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Latest & greatest articles for knee osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on knee osteoarthritis or other clinical topics then use Trip today.
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Short-term effects of 890-nanometer radiation on pain, physical activity, and postural stability in patients with kneeosteoarthritis: a double-blind, randomized, placebo-controlled study To investigate the effects of short-term light therapy with 890-nm radiation on pain, physical activity, and postural stability in patients with kneeosteoarthritis (OA).A double-blind, randomized, placebo-controlled study.Rehabilitation clinic.Women (n=62) and men (n=10) with a mean age of 61.2 years (range (...) , 40-88y). All patients fulfilled the combined clinical and radiographic criteria for kneeOA as established by the American College of Rheumatology, and all had obtained a Kellgren-Lawrence score of 2 or more.Participants received 6 sessions, lasting 40 minutes each, of active or placebo radiation treatment over the kneejoints for 2 weeks (wavelength, 890nm; radiant power output, 6.24W; power density, 34.7mW/cm(2) for 40 minutes; total energy, 41.6J/cm(2) per knee per session).Participants were
Viscosupplementation for osteoarthritis of the knee Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
types of abnormalities detectable by MRI. There were no significant differences in the prevalence of any of the features between BMI groups. The prevalence of at least one type of pathology ("any abnormality") was high in both painful (90-97%, depending on pain definition) and painless (86-88%) knees.MRI shows lesions in the tibiofemoral joint in most middle aged and elderly people in whom knee radiographs do not show any features of osteoarthritis, regardless of pain. (...) Prevalence of abnormalities in knees detected by MRI in adults without kneeosteoarthritis: population based observational study (Framingham Osteoarthritis Study). To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity.Population based observational study.Community cohort in Framingham, MA, United States (Framingham
A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic KneeOsteoarthritis This multicenter, double-blind clinical trial evaluated and compared the efficacy and safety of PRGF-Endoret (BTI Biotechnology Institute, Vitoria-Gasteiz, Spain), an autologous biological therapy for regenerative purposes, versus hyaluronic acid (HA) as a short-term treatment for knee pain from osteoarthritis.We randomly (...) assigned 176 patients with symptomatic kneeosteoarthritis to receive infiltrations with PRGF-Endoret or with HA (3 injections on a weekly basis). The primary outcome measure was a 50% decrease in knee pain from baseline to week 24. As secondary outcomes, we also assessed pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index; the rate of response using the criteria of the Outcome Measures for Rheumatology Committee and Osteoarthritis Research
American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee To update the American College of Rheumatology (ACR) 2000 recommendations for hip and kneeosteoarthritis (OA) and develop new recommendations for hand OA.A list of pharmacologic and nonpharmacologic modalities commonly used to manage knee, hip, and hand OA as well as clinical scenarios representing patients with symptomatic hand, hip (...) to undergo or had contraindications for total joint arthroplasty after having failed medical therapy. Recommendations for hip OA were similar to those for the management of knee OA.These recommendations are based on the consensus judgment of clinical experts from a wide range of disciplines, informed by available evidence, balancing the benefits and harms of both nonpharmacologic and pharmacologic modalities, and incorporating their preferences and values. It is hoped that these recommendations
Long-Term Comparison of Fixed-Bearing and Mobile-Bearing Total Knee Replacements in Patients Younger Than Fifty-one Years of Age with Osteoarthritis There is limited information comparing the results of fixed-bearing total knee replacement and mobile-bearing total knee replacement in patients with osteoarthritis who are younger than fifty-one years and who have a fixed-bearing implant in one knee and a mobile-bearing implant in the other. The purpose of this study was to compare our long-term (...) clinical and radiographic results of fixed-bearing total knee replacement and mobile-bearing total knee replacement in a group of patients from this population.We prospectively compared the results of 108 patients with osteoarthritis who were younger than fifty-one years (mean age, forty-five years) who had received a fixed-bearing prosthesis in one knee and a rotating platform mobile-bearing prosthesis in the other. The mean follow-up was 16.8 years (range, fifteen to eighteen years). The patients
Duloxetine for the management of pain in older adults with kneeosteoarthritis: randomised placebo-controlled trial pain is the leading symptom of osteoarthritis (OA) and is often chronic in nature, leading to significant morbidity and decreased quality of life. Duloxetine, a selective serotonin norepinephrine reuptake inhibitor has been demonstrated to have a centrally acting analgesic effect.the aim of the present study was to investigate the efficacy of duloxetine in reducing pain in older (...) adults with knee OA.totally, 288 patients aged 65 years and above with primary kneeOA were enrolled in this study. Patients were randomised 1:1. Totally, 144 received 60 mg/day of duloxetine HCL and 144 received placebo for 16 weeks. Outcome measures included pain reduction and improvement in physical functioning scores. Pain was assessed using the visual analogue pain scale (VAS; 0-100 mm). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were used to assess
