Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for knee osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on knee osteoarthritis or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on knee osteoarthritis and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via firstname.lastname@example.org
Could Activity Modifications Indicate Physical Decline Among Adults With Symptomatic KneeOsteoarthritis? Mobility activity modifications indicate early functional losses that act as precursors to future declines among community-dwelling older adults. However, there is scarce evidence on whether activity modifications indicate poorer physical health among adults with symptomatic osteoarthritis, a major cause of disability. Our purpose was to investigate whether patient-reported mobility (...) with symptomatic kneeosteoarthritis. If confirmed, patient-reported activity modifications may enhance symptom evaluation in osteoarthritis and enable a better understanding of the disablement process.
Effects of Platelet-Rich Plasma on Pain and Muscle Strength in Patients With KneeOsteoarthritis. No studies comparing the effects of platelet-rich plasma (PRP) injection and placebo injection in bilateral kneeosteoarthritis in the same patient, or discussing muscle strength after PRP injection, have been published.Twenty patients with bilateral kneeosteoarthritis were eligible, and 40 knees were randomized into two groups: PRP (knees [right or left by a coin toss] receiving a single intra (...) -articular PRP injection) and saline group (the contralateral knee of the same patient, into which single 4-mL intra-articular injection of normal saline was administered). The primary outcome measure was Western Ontario and McMaster's Universities Osteoarthritis Index and the secondary included isokinetic test results. The evaluation was at baseline and at 2 wks, 1, 3, and 6 mos after injection.The PRP group showed a significant reduction in the Western Ontario and McMaster's Universities Osteoarthritis
supervision . References 1. The Royal Australian College of General Practitioners (RACGP). 2018. Guideline for the management of knee and hip osteoarthritis. 2nd edn. East Melbourne, Vic: RACGP. https://www.racgp.org.au/FSDEDEV/media/documents/Clinical%20Resources/Guidelines/Joint%20replacement/Guidelin e-for-the-management-of-knee-and-hip-OA-2nd-edition.pdf 2. Allen S, Forney-Gorman A, Homan M, Kearns A, Kramlinger A, Sauer M. 2017. Diagnosis and treatment of osteoporosis. Bloomington (MN): Institute (...) Exercise for osteoarthritis of the knee and risk of subsequent osteoporotic vertebral fractures Exercise for osteoarthritis of the knee and subsequent vertebral fracture: An Evidence Snapshot 1 Exercise for osteoarthritis of the knee and risk of subsequent osteoporotic vertebral fractures Citation Garrubba M & Melder A. 2018. Exercise for Osteoarthritis of the knee and risk of subsequent osteoporotic vertebral fractures. Centre for Clinical Effectiveness, Monash Health, Victoria. Contact CCE
Biologic Therapies for the Treatment of KneeOsteoarthritis The use of biologic therapies for the management of kneeosteoarthritis has increased, despite insufficient evidence of efficacy. Our aim was to complete a systematic review and analysis of reports utilizing the highest level-of-evidence evaluating: (1) platelet-rich plasma injections (PRPs); (2) bone marrow-derived mesenchymal stem cells (BMSCs); (3) adipose-derived mesenchymal stem cells (ADSCs); and (4) amnion-derived mesenchymal (...) stem cells (AMSCs).PubMed, Embase, and Cochrane Library databases were queried for studies evaluating PRP injections, BMSCs, ADSCs, and AMSCs in patients with kneeosteoarthritis. Of 1009 studies identified within the last 5 years, 123 met inclusion criteria. A comprehensive analysis of all levels-of-evidence was performed, as well as separate analysis on level-of-evidence I studies. Level-of-evidence was determined by the American Academy of Orthopedic Surgeons classification system.Although
Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate KneeOsteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial To prospectively compare the efficacy of intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) with a sham control group (normal saline solution [NS]) for kneeosteoarthritis in a randomized, dose-controlled, placebo-controlled (...) , double-blind, triple-parallel clinical trial.A total of 87 osteoarthritic knees (53 patients) were randomly assigned to 1 of 3 groups receiving 3 weekly injections of either leukocyte-poor PRP (31 knees), HA (29 knees), or NS (27 knees). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and International Knee Documentation Committee (IKDC) subjective score were collected at baseline and at 1, 2, 6, and 12 months after treatment. Data were analyzed using generalized
Accuracy comparisons of intra-articular knee injection between the new modified anterolateral Approach and superolateral approach in patients with symptomatic kneeosteoarthritis without effusion. Intra-articular knee injection with steroid or various other agents have been used to control the local inflammation and relieve pain in the osteoarthritisknee. To achieve the maximal potential therapeutic worth and decrease the complications from the inaccurate knee injection, these medications (...) should be delivered directly into the intra-articular space. Injection technique is one of the most important factors for accuracy of knee injection. Therefore, this study was aimed to propose the new modified anterolateral injection technique for higher accuracy of knee injection in symptomatic osteoarthritisknee without effusion.Patients with symptomatic osteoarthritis without effusion were included prospectively from May 2014 to May 2015 and randomized into 2 groups for knee injection: Modified
