symptoms and individual symptoms of bloating, abdominal pain, and stool consistency during the 4 weeks after treatment and during the entire 3 months of the study.Significantly more patients in the rifaximin group than in the placebo group had adequate relief of global IBS symptoms during the first 4 weeks after treatment (40.8% vs. 31.2%, P=0.01, in TARGET 1; 40.6% vs. 32.2%, P=0.03, in TARGET 2; 40.7% vs. 31.7%, P<0.001, in the two

2011 NEJM Controlled trial quality: predicted high

66. Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis Full Text available with Trip Pro

Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis Sodium chenodeoxycholate (CDC) accelerates colonic transit in health. Our aim was to examine pharmacodynamics (colonic transit, bowel function) and pharmacogenetics of CDC in constipation-predominant irritable bowel syndrome (IBS-C).In a double-blind placebo-controlled study, 36 female patients with IBS-C were randomized to treatment with delayed-release oral formulations (...) of placebo, 500 mg CDC, or 1000 mg CDC for 4 days. We assessed gastrointestinal and colonic transit, stool characteristics, and associations of transit with fasting serum 7αC4 (surrogate of bile acid synthesis) and FGF19 (negative regulator of bile acid synthesis) levels. Candidate genetic polymorphisms involved in regulation of bile acid synthesis were analyzed in the 36 patients with IBS-C and 57 healthy volunteers to assess genetic influence on effects of CDC on transit.Overall colonic transit

2010 EvidenceUpdates Controlled trial quality: uncertain

67. A randomized, double-blind, placebo-controlled trial of St John`s wort for treating irritable bowel syndrome (Abstract)

A randomized, double-blind, placebo-controlled trial of St John`s wort for treating irritable bowel syndrome St John's wort (SJW) is known to effectively treat patients with mild-to-moderate depression. Antidepressants are frequently used to treat irritable bowel syndrome (IBS). To date, no study that examines the efficacy of SJW in IBS has been carried out. The aim of this study was to evaluate the efficacy of SJW in IBS after 12 weeks.In this randomized, double-blind, placebo-controlled trial (...) , 70 participants with an established diagnosis of IBS were randomized and assigned by concealed allocation to either SJW or placebo. Both treatment arms were balanced on symptom subtype. The primary end point was self-reported overall bowel symptom score (BSS) at 12 weeks. Secondary end points were individual BSS for diarrhea (D-BSS), constipation (C-BSS), pain or discomfort, and bloating; adequate relief (AR) of IBS on at least 50% of the last 4 weeks of therapy; and IBS quality-of-life score

2010 EvidenceUpdates Controlled trial quality: predicted high

68. Comprehensive self-management for irritable bowel syndrome: randomized trial of in-person vs. combined in-person and telephone sessions Full Text available with Trip Pro

Comprehensive self-management for irritable bowel syndrome: randomized trial of in-person vs. combined in-person and telephone sessions Psychological and behavioral therapies are being increasingly used for symptom management in patients with irritable bowel syndrome (IBS). The aims of this study were to compare two delivery modes for a comprehensive self-management (CSM) intervention, primarily by telephone vs. entirely in person, and to compare each with usual care (UC).Adults with IBS were (...) recruited through community advertisement. Subjects (N=188) were randomly assigned to three groups: one in which all nine weekly CSM sessions were delivered in person, one in which six of the nine sessions were conducted over telephone, and one in which subjects received UC. Primary outcome measures were a gastrointestinal (GI) symptom score based on six symptoms from a daily diary and disease-specific quality of life (QOL). These and other outcomes were assessed at baseline and at 3, 6, and 12 months

2010 EvidenceUpdates Controlled trial quality: uncertain

69. The place of antibiotics in management of irritable bowel syndrome: a systematic review and meta-analysis

The place of antibiotics in management of irritable bowel syndrome: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

70. Systematic review: self-management support interventions for irritable bowel syndrome

Systematic review: self-management support interventions for irritable bowel syndrome Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

71. [Burden of irritable bowel syndrome in Korea]

of medical costs was the highest at 60.0%, followed by transportation costs at 15.4% and productivity loss costs at 24.8%. If other medical costs incurred by patients, such as over-the-counter drug costs and health food costs, are added to the aforementioned costs, the total amount is estimated to be 773.8 billion won. Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Cost of Illness; Humans; Irritable Bowel Syndrome; Korea Language Published Korean Country of organisation South (...) [Burden of irritable bowel syndrome in Korea] [Burden of irritable bowel syndrome in Korea] [Burden of irritable bowel syndrome in Korea] Choi MG, Jung HK, Jang BH, Kim Y, Nam MH, Park SY, Park J, Park HJ, Lee PL, Lee JS, Lee KJ Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Choi MG, Jung HK, Jang BH, Kim Y, Nam MH, Park SY, Park J, Park

2010 Health Technology Assessment (HTA) Database.

72. Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof of concept study (Abstract)

Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof of concept study Intestinal immune infiltration contributes to symptoms in patients with irritable bowel syndrome (IBS).To assesses the effect of mesalazine (mesalamine) on mucosal immune cells in patients with IBS, through a pilot study.A randomized, double-blind, placebo-controlled trial in 20 patients with IBS in tertiary care setting. Patients were randomized to receive placebo (...) ). Mesalazine significantly increased general well-being (P = 0.038), but had no significant effects on abdominal pain (P = 0.084), bloating (P = 0.177) or bowel habits. No serious drug-related adverse events were reported during the study.Mesalazine is an effective and safe approach to reduce mast cell infiltration and may improve general well-being in patients with IBS. These results support the hypothesis that immune mechanisms represent potential therapeutic targets in IBS.