for the initial pharmaco- logic management of kneeosteoarthritis (OA). For patients who have an inadequate response to initial pharmacologic management, please see the Results for alternative strategies. NSAIDs non- steroidal antiin?ammatory drugs. 470 Hochberg et alper GI problems, or chronic kidney disease presents to her primary care provider for treatment. As few trials have been performed in patients with symptomatic hip OA, the TEP considered that patients with hip OA should be treated in a similar (...) of Rheumatology Subcommittee on Osteo- arthritis Guidelines. Recommendations for the medical man- agement of osteoarthritis of the hip and knee. 2005. URL: http://www.rheumatology.org/practice/clinical/guidelines/ oa-mgmt.asp. 4. Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P, et al. EULAR recommendations 2003: an evidence based approach to the management of kneeosteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutic
Physical therapy interventions for knee pain secondary to osteoarthritis Physical therapy interventions for knee pain secondary to osteoarthritis Physical therapy interventions for knee pain secondary to osteoarthritis Shamliyan TA, Wang SY, Olson-Kellogg B, Kane RL Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Shamliyan TA, Wang SY (...) , Olson-Kellogg B, Kane RL. Physical therapy interventions for knee pain secondary to osteoarthritis. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 77. 2012 Authors' objectives To assess the association between intermediate and patient-centered outcomes and harms with physical therapy interventions in community-dwelling adults with chronic knee pain secondary to osteoarthritis and to examine validity and minimum clinically important differences
Effects of impairment-based exercise on performance of specific self-reported functional tasks in individuals with kneeosteoarthritis Little is known regarding how impairment-based exercises may improve performance of specific functional tasks in people with kneeosteoarthritis (OA).The purpose of this study was to compare the probability that participation in an impairment-based exercise program or the same impairment-based program supplemented with agility and perturbation training (...) will improve patient-reported function on specific functional tasks.This study was a secondary analysis of data from a randomized clinical trial.The study was conducted in the outpatient physical therapy clinic of a large, university-based health center.One hundred eighty-three people with kneeOA (122 women, 61 men) participated.Participants were randomly assigned to either a group that received agility and perturbation training with standard exercise therapy or a group that received only the standard
Increasing prevalence of knee pain and symptomatic kneeosteoarthritis: survey and cohort data. A recent surge in knee replacements is assumed to be due to aging and increased obesity of the U.S. population.To assess whether age, obesity, and change in radiographic kneeosteoarthritis explain the trend in knee pain and osteoarthritis.Cross-sectional, using data from 6 NHANES (National Health and Nutrition Examination Survey) surveys between 1971 and 2004 and from 3 examination periods (...) in the FOA (Framingham Osteoarthritis) Study between 1983 through 2005.U.S. population.NHANES participants (white or African American; aged 60 to 74 years) and FOA Study participants (mostly white; aged ≥70 years) were included.NHANES participants were asked about pain in or around the knee on most days. In the FOA Study, participants were asked about knee pain and had bilateral weight-bearing anteroposterior knee radiography to define radiographic kneeosteoarthritis. Radiographic evidence and self
Cost-effectiveness of acupuncture care as an adjunct to exercise-based physical therapy for osteoarthritis of the knee Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Nottingham kneeosteoarthritis risk prediction models (1) To develop risk prediction models for kneeosteoarthritis (OA) and (2) to estimate the risk reduction that results from modification of potential risk factors.This was a 12-year retrospective cohort study undertaken in the general population in Nottingham, UK. Baseline risk factors were collected by questionnaire. Incident radiographic kneeOA was defined by Kellgren and Lawrence (KL) score ≥2. Incident symptomatic kneeOA was defined (...) by KL ≥2 plus knee pain. Progression of kneeOA was defined by KL ≥1 grade increase from baseline. A logistic regression model was used for prediction. Calibration and discrimination of the models were tested in the Osteoarthritis Initiative (OAI) population and Genetics of Osteoarthritis and Lifestyle (GOAL) population. ORs of the models were compared with those obtained from meta-analysis of existing literature.From a community sample of 424 people aged over 40, 3 risk prediction models were
