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Latest & greatest articles for knee osteoarthritis
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joint pain due to osteoarthritis ( OA ) is extremely prevalent and a major cause of physical dysfunction and psychosocial distress. Exercise is recommended to reduce joint pain and improve physical function, but the effect of exercise on psychosocial function (health beliefs, depression, anxiety and quality of life) in this population (...) or knee (or both) pain (defined as more than six months' duration).To be included in the qualitative synthesis, studies had to have reported people's opinions (...) in a randomized, double-blind, placebo-controlled clinical trial in patients with kneeosteoarthritis . 27477804 2016 08 26 2016 12 28 2326-5205 69 1 2017 Jan Arthritis & rheumatology (Hoboken, N.J.) Combined Treatment With Chondroitin Sulfate and Glucosamine Sulfate Shows No Superiority Over Placebo for Reduction of Joint Pain and Functional Impairment in Patients With KneeOsteoarthritis : A Six-Month Multicenter (...) , Randomized, Double-Blind, Placebo-Controlled Clinical Trial. 77-85 10.1002/art.39819
Kneeosteoarthritis in professional football is related to severe knee injury and knee surgery As a consequence of severe knee injuries, kneeosteoarthritis (OA) seems prevalent in retired professional footballers. However, some epidemiological data remain missing, for instance whether kneeOA is also prevalent in current professional footballers, whether kneeOA is associated with knee injuries and surgeries, and whether kneeOA leads to a lower level of functioning. Therefore, three research (...) questions were answered: (i) what is the prevalence of kneeosteoarthritis (OA) among current and retired professional footballers? (ii) is severe knee injury or knee surgery associated with kneeOA among current and retired professional footballers? (iii) what are the consequences of kneeOA on physical knee function among current and retired professional footballers?An observational study based on a cross-sectional design by means of questionnaires was conducted. Participants were current and retired
that the levels of serum MMP-3 correlated only with the synovial fluid levels of MMP-3 in the operated knee and not with the non-operated joint (p = 0.0252, r = 0.7706 vs. p = 0.0764, r = 0.6576). Multiple regression analysis for patient's quality of life based on these biomarkers revealed an almost perfect result with an R2 of 0.9998 and a p value = 0.0087.Our results suggest that serum levels of MMP3 could be used as a potential biomarker for kneeosteoarthritis, using a simple blood test. Larger cohorts (...) MMP-3 in the peripheral serum as a biomarker of kneeosteoarthritis, 40Â years after open total knee meniscectomy To explore potential biomarkers in a meniscectomy-induced kneeosteoarthritis model, at forty years after meniscectomy.We carried out a forty-year study of 53 patients who, as adolescents, underwent open total meniscectomy and assessed two potential synovial and serum biomarkers, namely glycosaminoglycan (GAG) and matrix metalloproteinase-3 (MMP-3). Of the 30 patients available
Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on KneeOsteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study Intra-articular corticosteroids relieve osteoarthritis pain, but rapid systemic absorption limits efficacy. FX006, a novel, microsphere-based, extended-release triamcinolone acetonide (TA) formulation, prolongs TA joint residence and reduces systemic exposure compared with standard TA crystalline (...) suspension (TAcs). We assessed symptomatic benefits and safety of FX006 compared with saline-solution placebo and TAcs.In this Phase-3, multicenter, double-blinded, 24-week study, adults ≥40 years of age with kneeosteoarthritis (Kellgren-Lawrence grade 2 or 3) and average-daily-pain (ADP)-intensity scores of ≥5 and ≤9 (0 to 10 numeric rating scale) were centrally randomized (1:1:1) to a single intra-articular injection of FX006 (32 mg), saline-solution placebo, or TAcs (40 mg). The primary end point
The effect of 12-week garlic supplementation on symptom relief in overweight or obese women with kneeosteoarthritis Chronic joint pain and stiffness, and functional disability, are the major debilitating features of osteoarthritis (OA). The aim of this study was to assess the effect of 12-week supplementation with a garlic supplement on kneeosteoarthritis outcomes in overweight or obese women.Seventy-six postmenopausal overweight or obese women (25≤BMI≤40 kg/m2 ) with medically diagnosed knee (...) OA participated in this randomised double-blind, placebo-controlled, parallel-design trial. After randomisation into 2 groups, patients received a daily dose of either 1000 mg odourless garlic tablet, or placebo, for 12 weeks. The total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), as well as pain, stiffness and physical function subscales, were evaluated pre- and poststudy. Anthropometric parameters and body composition (using bioelectrical impedance analysis) were also
Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of kneeosteoarthritis Pain and limitations in joint mobility associated with kneeosteoarthritis (OA) are clinically challenging to manage, and advanced progression of disease can often lead to total knee arthroplasty. Intra-articular injection of hyaluronic acid (HA), also referred to as viscosupplementation, is a non-surgical treatment approach for OA, the effectiveness of which may depend on the HA (...) composition, and the length of time over which it resides in the joint. One of the available options for such therapies includes NASHA (Durolane HA), a non-animal, biofermentation-derived product, which is manufactured using a process that stabilizes the HA molecules to slow down their rate of degradation and produce a unique formulation with a terminal half-life of ~1 month. The objectives of the current review were to assess, in patients with OA of the knee, the efficacy and safety of intra-articular
-Lawrence grade (safety) in either group.Duloxetine reduced pain and improved function in patients with kneeosteoarthritis, without causing X-ray abnormalities or altered kneejoint mobility. Reduced pain was associated with improved HRQoL. Adverse events were consistent with duloxetine's known safety profile. (...) A randomized, double-blind, placebo-controlled Phase III trial of duloxetine in Japanese patients with knee pain due to osteoarthritis To examine the efficacy and safety of duloxetine in Japanese patients with knee pain due to osteoarthritis.Patients were randomized to receive duloxetine 60 mg/day or placebo for 14 weeks in a double-blind manner (ClinicalTrials.gov Identifier: NCT02248480). The primary efficacy endpoint was mean change in Brief Pain Inventory pain severity (BPI-Severity
Fluoroscopic Guided Radiofrequency of Genicular Nerves for Pain Alleviation in Chronic KneeOsteoarthritis: A Single-Blind Randomized Controlled Trial Nowadays, pain and disability due to chronic kneearthritis is a very common problem in middle aged people. A lot of modalities for management are available, including conservative analgesics and up to surgical interventions. Radiofrequency ablation of genicular nerves is assumed to be an effective less invasive and safe pain alleviation (...) pretreatment values with the values during the whole follow-up period with regard to the VAS and total WOMAC index in both groups.No diagnostic block was done prior to radiofrequency. We recommend the use of such a technique on a larger number of OA patients, with a longer follow-up period.RF can ameliorate pain and disability in chronic kneeosteoarthritis in a safe and effective manner.Chronic pain, radiofrequency (RF), kneeosteoarthritis.
Effectiveness of aquatic exercises compared to patient-education on health status in individuals with kneeosteoarthritis: a randomized controlled trial To compare the effectiveness of aquatic exercises with patient-education in individuals with knee osteoarthritis.Randomized controlled trial with blinded assessor and intention-to-treat analysis.Aquatic Physiotherapy Centre and Primary Health Care Unit.A total of 60 patients, aged 68.3 (SD = 4.8) with clinical symptoms and radiographic grading (...) (Kellgren-Lawrence 1-4) of kneeosteoarthritis were included.An eight-week treatment protocol of aquatic exercise ( n = 31) (16 individual sessions, twice a week) and an educational program (group sessions, once a week) ( n = 29).Before, after eight-week intervention, and a three-month follow-up with results for the following outcome measures: pain, function, quality of life, functional mobility, and depression.At the end of treatment, the WOMAC (Western Ontario and McMaster Universities Osteoarthritis
