Latest & greatest articles for low back pain

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on low back pain or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on low back pain and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for low back pain

161. Effectiveness of Kinesio Taping in Patients With Chronic Nonspecific Low Back Pain: A Systematic Review With Meta-analysis (Abstract)

Effectiveness of Kinesio Taping in Patients With Chronic Nonspecific Low Back Pain: A Systematic Review With Meta-analysis Systematic review.To investigate the effects of Kinesio Taping (KT) in patients with nonspecific low back pain.KT is widely used in patients with low back pain.We conducted searches on PubMed, EMBASE, PEDro, SciELO, and LILACS up to February 26, 2018. We included only randomized controlled trials (RCTs) in adults with chronic nonspecific low back pain that compared KT (...) was no better than any other intervention for most the outcomes assessed in patients with chronic nonspecific low back pain. We found no evidence to support the use of KT in clinical practice for patients with chronic nonspecific low back pain.1.

2019 EvidenceUpdates

162. Do Regenerative Medicine Therapies Provide Long-Term Relief in Chronic Low Back Pain: A Systematic Review and Metaanalysis (Abstract)

Do Regenerative Medicine Therapies Provide Long-Term Relief in Chronic Low Back Pain: A Systematic Review and Metaanalysis Several cell-based therapies have been proposed in recent years the management of low back pain, including the injection of medicinal signaling cells or mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP). However, there is only emerging clinical evidence to support their use at this time.To assess the effectiveness of MSCs or PRP injections in the treatment of low (...) through V) evidence. Similarly, evidence for lumbar facet joint injections and sacroiliac joint injections without metaanalysis demonstrated Level 4 evidence (on a scale of Level I through V).Lack of high quality RCTs.The findings of this systematic review and single-arm metaanalysis shows that MSCs and PRP may be effective in managing discogenic low back pain, radicular pain, facet joint pain, and sacroiliac joint pain, with variable levels of evidence in favor of these techniques.Chronic low back

2019 EvidenceUpdates

163. Level of Evidence for Reliability, Validity, and Responsiveness of Physical Capacity Tasks Designed to Assess Functioning in Patients With Low Back Pain: A Systematic Review Using the COSMIN Standards. (Full text)

Level of Evidence for Reliability, Validity, and Responsiveness of Physical Capacity Tasks Designed to Assess Functioning in Patients With Low Back Pain: A Systematic Review Using the COSMIN Standards. Physical capacity tasks (ie, observer-administered outcome measures that comprise a standardized activity) are useful for assessing functioning in patients with low back pain.The purpose of this study was to systematically review the level of evidence for the reliability, validity (...) of functioning in patients with chronic low back pain. However, more research on the measurement error and responsiveness of these tasks is needed to be able to fully recommend them as outcome measures in research and clinical practice.© The Author(s) 2019. Published by Oxford University Press on behalf of the American Physical Therapy Association.

2018 Physical therapy PubMed abstract

164. Effectiveness of movement control exercise on patients with non-specific low back pain and movement control impairment: A systematic review and meta-analysis. (Abstract)

Effectiveness of movement control exercise on patients with non-specific low back pain and movement control impairment: A systematic review and meta-analysis. Patients with low back pain (LBP) and movement control impairment (MVCI) show altered spinal movement patterns. Treatment that aims to change movement behaviour could benefit these patients.To assess the effectiveness of movement control exercise (MVCE) in terms of clinically relevant measures (disability and pain) on patients (...) differences (SMD).Eleven eligible RCT's including a total of 781 patients were found. Results show 'very low to moderate quality' evidence of a positive effect of MVCE on disability, both at the end of treatment and after 12 months (SMD -0.38 95%CI -0.68, -0.09 respectively 0.37 95%CI -0.61,-0.04). Pain intensity was significantly reduced after MVCE at the end of treatment (SMD -0.39 95%CI -0.69, -0.04), but not after 12 months (SMD -0.27, 95%CI -0.62, 0.09).MVCE intervention for people with NSLBP

2018 Musculoskeletal science & practice

165. Reply to the letter to the editor YMATH_2018_15:"Two-point discrimination and the low back pain: Not as unreliable as it seems, but what about standardised procedures?" regarding our article MSKSP_168:"A systematic review and meta-analysis of the reliabil (Abstract)

