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Latest & greatest articles for knee osteoarthritis
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Efficacy of Cabbage Leaf Wraps in the Treatment of Symptomatic Osteoarthritis of the Knee: A Randomized Controlled Trial Osteoarthritis (OA) of the knee is one of the most common chronic diseases among older adults. This study aimed to test the effects of cabbage leaf wraps (CLWs) in the treatment of symptomatic OA.Patients with OA of the knee at stages II to III (Kellgren-Lawrence) were randomly assigned to 4 weeks of treatment with CLWs (daily for at least 2h), topical pain gel (TPG) (10 mg (...) of life after 12 weeks. Patients were satisfied with both active interventions, and except for 2 adverse events in both groups the applications were well tolerated.CLWs are more effective for kneeOA than UC, but not compared with diclofenac gel. Therefore, they might be recommended for patients with OA of the knee. Further research is warranted.
Unique aspects of pain reduction in osteoarthritis of the knee with LMWF-5A. Osteoarthritis of the knee (OAK) is a common form of arthritis that can lead to substantial pain and disability. This commentary highlights key aspects of the recently published phase 3 A Efficacy and Safety Study of Two Doses of Intra-Articular Injection of Ampion™ in Adults With Pain Due to Osteoarthritis of the Knee (SPRING) study. SPRING (NCT01839331) was a multicenter, randomized, vehicle-controlled, double-blind (...) trial that evaluated the safety and efficacy of the low-molecular-weight fraction of 5% human serum albumin (LMWF-5A) for treatment of pain, measured by the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain scale, in patients with symptomatic OAK (N=329). Patients in this study reflected many characteristics of "real-world" individuals with OAK, with a broad range of disease severity and disability. The most important finding from this study was that treatment with a single intra
Clinical efficacy of intra-articular injections in kneeosteoarthritis: a prospective randomized study comparing hyaluronic acid and betamethasone. Osteoarthritis (OA) is the most common jointdisease and leading cause of disability. Intra-articular (IA) administration of hyaluronic acid (HA) or corticosteroids (CS) have been previously studied, though using insufficient number of patients or short follow-up periods.We evaluate HA and CS in patients with kneeOA in terms of clinical efficacy (...) over 12 months.We used a prospective, randomized study with parallel groups. Randomized patients received IA injections of HA or betamethasone (BM). The primary outcomes were improvement in pain using Visual Analog Scale and function in the Western Ontario and McMaster University Osteoarthritis Index (Likert scale). Follow-up visits were scheduled at 3 months, 6 months, 9 months, and 12 months.A total of 200 patients were included. Pain was significantly reduced in both groups at the first follow
Efficacy of a natural mineral complex in North American adults with osteoarthritis of the knee: a randomized double-blind placebo-controlled study. This study evaluated the efficacy of a hydrothermal mineral complex (HMC) supplement in participants with knee osteoarthritis.This was a double-blind, placebo-controlled, 12-week crossover study with 150 participants receiving either placebo or HMC for 4 weeks, with a 4-week washout period. The primary endpoint was WOMAC™ pain, and secondary
Gait analysis of patients with kneeosteoarthritis highlights a pathological mechanical pathway and provides a basis for therapeutic interventions Kneeosteoarthritis (OA) is a painful and incapacitating disease affecting a large portion of the elderly population, for which no cure exists. There is a critical need to enhance our understanding of OA pathogenesis, as a means to improve therapeutic options.Knee OA is a complex disease influenced by many factors, including the loading environment (...) in OA development, and to design therapeutic interventions. Multidisciplinary research is necessary to relate the biomechanical alterations to the structural and biological components of OA. Cite this article: Favre J, Jolles BM. Analysis of gait, knee biomechanics and the physiopathology of kneeosteoarthritis in the development of therapeutic interventions. EFORT Open Rev 2016;1:368-374. DOI: 10.1302/2058-5241.1.000051.
