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Latest & greatest articles for knee osteoarthritis
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Structural and symptomatic efficacy of glucsamine and chondroitin in kneeosteoarthritis: a comprehensive meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
osteoarthritis. The available evidence suggested that Hylan G-F 20 injections decreased pain and improved knee function in the short term. The authors' conclusions are supported by the data presented, but differences between included studies, suggest they should be viewed with caution. Authors' objectives To review the efficacy, effectiveness and safety of intra-articular injections of Hylan G-F 20 for the treatment of painful kneeosteoarthritis (OA). Searching The manufacturers of Hylan G-F 20 supplied (...) ; n=386): a single course of Hylan G-F 20 produced a significant decrease of painful symptoms of kneeOA (as measured on the visual analogue scale), and a short-term improvement in joint function (up to 3 to 6 months post-treatment). The authors noted that significant decreases in symptoms, compared with baseline, were often reported in both the treatment and control groups. Hylan G-F 20 versus NSAIDs and other conventional therapies (3 RCTs; n=407): 2 RCTs found no evidence that intra-articular
A controlled trial of arthroscopic surgery for osteoarthritis of the knee. Many patients report symptomatic relief after undergoing arthroscopy of the knee for osteoarthritis, but it is unclear how the procedure achieves this result. We conducted a randomized, placebo-controlled trial to evaluate the efficacy of arthroscopy for osteoarthritis of the knee.A total of 180 patients with osteoarthritis of the knee were randomly assigned to receive arthroscopic débridement, arthroscopic lavage (...) , and 51.4+/-23.2, respectively, at two years (P=0.64 and P=0.96, respectively). Furthermore, the 95 percent confidence intervals for the differences between the placebo group and the intervention groups exclude any clinically meaningful difference.In this controlled trial involving patients with osteoarthritis of the knee, the outcomes after arthroscopic lavage or arthroscopic débridement were no better than those after a placebo procedure.
Home based exercise programme for knee pain and kneeosteoarthritis: randomised controlled trial. To determine whether a home based exercise programme can improve outcomes in patients with knee pain.Pragmatic, factorial randomised controlled trial of two years' duration.Two general practices in Nottingham.786 men and women aged >/=45 years with self reported knee pain.Participants were randomised to four groups to receive exercise therapy, monthly telephone contact, exercise therapy plus (...) telephone contact, or no intervention. Patients in the no intervention and combined exercise and telephone groups were randomised to receive or not receive a placebo health food tablet.Primary outcome was self reported score for knee pain on the Western Ontario and McMaster universities (WOMAC) osteoarthritis index at two years. Secondary outcomes included knee specific physical function and stiffness (scored on WOMAC index), general physical function (scored on SF-36 questionnaire), psychological
Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. Osteoarthritis (OA) is often treated with nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, or specific inhibitors of cyclooxygenase 2 (COX-2).To assess the relative therapeutic efficacy of rofecoxib, celecoxib, and acetaminophen in adults with OA.Randomized, parallel-group, double-blind trial, conducted from June 1999 to February 2000, in 29 clinical centers in the United (...) States.Three hundred eighty-two patients aged at least 40 years who had OA of the knee that was previously treated with NSAIDs or acetaminophen.Patients were randomly assigned to receive rofecoxib, 12.5 mg/d (n = 96); rofecoxib, 25 mg/d (n = 95); celecoxib, 200 mg/d (n = 97); or acetaminophen, 4000 mg/d (n = 94) for 6 weeks.Assessments over days 1 to 6 and over 6 weeks included pain on walking, night pain, pain at rest, and morning stiffness as measured on a Western Ontario McMaster Universities
