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Latest & greatest articles for knee osteoarthritis
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version of this Decision Box by . Osteoarthritis (OA) is condition where joint tissue breaks down causing joint pain , stiffness and swelling . It is most common in the knee, hip and hand and it worsens over time. There is no cure for progressive joint damage caused by OA but its symptoms can be managed and quality of life improved. Individuals with clinical symptoms or a diagnosis of OA. When choosing treatment, one should consider treatment costs, the severity of symptoms and an individual’s risk (...) for potentially adverse events. The following treatment options are presented from least to most invasive: Less invasive More invasive Medially wedged insoles Muscle strengthening, aerobic exercises and weight loss for overweight individuals Glucosamine Acetaminophen Acupuncture Oral or topical NSAID therapy Opioid therapy Corticosteroid injection (kneeOA) Referral for joint replacement surgery There are pros and cons to each option: PROS : Depending on the option, more or less people have a chance
Summary According to the Centers for Disease Control and Prevention (CDC), 13.9 percent of adults age 25 years and older and 33.6 percent of adults age 65 years and older are affected by osteoarthritis (OA). Arthritis appears to be a significant burden among Veterans of the United States (US) Armed Forces.  Research suggests that military service-related overuse and injuries may be a contributing factor for the increased risk of developing OA. One study examined the incidence of OA among active (...) of other joints outside the hip or knee expands the differential diagnosis beyond OA. A2. Plain Radiography Background Radiography can be useful in confirming a suspect diagnosis of OA and may eliminate other potential diagnoses from consideration. Recommendation 2. Clinicians may use plain radiography to confirm the clinical diagnosis of hip and kneeosteoarthritis. [C] Discussion In adults with non-traumatic knee pain, the consensus of the working group is to obtain a weight- bearing anterior
No Difference Between Intra-Articular Injection of Hyaluronic Acid and Placebo for Mild to Moderate KneeOsteoarthritis: A Randomized, Controlled, Double-Blind Trial The main goal of our study was to examine the effectiveness and safety of Fermathron plus, a specific brand of hyaluronic acid (HA), in patients with mild to moderate kneeosteoarthritis. In a randomized, controlled, double-blind trial, 196 patients with symptomatic kneeosteoarthritis (mean age ± SD, 59.4 ± 9.9 years, Kellgren
Publication. 2014 Authors' objectives Physical therapy may be beneficial both before and after joint replacement surgery in patients with severe osteoarthritis (OA). In general, the goal of physical therapy in patients with OA is to increase function and physical activity despite pain and stiffness. Perioperative goals include faster recovery time, shorter hospital length of stay (LOS), and increased range of motion (ROM) and function. Final publication URL The report may be purchased from: Indexing (...) Status Subject indexing assigned by CRD MeSH Activities of Daily Living; Adults; Arthroplasty, Replacement, Knee; Exercise Therapy; KneeJoint; Osteoarthritis, Knee; Pain; Physical Therapy Modalities; Preoperative Care; Range of Motion, Articular; Recovery of Function; Treatment Outcome Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446
of as a disease of “wear and tear” on the joints. Is running a risk factor for developing osteoarthritis? If so, is the damage worse for marathon runners? Maybe we should be advising our patients to stick to water aerobics. Approximately OA is a degenerativejointdisease characterized by articular cartilage failure, although all structures of the joint are involved in the pathologic process. Risks for developing osteoarthritis include systemic factors (age, female gender, genetic susceptibility), intrinsic (...) on the development of kneeosteoarthritis. Felson et al. published a longitudinal study of the Framinghmam Offspring cohort to evaluate the long-term A total of 1,279 subjects were included with a mean age at baseline of 53 years. Most reported walking for exercise. Subjects were asked about their knee pain and anteroposterior and lateral knee radiographs were obtained. Nine years later, subjects were reexamined for osteoarthritis. The primary outcomes of the study included incident radiographic OA, symptomatic
