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Latest & greatest articles for knee osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on knee osteoarthritis or other clinical topics then use Trip today.
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Impact of obesity and kneeosteoarthritis on morbidity and mortality in older americans. Obesity and kneeosteoarthritis are among the most frequent chronic conditions affecting Americans aged 50 to 84 years.To estimate quality-adjusted life-years lost due to obesity and kneeosteoarthritis and health benefits of reducing obesity prevalence to levels observed a decade ago.The U.S. Census and obesity data from national data sources were combined with estimated prevalence of symptomatic knee (...) osteoarthritis to assign persons aged 50 to 84 years to 4 subpopulations: nonobese without kneeosteoarthritis (reference group), nonobese with kneeosteoarthritis, obese without kneeosteoarthritis, and obese with kneeosteoarthritis. The Osteoarthritis Policy Model, a computer simulation model of kneeosteoarthritis and obesity, was used to estimate quality-adjusted life-year losses due to kneeosteoarthritis and obesity in comparison with the reference group.United States.U.S. population aged 50 to 84
Therapeutic trajectory following intra-articular hyaluronic acid injection in kneeosteoarthritis ? meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
of the knee. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication Dates. 2011 Authors' conclusions Osteoarthritis (OA), also known as degenerativejointdisease, is the most common form of arthritis. OA affects > 27 million individuals in the United States, generally aged > 45 years; approximately 9 million have kneeOA. OA is one of the five leading causes of physical disability, morbidity, and social isolation in older men and women in the community. Deterioration of the joint structure (...) and function not only reduces the quality of life and mobility but also significantly impacts the economy in terms of healthcare costs and lost productivity. Standard treatments for kneeOA include medications, physical therapy, and, if severe, total knee arthroplasty (TKA) to replace the affected joint. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Humans; Osteoarthritis, Knee Language Published English Country of organisation United States
neuropathies; had symptomatic co-morbidities affecting walking more than the kneeosteoarthritis; were unwilling to start new medication during the trial; had knee hip or ankle surgery; had peripheral or central nervous systema diseases; had hip lumbar spine and ankle osteoarthritis; had secondary kneeosteoarthritis or symptomatic deformity of the foot and ankle; had any other disease treated with insoles; or had received intra-articular injections in the previous six months. Non-steroidal anti (...) ; 67(1): 35-43 Indexing Status Subject indexing assigned by CRD MeSH Equipment Design; Humans; KneeJoint; Orthotic Devices; Osteoarthritis, Knee; Pain; Pain Management; Recovery of Function; Shoes AccessionNumber 12011004571 Date bibliographic record published 20/02/2012 Date abstract record published 28/05/2012 Record Status This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each critical abstract contains a brief summary of the review methods
NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
. The main effectiveness parameters were the time to failure and the failure rates of joint replacements due to short-term causes. This evidence was from revision rates over seven years reported in the Australian National Joint Replacement Registry. Monetary benefit and utility valuations: The disability weights were derived from the Burden of Disease study to quantify the impact of osteoarthritis on quality of life. Quality of life estimates, obtained using questionnaires like the European Quality (...) Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model Higashi H, Barendregt JJ Record Status This is a critical abstract of an economic
