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Latest & greatest articles for knee osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on knee osteoarthritis or other clinical topics then use Trip today.
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Inflammation related to synovectomy during total knee replacement in patients with primary osteoarthritis: a prospective, randomised study We compared inflammation in the knee after total knee replacement (TKR) for primary osteoarthritis between two groups of patients undergoing joint replacement with and without synovectomy. A total of 67 patients who underwent unilateral TKR were randomly divided into group I, TKR without synovectomy, and group II, TKR with synovectomy. Clinical outcomes (...) , serial serum inflammatory markers (including interleukin-6 (IL-6), CRP and ESR) and the difference in temperature of the skin of the knee, compared with the contralateral side, were sequentially evaluated until 26 weeks after surgery. Pre-operatively, there were no statistically different clinical parameters between groups I and II. At the 26-week follow-up, both groups had a similarly significantly improved American Knee Society clinical score (p < 0.001) and functional score (p < 0.001
Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in kneeosteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI To determine the effect of chondroitin sulphate (CS) treatment on cartilage volume loss, subchondral bone marrow lesions (BML), synovitis and disease symptoms in patients with kneeosteoarthritis (OA).In this pilot multicentre, randomised, double-blind (...) as 6 months for the global knee (p=0.030), lateral compartment (p=0.015) and tibial plateaus (p=0.002), with significance persisting at 12 months. Significantly lower BML scores were found for the CS group at 12 months in the lateral compartment (p=0.035) and the lateral femoral condyle (p=0.044). Disease symptoms were similar between the two groups.CS treatment significantly reduced the cartilage volume loss in kneeOA starting at 6 months of treatment, and BML at 12 months. These findings suggest
Risks of oral or transdermal opioids outweigh benefits for osteoarthritis of the knee or hip PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Risks of oral or transdermal opioids outweigh benefits for osteoarthritis of the knee or hip Clinical question How effective are oral or transdermal opioids in patients with osteoarthritis (OA) of the knee or hip? Bottom line Compared to placebo (...) poorer quality of life and reduced functional capacity, and does not seem to improve pain relief.² Context OA is the most common form of jointdisease and the leading cause of pain and physical disability in the elderly. Opioids may be a viable treatment option if patients suffer from severe pain, or if other analgesics are contraindicated. However, the evidence on their effectiveness and safety is contradictory. Cochrane Systematic Review Nuesch E et al. Oral or transdermal opioids
Osteoarthritis is a chronic jointdisease that involves degeneration of articular cartilage. Pre-clinical data has suggested that doxycycline might act as a disease- modifying agent for the treatment of osteoarthritis, with the potential to slow cartilage degeneration. Cochrane Systematic Review Nuesch E et al. Doxycycline for osteoarthritis of the knee or hip. Cochrane Reviews 2009, Issue 4. Article No. CD007323. DOI: 10.1002/14651858.CD007323.pub2. This review contains one study involving 431 participants (...) Doxycycline ineffective for osteoarthritis of the knee or hip PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Doxycycline ineffective for osteoarthritis of the knee or hip Clinical question How effective is doxycycline for osteoarthritis (OA) of the knee or hip? Bottom line Compared to placebo, there is minimal or no symptomatic benefit (pain reduction and improved physical function
Agility and perturbation training techniques in exercise therapy for reducing pain and improving function in people with kneeosteoarthritis: a randomized clinical trial Impairment-based exercise programs have yielded only small to moderate benefits in reducing pain and improving function in people with kneeosteoarthritis (OA). It has previously been proposed that adding agility and perturbation training to exercise programs for people with kneeOA may improve treatment effects for pain (...) and function.The purpose of this study was to examine the effectiveness of adding agility and perturbation techniques to standard exercise therapy compared with the standard exercise program alone for people with knee OA.This was a single-blinded randomized controlled trial.The study was conducted in the outpatient physical therapy clinic of a large, university-based health center.One hundred eighty-three people with kneeOA (122 women, 61 men) participated.Participants were randomly assigned to either a group
All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. To examine all cause and disease specific mortality in patients with osteoarthritis of the knee or hip.Population based cohort study.General practices in the southwest of England.1163 patients aged 35 years or over with symptoms and radiological confirmation of osteoarthritis of the knee or hip.Age and sex standardised mortality ratios and multivariable hazard ratios of death (...) after a median of 14 years' follow-up.Patients with osteoarthritis had excess all cause mortality compared with the general population (standardised mortality ratio 1.55, 95% confidence interval 1.41 to 1.70). Excess mortality was observed for all disease specific causes of death but was particularly pronounced for cardiovascular (standardised mortality ratio 1.71, 1.49 to 1.98) and dementia associated mortality (1.99, 1.22 to 3.25). Mortality increased with increasing age (P for trend <0.001), male
