Latest & greatest articles for knee osteoarthritis

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Top results for knee osteoarthritis

181. Inflammation related to synovectomy during total knee replacement in patients with primary osteoarthritis: a prospective, randomised study Full Text available with Trip Pro

Inflammation related to synovectomy during total knee replacement in patients with primary osteoarthritis: a prospective, randomised study We compared inflammation in the knee after total knee replacement (TKR) for primary osteoarthritis between two groups of patients undergoing joint replacement with and without synovectomy. A total of 67 patients who underwent unilateral TKR were randomly divided into group I, TKR without synovectomy, and group II, TKR with synovectomy. Clinical outcomes (...) , serial serum inflammatory markers (including interleukin-6 (IL-6), CRP and ESR) and the difference in temperature of the skin of the knee, compared with the contralateral side, were sequentially evaluated until 26 weeks after surgery. Pre-operatively, there were no statistically different clinical parameters between groups I and II. At the 26-week follow-up, both groups had a similarly significantly improved American Knee Society clinical score (p < 0.001) and functional score (p < 0.001

2011 EvidenceUpdates Controlled trial quality: uncertain

182. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI Full Text available with Trip Pro

Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI To determine the effect of chondroitin sulphate (CS) treatment on cartilage volume loss, subchondral bone marrow lesions (BML), synovitis and disease symptoms in patients with knee osteoarthritis (OA).In this pilot multicentre, randomised, double-blind (...) as 6 months for the global knee (p=0.030), lateral compartment (p=0.015) and tibial plateaus (p=0.002), with significance persisting at 12 months. Significantly lower BML scores were found for the CS group at 12 months in the lateral compartment (p=0.035) and the lateral femoral condyle (p=0.044). Disease symptoms were similar between the two groups.CS treatment significantly reduced the cartilage volume loss in knee OA starting at 6 months of treatment, and BML at 12 months. These findings suggest

2011 EvidenceUpdates Controlled trial quality: predicted high

183. Risks of oral or transdermal opioids outweigh benefits for osteoarthritis of the knee or hip

Risks of oral or transdermal opioids outweigh benefits for osteoarthritis of the knee or hip PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Risks of oral or transdermal opioids outweigh benefits for osteoarthritis of the knee or hip Clinical question How effective are oral or transdermal opioids in patients with osteoarthritis (OA) of the knee or hip? Bottom line Compared to placebo (...) poorer quality of life and reduced functional capacity, and does not seem to improve pain relief.² Context OA is the most common form of joint disease and the leading cause of pain and physical disability in the elderly. Opioids may be a viable treatment option if patients suffer from severe pain, or if other analgesics are contraindicated. However, the evidence on their effectiveness and safety is contradictory. Cochrane Systematic Review Nuesch E et al. Oral or transdermal opioids

2011 Cochrane PEARLS

184. Doxycycline ineffective for osteoarthritis of the knee or hip

Osteoarthritis is a chronic joint disease that involves degeneration of articular cartilage. Pre-clinical data has suggested that doxycycline might act as a disease- modifying agent for the treatment of osteoarthritis, with the potential to slow cartilage degeneration. Cochrane Systematic Review Nuesch E et al. Doxycycline for osteoarthritis of the knee or hip. Cochrane Reviews 2009, Issue 4. Article No. CD007323. DOI: 10.1002/14651858.CD007323.pub2. This review contains one study involving 431 participants (...) Doxycycline ineffective for osteoarthritis of the knee or hip PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Doxycycline ineffective for osteoarthritis of the knee or hip Clinical question How effective is doxycycline for osteoarthritis (OA) of the knee or hip? Bottom line Compared to placebo, there is minimal or no symptomatic benefit (pain reduction and improved physical function

2011 Cochrane PEARLS

185. Agility and perturbation training techniques in exercise therapy for reducing pain and improving function in people with knee osteoarthritis: a randomized clinical trial Full Text available with Trip Pro

