Latest & greatest articles for knee osteoarthritis

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Top results for knee osteoarthritis

1. The Non-Surgical Management of Hip & Knee Osteoarthritis (OA)

involvement and disease progression varies. Osteoarthritis is diagnosed at a median of 55 years of age, and patients may live approximately 30 years with the disease. Patients with OA may present to providers with minimal symptoms or have incidental findings on physical examination or radiologic testing. Patients with symptomatic OA typically present with joint pain, aching, stiffness, and limited walking ability.[29] Knee OA is usually bilateral but one knee may be affected more severely; hip OA (...) annually in direct healthcare costs. The combination of direct and indirect costs for OA and related disorders is estimated to be $461 billion.[18] Hip and knee joint replacements represent a major portion of these costs.[17] The indirect costs associated with OA greatly surpass healthcare costs and exert significant personal costs for people with OA due to work loss and premature retirement, leading to loss of income and subsequent reductions in personal savings.[17] Osteoarthritis also causes

2020 VA/DoD Clinical Practice Guidelines

2. Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials

), the visual analog scale (VAS), the EuroQol VAS, the International Knee Documentation Committee, the Tegner score, the Lequesne Scale, the Knee injury Osteoarthritis Outcome Score, satisfaction rate, and adverse events. Subgroup analyses was performed for patients with different doses, types, and times of PRP interventions and grades of OA. The Review Manager Database was used to analyze the included studies. Results: Twenty-six randomized controlled trials involving 2430 patients were included. The WOMAC (...) Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19

2020 EvidenceUpdates

3. Cooled radiofrequency ablation provides extended clinical utility in the management of knee osteoarthritis: 12-month results from a prospective, multi-center, randomized, cross-over trial comparing cooled radiofrequency ablation to a single hyaluronic aci Full Text available with Trip Pro

DH, et al. Number of persons with symptomatic knee osteoarthritis in the US: impact of race and ethnicity, age, sex, and obesity: symptomatic knee OA in the US. Arthritis Care Res. 2016;68(12):1743–1750. doi: 10.1002/acr.22897. - - - KS&R, Inc. Halyard-sponsored qualitative market research, OA Pain Landscape & Patient Journey. 2015. Brown GA. AAOS clinical practice guideline: treatment of osteoarthritis of the knee: evidence-based guideline, 2nd Edition. J Am Acad Orthop Surg. 2013;21(9):577–9 (...) PMCID: DOI: Item in Clipboard Full-text links Cite Abstract Background: Safe and effective non-surgical treatments are an important part of the knee osteoarthritis (OA) treatment algorithm. Cooled radiofrequency ablation (CRFA) and hyaluronic acid (HA) injections are two commonly used modalities to manage symptoms associated with knee OA. Methods: A prospective 1:1 randomized study was conducted in 177 patients comparing CRFA to HA injection with follow-ups at 1, 3, 6 and 12 months. HA subjects

2020 EvidenceUpdates

4. An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis

, but a greater incidence of diarrhoea occurred with diacerein (10.2% vs 3.7%). Diarrhoea was considered mild-to-moderate in all but one case with complete resolution. Conclusions: Diacerein was non-inferior to celecoxib in reducing knee OA pain and improving physical function. Diacerein also demonstrated a good safety profile. Trial registration: A multicentre study on the effect of DIacerein on Structure and Symptoms vs Celecoxib in Osteoarthritis is a National Institutes of Health ( ) and European Clinical (...) An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID

2020 EvidenceUpdates

5. Effectiveness of Kinesio Taping on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials Full Text available with Trip Pro

demonstrated that there were significant differences between Kinesio Taping groups and control groups in terms of visual analog scale (VAS), Western Ontario and MacMaster Universities Osteoarthritis Index (WOMAC) scale and flexion range of motion. Kinesio Taping is effective in improving pain and joint function in patients with knee OA. Keywords: Kinesio Taping; knee joint; osteoarthritis; systematic review. © 2020 Melese et al. Conflict of interest statement The authors report no conflicts of interest (...) Effectiveness of Kinesio Taping on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials Effectiveness of Kinesio Taping on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly

2020 EvidenceUpdates

6. Comparative effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis

Comparative effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis Comparative effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other (...) effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis , , , , , Affiliations Expand Affiliations 1 Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chiayi, Taiwan. 2 School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 3 Department of Neurology, Chang Gung Memorial Hospital, Chiayi, Taiwan. 4 Department of Nursing, Chang Gung University

2020 EvidenceUpdates

7. Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis

Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis , , , , , , , , Affiliations Expand Affiliations 1 Department of Orthopaedic Surgery, Division of Sports Medicine, Rush University, Medical Center, Chicago, Illinois, U.S.A. 2 Loyola University Chicago, Chicago, Illinois, U.S.A. 3 Department of Orthopaedic Surgery, Division of Sports Medicine, Rush University, Medical Center, Chicago, Illinois, U.S.A.. Electronic address

2020 EvidenceUpdates

8. Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated?

Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Prescrire IN ENGLISH - Spotlight ''Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated?'', 1 July 2020 {1} {1} {1} | | > > > Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |  (...)  |   |   |   |   |   |   |   |  Spotlight Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Queries and Comments Prescrire concluded in 2016 that the harm-benefit balance of hyaluronic acid by intra-articular injection seemed unfavourable. Several readers have since expressed their profound disagreement, citing the effects noted in their daily practice. How can

2020 Prescrire

9. Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial Full Text available with Trip Pro

Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Ann Fam Med Actions . 2020 May;18(3):235-242. doi: 10.1370/afm.2520. Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial , , , , , , , Affiliations Expand Affiliations 1 Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong reginasit@cuhk.edu.hk. 2 Jockey Club School of Public Health and Primary Care

2020 EvidenceUpdates

10. The effectiveness of Kinesio Taping((R)) for mobility and functioning improvement in knee osteoarthritis: a randomized, double-blind, controlled trial

The effectiveness of Kinesio Taping((R)) for mobility and functioning improvement in knee osteoarthritis: a randomized, double-blind, controlled trial The Effectiveness of Kinesio Taping ® for Mobility and Functioning Improvement in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 May 6;269215520916859. doi: 10.1177/0269215520916859. Online ahead of print. The Effectiveness of Kinesio Taping ® for Mobility and Functioning Improvement in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial , Affiliations Expand Affiliation 1 Department of Rehabilitation, Medical Academy

2020 EvidenceUpdates

11. Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial. (Abstract)

Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial. Individually calibrated biomechanical footwear therapy may improve pain and physical function in people with symptomatic knee osteoarthritis, but the benefits of this therapy are unclear.To assess the effect of a biomechanical footwear therapy vs control footwear over 24 weeks of follow-up.Randomized clinical trial conducted at a Swiss university hospital. Participants (N (...)  = 220) with symptomatic, radiologically confirmed knee osteoarthritis were recruited between April 20, 2015, and January 10, 2017. The last participant visit occurred on August 15, 2017.Participants were randomized to biomechanical footwear involving shoes with individually adjustable external convex pods attached to the outsole (n = 111) or to control footwear (n = 109) that had visible outsole pods that were not adjustable and did not create a convex walking surface.The primary outcome was knee

2020 JAMA

12. Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period

Full-text links Cite Abstract Objective: Tanezumab, a nerve growth factor inhibitor, was investigated for osteoarthritis (OA) of the hip or knee in a study with 24-week treatment and 24-week safety follow-up. Methods: This double-blind, randomised, phase III study enrolled adults in Europe and Japan with moderate-to-severe OA who had not responded to or could not tolerate standard-of-care analgesics. Patients were randomised to tanezumab 2.5 mg or 5 mg subcutaneously or matching placebo every 8 (...) weeks (three doses). Co-primary end points were change from baseline to week 24 in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Physical Function, and Patient's Global Assessment of OA (PGA-OA). Joint safety and neurological assessments continued throughout the 48-week study. Results: From March 2016 to December 2017, 849 patients were randomised and evaluated (placebo n=282, tanezumab 2.5 mg n=283, tanezumab 5 mg n=284). At week 24, there was a statistically

2020 EvidenceUpdates

13. MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis Full Text available with Trip Pro

of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Paper presented at: Seminars in arthritis and rheumatism; 1990. doi:10.1099/00221287-136-2-327 - - Kon E, Filardo G, Drobnic M, et al. Non-surgical management of early knee osteoarthritis. Knee Surg Sports Traumatol Arthroscopy. 2012;20(3):436–449. doi:10.1007/s00167-011-1713-8 - - Raeissadat SA, Tabibian E, Rayegani SM, Rahimi-Dehgolan S, Babaei-Ghazani A. An inestigation into the efficacy of intra-articular ozone (O2-O3 (...) MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial) - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show

2020 EvidenceUpdates

14. Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT Full Text available with Trip Pro

Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you (...) need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Both total and partial knee replacement were effective and offered similar clinical outcomes at 5 years. {{author}} {{($index , , , , , , , , , , , , & . David J Beard 1, * , Loretta J Davies 1 , Jonathan A Cook 2 , Graeme MacLennan 2 , Andrew Price 1 , Seamus Kent 3 , Jemma Hudson 2 , Andrew Carr 1 , Jose Leal 3 , Helen Campbell 3 , Ray Fitzpatrick 3 , Nigel Arden 1 , David Murray 1

