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Latest & greatest articles for knee osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on knee osteoarthritis or other clinical topics then use Trip today.
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Effects of intensive diet and exercise on kneejoint loads, inflammation, and clinical outcomes among overweight and obese adults with kneeosteoarthritis: the IDEA randomized clinical trial. Kneeosteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity.To determine whether a ≥10% reduction in body weight induced by diet, with or without exercise, would improve mechanistic and clinical outcomes more than (...) , or exercise.Mechanistic primary outcomes: kneejoint compressive force and plasma IL-6 levels; secondary clinical outcomes: self-reported pain (range, 0-20), function (range, 0-68), mobility, and health-related quality of life (range, 0-100).Three hundred ninety-nine participants (88%) completed the study. Mean weight loss for diet + exercise participants was 10.6 kg (11.4%); for the diet group, 8.9 kg (9.5%); and for the exercise group, 1.8 kg (2.0%). After 18 months, knee compressive forces were lower in diet
A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic kneeosteoarthritis To compare the effects of an intermediate molecular weight (MW) intra-articular hyaluronic acid (HA) with a low MW product on kneeosteoarthritis (OA) symptoms.Patients with symptomatic kneeOA were enrolled inarandomised, controlled, double-blind, parallel-group, non-inferiority trial with the possibility to shift (...) all>0, p=0.021). Ahigher proportion of OARSI/OMERACT responders was observed with GO-ONthan with Hyalgan (73.3% vs58.4%, p=0.001). Both preparations were well tolerated.Treatment with 3-weekly injections of intermediate MW HA may be superior to low MW HA on kneeOA symptoms over 6 months, with similar safety.
Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. Kneeosteoarthritis (OA), a disorder of cartilage and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression.To determine whether vitamin D supplementation reduces symptom and structural progression of knee OA.A 2 (...) -year randomized, placebo-controlled, double-blind, clinical trial involving 146 participants with symptomatic kneeOA (mean age, 62.4 years [SD, 8.5]; 57 women [61%], 115 white race [79%]). Patients were enrolled at Tufts Medical Center in Boston between March 2006 and June 2009.Participants were randomized to receive either placebo or oral cholecalciferol, 2000 IU/d, with dose escalation to elevate serum levels to more than 36 ng/mL.Primary outcomes were knee pain severity (Western Ontario
-comparative 4. Sarda PK, Shetty A, Maheswaran SS. Medium term results of Avon patellofemoral joint replacement. Indian J Orthop [Internet]. 2011 Sep [cited 2012 Nov 22];45(5):439-44. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162681 PubMed: PM21886926 5. Dahm DL, Al-Rayashi W, Dajani K, Shah JP, Levy BA, Stuart MJ. Patellofemoral arthroplasty versus total knee arthroplasty in patients with isolated patellofemoral osteoarthritis. Am J Orthop (Belle Mead NJ ) [Internet]. 2010 Oct [cited (...) Knee Prostheses for Patellar Resurfacing for Adults with Osteoarthritis: Comparative Clinical Effectiveness Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time
Physical therapy interventions for knee pain secondary to osteoarthritis: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
, multicenter trial.Departments of physical medicine and rehabilitation in 4 centers.Patients (N=203) with kneeosteoarthritis (OA).The patients were randomized by the principal center into the following 6 treatment groups: TENS sham, TENS, IFCs sham, IFCs, SWD sham, and SWD. All interventions were applied 5 times a week for 3 weeks. In addition, exercises and an education program were given. The exercises were carried out as part of a home-based training program after 3 weeks' supervised group (...) Comparison of the efficacy of transcutaneous electrical nerve stimulation, interferential currents, and shortwave diathermy in kneeosteoarthritis: a double-blind, randomized, controlled, multicenter study To compare the effectiveness of transcutaneous electrical nerve stimulation (TENS), interferential currents (IFCs), and shortwave diathermy (SWD) against each other and sham intervention with exercise training and education as a multimodal package.A double-blind, randomized, controlled
Short-term effects of 890-nanometer radiation on pain, physical activity, and postural stability in patients with kneeosteoarthritis: a double-blind, randomized, placebo-controlled study To investigate the effects of short-term light therapy with 890-nm radiation on pain, physical activity, and postural stability in patients with kneeosteoarthritis (OA).A double-blind, randomized, placebo-controlled study.Rehabilitation clinic.Women (n=62) and men (n=10) with a mean age of 61.2 years (range (...) , 40-88y). All patients fulfilled the combined clinical and radiographic criteria for kneeOA as established by the American College of Rheumatology, and all had obtained a Kellgren-Lawrence score of 2 or more.Participants received 6 sessions, lasting 40 minutes each, of active or placebo radiation treatment over the kneejoints for 2 weeks (wavelength, 890nm; radiant power output, 6.24W; power density, 34.7mW/cm(2) for 40 minutes; total energy, 41.6J/cm(2) per knee per session).Participants were
