Latest & greatest articles for knee osteoarthritis

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Top results for knee osteoarthritis

1. The Effectiveness of Anti-Nerve Growth Factor Monoclonal Antibodies in the Management of Pain in Osteoarthritis of the Hip and Knee: A PRISMA Systematic Review and Meta-Analysis

antibodies. The Jadad Scale score was used to assess the quality of the included studies. Results: Thirteen studies were included in the analysis, involving 8145 participants with a diagnosis of hip and/or knee osteoarthritis. Anti-NGF antibody treatment was associated with a significant improvement in all Western Ontario and McMaster Universities Arthritis Index (WOMAC) indices when compared to placebo. These agents were not associated with a significantly increased incidence of serious adverse events (...) The Effectiveness of Anti-Nerve Growth Factor Monoclonal Antibodies in the Management of Pain in Osteoarthritis of the Hip and Knee: A PRISMA Systematic Review and Meta-Analysis The Effectiveness of Anti-Nerve Growth Factor Monoclonal Antibodies in the Management of Pain in Osteoarthritis of the Hip and Knee: A PRISMA Systematic Review and Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search

2021 EvidenceUpdates

2. Platelet-Rich Plasma Combined With Hyaluronic Acid Improves Pain and Function Compared With Hyaluronic Acid Alone in Knee Osteoarthritis: A Systematic Review and Meta-analysis

the efficacy of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) injections versus HA injections alone for the management of knee osteoarthritis (OA). Methods: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eligible randomized-controlled trials and observational studies directly comparing combined PRP-HA injections with HA injections alone were identified through a search of PubMed, Scopus, and Cochrane Central databases (...) Platelet-Rich Plasma Combined With Hyaluronic Acid Improves Pain and Function Compared With Hyaluronic Acid Alone in Knee Osteoarthritis: A Systematic Review and Meta-analysis Platelet-Rich Plasma Combined With Hyaluronic Acid Improves Pain and Function Compared With Hyaluronic Acid Alone in Knee Osteoarthritis: A Systematic Review and Meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History

2021 EvidenceUpdates

3. Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients <60 Years of Age With Osteoarthritis

Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients <60 Years of Age With Osteoarthritis Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) )31149-9. doi: 10.1016/j.arth.2020.10.050. Online ahead of print. Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients , , Affiliations Expand Affiliations 1 The Joint Replacement Center of Seoul Metropolitan SeoNam Hospital, Seoul, Republic of Korea. 2 The Joint Replacement Center of Ewha Womans University Seoul Hospital, Seoul, Republic of Korea. PMID: 33223412 DOI: Item in Clipboard Long-Term (Up to 27 Years) Prospective

2021 EvidenceUpdates

4. Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function

Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function - PubMed This site needs JavaScript to work properly (...) Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Arthroscopy Actions . 2020 Oct 20;S0749-8063(20)30843-4. doi: 10.1016/j.arthro.2020.10.013. Online ahead of print. Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function , , , , , Affiliations Expand Affiliations 1 Department

2021 EvidenceUpdates

5. Safety of Low-Dose Tanezumab in the Treatment of Hip or Knee Osteoarthritis: A Systemic Review and Meta-analysis of Randomized Phase III Clinical Trials

options Format Abstract Objectives: To evaluate the safety of low-dose tanezumab in the treatment of knee or hip osteoarthritis (OA). Methods: Databases were searched up to September 2019 for phase III randomized controlled trials (RCTs). Eleven phase III RCTs comprising 11,455 patients were eligible. The pooled estimates of safety outcomes were assessed and expressed using relative risks (RRs) and 95% confidence intervals with a random-effects model. Results: Tanezumab significantly increased (...) Safety of Low-Dose Tanezumab in the Treatment of Hip or Knee Osteoarthritis: A Systemic Review and Meta-analysis of Randomized Phase III Clinical Trials Safety of Low-Dose Tanezumab in the Treatment of Hip or Knee Osteoarthritis: A Systemic Review and Meta-analysis of Randomized Phase III Clinical Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features

2021 EvidenceUpdates

6. Intra-articular Mesenchymal Stromal Cell Injections Are No Different From Placebo in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Abstract Purpose: To evaluate the efficacy and safety of intra-articular mesenchymal stromal cells (MSCs) injections for knee osteoarthritis (OA) treatment. Methods: We performed a systematic literature search in PubMed, Embase, Scopus, and the Cochrane Library through April 2020 to identify level I randomized controlled trials (RCTs) that evaluated the clinical efficacy of MSCs versus control treatments for knee OA. Outcomes were analyzed on an intention-to-treat basis with random-effects models (...) Intra-articular Mesenchymal Stromal Cell Injections Are No Different From Placebo in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials Intra-Articular Mesenchymal Stromal Cell Injections Are No Different From Placebo in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set