Impact of obesity and kneeosteoarthritis on morbidity and mortality in older americans. Obesity and kneeosteoarthritis are among the most frequent chronic conditions affecting Americans aged 50 to 84 years.To estimate quality-adjusted life-years lost due to obesity and kneeosteoarthritis and health benefits of reducing obesity prevalence to levels observed a decade ago.The U.S. Census and obesity data from national data sources were combined with estimated prevalence of symptomatic knee (...) osteoarthritis to assign persons aged 50 to 84 years to 4 subpopulations: nonobese without kneeosteoarthritis (reference group), nonobese with kneeosteoarthritis, obese without kneeosteoarthritis, and obese with kneeosteoarthritis. The Osteoarthritis Policy Model, a computer simulation model of kneeosteoarthritis and obesity, was used to estimate quality-adjusted life-year losses due to kneeosteoarthritis and obesity in comparison with the reference group.United States.U.S. population aged 50 to 84
Therapeutic trajectory following intra-articular hyaluronic acid injection in kneeosteoarthritis ? meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
of the knee. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication Dates. 2011 Authors' conclusions Osteoarthritis (OA), also known as degenerativejointdisease, is the most common form of arthritis. OA affects > 27 million individuals in the United States, generally aged > 45 years; approximately 9 million have kneeOA. OA is one of the five leading causes of physical disability, morbidity, and social isolation in older men and women in the community. Deterioration of the joint structure (...) and function not only reduces the quality of life and mobility but also significantly impacts the economy in terms of healthcare costs and lost productivity. Standard treatments for kneeOA include medications, physical therapy, and, if severe, total knee arthroplasty (TKA) to replace the affected joint. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Humans; Osteoarthritis, Knee Language Published English Country of organisation United States
neuropathies; had symptomatic co-morbidities affecting walking more than the kneeosteoarthritis; were unwilling to start new medication during the trial; had knee hip or ankle surgery; had peripheral or central nervous systema diseases; had hip lumbar spine and ankle osteoarthritis; had secondary kneeosteoarthritis or symptomatic deformity of the foot and ankle; had any other disease treated with insoles; or had received intra-articular injections in the previous six months. Non-steroidal anti (...) ; 67(1): 35-43 Indexing Status Subject indexing assigned by CRD MeSH Equipment Design; Humans; KneeJoint; Orthotic Devices; Osteoarthritis, Knee; Pain; Pain Management; Recovery of Function; Shoes AccessionNumber 12011004571 Date bibliographic record published 20/02/2012 Date abstract record published 28/05/2012 Record Status This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each critical abstract contains a brief summary of the review methods
NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
. The main effectiveness parameters were the time to failure and the failure rates of joint replacements due to short-term causes. This evidence was from revision rates over seven years reported in the Australian National Joint Replacement Registry. Monetary benefit and utility valuations: The disability weights were derived from the Burden of Disease study to quantify the impact of osteoarthritis on quality of life. Quality of life estimates, obtained using questionnaires like the European Quality (...) Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model Higashi H, Barendregt JJ Record Status This is a critical abstract of an economic
Lateral wedge insoles for medial kneeosteoarthritis: 12 month randomised controlled trial. To assess the effect of lateral wedge insoles compared with flat control insoles on improving symptoms and slowing structural disease progression in medial knee osteoarthritis.Randomised controlled trial.Community in Melbourne, Australia.200 people aged 50 or more with clinical and radiographic diagnosis of mild to moderately severe medial knee osteoarthritis.Full length 5 degree lateral wedged insoles (...) or flat control insoles worn inside the shoes daily for 12 months.Primary symptomatic outcome was change in overall knee pain (past week) measured on an 11 point numerical rating scale. Primary structural outcome was change in volume of medial tibial cartilage from magnetic resonance imaging scans. Secondary clinical outcomes included changes in measures of pain, function, stiffness, and health related quality of life. Secondary structural outcomes included progression of medial cartilage defects