with standard strengthening exercises? Clinical bottom line There was no evidence that answered this specific question. Whilst appraising the identified articles we found information of interest pertaining to running and arthritis however these were not comparative studies. Why is this important? Patients with kneeosteoarthritis often ask if running will cause harm or whether they should only do the standard prescribed physiotherapy exercises. As a group of clinicians we felt we needed more evidence (...) to appropriately give evidence based advice whilst keeping patients as functional as possible and not limiting their desired sporting activities. Search timeframe 1946 - 2018 Inclusion Criteria Description Search terms Population and Setting Adults, Clinical diagnosis of PFJ OA and/or Tibiofemoral OA Runners. Adults Runner/s Patello femoral jointosteoarthritis Tibiofemoral jointosteoarthritisOsteoarthritis Jogging Intervention or Exposure Running High impact lower limb exercise Plyometric exercises Running
to compare their long-term effects.To compare the long-term clinical outcomes provided by intra-articular injections of either PRP or hyaluronic acid (HA) to treat kneedegenerative disease.Randomized controlled trial; Level of evidence, 1.Patients with a history of chronic symptomatic kneedegenerative changes and osteoarthritis (Kellgren-Lawrence grade 0-3) were enrolled: 192 patients were randomized to undergo 3 blinded weekly intra-articular injections of either PRP or HA. Patients were prospectively (...) Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of KneeOsteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial Platelet-rich plasma (PRP) injections have been proposed as a new conservative option for knee degeneration to provide symptomatic relief and delay surgical intervention. Although the current literature provides some evidence on the benefits of this technique compared with viscosupplementation, no studies have been performed
Short-term effects of neuromuscular electrical stimulation and ultrasound therapies on muscle architecture and functional capacity in kneeosteoarthritis: a randomized study To determine the effects of ultrasound therapy and neuromuscular electrical stimulation (NMES) application on the muscle architecture and functional capacity in patients with knee osteoarthritis.A randomized study.A total of 60 patients with knee osteoarthritis.Participants were randomized into one of the following two (...) intervention groups, five days a week, for three weeks: the combination of NMES application, hot pack, and exercise therapy was applied to the NMES group. The combination of therapeutic ultrasound, hot pack and exercise therapy was applied to the ultrasound therapy group.Subjects were evaluated for pain and functional capacity with the use of the visual analog pain scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), and 15 meter walking test. The muscle architecture (muscle
Efficacy and Safety of Massage for Osteoarthritis of the Knee: a Randomized Clinical Trial Current treatment options for kneeosteoarthritis have limited effectiveness and potentially adverse side effects. Massage may offer a safe and effective complement to the management of knee osteoarthritis.Examine effects of whole-body massage on kneeosteoarthritis, compared to active control (light-touch) and usual care.Multisite RCT assessing the efficacy of massage compared to light-touch and usual (...) care in adults with kneeosteoarthritis, with assessments at baseline and weeks 8, 16, 24, 36, and 52. Subjects in massage or light-touch groups received eight weekly treatments, then were randomized to biweekly intervention or usual care to week 52. The original usual care group continued to week 24. Analysis was performed on an intention-to-treat basis.Five hundred fifty-one screened for eligibility, 222 adults with kneeosteoarthritis enrolled, 200 completed 8-week assessments, and 175 completed
The efficacy of electromyographic biofeedback on pain, function, and maximal thickness of vastus medialis oblique muscle in patients with kneeosteoarthritis: a randomized clinical trial The aim of this survey was to examine the effect of adding electromyographic biofeedback (EMGBF) to isometric exercise, on pain, function, thickness, and maximal electrical activity in isometric contraction of the vastus medialis oblique (VMO) muscle in patients with kneeosteoarthritis (OA).In this clinical (...) trial, 46 patients with a diagnosis of kneeOA were recruited and assigned to two groups. The case group consisted of 23 patients with EMGBF-associated exercise, and the control group was made up of 23 patients with only isometric exercise. Data were gathered via visual analog scale (VAS) score, the Persian version of the Western Ontario and McMaster Universities Osteoarthritis Index and Lequesne questionnaires, ultrasonography of the VMO, and surface electromyography of this muscle at baseline
Periosteal Electrical Dry Needling as an Adjunct to Exercise and Manual Therapy for KneeOsteoarthritis: A Multicenter Randomized Clinical Trial To compare the effects of adding electrical dry needling into a manual therapy (MT) and exercise program on pain, stiffness, function, and disability in individuals with painful kneeosteoarthritis (OA).In total, 242 participants (n=242) with painful kneeOA were randomized to receive 6 weeks of electrical dry needling, MT, and exercise (n=121) or MT (...) and exercise (n=121). The primary outcome was related-disability as assessed by the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index at 3 months.Individuals receiving the combination of electrical dry needling, MT, and exercise experienced significantly greater improvements in related-disability (WOMAC: F=35.504; P<0.001) than those receiving MT and exercise alone at 6 weeks and 3 months. Patients receiving electrical dry needling were 1.7 times more likely to have completely stopped
