Latest & greatest articles for knee osteoarthritis

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Top results for knee osteoarthritis

1. Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients <60 Years of Age With Osteoarthritis

Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients <60 Years of Age With Osteoarthritis Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) )31149-9. doi: 10.1016/j.arth.2020.10.050. Online ahead of print. Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients , , Affiliations Expand Affiliations 1 The Joint Replacement Center of Seoul Metropolitan SeoNam Hospital, Seoul, Republic of Korea. 2 The Joint Replacement Center of Ewha Womans University Seoul Hospital, Seoul, Republic of Korea. PMID: 33223412 DOI: Item in Clipboard Long-Term (Up to 27 Years) Prospective

2021 EvidenceUpdates

2. Intra-articular Mesenchymal Stromal Cell Injections Are No Different From Placebo in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Abstract Purpose: To evaluate the efficacy and safety of intra-articular mesenchymal stromal cells (MSCs) injections for knee osteoarthritis (OA) treatment. Methods: We performed a systematic literature search in PubMed, Embase, Scopus, and the Cochrane Library through April 2020 to identify level I randomized controlled trials (RCTs) that evaluated the clinical efficacy of MSCs versus control treatments for knee OA. Outcomes were analyzed on an intention-to-treat basis with random-effects models (...) Intra-articular Mesenchymal Stromal Cell Injections Are No Different From Placebo in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials Intra-Articular Mesenchymal Stromal Cell Injections Are No Different From Placebo in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set

2021 EvidenceUpdates

3. Safety of Low-Dose Tanezumab in the Treatment of Hip or Knee Osteoarthritis: A Systemic Review and Meta-analysis of Randomized Phase III Clinical Trials

options Format Abstract Objectives: To evaluate the safety of low-dose tanezumab in the treatment of knee or hip osteoarthritis (OA). Methods: Databases were searched up to September 2019 for phase III randomized controlled trials (RCTs). Eleven phase III RCTs comprising 11,455 patients were eligible. The pooled estimates of safety outcomes were assessed and expressed using relative risks (RRs) and 95% confidence intervals with a random-effects model. Results: Tanezumab significantly increased (...) Safety of Low-Dose Tanezumab in the Treatment of Hip or Knee Osteoarthritis: A Systemic Review and Meta-analysis of Randomized Phase III Clinical Trials Safety of Low-Dose Tanezumab in the Treatment of Hip or Knee Osteoarthritis: A Systemic Review and Meta-analysis of Randomized Phase III Clinical Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features

2021 EvidenceUpdates

4. Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function

Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function - PubMed This site needs JavaScript to work properly (...) Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Arthroscopy Actions . 2020 Oct 20;S0749-8063(20)30843-4. doi: 10.1016/j.arthro.2020.10.013. Online ahead of print. Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function , , , , , Affiliations Expand Affiliations 1 Department

2021 EvidenceUpdates

5. Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis

Disease, Chinese PLA General Hospital, Beijing, China. PMID: 32954819 DOI: Item in Clipboard Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis Lidong Hu et al. Clin Rehabil . 2020 . Show details Display options Display options Format Clin Rehabil Actions . 2020 Sep 21;269215520954343. doi: 10.1177/0269215520954343. Online ahead of print. Authors , , , , , , , , Affiliations 1 Department of Rheumatology, Xiang'an (...) Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19

2020 EvidenceUpdates

6. Acupuncture of different treatment frequencies in knee osteoarthritis: a pilot randomised controlled trial

Acupuncture of different treatment frequencies in knee osteoarthritis: a pilot randomised controlled trial Acupuncture of different treatment frequencies in knee osteoarthritis: a pilot randomised controlled trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest (...) frequencies in knee osteoarthritis: a pilot randomised controlled trial , , , , , , , , , Affiliations Expand Affiliations 1 Acupuncture Research Center, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China. 2 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, affiliated with Capital Medical University, Beijing, China. PMID: 32483056 DOI: Item in Clipboard Acupuncture of different treatment frequencies in knee