Lateral wedge insoles for medial kneeosteoarthritis: 12 month randomised controlled trial. To assess the effect of lateral wedge insoles compared with flat control insoles on improving symptoms and slowing structural disease progression in medial knee osteoarthritis.Randomised controlled trial.Community in Melbourne, Australia.200 people aged 50 or more with clinical and radiographic diagnosis of mild to moderately severe medial knee osteoarthritis.Full length 5 degree lateral wedged insoles (...) or flat control insoles worn inside the shoes daily for 12 months.Primary symptomatic outcome was change in overall knee pain (past week) measured on an 11 point numerical rating scale. Primary structural outcome was change in volume of medial tibial cartilage from magnetic resonance imaging scans. Secondary clinical outcomes included changes in measures of pain, function, stiffness, and health related quality of life. Secondary structural outcomes included progression of medial cartilage defects
Prognostic factors for the two-year course of activity limitations in early osteoarthritis of the hip and/or knee To predict the 2-year course of activity limitations in patients with early knee and/or hip osteoarthritis (OA).The Cohort Hip & Cohort Knee (CHECK) study is a prospective followup study. The CHECK cohort, comprising participants (n = 1,002) with early OA-related knee and/or hip symptoms, was followed for 2 years. Participants completed questionnaires and underwent physical (...) , laboratory, and radiographic examination. Regression models were used to examine whether baseline variables predicted the course of activity limitations as measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Analyses were performed separately for participants with knee symptoms and participants with hip symptoms.After 2 years of followup, activity limitations slightly decreased. Large between-subject variation was observed in WOMAC change scores. In participants
ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety ALO-01 (EMBEDA [morphine sulfate and naltrexone hydrochloride] extended-release capsules [King Pharmaceuticals, Inc, Bridgewater, NJ]), indicated for chronic moderate-to-severe pain, is designed to release naltrexone upon tampering (eg, by crushing), reducing morphine-induced subjective effects (...) . This multicenter, randomized, double-blind, crossover study assessed pharmacokinetics, efficacy, and safety of ALO-01 and compared them with extended-release morphine sulfate (ERMS, KADIAN [morphine sulfate extended-release] capsules [Actavis US, Morristown, NJ]) in adults (N = 113) with osteoarthritis pain. Study periods included washout until pain flare (intensity > or =5, 0 to 10; 0 = no pain, 10 = worst pain); dose titration with ERMS (20 to 160mg BID); and randomization to 2 (crossover) 14-day treatment
Spa therapy in the treatment of kneeosteoarthritis: a large randomised multicentre trial To determine whether spa therapy, plus home exercises and usual medical treatment provides any benefit over exercises and usual treatment, in the management of knee osteoarthritis.Large multicentre randomised prospective clinical trial of patients with kneeosteoarthritis according to the American College of Rheumatology criteria, attending French spa resorts as outpatients between June 2006 and April 2007 (...) as > or =19.9 mm on the visual analogue pain scale and/or > or =9.1 points in a normalised Western Ontario and McMaster Universities osteoarthritis index function score and no knee surgery.The intention to treat analysis included 187 controls and 195 spa therapy patients. At 6 months, 99/195 (50.8%) spa group patients had MCII and 68/187 (36.4%) controls (chi(2)=8.05; df=1; p=0.005). However, no improvement in quality of life (Short Form 36) or patient acceptable symptom state was observed at 6 months.For
osteoarthritis.The exposure was leg-length inequality, measured by full-limb radiography. The outcomes were prevalent, incident, and progressive kneeosteoarthritis. Radiographic osteoarthritis was defined as Kellgren and Lawrence grade 2 or greater, and symptomatic osteoarthritis was defined as radiographic disease in a consistently painful knee.Compared with leg-length inequality less than 1 cm, leg-length inequality of 1 cm or more was associated with prevalent radiographic (53% vs. 36%; odds ratio [OR], 1.9 (...) Association of leg-length inequality with kneeosteoarthritis: a cohort study. Leg-length inequality is common in the general population and may accelerate development of knee osteoarthritis.To determine whether leg-length inequality is associated with prevalent, incident, and progressive knee osteoarthritis.Prospective observational cohort study.Population samples from Birmingham, Alabama, and Iowa City, Iowa.3026 participants aged 50 to 79 years with or at high risk for knee