Viscosupplementation for osteoarthritis of the knee Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
types of abnormalities detectable by MRI. There were no significant differences in the prevalence of any of the features between BMI groups. The prevalence of at least one type of pathology ("any abnormality") was high in both painful (90-97%, depending on pain definition) and painless (86-88%) knees.MRI shows lesions in the tibiofemoral joint in most middle aged and elderly people in whom knee radiographs do not show any features of osteoarthritis, regardless of pain. (...) Prevalence of abnormalities in knees detected by MRI in adults without kneeosteoarthritis: population based observational study (Framingham Osteoarthritis Study). To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity.Population based observational study.Community cohort in Framingham, MA, United States (Framingham
A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic KneeOsteoarthritis This multicenter, double-blind clinical trial evaluated and compared the efficacy and safety of PRGF-Endoret (BTI Biotechnology Institute, Vitoria-Gasteiz, Spain), an autologous biological therapy for regenerative purposes, versus hyaluronic acid (HA) as a short-term treatment for knee pain from osteoarthritis.We randomly (...) assigned 176 patients with symptomatic kneeosteoarthritis to receive infiltrations with PRGF-Endoret or with HA (3 injections on a weekly basis). The primary outcome measure was a 50% decrease in knee pain from baseline to week 24. As secondary outcomes, we also assessed pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index; the rate of response using the criteria of the Outcome Measures for Rheumatology Committee and Osteoarthritis Research
American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee To update the American College of Rheumatology (ACR) 2000 recommendations for hip and kneeosteoarthritis (OA) and develop new recommendations for hand OA.A list of pharmacologic and nonpharmacologic modalities commonly used to manage knee, hip, and hand OA as well as clinical scenarios representing patients with symptomatic hand, hip (...) to undergo or had contraindications for total joint arthroplasty after having failed medical therapy. Recommendations for hip OA were similar to those for the management of knee OA.These recommendations are based on the consensus judgment of clinical experts from a wide range of disciplines, informed by available evidence, balancing the benefits and harms of both nonpharmacologic and pharmacologic modalities, and incorporating their preferences and values. It is hoped that these recommendations
Long-Term Comparison of Fixed-Bearing and Mobile-Bearing Total Knee Replacements in Patients Younger Than Fifty-one Years of Age with Osteoarthritis There is limited information comparing the results of fixed-bearing total knee replacement and mobile-bearing total knee replacement in patients with osteoarthritis who are younger than fifty-one years and who have a fixed-bearing implant in one knee and a mobile-bearing implant in the other. The purpose of this study was to compare our long-term (...) clinical and radiographic results of fixed-bearing total knee replacement and mobile-bearing total knee replacement in a group of patients from this population.We prospectively compared the results of 108 patients with osteoarthritis who were younger than fifty-one years (mean age, forty-five years) who had received a fixed-bearing prosthesis in one knee and a rotating platform mobile-bearing prosthesis in the other. The mean follow-up was 16.8 years (range, fifteen to eighteen years). The patients
Duloxetine for the management of pain in older adults with kneeosteoarthritis: randomised placebo-controlled trial pain is the leading symptom of osteoarthritis (OA) and is often chronic in nature, leading to significant morbidity and decreased quality of life. Duloxetine, a selective serotonin norepinephrine reuptake inhibitor has been demonstrated to have a centrally acting analgesic effect.the aim of the present study was to investigate the efficacy of duloxetine in reducing pain in older (...) adults with knee OA.totally, 288 patients aged 65 years and above with primary kneeOA were enrolled in this study. Patients were randomised 1:1. Totally, 144 received 60 mg/day of duloxetine HCL and 144 received placebo for 16 weeks. Outcome measures included pain reduction and improvement in physical functioning scores. Pain was assessed using the visual analogue pain scale (VAS; 0-100 mm). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were used to assess