Prognostic factors for the two-year course of activity limitations in early osteoarthritis of the hip and/or knee To predict the 2-year course of activity limitations in patients with early knee and/or hip osteoarthritis (OA).The Cohort Hip & Cohort Knee (CHECK) study is a prospective followup study. The CHECK cohort, comprising participants (n = 1,002) with early OA-related knee and/or hip symptoms, was followed for 2 years. Participants completed questionnaires and underwent physical (...) , laboratory, and radiographic examination. Regression models were used to examine whether baseline variables predicted the course of activity limitations as measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Analyses were performed separately for participants with knee symptoms and participants with hip symptoms.After 2 years of followup, activity limitations slightly decreased. Large between-subject variation was observed in WOMAC change scores. In participants
ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety ALO-01 (EMBEDA [morphine sulfate and naltrexone hydrochloride] extended-release capsules [King Pharmaceuticals, Inc, Bridgewater, NJ]), indicated for chronic moderate-to-severe pain, is designed to release naltrexone upon tampering (eg, by crushing), reducing morphine-induced subjective effects (...) . This multicenter, randomized, double-blind, crossover study assessed pharmacokinetics, efficacy, and safety of ALO-01 and compared them with extended-release morphine sulfate (ERMS, KADIAN [morphine sulfate extended-release] capsules [Actavis US, Morristown, NJ]) in adults (N = 113) with osteoarthritis pain. Study periods included washout until pain flare (intensity > or =5, 0 to 10; 0 = no pain, 10 = worst pain); dose titration with ERMS (20 to 160mg BID); and randomization to 2 (crossover) 14-day treatment
Spa therapy in the treatment of kneeosteoarthritis: a large randomised multicentre trial To determine whether spa therapy, plus home exercises and usual medical treatment provides any benefit over exercises and usual treatment, in the management of knee osteoarthritis.Large multicentre randomised prospective clinical trial of patients with kneeosteoarthritis according to the American College of Rheumatology criteria, attending French spa resorts as outpatients between June 2006 and April 2007 (...) as > or =19.9 mm on the visual analogue pain scale and/or > or =9.1 points in a normalised Western Ontario and McMaster Universities osteoarthritis index function score and no knee surgery.The intention to treat analysis included 187 controls and 195 spa therapy patients. At 6 months, 99/195 (50.8%) spa group patients had MCII and 68/187 (36.4%) controls (chi(2)=8.05; df=1; p=0.005). However, no improvement in quality of life (Short Form 36) or patient acceptable symptom state was observed at 6 months.For
osteoarthritis.The exposure was leg-length inequality, measured by full-limb radiography. The outcomes were prevalent, incident, and progressive kneeosteoarthritis. Radiographic osteoarthritis was defined as Kellgren and Lawrence grade 2 or greater, and symptomatic osteoarthritis was defined as radiographic disease in a consistently painful knee.Compared with leg-length inequality less than 1 cm, leg-length inequality of 1 cm or more was associated with prevalent radiographic (53% vs. 36%; odds ratio [OR], 1.9 (...) Association of leg-length inequality with kneeosteoarthritis: a cohort study. Leg-length inequality is common in the general population and may accelerate development of knee osteoarthritis.To determine whether leg-length inequality is associated with prevalent, incident, and progressive knee osteoarthritis.Prospective observational cohort study.Population samples from Birmingham, Alabama, and Iowa City, Iowa.3026 participants aged 50 to 79 years with or at high risk for knee
High systemic bone mineral density increases the risk of incident kneeOA and joint space narrowing, but not radiographic progression of existing kneeOA: the MOST study Previous studies suggest that high systemic bone mineral density (BMD) is associated with incident kneeosteoarthritis (OA) defined by osteophytes but not with joint space narrowing (JSN), and are inconsistent regarding BMD and progression of existing OA. The association of BMD with incident and progressive tibiofemoral OA (...) was tested in a large prospective study of men and women aged 50-79 years with or at risk for knee OA.Baseline and 30-month weight-bearing posteroanterior and lateral knee radiographs were scored for Kellgren-Lawrence (K-L) grade, JSN and osteophytes. Incident OA was defined as the development of K-L grade > or =2 at follow-up. All knees were classified for increases in grade of JSN and osteophytes from baseline. The association of gender-specific quartiles of baseline BMD with risk of incident
Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial The primary objective was to compare a single, 6 ml, intra-articular injection of hylan G-F 20 with placebo in patients with symptomatic kneeosteoarthritis. The safety of a repeat injection of hylan G-F 20 was also assessed.Patients with primary osteoarthritisknee pain were randomly assigned (...) . There was no difference between the safety results of the two groups. No increased risk of local adverse events was observed in the open, repeat treatment phase.This placebo-controlled study demonstrated that, in patients with kneeosteoarthritis, a single 6 ml intra-articular injection of hylan G-F 20 is safe and effective in providing statistically significant, clinically relevant pain relief over 26 weeks, with a modest difference versus placebo.