Agility and perturbation training techniques in exercise therapy for reducing pain and improving function in people with knee osteoarthritis: a randomized clinical trial Impairment-based exercise programs have yielded only small to moderate benefits in reducing pain and improving function in people with knee osteoarthritis (OA). It has previously been proposed that adding agility and perturbation training to exercise programs for people with knee OA may improve treatment effects for pain (...) and function.The purpose of this study was to examine the effectiveness of adding agility and perturbation techniques to standard exercise therapy compared with the standard exercise program alone for people with knee OA.This was a single-blinded randomized controlled trial.The study was conducted in the outpatient physical therapy clinic of a large, university-based health center.One hundred eighty-three people with knee OA (122 women, 61 men) participated.Participants were randomly assigned to either a group

2011 EvidenceUpdates Controlled trial quality: uncertain

186. All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. Full Text available with Trip Pro

All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. To examine all cause and disease specific mortality in patients with osteoarthritis of the knee or hip.Population based cohort study.General practices in the southwest of England.1163 patients aged 35 years or over with symptoms and radiological confirmation of osteoarthritis of the knee or hip.Age and sex standardised mortality ratios and multivariable hazard ratios of death (...) after a median of 14 years' follow-up.Patients with osteoarthritis had excess all cause mortality compared with the general population (standardised mortality ratio 1.55, 95% confidence interval 1.41 to 1.70). Excess mortality was observed for all disease specific causes of death but was particularly pronounced for cardiovascular (standardised mortality ratio 1.71, 1.49 to 1.98) and dementia associated mortality (1.99, 1.22 to 3.25). Mortality increased with increasing age (P for trend <0.001), male

2011 BMJ

187. Impact of obesity and knee osteoarthritis on morbidity and mortality in older americans. Full Text available with Trip Pro

Impact of obesity and knee osteoarthritis on morbidity and mortality in older americans. Obesity and knee osteoarthritis are among the most frequent chronic conditions affecting Americans aged 50 to 84 years.To estimate quality-adjusted life-years lost due to obesity and knee osteoarthritis and health benefits of reducing obesity prevalence to levels observed a decade ago.The U.S. Census and obesity data from national data sources were combined with estimated prevalence of symptomatic knee (...) osteoarthritis to assign persons aged 50 to 84 years to 4 subpopulations: nonobese without knee osteoarthritis (reference group), nonobese with knee osteoarthritis, obese without knee osteoarthritis, and obese with knee osteoarthritis. The Osteoarthritis Policy Model, a computer simulation model of knee osteoarthritis and obesity, was used to estimate quality-adjusted life-year losses due to knee osteoarthritis and obesity in comparison with the reference group.United States.U.S. population aged 50 to 84

2011 Annals of Internal Medicine

188. Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis ? meta-analysis

Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis ? meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

189. BioniCare Knee System (VQ OrthoCare) for treatment of osteoarthritis of the knee

of the knee. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication Dates. 2011 Authors' conclusions Osteoarthritis (OA), also known as degenerative joint disease, is the most common form of arthritis. OA affects > 27 million individuals in the United States, generally aged > 45 years; approximately 9 million have knee OA. OA is one of the five leading causes of physical disability, morbidity, and social isolation in older men and women in the community. Deterioration of the joint structure (...) and function not only reduces the quality of life and mobility but also significantly impacts the economy in terms of healthcare costs and lost productivity. Standard treatments for knee OA include medications, physical therapy, and, if severe, total knee arthroplasty (TKA) to replace the affected joint. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Humans; Osteoarthritis, Knee Language Published English Country of organisation United States

2011 Health Technology Assessment (HTA) Database.

190. A meta-analysis into the effect of lateral-wedged insoles with subtalar strapping versus traditional insoles in adults with medial knee osteoarthritis

neuropathies; had symptomatic co-morbidities affecting walking more than the knee osteoarthritis; were unwilling to start new medication during the trial; had knee hip or ankle surgery; had peripheral or central nervous systema diseases; had hip lumbar spine and ankle osteoarthritis; had secondary knee osteoarthritis or symptomatic deformity of the foot and ankle; had any other disease treated with insoles; or had received intra-articular injections in the previous six months. Non-steroidal anti (...) ; 67(1): 35-43 Indexing Status Subject indexing assigned by CRD MeSH Equipment Design; Humans; Knee Joint; Orthotic Devices; Osteoarthritis, Knee; Pain; Pain Management; Recovery of Function; Shoes AccessionNumber 12011004571 Date bibliographic record published 20/02/2012 Date abstract record published 28/05/2012 Record Status This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each critical abstract contains a brief summary of the review methods