Simultaneous anterior cruciate ligament reconstruction and dome-shaped high tibial osteotomy for severe medial compartment osteoarthritis of the knee The optimal surgical procedure to address both anterior cruciate ligament (ACL) deficiency and medial compartment osteoarthritis (OA) has been controversial.A 49-year-old woman with a 30-year history of chronic anterior cruciate ligament (ACL) deficiency, medial compartment osteoarthritis, and varus deformity presented with medial knee pain (...) and apprehension with walking and playing soccer. Her preoperative range of motion was from 0° of extension to 135° of flexion. The anterior drawer sign (1+), Lachman test (1+), and pivot shift test (glide) were positive before surgery, as measured by the International Knee Documentation Committee knee examination form. The patient underwent simultaneous arthroscopic ACL single-socket and single-bundle reconstruction using hamstring tendons, dome-shaped high tibial osteotomy using the TomoFix fixation device
Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study Kneeosteoarthritis is a disabling disease that costs billions of dollars to treat. Corticosteroid gives varying pain relief and costs $12 per injection, whereas ketorolac costs $2 per injection, per institutional costs. The aim of this study was to compare ketorolac with corticosteroid based on pain relief using patient outcome measures and cost (...) data.A total of 35 patients were randomized to ketorolac or corticosteroid intra-articular knee injection in a double-blind, prospective study. Follow-up was 24 weeks. Osteoarthritis was evaluated using Kellgren-Lawrence grading. Visual analog scale (VAS) was the primary outcome measure. A query of the institutional database was performed for International Classification of Diseases, Ninth Revision codes 715.16 and 719.46, and procedure code 20610 over a 3-year period. Two-way, repeated measures
Unloading Shoes for Self-Management of KneeOsteoarthritis: A Randomized Trial. Appropriate footwear is recommended for self-management of kneeosteoarthritis. Shoes that reduce harmful knee loads are available, but symptomatic effects are uncertain.To evaluate the efficacy of unloading shoes in alleviating kneeosteoarthritis symptoms.Participant- and assessor-blinded comparative effectiveness randomized, controlled trial. (Australian New Zealand Clinical Trials Registry: ACTRN12613000851763 (...) ).Community.164 persons with medial knee osteoarthritis.Walking shoes with triple-density, variable-stiffness midsoles and mild lateral-wedge insoles designed to unload the medial knee and worn daily (intervention) versus conventional walking shoes (comparator).Primary outcomes were pain with walking (assessed on a numerical rating scale [NRS]) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]) at 6 months. Secondary outcomes were knee pain and stiffness (WOMAC
Exploring Fatigue Trajectories in Early Symptomatic Knee and Hip Osteoarthritis: 6-year Results from the CHECK Study To examine whether different groups of fatigue trajectories can be identified among patients with early symptomatic osteoarthritis (OA) of the knee or hip, to describe the level of fatigue severity within each of these fatigue groups, and to investigate the involvement of age, sex, use of medication, comorbidity, and OA severity in relation to group membership.Six years (...) in comparison with each other and in comparison with the low fatigue group. Comorbidity, medication use, and sex were significantly associated with the identified trajectories. Women, individuals with a comorbid disease, and those who used medication were more likely to follow a high fatigue trajectory.These findings suggest heterogeneous development of fatigue in the early OA population associated with varying patient characteristics. Further, this study shows that a considerable number of patients with OA
compared with ibuprofen on the severity of disease in patients with kneeOA. This study was designed as a randomized, double blind, active-controlled and parallel group trial. Patients with OA were randomized to receive 300 mg/day (n=33) or 600 mg/day (n=32) of EA aqueous extract, or 800 mg/day ibuprofen (n=32) for 7 weeks. EA extract contained 0.21 % (w/w) kaempferol according to HPLC. Efficacy of treatment was assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC (...) Efficacy of Elaeagnus Angustifolia extract in the treatment of kneeosteoarthritis: a randomized controlled trial. Osteoarthritis (OA) is one of the most common musculoskeletal disorders all over the world. Available anti-arthritic medications have only partial efficacy and their long-term use is associated with adverse events. Elaeagnus Angustifolia (EA) is a medicinal plant with analgesic and anti-inflammatory properties. The present study evaluated the impact of two doses of EA extract