for the initial pharmaco- logic management of kneeosteoarthritis (OA). For patients who have an inadequate response to initial pharmacologic management, please see the Results for alternative strategies. NSAIDs non- steroidal antiin?ammatory drugs. 470 Hochberg et alper GI problems, or chronic kidney disease presents to her primary care provider for treatment. As few trials have been performed in patients with symptomatic hip OA, the TEP considered that patients with hip OA should be treated in a similar (...) of Rheumatology Subcommittee on Osteo- arthritis Guidelines. Recommendations for the medical man- agement of osteoarthritis of the hip and knee. 2005. URL: http://www.rheumatology.org/practice/clinical/guidelines/ oa-mgmt.asp. 4. Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P, et al. EULAR recommendations 2003: an evidence based approach to the management of kneeosteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutic
Physical therapy interventions for knee pain secondary to osteoarthritis Physical therapy interventions for knee pain secondary to osteoarthritis Physical therapy interventions for knee pain secondary to osteoarthritis Shamliyan TA, Wang SY, Olson-Kellogg B, Kane RL Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Shamliyan TA, Wang SY (...) , Olson-Kellogg B, Kane RL. Physical therapy interventions for knee pain secondary to osteoarthritis. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 77. 2012 Authors' objectives To assess the association between intermediate and patient-centered outcomes and harms with physical therapy interventions in community-dwelling adults with chronic knee pain secondary to osteoarthritis and to examine validity and minimum clinically important differences
Effects of impairment-based exercise on performance of specific self-reported functional tasks in individuals with kneeosteoarthritis Little is known regarding how impairment-based exercises may improve performance of specific functional tasks in people with kneeosteoarthritis (OA).The purpose of this study was to compare the probability that participation in an impairment-based exercise program or the same impairment-based program supplemented with agility and perturbation training (...) will improve patient-reported function on specific functional tasks.This study was a secondary analysis of data from a randomized clinical trial.The study was conducted in the outpatient physical therapy clinic of a large, university-based health center.One hundred eighty-three people with kneeOA (122 women, 61 men) participated.Participants were randomly assigned to either a group that received agility and perturbation training with standard exercise therapy or a group that received only the standard
Increasing prevalence of knee pain and symptomatic kneeosteoarthritis: survey and cohort data. A recent surge in knee replacements is assumed to be due to aging and increased obesity of the U.S. population.To assess whether age, obesity, and change in radiographic kneeosteoarthritis explain the trend in knee pain and osteoarthritis.Cross-sectional, using data from 6 NHANES (National Health and Nutrition Examination Survey) surveys between 1971 and 2004 and from 3 examination periods (...) in the FOA (Framingham Osteoarthritis) Study between 1983 through 2005.U.S. population.NHANES participants (white or African American; aged 60 to 74 years) and FOA Study participants (mostly white; aged ≥70 years) were included.NHANES participants were asked about pain in or around the knee on most days. In the FOA Study, participants were asked about knee pain and had bilateral weight-bearing anteroposterior knee radiography to define radiographic kneeosteoarthritis. Radiographic evidence and self
Cost-effectiveness of acupuncture care as an adjunct to exercise-based physical therapy for osteoarthritis of the knee Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Nottingham kneeosteoarthritis risk prediction models (1) To develop risk prediction models for kneeosteoarthritis (OA) and (2) to estimate the risk reduction that results from modification of potential risk factors.This was a 12-year retrospective cohort study undertaken in the general population in Nottingham, UK. Baseline risk factors were collected by questionnaire. Incident radiographic kneeOA was defined by Kellgren and Lawrence (KL) score ≥2. Incident symptomatic kneeOA was defined (...) by KL ≥2 plus knee pain. Progression of kneeOA was defined by KL ≥1 grade increase from baseline. A logistic regression model was used for prediction. Calibration and discrimination of the models were tested in the Osteoarthritis Initiative (OAI) population and Genetics of Osteoarthritis and Lifestyle (GOAL) population. ORs of the models were compared with those obtained from meta-analysis of existing literature.From a community sample of 424 people aged over 40, 3 risk prediction models were