2011 DARE.

191. NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes

NSAIDs vs acetaminophen in knee and hip osteoarthritis: a systematic review regarding heterogeneity influencing the outcomes Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

192. Systematic review: Large review finds no clinically important effect of glucosamine or chondroitin on pain in people with osteoarthritis of the knee or hip but results are questionable and likely due to heterogeneity

Altmetric.com Commentary on: Wandel S , Jüni P , Tendal B , et al . Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. Context Treatment of osteoarthritis with unspecific symptomatic agents is not satisfactory and burdened with safety issues. The use of glucosamine and/or chondroitin as disease-modifying agents is increasingly popular, despite conflicting clinical trial evidence with the many available products. Wandel and colleagues (...) Systematic review: Large review finds no clinically important effect of glucosamine or chondroitin on pain in people with osteoarthritis of the knee or hip but results are questionable and likely due to heterogeneity Large review finds no clinically important effect of glucosamine or chondroitin on pain in people with osteoarthritis of the knee or hip but results are questionable and likely due to heterogeneity | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor

2011 Evidence-Based Medicine

193. Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model Full Text available with Trip Pro

. The main effectiveness parameters were the time to failure and the failure rates of joint replacements due to short-term causes. This evidence was from revision rates over seven years reported in the Australian National Joint Replacement Registry. Monetary benefit and utility valuations: The disability weights were derived from the Burden of Disease study to quantify the impact of osteoarthritis on quality of life. Quality of life estimates, obtained using questionnaires like the European Quality (...) Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model Cost-effectiveness of total hip and knee replacements for the Australian population with osteoarthritis: discrete-event simulation model Higashi H, Barendregt JJ Record Status This is a critical abstract of an economic

2011 NHS Economic Evaluation Database.

194. Lateral wedge insoles for medial knee osteoarthritis: 12 month randomised controlled trial. Full Text available with Trip Pro

Lateral wedge insoles for medial knee osteoarthritis: 12 month randomised controlled trial. To assess the effect of lateral wedge insoles compared with flat control insoles on improving symptoms and slowing structural disease progression in medial knee osteoarthritis.Randomised controlled trial.Community in Melbourne, Australia.200 people aged 50 or more with clinical and radiographic diagnosis of mild to moderately severe medial knee osteoarthritis.Full length 5 degree lateral wedged insoles (...) or flat control insoles worn inside the shoes daily for 12 months.Primary symptomatic outcome was change in overall knee pain (past week) measured on an 11 point numerical rating scale. Primary structural outcome was change in volume of medial tibial cartilage from magnetic resonance imaging scans. Secondary clinical outcomes included changes in measures of pain, function, stiffness, and health related quality of life. Secondary structural outcomes included progression of medial cartilage defects

2011 BMJ Controlled trial quality: predicted high

195. Prognostic factors for the two-year course of activity limitations in early osteoarthritis of the hip and/or knee (Abstract)

Prognostic factors for the two-year course of activity limitations in early osteoarthritis of the hip and/or knee To predict the 2-year course of activity limitations in patients with early knee and/or hip osteoarthritis (OA).The Cohort Hip & Cohort Knee (CHECK) study is a prospective followup study. The CHECK cohort, comprising participants (n = 1,002) with early OA-related knee and/or hip symptoms, was followed for 2 years. Participants completed questionnaires and underwent physical (...) , laboratory, and radiographic examination. Regression models were used to examine whether baseline variables predicted the course of activity limitations as measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Analyses were performed separately for participants with knee symptoms and participants with hip symptoms.After 2 years of followup, activity limitations slightly decreased. Large between-subject variation was observed in WOMAC change scores. In participants

2010 EvidenceUpdates

196. ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety (Abstract)

ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety ALO-01 (EMBEDA [morphine sulfate and naltrexone hydrochloride] extended-release capsules [King Pharmaceuticals, Inc, Bridgewater, NJ]), indicated for chronic moderate-to-severe pain, is designed to release naltrexone upon tampering (eg, by crushing), reducing morphine-induced subjective effects (...) . This multicenter, randomized, double-blind, crossover study assessed pharmacokinetics, efficacy, and safety of ALO-01 and compared them with extended-release morphine sulfate (ERMS, KADIAN [morphine sulfate extended-release] capsules [Actavis US, Morristown, NJ]) in adults (N = 113) with osteoarthritis pain. Study periods included washout until pain flare (intensity > or =5, 0 to 10; 0 = no pain, 10 = worst pain); dose titration with ERMS (20 to 160mg BID); and randomization to 2 (crossover) 14-day treatment