2020 NIHR HTA programme

15. Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial. (Abstract)

Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial. A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are lacking.To determine the effects of intravenous zoledronic acid on knee cartilage volume loss in patients with symptomatic knee (...) osteoarthritis and bone marrow lesions.A 24-month multicenter, double-blind placebo-controlled randomized clinical trial conducted at 4 sites in Australia (1 research center and 3 hospitals). Adults aged 50 years or older with symptomatic knee osteoarthritis and subchondral bone marrow lesions detected by magnetic resonance imaging (MRI) were enrolled from November 2013 through September 2015. The final date of follow-up was October 9, 2017.Intravenous infusion with either 5 mg of zoledronic acid in a 100-mL

2020 JAMA

16. Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee. (Abstract)

Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee. Both physical therapy and intraarticular injections of glucocorticoids have been shown to confer clinical benefit with respect to osteoarthritis of the knee. Whether the short-term and long-term effectiveness for relieving pain and improving physical function differ between these two therapies is uncertain.We conducted a randomized trial to compare physical therapy with glucocorticoid injection in the primary care (...) setting in the U.S. Military Health System. Patients with osteoarthritis in one or both knees were randomly assigned in a 1:1 ratio to receive a glucocorticoid injection or to undergo physical therapy. The primary outcome was the total score on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 1 year (scores range from 0 to 240, with higher scores indicating worse pain, function, and stiffness). The secondary outcomes were the time needed to complete the Alternate Step Test

2020 NEJM

17. American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

an evidence- based guideline for the comprehensive management of osteoarthritis (OA) as a collabora- tion between the American College of Rheumatology (ACR) and the Arthritis Foundation, updating the 2012 ACR recommenda- tions for the management of hand, hip, and knee OA. Methods. We identified clinically relevant population, intervention, comparator, outcomes questions and critical outcomes in OA. A Literature Review T eam performed a systematic literature review to summarize evidence supporting (...) low and/ Figure 1. Recommended therapies for the management of osteoarthritis (OA). Strongly and conditionally recommended approaches to management of hand, knee, and/or hip OA are shown. No hierarchy within categories is implied in the figure, with the recognition that the various options may be used (and reused) at various times during the course of a particular patient’s disease. * = Exercise for knee and hip OA could include walking, strengthening, neuromuscular training, and aquatic exercise

2020 American College of Rheumatology

18. Technology-assisted rehabilitation following total knee or hip replacement for people with osteoarthritis: a systematic review and meta-analysis Full Text available with Trip Pro

PMCID: DOI: Item in Clipboard Technology-assisted Rehabilitation Following Total Knee or Hip Replacement for People With Osteoarthritis: A Systematic Review and Meta-Analysis Xia Wang et al. BMC Musculoskelet Disord . 2019 Show details BMC Musculoskelet Disord Actions , 20 (1), 506 Authors , , , , Affiliations 1 Level 10 Kolling Institute, Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Reserve Road, St. Leonards, Sydney, NSW, 2065, Australia. xia.wang (...) Technology-assisted rehabilitation following total knee or hip replacement for people with osteoarthritis: a systematic review and meta-analysis Technology-assisted Rehabilitation Following Total Knee or Hip Replacement for People With Osteoarthritis: A Systematic Review and Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History

2020 EvidenceUpdates

19. Partial knee replacement could be first choice for some patients with osteoarthritis. (Abstract)

Partial knee replacement could be first choice for some patients with osteoarthritis. The studyBeard D, Davies L, Cook J, et al. The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial. Lancet 2019;394:746-56.The study was funded by the NIHR Health Technology Assessment Programme (project number 08/14/08).To read the full NIHR Signal, go to https (...) ://discover.dc.nihr.ac.uk/content/signal-000824/partial-knee-replacement-could-be-first-choice-in-some-patients.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

2019 BMJ

20. Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study. (Abstract)

Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study. To compare the clinical effectiveness of the triple intra-articular injection of platelet-rich plasma (PRP) with respect to the single injection in patients with mild osteoarthritis of the knee.A total of 35 patients with a clinical and radiographic diagnosis of osteoarthritis grade I and II were analyzed. They were randomized into two groups: single application (18 (...) ±7.3; p lt 0.05) at the end of the study. The triple application showed better improvement in the VAS (p= 0.0007) and the total WOMAC (p= 0.0209) scores when comparing the final results between groups.The triple infiltration of PRP in patients with mild knee osteoarthritis is clinically more effective than the single application at 48 weeks of follow-up.

2019 Acta reumatologica portuguesa Controlled trial quality: uncertain