, research should aim to determine the most effective treatment to introduce at the various stages of the disease. Funding Arthritis Society (Canada); Ontario Ministry of Health; Department of Human Resources Development of Canada (Summer Student Program). Bibliographic details Brosseau L, MacLeay L, Robinson V, Casimiro L, Pelland L, Wells G, Tugwell P, McGowan J. Efficacy of balneotherapy for osteoarthritis of the knee: a systematic review. Physical Therapy Reviews 2002; 7(4): 209-222 Other (...) publications of related interest Brosseau L, Robinson V, Pelland L, Casimiro L, Milne S, Judd M et al. Efficacy of balneotherapy in rheumatoid arthritis: a meta-analysis. Phys Ther Rev 2002;7:67-87. Indexing Status Subject indexing assigned by CRD MeSH Arthritis, Rheumatoid /therapy; Balneology; Hydrotherapy; KneeJoint; Osteoarthritis /therapy; Range of Motion, Articular AccessionNumber 12005005093 Date bibliographic record published 31/05/2007 Date abstract record published 31/05/2007 Record Status
drawn. Health technology The study examined viscosupplementation with hylan G-F 20 for the treatment of osteoarthritis (OA) of the knee in Canada. The comparator was treatment without hylan G-F 20 Type of intervention Treatment. Economic study type Cost-utility analysis. Study population The study population included ambulatory patients over 40 years old in Canada with a primary diagnosis of radiologically verified OA in the study knee (knee most symptomatic or with the most predominant (...) A prospective, randomized, pragmatic, health outcomes trial evaluating the incorporation of hylan G-F 20 into the treatment paradigm for patients with kneeosteoarthritis (Part 2 of 2): economic results A prospective, randomized, pragmatic, health outcomes trial evaluating the incorporation of hylan G-F 20 into the treatment paradigm for patients with kneeosteoarthritis (Part 2 of 2): economic results A prospective, randomized, pragmatic, health outcomes trial evaluating the incorporation
galvanic current or short wave diathermy for the outcomes of pain and patient-assessed improvement.Ultrasound therapy appears to have no benefit over placebo or short wave diathermy for patients with kneeOA. These conclusions are limited by the poor reporting of the characteristics of the device, of the population, of the OA,and therapeutic application of the ultrasound and low methodological quality of the trials included. No conclusions can be drawn about the use of ultrasound in smaller joints (...) Therapeutic ultrasound for osteoarthritis of the knee. Therapeutic ultrasound is one of several physical therapy modalities suggested for the management of pain and loss of function due to OA.To assess the effectiveness of therapeutic ultrasound therapy for treating OA.We searched the Cochrane Musculoskeletal Group trials register, and MEDLINE, up to the end of December 2000, using the sensitive search strategy developed by the Cochrane Collaboration. The search was complemented
The Oxford unicompartmental knee replacement for osteoarthritis The Oxford unicompartmental knee replacement for osteoarthritis The Oxford unicompartmental knee replacement for osteoarthritis Brown A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Brown A. The Oxford unicompartmental knee replacement for osteoarthritis. Ottawa: Canadian (...) Coordinating Office for Health Technology Assessment/Office Canadien de Coordination de l'Evaluation des Technologies de la Sante (CCOHTA) 2001: 4 Authors' objectives To summarise the available evidence on the use of the Oxford unicompartmental knee replacement for osteoarthritis. Authors' conclusions The Oxford unicompartmental knee replacement is a reliable treatment for medial knee compartment osteoarthritis, provided patients with the correct indications are chosen and the appropriate surgical
Use of Hyaluronan in osteoarthritis of the knee (Sodium hyaluronate for intra-articular injection) Use of Hyaluronan in osteoarthritis of the knee (Sodium hyaluronate for intra-articular injection) Use of Hyaluronan in osteoarthritis of the knee (Sodium hyaluronate for intra-articular injection) Medical Technology Unit - Swiss Federal Office of Public Health Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Medical Technology Unit - Swiss Federal Office of Public Health. Use of Hyaluronan in osteoarthritis of the knee (Sodium hyaluronate for intra-articular injection) Medical Technology Unit - Swiss Federal Office of Public Health (MTU-SFOPH). 2001 Authors' objectives The aim of this report was to assess the statistical significance for the efficacy, tolerability and safety of Ostenil compared to Synvisc for the treatment