Physical Therapist-Delivered Pain Coping Skills Training and Exercise for KneeOsteoarthritis: Randomized Controlled Trial To investigate whether a 12-week physical therapist-delivered combined pain coping skills training (PCST) and exercise (PCST/exercise) is more efficacious and cost effective than either treatment alone for kneeosteoarthritis (OA).This was an assessor-blinded, 3-arm randomized controlled trial in 222 people (73 PCST/exercise, 75 exercise, and 74 PCST) ages ≥50 years (...) with kneeOA. All participants received 10 treatments over 12 weeks plus a home program. PCST covered pain education and training in cognitive and behavioral pain coping skills, exercise comprised strengthening exercises, and PCST/exercise integrated both. Primary outcomes were self-reported average knee pain (visual analog scale, range 0-100 mm) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index, range 0-68) at week 12. Secondary outcomes included other pain measures
Comparative Effectiveness of Tai Chi Versus Physical Therapy for KneeOsteoarthritis: A Randomized Trial. Few remedies effectively treat long-term pain and disability from kneeosteoarthritis. Studies suggest that Tai Chi alleviates symptoms, but no trials have directly compared Tai Chi with standard therapies for osteoarthritis.To compare Tai Chi with standard physical therapy for patients with knee osteoarthritis.Randomized, 52-week, single-blind comparative effectiveness trial (...) . (ClinicalTrials.gov: NCT01258985).An urban tertiary care academic hospital.204 participants with symptomatic kneeosteoarthritis (mean age, 60 years; 70% women; 53% white).Tai Chi (2 times per week for 12 weeks) or standard physical therapy (2 times per week for 6 weeks, followed by 6 weeks of monitored home exercise).The primary outcome was Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at 12 weeks. Secondary outcomes included physical function, depression, medication use
Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study To evaluate the effectiveness of spironolactone as a treatment for osteoarthritis (OA)-related knee effusion in comparison to ibuprofen, cold compresses, and placebo.This study was carried out on 200 patients, aged 40 years or older, attending the outpatient clinic of the Rheumatology Department of Sohag University Hospital with unilateral knee effusion related to OA (...) , 10% partial improvement, and 84% no response.Low-dose spironolactone is a safe and effective medical treatment for OA-related knee effusion.
Therapy, Gachon University College of Health Science, Incheon, South Korea Department of Physiology, Korea University College of Medicine, Seoul, South Korea. Yoon Young Wook YW eng Letter Comment United States Am J Phys Med Rehabil 8803677 0894-9115 AIM IM Am J Phys Med Rehabil. 2015 Mar;94(3):192-200 25706053 Am J Phys Med Rehabil. 2016 Jan;95(1):e7 26390398 Athletic Tape Female Humans KneeJoint physiopathology Male Osteoarthritis, Knee therapy Proprioception Range of Motion, Articular 2015 10 27 6 (...) Re: "Kinesio Taping Improves Pain, Range of Motion, and Proprioception in Older Patients with KneeOsteoarthritis: A Randomized Controlled Trial". 26495811 2016 04 11 2018 12 02 1537-7385 95 1 2016 Jan American journal of physical medicine & rehabilitation Am J Phys Med Rehabil Re: "Kinesio Taping Improves Pain, Range of Motion, and Proprioception in Older Patients with KneeOsteoarthritis: A Randomized Controlled Trial". e7-8 10.1097/PHM.0000000000000394 Cho Hwi-Young HY Department of Physical
Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2016 Authors' conclusions Osteoarthritis is the most common type of arthritis in the UK and leads to painful and stiff joints. Osteoarthritis can affect any joint, but commonly affects kneejoints. Daily routine activities can become difficult for patients with osteoarthritis of the knee. There is no cure for osteoarthritis of the knee but there are treatments which help to reduce the pain. In cases where treatment does not work (...) , knee surgery may be offered. Ampion is a new drug for the treatment of osteoarthritis of the knee given as an injection into the affected joint. Some studies have suggested that Ampion may help in reducing knee pain in patients who have osteoarthritis of the knee. If Ampion is licensed for use in the UK, it could be a new treatment option for patients with osteoarthritis of the knee which may improve patient quality of life better than existing treatments. Final publication URL Indexing Status
Feasibility of a Randomized Controlled Trial of Self-Administered Acupressure for Symptom Management in Older Adults with KneeOsteoarthritis. To assess the feasibility of a study to evaluate the efficacy of self-administered acupressure in pain and related symptom management for older people with symptomatic kneeosteoarthritis. Feasibility with regard to (1) sample recruitment and retention, (2) treatment fidelity and adherence, and (3) tolerability and adverse events was examined.The study (...) from performing the acupressure. Thirty adverse events were reported; most were related to pre-existing health conditions.It is feasible to conduct a study of self-administered acupressure for symptom management in community-living older adults with kneeosteoarthritis, although sample recruitment may be challenging.
Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic KneeOsteoarthritis: A Randomized Clinical Trial. Observational studies suggest that vitamin D supplementation is associated with benefits for kneeosteoarthritis, but current trial evidence is contradictory.To compare the effects of vitamin D supplementation vs placebo on knee pain and knee cartilage volume in patients with symptomatic kneeosteoarthritis and low vitamin D levels.A (...) multicenter randomized, double-blind, placebo-controlled clinical trial in Tasmania and Victoria, Australia. Participants with symptomatic kneeosteoarthritis and low 25-hydroxyvitamin D (12.5-60 nmol/L) were enrolled from June 2010 to December 2011. The trial was completed in December 2013.Participants were randomly assigned to receive monthly treatment with oral vitamin D3 (50,000 IU; n = 209) or an identical placebo (n = 204) for 2 years.Primary outcomes were change in tibial cartilage volume (assessed
The Incremental Effects of Manual Therapy or Booster Sessions in Addition to Exercise Therapy for KneeOsteoarthritis: A Randomized Clinical Trial A factorial randomized controlled trial.To investigate the addition of manual therapy to exercise therapy for the reduction of pain and increase of physical function in people with kneeosteoarthritis (OA), and whether "booster sessions" compared to consecutive sessions may improve outcomes.The benefits of providing manual therapy in addition (...) to exercise therapy, or of distributing treatment sessions over time using periodic booster sessions, in people with kneeOA are not well established.All participants had kneeOA and were provided 12 sessions of multimodal exercise therapy supervised by a physical therapist. Participants were randomly allocated to 1 of 4 groups: exercise therapy in consecutive sessions, exercise therapy distributed over a year using booster sessions, exercise therapy plus manual therapy without booster sessions
and Quality (AHRQ); 2016 Jun. [cited YYYY Mon DD]. Available: http://www.guideline.gov. A direct comparison of recommendations presented in the above guidelines for nonsurgical management of osteoarthritis (OA) of the knee is provided. The AAOS guideline provides recommendations for surgical interventions that are less invasive than knee replacement, which are beyond the scope of this synthesis. The VA/DoD guideline addresses OA of the hip, which is also beyond the scope of this synthesis (recommendations (...) AAOS and VA/DoD agree that overweight or obese patients (defined by a BMI >25 kg/m 2 [VA/DoD] or ≥25 kg/m 2 [AAOS]) with symptomatic OA of the knee should attempt weight loss. Ideally, patients should lose a minimum of five percent body weight and maintain this new level of weight, specifies VA/DoD. Complementary and Alternative Medicine The developers recommend against the use of chondroitin sulfate and/or glucosamine to treat joint pain or improve function in patients with symptomatic OA
Media Releases 2013 Media Releases 2012 Media Releases Search Knee taping for osteoarthritisKnee taping for osteoarthritis Introduction Kneeosteoarthritis is the most common cause of knee pain in people older than 50. Intervention Application of strong, adhesive tape or strapping aiming to unload painful soft tissues. Indication Chronic pain related to kneeosteoarthritis (OA). Malalignment of the patella, with abnormal distribution of force on the lateral facet, is thought to contribute to pain (...) in kneeosteoarthritis. Taping increases patellofemoral contact area, decreasing joint stress and thereby reducing pain. Taping is a very effective pain-relieving strategy and can assist participation in other strongly recommended therapies for kneeosteoarthritis, such as cardiovascular and resistance land-based and aquatic exercises. Precautions A physiotherapist experienced in assessment and taping techniques should show the patient how to apply the tape: Precise placement of tape is needed