Inflammation related to synovectomy during total knee replacement in patients with primary osteoarthritis: a prospective, randomised study We compared inflammation in the knee after total knee replacement (TKR) for primary osteoarthritis between two groups of patients undergoing joint replacement with and without synovectomy. A total of 67 patients who underwent unilateral TKR were randomly divided into group I, TKR without synovectomy, and group II, TKR with synovectomy. Clinical outcomes (...) , serial serum inflammatory markers (including interleukin-6 (IL-6), CRP and ESR) and the difference in temperature of the skin of the knee, compared with the contralateral side, were sequentially evaluated until 26 weeks after surgery. Pre-operatively, there were no statistically different clinical parameters between groups I and II. At the 26-week follow-up, both groups had a similarly significantly improved American Knee Society clinical score (p < 0.001) and functional score (p < 0.001
Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in kneeosteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI To determine the effect of chondroitin sulphate (CS) treatment on cartilage volume loss, subchondral bone marrow lesions (BML), synovitis and disease symptoms in patients with kneeosteoarthritis (OA).In this pilot multicentre, randomised, double-blind (...) as 6 months for the global knee (p=0.030), lateral compartment (p=0.015) and tibial plateaus (p=0.002), with significance persisting at 12 months. Significantly lower BML scores were found for the CS group at 12 months in the lateral compartment (p=0.035) and the lateral femoral condyle (p=0.044). Disease symptoms were similar between the two groups.CS treatment significantly reduced the cartilage volume loss in kneeOA starting at 6 months of treatment, and BML at 12 months. These findings suggest
Risks of oral or transdermal opioids outweigh benefits for osteoarthritis of the knee or hip PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Risks of oral or transdermal opioids outweigh benefits for osteoarthritis of the knee or hip Clinical question How effective are oral or transdermal opioids in patients with osteoarthritis (OA) of the knee or hip? Bottom line Compared to placebo (...) poorer quality of life and reduced functional capacity, and does not seem to improve pain relief.² Context OA is the most common form of jointdisease and the leading cause of pain and physical disability in the elderly. Opioids may be a viable treatment option if patients suffer from severe pain, or if other analgesics are contraindicated. However, the evidence on their effectiveness and safety is contradictory. Cochrane Systematic Review Nuesch E et al. Oral or transdermal opioids
Osteoarthritis is a chronic jointdisease that involves degeneration of articular cartilage. Pre-clinical data has suggested that doxycycline might act as a disease- modifying agent for the treatment of osteoarthritis, with the potential to slow cartilage degeneration. Cochrane Systematic Review Nuesch E et al. Doxycycline for osteoarthritis of the knee or hip. Cochrane Reviews 2009, Issue 4. Article No. CD007323. DOI: 10.1002/14651858.CD007323.pub2. This review contains one study involving 431 participants (...) Doxycycline ineffective for osteoarthritis of the knee or hip PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Doxycycline ineffective for osteoarthritis of the knee or hip Clinical question How effective is doxycycline for osteoarthritis (OA) of the knee or hip? Bottom line Compared to placebo, there is minimal or no symptomatic benefit (pain reduction and improved physical function
Agility and perturbation training techniques in exercise therapy for reducing pain and improving function in people with kneeosteoarthritis: a randomized clinical trial Impairment-based exercise programs have yielded only small to moderate benefits in reducing pain and improving function in people with kneeosteoarthritis (OA). It has previously been proposed that adding agility and perturbation training to exercise programs for people with kneeOA may improve treatment effects for pain (...) and function.The purpose of this study was to examine the effectiveness of adding agility and perturbation techniques to standard exercise therapy compared with the standard exercise program alone for people with knee OA.This was a single-blinded randomized controlled trial.The study was conducted in the outpatient physical therapy clinic of a large, university-based health center.One hundred eighty-three people with kneeOA (122 women, 61 men) participated.Participants were randomly assigned to either a group
All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. To examine all cause and disease specific mortality in patients with osteoarthritis of the knee or hip.Population based cohort study.General practices in the southwest of England.1163 patients aged 35 years or over with symptoms and radiological confirmation of osteoarthritis of the knee or hip.Age and sex standardised mortality ratios and multivariable hazard ratios of death (...) after a median of 14 years' follow-up.Patients with osteoarthritis had excess all cause mortality compared with the general population (standardised mortality ratio 1.55, 95% confidence interval 1.41 to 1.70). Excess mortality was observed for all disease specific causes of death but was particularly pronounced for cardiovascular (standardised mortality ratio 1.71, 1.49 to 1.98) and dementia associated mortality (1.99, 1.22 to 3.25). Mortality increased with increasing age (P for trend <0.001), male