Transcutaneous electrical nerve stimulation for kneeosteoarthritis. Osteoarthritis (OA) is a disease that affects synovial joints, which mainly causes degeneration and destruction of hyaline cartilage. To date, no curative treatment for OA exists. The primary goals for OA therapy are to relieve pain, maintain or improve functional status, and minimize deformity. Transcutaneous electrical nerve stimulation (TENS) is a noninvasive modality in physiotherapy that is commonly used to control both (...) acute and chronic pain arising from several conditions. A number of trials evaluating the efficacy of TENS in OA have been published.To assess the effectiveness of TENS in the treatment of kneeOA. The primary outcomes of interest were those described by the Outcome Measures in Rheumatology Clinical Trials (OMERACT) 3, which included pain relief, functional status, patient global assessment, and change in joint imaging for studies of one year or longer. The secondary objective was to determine
Non-aspirin, non-steroidal anti-inflammatory drugs for osteoarthritis of the knee. To determine whether there is a difference in the relative efficacy of individual non-steroidal anti-inflammatory drugs (NSAIDs) when used in the management of osteoarthritis (OA) of the knee.We searched Medline (1966-1995) and Bids Embase (Jan-Dec, 1980-1995). The searches were limited to publications in the English language, and were last perfomed in November 1996. We used modified Cochrane Collaboration search (...) , in the English language, comparing the efficacy of two non-aspirin NSAIDs in the management of osteoarthritis of the knee, were selected. Only trials with subjects aged 16 years and over, with clinical and/or radiological confirmation of the diagnosis of OAknee were included. Studies which compared one "trial" NSAID with one "reference" NSAID were included provided they were non-aspirin NSAIDs available in the UK and were licensed for the treatment of OA by general practitioners. Trials which were placebo
Is exercise effective treatment for osteoarthritis of the knee? Is exercise effective treatment for osteoarthritis of the knee? Is exercise effective treatment for osteoarthritis of the knee? Petrella R J Authors' objectives To review and determine the effectiveness of exercise treatment for osteoarthritis of the knee. Searching The author searched MEDLINE from June 1966 to January 2000 using the following MeSH terms and textwords: 'osteoarthritis' or 'arthritis' and 'knee', 'exercise (...) , motor function or motor development. The treatments could be performed actively, passively or against resistance. Additional interventions were allowed. Studies were excluded if they concerned peri-operative exercise treatment, or if the intervention groups received identical exercise treatment and, therefore, no contrast existed between the intervention groups. Participants included in the review Patients with osteoarthritis of the knee, assessed using either clinical or radiological criteria
, Shumaker S. The evaluation of pain in patients with kneeosteoarthritis: the knee pain scale. Journal of Rheumatology 1995;22:1124-9. Indexing Status Subject indexing assigned by NLM MeSH Aged; Community Health Services /economics; Cost-Benefit Analysis; Disabled Persons; Exercise Therapy /economics; Female; Geriatrics; Humans; KneeJoint /pathology; Male; Middle Aged; Osteoarthritis /economics /pathology /rehabilitation; Patient Education as Topic; Weight Lifting AccessionNumber 22000007671 Date (...) Cost-effectiveness of aerobic and resistance exercise in seniors with kneeosteoarthritis Cost-effectiveness of aerobic and resistance exercise in seniors with kneeosteoarthritis Cost-effectiveness of aerobic and resistance exercise in seniors with kneeosteoarthritis Sevick M A, Bradham D D, Muender M, Chen G J, Enarson C, Dailey M, Ettinger W H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief
status of people with kneeosteoarthritis (OA). Searching The following sources were searched for articles published in the English language: MEDLINE from 1966 to 1999, CINAHL from 1982 to 1999, and EMBASE from 1980 to 1999. The keywords were 'electrical stimulation', 'electrostimulation therapy', 'osteoarthritis', 'knee', 'physiotherapy', 'randomised clinical trials', 'randomised controlled trials' and 'muscle'. In addition, the Cochrane Database of Systematic Reviews was searched from 1991 to 1999 (...) parameters. Participants included in the review Patients with OA of the knee were eligible. The included participants were those with OA, severe OA, total knee arthroplasty, and those awaiting knee surgery. The majority of trials only included individuals with severe OA. The documented age ranged from 53 to 86 years; the mean age was 68.4 years. Details of disease severity and disability, gender, co-morbid conditions, disease duration and weight were either unclear or were not generally documented