2021 EvidenceUpdates

7. Acupuncture of different treatment frequencies in knee osteoarthritis: a pilot randomised controlled trial

Acupuncture of different treatment frequencies in knee osteoarthritis: a pilot randomised controlled trial Acupuncture of different treatment frequencies in knee osteoarthritis: a pilot randomised controlled trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest (...) frequencies in knee osteoarthritis: a pilot randomised controlled trial , , , , , , , , , Affiliations Expand Affiliations 1 Acupuncture Research Center, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China. 2 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, affiliated with Capital Medical University, Beijing, China. PMID: 32483056 DOI: Item in Clipboard Acupuncture of different treatment frequencies in knee

2020 EvidenceUpdates

8. Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis

Disease, Chinese PLA General Hospital, Beijing, China. PMID: 32954819 DOI: Item in Clipboard Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis Lidong Hu et al. Clin Rehabil . 2020 . Show details Display options Display options Format Clin Rehabil Actions . 2020 Sep 21;269215520954343. doi: 10.1177/0269215520954343. Online ahead of print. Authors , , , , , , , , Affiliations 1 Department of Rheumatology, Xiang'an (...) Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19

2020 EvidenceUpdates

9. Efficacy and safety of thunder-fire moxibustion for patients with Knee Osteoarthritis: protocol of a systematic review and meta-analysis Full Text available with Trip Pro

Efficacy and safety of thunder-fire moxibustion for patients with Knee Osteoarthritis: protocol of a systematic review and meta-analysis Inplasy Protocol 846 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

10. The Non-Surgical Management of Hip & Knee Osteoarthritis

involvement and disease progression varies. Osteoarthritis is diagnosed at a median of 55 years of age, and patients may live approximately 30 years with the disease. Patients with OA may present to providers with minimal symptoms or have incidental findings on physical examination or radiologic testing. Patients with symptomatic OA typically present with joint pain, aching, stiffness, and limited walking ability.[29] Knee OA is usually bilateral but one knee may be affected more severely; hip OA (...) annually in direct healthcare costs. The combination of direct and indirect costs for OA and related disorders is estimated to be $461 billion.[18] Hip and knee joint replacements represent a major portion of these costs.[17] The indirect costs associated with OA greatly surpass healthcare costs and exert significant personal costs for people with OA due to work loss and premature retirement, leading to loss of income and subsequent reductions in personal savings.[17] Osteoarthritis also causes

2020 VA/DoD Clinical Practice Guidelines

11. Lorecivivint, a Novel Intraarticular CDC-Like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial Full Text available with Trip Pro

of knee OA. © 2020 Samumed, LLC. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. Similar articles Yazici Y, McAlindon TE, Fleischmann R, Gibofsky A, Lane NE, Kivitz AJ, Skrepnik N, Armas E, Swearingen CJ, DiFrancesco A, Tambiah JRS, Hood J, Hochberg MC. Yazici Y, et al. Osteoarthritis Cartilage. 2017 Oct;25(10):1598-1606. doi: 10.1016/j.joca.2017.07.006. Epub 2017 Jul 13. Osteoarthritis Cartilage. 2017. PMID: 28711582 Clinical Trial. Deshmukh (...) Actions Cite Display options Display options Format Share Permalink Copy Page navigation Arthritis Rheumatol Actions . 2020 May 20. doi: 10.1002/art.41315. Online ahead of print. Lorecivivint, a Novel Intraarticular CDC-Like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial , , , , , , , , , , , Affiliations Expand Affiliations 1 Samumed LLC, San Diego, California. 2 Tufts

2020 EvidenceUpdates

12. Aquatic Cycling Improves Knee Pain and Physical Functioning in Patients With Knee Osteoarthritis: A Randomized Controlled Trial

-text links Cite Display options Display options Format Abstract Objective: To assess the efficacy of a 12-week aquatic cycling training program for improving knee pain and physical functioning in patients with knee osteoarthritis (OA). Design: Two-arm, single-blind, parallel-group randomized controlled trial. Settings: OA outpatient clinic of the Maastricht University Medical Center+. Participants: Patients (N=111, 50-70y) with unilateral mild-to-moderate knee OA. Interventions: Participants (...) ) and physical functioning (UC pretest, 66.32±16.28; posttest, 66.80±19.04; follow-up, 65.42±17.98; and AC pretest, 61.89±17.151; posttest, 70.14±17.52; follow-up, 69.00±16.84; estimate, 7.16; SE, 3.19; 95% CI, 0.83-13.49; ES, 0.43) in favor of the aquatic group. Conclusions: The results suggest that a 12-week AC training program improves self-reported knee pain and physical functioning in patients with mild-to-moderate knee OA compared to UC. Keywords: Exercise therapy; Knee; Osteoarthritis; Pain