with hip or kneeosteoarthritis (OA) pain.Patients (N=604) with moderate to severe knee or hip OA tolerating stable DSR were randomised and treated with DSR 75 mg twice daily combined with intravenous tanezumab 10, 5 or 2.5 mg or placebo at weeks 0, 8 and 16. Co-primary efficacy endpoints (Western Ontario and McMaster Universities OA Index (WOMAC) Pain and Physical Function subscales and patient's global assessment of OA) were assessed at week 16.All co-primary endpoints were significantly improved (...) Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial Tanezumab, a monoclonal antibody, inhibits nerve growth factor and reduces chronic pain. This randomised, double-blind, controlled multicentre study was conducted to evaluate the efficacy and safety of tanezumab added to oral diclofenac sustained release (DSR) in patients
Meniscectomy in Patients with KneeOsteoarthritis and a Meniscal Tear? 23506467 2013 05 21 2018 12 02 1533-4406 368 18 2013 May 02 The New England journal of medicine N. Engl. J. Med. Meniscectomy in patients with kneeosteoarthritis and a meniscal tear? 1740-1 10.1056/NEJMe1302696 Buchbinder Rachelle R eng Editorial Comment 2013 03 18 United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2013 May 2;368(18):1675-84 23506518 Female Humans Male Osteoarthritis, Knee surgery therapy
Efficacy and safety of strontium ranelate in the treatment of kneeosteoarthritis: results of a double-blind, randomised placebo-controlled trial Strontium ranelate is currently used for osteoporosis. The international, double-blind, randomised, placebo-controlled Strontium ranelate Efficacy in KneeOsteoarthrItis triAl evaluated its effect on radiological progression of knee osteoarthritis.Patients with kneeosteoarthritis (Kellgren and Lawrence grade 2 or 3, and joint space width (JSW) 2.5-5 (...) mm) were randomly allocated to strontium ranelate 1 g/day (n=558), 2 g/day (n=566) or placebo (n=559). The primary endpoint was radiographical change in JSW (medial tibiofemoral compartment) over 3 years versus placebo. Secondary endpoints included radiological progression, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and knee pain. The trial is registered (ISRCTN41323372).The intention-to-treat population included 1371 patients. Treatment with strontium ranelate
of motion values (P=0.300).Joint traction was found to be beneficial for the improvement of pain and physical function loss related to kneeosteoarthritis. (...) A randomized controlled trial on the efficacy of intermittent and continuous traction for patients with kneeosteoarthritis To investigate the efficacy of intermittent and continuous traction in the treatment of knee osteoarthritis.A randomized, controlled, observer-blind seven-week trial.Hospital-based outpatient practice.Ninety-eight patients with stage 3 kneeosteoarthritis according to Kellgren-Lawrence radiological rating scale.All 98 patients were randomly assigned to three treatment
Osteoarthritis of the Knee TREATMENT OF OSTEOARTHRITIS OF THE KNEE EVIDENCE-BASED GUIDELINE 2 ND EDITION Adopted by the American Academy of Orthopaedic Surgeons Board of Directors May 18, 2013 i Disclaimer This clinical practice guideline was developed by an AAOS work group comprised of volunteer physicians and interdisciplinary clinicians as well as staff researchers with expertise in systematic reviews and statistical methods used to evaluate empirical evidence. It is an educational tool (...) Peer Review 26 Public Comment 27 The AAOS Guideline Approval Process 28 Revision Plans 28 Guideline Dissemination Plans 28 AAOS Clinical Guideline on Treating Osteoarthritis of the Knee 31 Guideline Recommendations 31 Recommendation 1 31 Rationale 31 Supporting Evidence 32 Quality 32 Applicability 34 Final Strength of Evidence 35 Results 46 Evidence Tables and Figures 61 Quality and Applicability 61 Findings 98 Recommendation 2 138 Rationale 138 Supporting Evidence 138 Quality 138 Applicability 139
Media Releases 2015 Media Releases 2014 Media Releases 2013 Media Releases 2012 Media Releases Search Aquatic exercise for knee and hip osteoarthritis Aquatic exercise for knee and hip osteoarthritis Introduction Warm-water therapy is one of the oldest recorded treatments, with effects lasting well beyond the period of immersion. Intervention Physical exercise while immersed in water (typically 32–36°C). Indication People with osteoarthritis (OA) of the knee or hip with the aim of reducing pain (...) Aquatic exercise for knee and hip osteoarthritis RACGP - Aquatic exercise for knee and hip osteoarthritis Search Become a student member today for free and be part of the RACGP community A career in general practice Starting the GP journey Enrolments for the 2019.1 OSCE FRACGP exams closing 29 March 2019 Fellowship FRACGP exams Research Practice Experience Program is a self-directed education program designed to support non vocationally registered doctors on their pathway to RACGP Fellowship