Exercise interventions and patient beliefs for people with hip, knee or hip and kneeosteoarthritis: a mixed methods review. Chronic peripheral joint pain due to osteoarthritis (OA) is extremely prevalent and a major cause of physical dysfunction and psychosocial distress. Exercise is recommended to reduce joint pain and improve physical function, but the effect of exercise on psychosocial function (health beliefs, depression, anxiety and quality of life) in this population is unknown.To (...) of land- or water-based exercise programmes compared with a control group consisting of no treatment or non-exercise intervention (such as medication, patient education) that measured either pain or function and at least one psychosocial outcome (self-efficacy, depression, anxiety, quality of life). Participants had to be aged 45 years or older, with a clinical diagnosis of OA (as defined by the study) or self-reported chronic hip or knee (or both) pain (defined as more than six months' duration
Osteoarthritis – A Randomized Clinical Trial April 6, 2018 6 min read By Rebecca Lazarus, MD Peer Reviewed Why does this matter? Osteoarthritis (OA) is a leading cause of disability in the United States and is the most common type of arthritis. The pathogenesis involves the progressive destruction of articular cartilage in a joint, which is accompanied by new bone formation and synovial proliferation. On a cellular level, this process is believed to involve mononuclear cells and pro-inflammatory mediators (...) age 45 years or older, and met kneeOA criteria as defined by the American College of Rheumatology. These criteria are based on a standardized questionnaire about knee pain, as well as tibiofemoral OA evident on radiographs. Eligibility criteria further included ultrasonographic evidence of effusion and synovitis. Participants were excluded if they had other disorders affecting the study joint, including systemic inflammatory jointdisease, prior sepsis, or osteonecrosis; chronic or recent use
Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or KneeOsteoarthritis Pain: The SPACE Randomized Clinical Trial. Limited evidence is available regarding long-term outcomes of opioids compared with nonopioid medications for chronic pain.To compare opioid vs nonopioid medications over 12 months on pain-related function, pain intensity, and adverse effects.Pragmatic, 12-month, randomized trial with masked outcome assessment. Patients (...) were recruited from Veterans Affairs primary care clinics from June 2013 through December 2015; follow-up was completed December 2016. Eligible patients had moderate to severe chronic back pain or hip or kneeosteoarthritis pain despite analgesic use. Of 265 patients enrolled, 25 withdrew prior to randomization and 240 were randomized.Both interventions (opioid and nonopioid medication therapy) followed a treat-to-target strategy aiming for improved pain and function. Each intervention had its own
Ultrasound-Guided Genicular Nerve Block for KneeOsteoarthritis: A Double-Blind, Randomized Controlled Trial of Local Anesthetic Alone or in Combination with Corticosteroid Recently, several studies suggested that radiofrequency (RF) ablation of the genicular nerves is a safe and effective therapeutic procedure for intractable pain associated with chronic kneeosteoarthritis (OA). Diagnostic genicular nerve block (GNB) with local anesthetic has been generally conducted before making decisions (...) regarding RF ablation. Although GNB has been recently performed together with corticosteroid, the analgesic effects of corticosteroids for treating chronic pain remain controversial.The current study aims to assess the effects of combining corticosteroids and local anesthesia during ultrasound-guided GNB in patients with chronic knee OA.A randomized, double-blinded institutional study.This study took place at Asan Medical Center in Seoul, Korea.Forty-eight patients with chronic kneeOA were randomly
Intra-articular ozone or hyaluronic acid injection: Which one is superior in patients with kneeosteoarthritis? A 6-month randomized clinical trial Kneeosteoarthritis (OA) is a common disease, imposing a great burden through pain and decreased function. There are many therapeutic modalities including non-pharmacologic choices and oral, topical, and intra-articular medications. New studies have shown promising results for ozone application in kneeOA. Our aim was to compare the effects of ozone (...) therapy versus hyaluronic acid (HA) intra-articular injection in kneeOA patients.In this randomized clinical trial, a total of 174 patients with more than 3 months of chronic pain or swelling in the kneejoints along with consistent imaging findings were enrolled and randomly allocated into two groups of HA and ozone, which were planned to undergo 3 weekly injections of HA (Hyalgan®) and 10 mL of a 30 μg/mL ozone solution, respectively. Patients were evaluated at baseline and 6 months after the last
Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in KneeOsteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With Viscosupplementation To assess the noninferiority of a single platelet-rich plasma (PRP) injection compared with hyaluronic acid (HA), to alleviate pain and enhance functional capacity in kneeosteoarthritis, and identify biological characteristics of PRP that may affect their efficacy.Fifty-four patients with symptomatic knee (...) osteoarthritis received a single injection of either PRP (26 patients) or HA (28 patients). They were assessed at baseline and at 1, 3, and 6 months. The primary endpoint was the change in Western Ontario and McMaster Universities Arthritis Index (WOMAC) score at 3 months, and secondary endpoints were responders' rate (improvement of at least 5 points or 40% of WOMAC total score at 3 months) of pain evaluation and patient's subjective satisfaction. Cell counts and the contents of vascular endothelial growth
Mucoid degeneration of the cruciate ligaments in osteoarthritis under primary total knee arthroplasty Mucoid degeneration of the anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) with osteoarthritis is rarely reported. We experienced two knee osteoarthritic patients who had symptomatic mucoid degeneration of their ACL, and their PCL was also diagnosed as mucoid degeneration in histological evaluation. Preoperative radiological evaluation could not reveal precisely whether (...) the degeneration had extended to the PCL. We obtained good clinical results treating them with posterior-stabilized (PS) total knee arthroplasty (TKA) sacrificing both ligaments. In cases of osteoarthritis with mucoid degenerated ACL, PS TKA should be considered, sacrificing both cruciate ligaments, because mucoid degeneration might expand both cruciate ligaments.
Monoclonal Antibodies for Osteoarthritis of the Hip or Knee Monoclonal Antibodies for Osteoarthritis of the Hip or Knee | CADTH.ca CADTH Document Viewer Monoclonal Antibodies for Osteoarthritis of the Hip or Knee Table of Contents Search this document Monoclonal Antibodies for Osteoarthritis of the Hip or Knee July 2018 Summary Osteoarthritis (OA) is a common and chronic disease of the synovial joints caused by biomechanical factors, inflammation, and joint tissue damage. The current (...) therapeutic options include non-pharmacologic therapy and topical analgesics, followed by oral analgesics and injectable agents, followed by surgery for end-stage disease. OA typically affects the knees, hips, hands, spine, and feet. Treatment with anti-nerve growth factors monoclonal antibodies (anti-NGFs) may improve joint pain and physical function, as nerve growth factor is associated with chronic pain conditions, and is elevated in the joints of patients with osteoarthritis. Within the indication
Exercise, Manual Therapy, and Booster Sessions in KneeOsteoarthritis: Cost-Effectiveness Analysis From a Multicenter Randomized Controlled Trial 29088393 2019 04 19 2019 04 19 1538-6724 98 1 2018 01 01 Physical therapy Phys Ther Exercise, Manual Therapy, and Booster Sessions in KneeOsteoarthritis: Cost-Effectiveness Analysis From a Multicenter Randomized Controlled Trial. 16-27 10.1093/ptj/pzx104 Bove Allyn M AM Department of Physical Therapy, School of Health and Rehabilitation Sciences (...) States P30 AG024827 AG NIA NIH HHS United States Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States Phys Ther 0022623 0031-9023 AIM IM Aged Combined Modality Therapy Cost-Benefit Analysis Exercise Therapy economics methods Female Follow-Up Studies Health Care Costs statistics & numerical data Humans Male Middle Aged Musculoskeletal Manipulations economics methods Osteoarthritis, Knee economics
Cost-Utility Analysis of High Molecular Weight Hyaluronic Acid for KneeOsteoarthritis in Everyday Clinical Care in Patients at a Working Age: An Economic Evaluation of a Randomized Clinical Trial Kneeosteoarthritis (OA) is associated with high medical costs and especially with high productivity costs, in particular in patients in their working years. High molecular weight (HMW) hyaluronic acid (HA) is an alternative treatment for nonsteroidal antiinflammatory drugs, which are known (...) for their serious side-effects. The cost-utility of intraarticular HMW-HA treatment in these patients is unknown, however, and was assessed in this study.Secondary care patients ages 18-65 years with kneeOA were randomized to usual care plus HMW-HA (intervention group) or to usual care only (control group). A cost-utility analysis over 52 weeks from the societal and health care perspective was performed. Uncertainty for costs, effects, and cost-utility ratio was analyzed by nonparametric bootstrapping