the intervention in the Osteoarthritis of the Knee (OAK) study 3. To estimate the impact of the programme on the direct and indirect costs of health care related to kneearthritis over the year of follow-up. Authors' conclusions The OAK study failed to demonstrate improvements in knowledge, self-efficacy in arthritis management, or health outcomes after one year. The evidence in this study lends support to the contention that general practice based patient education programmes for kneeosteoarthritis (...) Economic evaluation of a primary care-based education programme for patients with osteoarthritis of the knee Economic evaluation of a primary care-based education programme for patients with osteoarthritis of the knee Economic evaluation of a primary care-based education programme for patients with osteoarthritis of the knee Lord J, Victor C, Littlejohns P, Ross F M, Axford J S Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA
Kneeosteoarthritis and high-heeled shoes. Little is known about the effects of walking in high heels on joints in the legs. Since osteoarthritis of the knee is twice as common in women as in men, we investigated torques (forces applied about the leg joints) of women who wore high-heeled shoes.We studied 20 healthy women who were comfortable wearing high-heeled shoes. The women walked with their own high-heeled shoes and barefoot. Data were plotted and qualitatively compared; major peak values (...) for high-heeled and barefoot walking were statistically compared. Bonferroni adjustment was made for multiple comparisons.Measurement showed increased force across the patellofemoral joint and a greater compressive force on the medial compartment of the knee (average 23% greater forces) during walking in high heels than barefoot.The altered forces at the knee caused by walking in high heels may predispose to degenerative changes in the joint.
A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with kneeosteoarthritis. The Fitness Arthritis and Seniors Trial (FAST). To determine the effects of structured exercise programs on self-reported disability in older adults with knee osteoarthritis.A randomized, single-blind clinical trial lasting 18 months conducted at 2 academic medical centers.A total of 439 community-dwelling adults, aged 60 years or older (...) , with radiographically evident kneeosteoarthritis, pain, and self-reported physical disability.An aerobic exercise program, a resistance exercise program, and a health education program.The primary outcome was self-reported disability score (range, 1-5). The secondary outcomes were knee pain score (range, 1-6), performance measures of physical function, x-ray score, aerobic capacity, and knee muscle strength.A total of 365 (83%) participants completed the trial. Overall compliance with the exercise prescription
in Arthritis and Rheumatism 1997; 26(5): 755-770 PubMedID Other publications of related interest Gotzche P. Methodology and overt hidden bias in reports of 196 double-blind trials of non-steroidal anti-inflammatory drugs in rheumatoid arthritis. Control Clin Trials 1989;10:31-56. Indexing Status Subject indexing assigned by NLM MeSH Humans; KneeJoint; Osteoarthritis /drug therapy; Randomized Controlled Trials as Topic /methods; Research Design AccessionNumber 11997000656 Date bibliographic record (...) To compare the efficacy of pharmacological agents for the treatment of osteoarthritis of the knee. Searching MEDLINE was searched from 1966 to 1994, using MeSH terms 'osteoarthritis', 'knee', 'kneejoint'. Only English language publications were included. Reference lists of publications retrieved were also searched. Study selection Study designs of evaluations included in the review Only randomised controlled trials (RCTs) were included. Specific interventions included in the review Nonsteroidal anti
commentary Overall, this is a poorly designed review, constructed from 3 RCTs that suffer from methodological problems such as a potential sampling bias (i.e. use of volunteers) and failure to blind outcome assessors. One study included patients with both osteoarthritis and rheumatoid arthritis of both the hip and kneejoint, and it is unclear if the data relevant to this review was available separately. Since the search strategy was limited to English language papers, relevant literature may have been (...) The efficacy of aerobic exercises for treating osteoarthritis of the knee The efficacy of aerobic exercises for treating osteoarthritis of the knee The efficacy of aerobic exercises for treating osteoarthritis of the knee La Mantia K, Marks R Authors' objectives To critically examine the efficacy of aerobic exercise for treating osteoarthritis of the knee. Searching MEDLINE was searched from 1985 to 94 with search terms (explode) 'arthritis', (explode) 'osteoarthritis', 'exercise', (explode