Effects of intensive diet and exercise on kneejoint loads, inflammation, and clinical outcomes among overweight and obese adults with kneeosteoarthritis: the IDEA randomized clinical trial. Kneeosteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity.To determine whether a ≥10% reduction in body weight induced by diet, with or without exercise, would improve mechanistic and clinical outcomes more than (...) , or exercise.Mechanistic primary outcomes: kneejoint compressive force and plasma IL-6 levels; secondary clinical outcomes: self-reported pain (range, 0-20), function (range, 0-68), mobility, and health-related quality of life (range, 0-100).Three hundred ninety-nine participants (88%) completed the study. Mean weight loss for diet + exercise participants was 10.6 kg (11.4%); for the diet group, 8.9 kg (9.5%); and for the exercise group, 1.8 kg (2.0%). After 18 months, knee compressive forces were lower in diet
A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic kneeosteoarthritis To compare the effects of an intermediate molecular weight (MW) intra-articular hyaluronic acid (HA) with a low MW product on kneeosteoarthritis (OA) symptoms.Patients with symptomatic kneeOA were enrolled inarandomised, controlled, double-blind, parallel-group, non-inferiority trial with the possibility to shift (...) all>0, p=0.021). Ahigher proportion of OARSI/OMERACT responders was observed with GO-ONthan with Hyalgan (73.3% vs58.4%, p=0.001). Both preparations were well tolerated.Treatment with 3-weekly injections of intermediate MW HA may be superior to low MW HA on kneeOA symptoms over 6 months, with similar safety.
Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. Kneeosteoarthritis (OA), a disorder of cartilage and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression.To determine whether vitamin D supplementation reduces symptom and structural progression of knee OA.A 2 (...) -year randomized, placebo-controlled, double-blind, clinical trial involving 146 participants with symptomatic kneeOA (mean age, 62.4 years [SD, 8.5]; 57 women [61%], 115 white race [79%]). Patients were enrolled at Tufts Medical Center in Boston between March 2006 and June 2009.Participants were randomized to receive either placebo or oral cholecalciferol, 2000 IU/d, with dose escalation to elevate serum levels to more than 36 ng/mL.Primary outcomes were knee pain severity (Western Ontario
-comparative 4. Sarda PK, Shetty A, Maheswaran SS. Medium term results of Avon patellofemoral joint replacement. Indian J Orthop [Internet]. 2011 Sep [cited 2012 Nov 22];45(5):439-44. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162681 PubMed: PM21886926 5. Dahm DL, Al-Rayashi W, Dajani K, Shah JP, Levy BA, Stuart MJ. Patellofemoral arthroplasty versus total knee arthroplasty in patients with isolated patellofemoral osteoarthritis. Am J Orthop (Belle Mead NJ ) [Internet]. 2010 Oct [cited (...) Knee Prostheses for Patellar Resurfacing for Adults with Osteoarthritis: Comparative Clinical Effectiveness Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time
Physical therapy interventions for knee pain secondary to osteoarthritis: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
, multicenter trial.Departments of physical medicine and rehabilitation in 4 centers.Patients (N=203) with kneeosteoarthritis (OA).The patients were randomized by the principal center into the following 6 treatment groups: TENS sham, TENS, IFCs sham, IFCs, SWD sham, and SWD. All interventions were applied 5 times a week for 3 weeks. In addition, exercises and an education program were given. The exercises were carried out as part of a home-based training program after 3 weeks' supervised group (...) Comparison of the efficacy of transcutaneous electrical nerve stimulation, interferential currents, and shortwave diathermy in kneeosteoarthritis: a double-blind, randomized, controlled, multicenter study To compare the effectiveness of transcutaneous electrical nerve stimulation (TENS), interferential currents (IFCs), and shortwave diathermy (SWD) against each other and sham intervention with exercise training and education as a multimodal package.A double-blind, randomized, controlled