2009 EvidenceUpdates Controlled trial quality: predicted high

73. Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. (Abstract)

Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Between 4% and 25% of school-age children complain of recurrent abdominal pain (RAP) of sufficient severity to interfere with daily activities. It is unclear whether the diagnosis includes children with different aetiologies for their pain. For the majority no organic cause for their pain can be found on physical examination or investigation. Although most children are likely managed (...) by reassurance and simple measures, a large range of interventions have been recommended.To determine the effectiveness of dietary interventions for recurrent abdominal pain in school-age children.The Cochrane Library (CENTRAL) 2006 (Issue 4), MEDLINE (1966 to Dec 2006), EMBASE (1980 to Dec 2006), CINAHL (1982 to Dec 2007), ERIC (1966 to Dec 2006), PsycINFO (1872 to Dec 2006), LILACS (1982 to Dec 2006), SIGLE (1980 to March 2005), and JICST (1985 to 06/2000) were searched . Where appropriate, search filters

2009 Cochrane

74. Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial. Full Text available with Trip Pro

was adequate symptom relief during at least two weeks in the previous month, analysed after one, two, and three months of treatment to assess both short term and sustained effectiveness. Secondary end points included irritable bowel syndrome symptom severity score, severity of abdominal pain, and irritable bowel syndrome quality of life scale.The proportion of responders was significantly greater in the psyllium group than in the placebo group during the first month (57% v 35%; relative risk 1.60, 95 (...) Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial. To determine the effectiveness of increasing the dietary content of soluble fibre (psyllium) or insoluble fibre (bran) in patients with irritable bowel syndrome.Randomised controlled trial.General practice.275 patients aged 18-65 years with irritable bowel syndrome.12 weeks of treatment with 10 g psyllium (n=85), 10 g bran (n=97), or 10 g placebo (rice flour) (n=93).The primary end point

2009 BMJ Controlled trial quality: predicted high

75. Review: antidepressants and psychological therapies improve symptoms of irritable bowel syndrome

Review: antidepressants and psychological therapies improve symptoms of irritable bowel syndrome Review: antidepressants and psychological therapies improve symptoms of irritable bowel syndromeCommentary | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal (...) improve symptoms of irritable bowel syndrome Commentary Statistics from Altmetric.com QUESTION In patients with irritable bowel syndrome (IBS), do antidepressant medications or psychological therapies improve symptoms? REVIEW SCOPE Included studies compared antidepressants with placebo or psychological therapies with no treatment or usual care in adults (⩾16 y of age) with IBS diagnosed by established criteria or by a clinician’s opinion. Outcomes were persistent IBS symptoms and adverse events

2009 Evidence-Based Medicine

76. Psychological treatments may be effective for managing irritable bowel syndrome

Psychological treatments may be effective for managing irritable bowel syndrome PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Psychological treatments may be effective for managing irritable bowel syndrome Clinical question How effective are psychological interventions for the treatment of irritable bowel syndrome (IBS)? Bottom line Psychological interventions (cognitive behavioural therapy (...) of irritable bowel syndrome. Cochrane Reviews 2009, Issue 1. Article No: CD006442. DOI: 10.1002/14651858.CD006442.pub2. This review contains 25 studies involving 1858 participants. PEARLS 156, April 2009, written by Brian R McAvoy [References] 1. Drossman DA et al. Gastroenterology 1997;112:2120-2137 are funded by the New Zealand Guidelines Group. PEARLS provide guidance on whether a treatment is effective or ineffective. PEARLS are prepared as an educational resource and do not replace clinician judgement

2009 Cochrane PEARLS

77. Review: clinical findings had moderate sensitivity and specificity for diagnosing irritable bowel syndrome

and specificity for diagnosing irritable bowel syndrome Statistics from Altmetric.com QUESTION What is the accuracy of individual symptoms and combinations of clinical findings for diagnosing irritable bowel syndrome (IBS)? REVIEW SCOPE Included studies compared individual symptoms or combinations of clinical findings with investigational tests (colonoscopy, barium enema, or computed tomographic colography) for diagnosing IBS in unselected patients >16 years of age who had lower gastrointestinal (GI) symptoms (...) Review: clinical findings had moderate sensitivity and specificity for diagnosing irritable bowel syndrome Review: clinical findings had moderate sensitivity and specificity for diagnosing irritable bowel syndrome | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password

2009 Evidence-Based Medicine

78. Review: fibre, antispasmodics, and peppermint oil are all effective for irritable bowel syndrome

Review: fibre, antispasmodics, and peppermint oil are all effective for irritable bowel syndrome Review: fibre, antispasmodics, and peppermint oil are all effective for irritable bowel syndrome | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: fibre, antispasmodics, and peppermint oil are all effective for irritable bowel syndrome Article Text Therapeutics Review: fibre, antispasmodics, and peppermint oil are all effective

2009 Evidence-Based Medicine

79. A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome

A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

80. Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis

anticholinergic effects for elderly patients or C-IBS and imipramine or amitriptyline for D-IBS and patients with insomnia. Research : The authors stated that additional large RCTs with strict surveillance on compliance were needed to further explain the role of antidepressants for management of IBS in routine practice. Funding National Science Foundation, Tehran. Bibliographic details Rahimi R, Nikfar S, Rezaie A, Abdollahi M. Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis (...) Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis Rahimi R, Nikfar S, Rezaie A, Abdollahi M CRD summary This review concluded that low-dose tricyclic antidepressants (TCAs) exhibited clinically and statistically significant control of irritable bowel syndrome (IBS) symptoms. Caution is warranted

2009 DARE.