2020 EvidenceUpdates

7. Lorecivivint, a Novel Intraarticular CDC-Like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial Full Text available with Trip Pro

of knee OA. © 2020 Samumed, LLC. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. Similar articles Yazici Y, McAlindon TE, Fleischmann R, Gibofsky A, Lane NE, Kivitz AJ, Skrepnik N, Armas E, Swearingen CJ, DiFrancesco A, Tambiah JRS, Hood J, Hochberg MC. Yazici Y, et al. Osteoarthritis Cartilage. 2017 Oct;25(10):1598-1606. doi: 10.1016/j.joca.2017.07.006. Epub 2017 Jul 13. Osteoarthritis Cartilage. 2017. PMID: 28711582 Clinical Trial. Deshmukh (...) Actions Cite Display options Display options Format Share Permalink Copy Page navigation Arthritis Rheumatol Actions . 2020 May 20. doi: 10.1002/art.41315. Online ahead of print. Lorecivivint, a Novel Intraarticular CDC-Like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial , , , , , , , , , , , Affiliations Expand Affiliations 1 Samumed LLC, San Diego, California. 2 Tufts

2020 EvidenceUpdates

8. The Non-Surgical Management of Hip & Knee Osteoarthritis

involvement and disease progression varies. Osteoarthritis is diagnosed at a median of 55 years of age, and patients may live approximately 30 years with the disease. Patients with OA may present to providers with minimal symptoms or have incidental findings on physical examination or radiologic testing. Patients with symptomatic OA typically present with joint pain, aching, stiffness, and limited walking ability.[29] Knee OA is usually bilateral but one knee may be affected more severely; hip OA (...) annually in direct healthcare costs. The combination of direct and indirect costs for OA and related disorders is estimated to be $461 billion.[18] Hip and knee joint replacements represent a major portion of these costs.[17] The indirect costs associated with OA greatly surpass healthcare costs and exert significant personal costs for people with OA due to work loss and premature retirement, leading to loss of income and subsequent reductions in personal savings.[17] Osteoarthritis also causes

2020 VA/DoD Clinical Practice Guidelines

9. Effectiveness of <i>Curcuma longa</i> Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. (Abstract)

Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Current pharmacologic therapies for patients with osteoarthritis are suboptimal.To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion-synovitis in patients with symptomatic knee osteoarthritis and knee effusion-synovitis.Randomized, double-blind, placebo-controlled trial. (Australian New Zealand Clinical Trials (...) Registry: ACTRN12618000080224).Single-center study with patients from southern Tasmania, Australia.70 participants with symptomatic knee osteoarthritis and ultrasonography-defined effusion-synovitis.2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks.The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion-synovitis volume on magnetic resonance imaging (MRI). The key secondary outcomes were change in Western Ontario and McMaster Universities

2020 Annals of Internal Medicine

10. In knee OA, physical therapy reduced pain and improved function more than glucocorticoid injections at 1 year. (Abstract)

In knee OA, physical therapy reduced pain and improved function more than glucocorticoid injections at 1 year. Deyle GD, Allen CS, Allison SC, et al. Physical therapy versus glucocorticoid injection for osteoarthritis of the knee. N Engl J Med. 2020;382:1420-9. 32268027.

2020 Annals of Internal Medicine

11. Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials

), the visual analog scale (VAS), the EuroQol VAS, the International Knee Documentation Committee, the Tegner score, the Lequesne Scale, the Knee injury Osteoarthritis Outcome Score, satisfaction rate, and adverse events. Subgroup analyses was performed for patients with different doses, types, and times of PRP interventions and grades of OA. The Review Manager Database was used to analyze the included studies. Results: Twenty-six randomized controlled trials involving 2430 patients were included. The WOMAC (...) Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19

2020 EvidenceUpdates

12. Effectiveness of Kinesio Taping on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials Full Text available with Trip Pro

demonstrated that there were significant differences between Kinesio Taping groups and control groups in terms of visual analog scale (VAS), Western Ontario and MacMaster Universities Osteoarthritis Index (WOMAC) scale and flexion range of motion. Kinesio Taping is effective in improving pain and joint function in patients with knee OA. Keywords: Kinesio Taping; knee joint; osteoarthritis; systematic review. © 2020 Melese et al. Conflict of interest statement The authors report no conflicts of interest (...) Effectiveness of Kinesio Taping on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials Effectiveness of Kinesio Taping on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly

2020 EvidenceUpdates

13. Cooled radiofrequency ablation provides extended clinical utility in the management of knee osteoarthritis: 12-month results from a prospective, multi-center, randomized, cross-over trial comparing cooled radiofrequency ablation to a single hyaluronic aci Full Text available with Trip Pro