2010 EvidenceUpdates Controlled trial quality: uncertain

197. Spa therapy in the treatment of knee osteoarthritis: a large randomised multicentre trial Full Text available with Trip Pro

Spa therapy in the treatment of knee osteoarthritis: a large randomised multicentre trial To determine whether spa therapy, plus home exercises and usual medical treatment provides any benefit over exercises and usual treatment, in the management of knee osteoarthritis.Large multicentre randomised prospective clinical trial of patients with knee osteoarthritis according to the American College of Rheumatology criteria, attending French spa resorts as outpatients between June 2006 and April 2007 (...) as > or =19.9 mm on the visual analogue pain scale and/or > or =9.1 points in a normalised Western Ontario and McMaster Universities osteoarthritis index function score and no knee surgery.The intention to treat analysis included 187 controls and 195 spa therapy patients. At 6 months, 99/195 (50.8%) spa group patients had MCII and 68/187 (36.4%) controls (chi(2)=8.05; df=1; p=0.005). However, no improvement in quality of life (Short Form 36) or patient acceptable symptom state was observed at 6 months.For

2010 EvidenceUpdates Controlled trial quality: uncertain

198. Association of leg-length inequality with knee osteoarthritis: a cohort study. Full Text available with Trip Pro

osteoarthritis.The exposure was leg-length inequality, measured by full-limb radiography. The outcomes were prevalent, incident, and progressive knee osteoarthritis. Radiographic osteoarthritis was defined as Kellgren and Lawrence grade 2 or greater, and symptomatic osteoarthritis was defined as radiographic disease in a consistently painful knee.Compared with leg-length inequality less than 1 cm, leg-length inequality of 1 cm or more was associated with prevalent radiographic (53% vs. 36%; odds ratio [OR], 1.9 (...) Association of leg-length inequality with knee osteoarthritis: a cohort study. Leg-length inequality is common in the general population and may accelerate development of knee osteoarthritis.To determine whether leg-length inequality is associated with prevalent, incident, and progressive knee osteoarthritis.Prospective observational cohort study.Population samples from Birmingham, Alabama, and Iowa City, Iowa.3026 participants aged 50 to 79 years with or at high risk for knee

2010 Annals of Internal Medicine

199. High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study Full Text available with Trip Pro

High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study Previous studies suggest that high systemic bone mineral density (BMD) is associated with incident knee osteoarthritis (OA) defined by osteophytes but not with joint space narrowing (JSN), and are inconsistent regarding BMD and progression of existing OA. The association of BMD with incident and progressive tibiofemoral OA (...) was tested in a large prospective study of men and women aged 50-79 years with or at risk for knee OA.Baseline and 30-month weight-bearing posteroanterior and lateral knee radiographs were scored for Kellgren-Lawrence (K-L) grade, JSN and osteophytes. Incident OA was defined as the development of K-L grade > or =2 at follow-up. All knees were classified for increases in grade of JSN and osteophytes from baseline. The association of gender-specific quartiles of baseline BMD with risk of incident

2010 EvidenceUpdates

200. Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial Full Text available with Trip Pro

Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial The primary objective was to compare a single, 6 ml, intra-articular injection of hylan G-F 20 with placebo in patients with symptomatic knee osteoarthritis. The safety of a repeat injection of hylan G-F 20 was also assessed.Patients with primary osteoarthritis knee pain were randomly assigned (...) . There was no difference between the safety results of the two groups. No increased risk of local adverse events was observed in the open, repeat treatment phase.This placebo-controlled study demonstrated that, in patients with knee osteoarthritis, a single 6 ml intra-articular injection of hylan G-F 20 is safe and effective in providing statistically significant, clinically relevant pain relief over 26 weeks, with a modest difference versus placebo.

2010 EvidenceUpdates Controlled trial quality: predicted high