High systemic bone mineral density increases the risk of incident kneeOA and joint space narrowing, but not radiographic progression of existing kneeOA: the MOST study Previous studies suggest that high systemic bone mineral density (BMD) is associated with incident kneeosteoarthritis (OA) defined by osteophytes but not with joint space narrowing (JSN), and are inconsistent regarding BMD and progression of existing OA. The association of BMD with incident and progressive tibiofemoral OA (...) was tested in a large prospective study of men and women aged 50-79 years with or at risk for knee OA.Baseline and 30-month weight-bearing posteroanterior and lateral knee radiographs were scored for Kellgren-Lawrence (K-L) grade, JSN and osteophytes. Incident OA was defined as the development of K-L grade > or =2 at follow-up. All knees were classified for increases in grade of JSN and osteophytes from baseline. The association of gender-specific quartiles of baseline BMD with risk of incident
Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial The primary objective was to compare a single, 6 ml, intra-articular injection of hylan G-F 20 with placebo in patients with symptomatic kneeosteoarthritis. The safety of a repeat injection of hylan G-F 20 was also assessed.Patients with primary osteoarthritisknee pain were randomly assigned (...) . There was no difference between the safety results of the two groups. No increased risk of local adverse events was observed in the open, repeat treatment phase.This placebo-controlled study demonstrated that, in patients with kneeosteoarthritis, a single 6 ml intra-articular injection of hylan G-F 20 is safe and effective in providing statistically significant, clinically relevant pain relief over 26 weeks, with a modest difference versus placebo.
Tai Chi is effective in treating kneeosteoarthritis: a randomized controlled trial To evaluate the effectiveness of Tai Chi in the treatment of kneeosteoarthritis (OA) symptoms.We conducted a prospective, single-blind, randomized controlled trial of 40 individuals with symptomatic tibiofemoral OA. Patients were randomly assigned to 60 minutes of Tai Chi (10 modified forms from classic Yang style) or attention control (wellness education and stretching) twice weekly for 12 weeks. The primary (...) Studies Depression Scale (-6.70 [95% CI -11.63, -1.77; P = 0.009]), self-efficacy score (0.71 [95% CI 0.03, 1.39; P = 0.04]), and Short Form 36 physical component summary (7.43 [95% CI 2.50, 12.36; P = 0.004]). No severe adverse events were observed.Tai Chi reduces pain and improves physical function, self-efficacy, depression, and health-related quality of life for kneeOA.
Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of osteoarthritis of the knee: a mixed methods study of the feasibility of conducting a surgical placebo-controlled trial (the KORAL study) Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
with tanezumab was associated with a reduction in joint pain and improvement in function, with mild and moderate adverse events, among patients with moderate-to-severe osteoarthritis of the knee. (Funded by Rinat Neuroscience; ClinicalTrials.gov number, NCT00394563.). (...) Tanezumab for the treatment of pain from osteoarthritis of the knee. Increased expression of nerve growth factor in injured or inflamed tissue is associated with increased pain. This proof-of-concept study was designed to investigate the safety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits nerve growth factor.We randomly assigned 450 patients with osteoarthritis of the knee to receive tanezumab (administered at a dose of 10, 25, 50, 100, or 200 μg
Comparison of unicompartmental knee arthroplasty and total knee arthroplasty in the treatment of unicompartmental osteoarthritis: a meta-analysis Comparison of unicompartmental knee arthroplasty and total knee arthroplasty in the treatment of unicompartmental osteoarthritis: a meta-analysis Comparison of unicompartmental knee arthroplasty and total knee arthroplasty in the treatment of unicompartmental osteoarthritis: a meta-analysis Zhang Q, Guo W, Zhang Q, Sun R, Liu Z, Cheng L, Xia Y, Chen G (...) , Ding R, Zhu D, Li Z CRD summary This review compared clinical outcomes of unicompartmental knee arthroplasty with total knee arthroplasty in the treatment of unicompartmental kneeosteoarthritis and concluded that unicompartmental knee arthroplasty provided better postoperative function and had fewer complications than total knee arthroplasty. Uncertainty about the review process and the poor quality of included studies mean that the authors' conclusions should be interpreted with caution. Authors