2020 EvidenceUpdates

13. Effectiveness of <i>Curcuma longa</i> Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. (Abstract)

Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Current pharmacologic therapies for patients with osteoarthritis are suboptimal.To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion-synovitis in patients with symptomatic knee osteoarthritis and knee effusion-synovitis.Randomized, double-blind, placebo-controlled trial. (Australian New Zealand Clinical Trials (...) Registry: ACTRN12618000080224).Single-center study with patients from southern Tasmania, Australia.70 participants with symptomatic knee osteoarthritis and ultrasonography-defined effusion-synovitis.2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks.The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion-synovitis volume on magnetic resonance imaging (MRI). The key secondary outcomes were change in Western Ontario and McMaster Universities

2020 Annals of Internal Medicine

14. In knee OA, physical therapy reduced pain and improved function more than glucocorticoid injections at 1 year. (Abstract)

In knee OA, physical therapy reduced pain and improved function more than glucocorticoid injections at 1 year. Deyle GD, Allen CS, Allison SC, et al. Physical therapy versus glucocorticoid injection for osteoarthritis of the knee. N Engl J Med. 2020;382:1420-9. 32268027.

2020 Annals of Internal Medicine

15. Physical Therapy and Orthopedic Equipment-induced Reduction in the Biomechanical Risk Factors Related to Knee Osteoarthritis: a Bayesian network meta-analysis of randomized controlled trials Full Text available with Trip Pro

Physical Therapy and Orthopedic Equipment-induced Reduction in the Biomechanical Risk Factors Related to Knee Osteoarthritis: a Bayesian network meta-analysis of randomized controlled trials Inplasy Protocol 782 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

16. Chinese herbal medicine Wutou decoction for knee osteoarthritis: A protocol for systematic review and meta-analysis Full Text available with Trip Pro

Chinese herbal medicine Wutou decoction for knee osteoarthritis: A protocol for systematic review and meta-analysis Inplasy Protocol 750 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

17. Prognostic Models for Knee Osteoarthritis: A Protocol for Systematic Review, Critical Appraisal and Meta-Analysis Full Text available with Trip Pro

Author DOI: License: This work is licensed under a CC BY 4.0 License. Abstract Background: Osteoarthritis is the most common degenerative joint disease diagnosed in clinical practice. It is associated with significant socioeconomic burden and poor quality of life, a large proportion of which is due to knee osteoarthritis (KOA), mainly driven by total knee arthroplasty (TKA). As the difficulty of being detected early and deficiency of disease-modifying drug, the focus of KOA is shifting to disease (...) , 2020 Metrics Metrics Comments : 0 PDF Downloads : ... HTML Views : ... Subject Areas Subject Areas DOI & PDF DOI: License License: This work is licensed under a CC BY 4.0 License. Declarations Abstract Background: Osteoarthritis is the most common degenerative joint disease diagnosed in clinical practice. It is associated with significant socioeconomic burden and poor quality of life, a large proportion of which is due to knee osteoarthritis (KOA), mainly driven by total knee arthroplasty (TKA

2020 Research Square

18. Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials

), the visual analog scale (VAS), the EuroQol VAS, the International Knee Documentation Committee, the Tegner score, the Lequesne Scale, the Knee injury Osteoarthritis Outcome Score, satisfaction rate, and adverse events. Subgroup analyses was performed for patients with different doses, types, and times of PRP interventions and grades of OA. The Review Manager Database was used to analyze the included studies. Results: Twenty-six randomized controlled trials involving 2430 patients were included. The WOMAC (...) Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19

2020 EvidenceUpdates

19. Regarding “Intra-Articular Injections of Hyaluronic Acid or Steroid Associated With Better Outcomes Than Platelet-Rich Plasma, Adipose Mesenchymal Stromal Cell, or Placebo in Knee Osteoarthritis: A Network Meta-Analysis” Full Text available with Trip Pro

Regarding “Intra-Articular Injections of Hyaluronic Acid or Steroid Associated With Better Outcomes Than Platelet-Rich Plasma, Adipose Mesenchymal Stromal Cell, or Placebo in Knee Osteoarthritis: A Network Meta-Analysis” Redirecting

2020 Arthroscopy: The Journal of Arthroscopic & Related Surgery

20. Letter to the Editor Regarding “Intra-Articular Injections of Hyaluronic Acid or Steroid Associated With Better Outcomes Than Platelet-Rich Plasma, Adipose Mesenchymal Stromal Cell, or Placebo in Knee Osteoarthritis: A Network Meta-Analysis” Full Text available with Trip Pro

Letter to the Editor Regarding “Intra-Articular Injections of Hyaluronic Acid or Steroid Associated With Better Outcomes Than Platelet-Rich Plasma, Adipose Mesenchymal Stromal Cell, or Placebo in Knee Osteoarthritis: A Network Meta-Analysis” Redirecting

2020 Arthroscopy: The Journal of Arthroscopic & Related Surgery