Effectiveness of low-dose radiation therapy on symptoms in patients with kneeosteoarthritis: a randomised, double-blinded, sham-controlled trial Low-dose radiation therapy (LDRT) for benign disorders such as kneeosteoarthritis (OA) is widely used in some parts of the world, despite absence of controlled studies. We evaluated the effect of LDRT on symptoms and inflammation in patients with knee OA.In this randomised, double-blinded, sham-controlled clinical trial (RCT), we recruited patients (...) with kneeOA (clinical ACR criteria) in the Netherlands, aged ≥50 years, pain score ≥5/10 and non-responding to analgesics and exercise therapy. Patients were randomised 1:1 to receive LDRT (1 Gray per fraction) or sham intervention six times in 2 weeks, stratified by pain (<8 versus ≥8/10). Primary outcome was the proportion of OMERACT-OARSI responders, 3 months postintervention. Secondary outcomes included pain, function and inflammatory signs assessed by ultrasound, MRI and serum inflammatory
Structured Education and Neuromuscular Exercise Program for Hip and/or KneeOsteoarthritis Public Comment: Held July 19 to August 9, 2018. Structured Education and Neuromuscular Exercise Program for Hip and/or KneeOsteoarthritis: Health Quality Ontario Recommendation FINAL RECOMMENDATION • Health Quality Ontario, under the guidance of the Ontario Health Technology Advisory Committee, recommends publicly funding a structured education and neuromuscular exercise program for the management (...) of people with osteoarthritis of the hip and/or knee RATIONALE FOR THE RECOMMENDATION The Ontario Health Technology Advisory Committee has reviewed the findings of the health technology assessment 1 and concluded that a structured education and neuromuscular exercise program provides clinical benefit in the management of hip and/or kneeosteoarthritis and is consistent with patient values and preferences. The Ontario Health Technology Advisory Committee supported data collection and outcome monitoring
Smoothness of the kneejoint movement during the stance phase in patients with severe kneeosteoarthritis Patients with kneeosteoarthritis can significantly affect the function of the kneejoint in terms of joint range and mobility and have a stereotypical pattern of knee stiffness during gait, caused by an increased resistance in the muscles and soft tissues during the stance phase of kneejoint movement. Smoothness in movement, such as during walking and running, is assumed to be attained (...) by adulthood; however, disruptions in gait pattern due to injury or performance enhancement can alter the smoothness of the movement, and this is often quantified in terms of "jerk". A higher jerk value is linked with a decrease in smoothness. However few have reported to evaluate the smoothness of the kneejoint movement during walking in patients with kneeosteoarthritis. The purpose of the present study was to quantify the smoothness of the kneejoint movement during walking in people with knee
questions for hip OA 691 Guideline for the management of knee and hip osteoarthritis Second edition Summary: Plain language Osteoarthritis (OA) is a chronic disease and the most common form of chronic arthritis. It is characterised by joint pain, stiffness and swelling, and mainly affects the hands, knees and hips. OA most frequently occurs in people aged >55 years, although younger people can also be affected. Risk factors for OA include joint injury, being overweight or obese, and older age (...) management of hip and kneeosteoarthritis in 2009. Since then, there has been substantial progress in evaluating the effectiveness and safety of commonly used and new therapies for osteoarthritis (OA). The objective of this new guideline is to present the best available, current scientific evidence for OA interventions, covering all interventions other than joint replacement for the hip and knee. Target population and audience This guideline applies to all adults diagnosed with symptomatic OA of the hip
Is four-week underwater treadmill exercise regimen compared to home exercise efficacious for pain relief and functional improvement in obese patients with kneeosteoarthritis? A randomized controlled trial To investigate the efficacy of a four-week underwater treadmill exercise regimen compared to a home exercise regimen relative to pain relief and functional improvement in obese patients with knee osteoarthritis.Single-blind randomized controlled trial.Outpatient.Eighty primary knee (...) improvement and higher patient satisfaction than those in control group (13 (39.4%) vs. 4 (10.8%); P = 0.014 and 23 (69.7%) vs. 16 (43.2%); P = 0.021, respectively).Exercise using an underwater treadmill was found to be as efficacious as home exercise for relieving pain and improving function in obese people with mild to moderate kneeosteoarthritis.
Effectiveness and feasibility of acupuncture for kneeosteoarthritis: a pilot randomized controlled trial To evaluate the effectiveness of acupuncture for pain relief and function improvement in patients with kneeosteoarthritis and to determine the feasibility of an eight-week acupuncture intervention.Pilot randomized controlled trial.Three teaching hospitals in China.Patients with kneeosteoarthritis (Kellgren grade II or III).Patients were randomly assigned to an eight-week (three sessions (...) intervention of kneeosteoarthritis was feasible and safe. No difference was observed between groups due to small sample size. Larger (sample size ⩾ 296) randomized controlled trials of this intervention appear justified.