DH, et al. Number of persons with symptomatic knee osteoarthritis in the US: impact of race and ethnicity, age, sex, and obesity: symptomatic knee OA in the US. Arthritis Care Res. 2016;68(12):1743–1750. doi: 10.1002/acr.22897. - - - KS&R, Inc. Halyard-sponsored qualitative market research, OA Pain Landscape & Patient Journey. 2015. Brown GA. AAOS clinical practice guideline: treatment of osteoarthritis of the knee: evidence-based guideline, 2nd Edition. J Am Acad Orthop Surg. 2013;21(9):577–9 (...) PMCID: DOI: Item in Clipboard Full-text links Cite Abstract Background: Safe and effective non-surgical treatments are an important part of the knee osteoarthritis (OA) treatment algorithm. Cooled radiofrequency ablation (CRFA) and hyaluronic acid (HA) injections are two commonly used modalities to manage symptoms associated with knee OA. Methods: A prospective 1:1 randomized study was conducted in 177 patients comparing CRFA to HA injection with follow-ups at 1, 3, 6 and 12 months. HA subjects

2020 EvidenceUpdates

14. An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis

, but a greater incidence of diarrhoea occurred with diacerein (10.2% vs 3.7%). Diarrhoea was considered mild-to-moderate in all but one case with complete resolution. Conclusions: Diacerein was non-inferior to celecoxib in reducing knee OA pain and improving physical function. Diacerein also demonstrated a good safety profile. Trial registration: A multicentre study on the effect of DIacerein on Structure and Symptoms vs Celecoxib in Osteoarthritis is a National Institutes of Health ( ) and European Clinical (...) An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID

2020 EvidenceUpdates

15. Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis

Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis , , , , , , , , Affiliations Expand Affiliations 1 Department of Orthopaedic Surgery, Division of Sports Medicine, Rush University, Medical Center, Chicago, Illinois, U.S.A. 2 Loyola University Chicago, Chicago, Illinois, U.S.A. 3 Department of Orthopaedic Surgery, Division of Sports Medicine, Rush University, Medical Center, Chicago, Illinois, U.S.A.. Electronic address

2020 EvidenceUpdates

16. Comparative effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis

Comparative effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis Comparative effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other (...) effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis , , , , , Affiliations Expand Affiliations 1 Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chiayi, Taiwan. 2 School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 3 Department of Neurology, Chang Gung Memorial Hospital, Chiayi, Taiwan. 4 Department of Nursing, Chang Gung University

2020 EvidenceUpdates

17. Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated?

Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Prescrire IN ENGLISH - Spotlight ''Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated?'', 1 July 2020 {1} {1} {1} | | > > > Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |  (...)  |   |   |   |   |   |   |   |  Spotlight Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Queries and Comments Prescrire concluded in 2016 that the harm-benefit balance of hyaluronic acid by intra-articular injection seemed unfavourable. Several readers have since expressed their profound disagreement, citing the effects noted in their daily practice. How can

2020 Prescrire

18. The effectiveness of Kinesio Taping((R)) for mobility and functioning improvement in knee osteoarthritis: a randomized, double-blind, controlled trial Full Text available with Trip Pro

The effectiveness of Kinesio Taping((R)) for mobility and functioning improvement in knee osteoarthritis: a randomized, double-blind, controlled trial The Effectiveness of Kinesio Taping ® for Mobility and Functioning Improvement in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 May 6;269215520916859. doi: 10.1177/0269215520916859. Online ahead of print. The Effectiveness of Kinesio Taping ® for Mobility and Functioning Improvement in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial , Affiliations Expand Affiliation 1 Department of Rehabilitation, Medical Academy

2020 EvidenceUpdates

19. Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial Full Text available with Trip Pro

Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Ann Fam Med Actions . 2020 May;18(3):235-242. doi: 10.1370/afm.2520. Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial , , , , , , , Affiliations Expand Affiliations 1 Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong reginasit@cuhk.edu.hk. 2 Jockey Club School of Public Health and Primary Care

2020 EvidenceUpdates

20. Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial. (Abstract)

Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial. Individually calibrated biomechanical footwear therapy may improve pain and physical function in people with symptomatic knee osteoarthritis, but the benefits of this therapy are unclear.To assess the effect of a biomechanical footwear therapy vs control footwear over 24 weeks of follow-up.Randomized clinical trial conducted at a Swiss university hospital. Participants (N (...)  = 220) with symptomatic, radiologically confirmed knee osteoarthritis were recruited between April 20, 2015, and January 10, 2017. The last participant visit occurred on August 15, 2017.Participants were randomized to biomechanical footwear involving shoes with individually adjustable external convex pods attached to the outsole (n = 111) or to control footwear (n = 109) that had visible outsole pods that were not adjustable and did not create a convex walking surface.The primary outcome was knee

2020 JAMA