Reply to the letter to the editor YMATH_2018_15:"Two-point discrimination and the low back pain: Not as unreliable as it seems, but what about standardised procedures?" regarding our article MSKSP_168:"A systematic review and meta-analysis of the reliabil 29650367 2018 06 07 2018 12 02 2468-7812 35 2018 06 Musculoskeletal science & practice Musculoskelet Sci Pract Reply to the letter to the editor YMATH_2018_15:"Two-point discrimination and the low back pain: Not as unreliable as it seems (...) , but what about standardised procedures?" regarding our article MSKSP_168:"A systematic review and meta-analysis of the reliability and validity of sensorimotor measurement instruments in people with chronic low back pain". e112-e113 S2468-7812(18)30102-4 10.1016/j.msksp.2018.04.003 Ehrenbrusthoff Katja K Health and Social Care Institute, Teesside University, Middlesbrough, Tees Valley, TS1 3BX, United Kingdom; Hochschule für Gesundheit, Department of Applied Health Sciences, Gesundheitscampus 6-8

2018 Musculoskeletal science & practice

166. Low back pain patients' perspectives on long-term adherence to home-based exercise programmes in physiotherapy. (Abstract)

Low back pain patients' perspectives on long-term adherence to home-based exercise programmes in physiotherapy. Adherence to an exercise programme impacts the outcome of physiotherapy treatment in patients with non-specific low back pain.The aim of this study was to explore the patients' perspectives on long term adherence to such exercise programmes.This qualitative study was embedded in a randomised controlled trial (RCT) which compared the effectiveness of two types of exercise programme (...) on patients with nonspecific low back pain.Answers from 44 participants to three open-ended questions were analysed using thematic analysis.Patients' perceptions related to the following themes: 1) the role of knowledge in long-term exercise adherence; 2) strategies to support exercise adherence; 3) barriers to exercise adherence 4) the role of perceived effects of exercise.Adherence to long-term exercise is supported through knowledge of the exercises and correct performance. A self-initiated training

2018 Musculoskeletal science & practice

167. Identifying and Engaging Neuronal Oscillations by Transcranial Alternating Current Stimulation in Patients With Chronic Low Back Pain: A Randomized, Crossover, Double-Blind, Sham-Controlled Pilot Study (Full text)

Identifying and Engaging Neuronal Oscillations by Transcranial Alternating Current Stimulation in Patients With Chronic Low Back Pain: A Randomized, Crossover, Double-Blind, Sham-Controlled Pilot Study Chronic pain is associated with maladaptive reorganization of the central nervous system. Recent studies have suggested that disorganization of large-scale electrical brain activity patterns, such as neuronal network oscillations in the thalamocortical system, plays a key role (...) in the pathophysiology of chronic pain. Yet, little is known about whether and how such network pathologies can be targeted with noninvasive brain stimulation as a nonpharmacological treatment option. We hypothesized that alpha oscillations, a prominent thalamocortical activity pattern in the human brain, are impaired in chronic pain and can be modulated with transcranial alternating current stimulation (tACS). We performed a randomized, crossover, double-blind, sham-controlled study in patients with chronic low

2018 EvidenceUpdates PubMed abstract

168. Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial (Full text)

Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial Antidepressants at low dose are commonly prescribed for the management of chronic low back pain and their use is recommended in international clinical guidelines. However, there is no evidence for their efficacy.To examine the efficacy of a low-dose antidepressant compared with an active comparator in reducing pain, disability, and work absence and hindrance in individuals with chronic low back pain.A (...) double-blind, randomized clinical trial with a 6-month follow-up of adults with chronic, nonspecific, low back pain who were recruited through hospital/medical clinics and advertising was carried out.Low-dose amitriptyline (25 mg/d) or an active comparator (benztropine mesylate, 1 mg/d) for 6 months.The primary outcome was pain intensity measured at 3 and 6 months using the visual analog scale and Descriptor Differential Scale. Secondary outcomes included disability assessed using the Roland Morris

2018 EvidenceUpdates PubMed abstract

169. The Effect of Combination Pharmacotherapy on Low Back Pain: A Meta-analysis (Abstract)

The Effect of Combination Pharmacotherapy on Low Back Pain: A Meta-analysis To evaluate the difference between combination pharmacotherapy and monotherapy on low back pain (LBP).We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials databases up to March 14, 2017. Two authors independently extracted the data and assessed the validity of included trials.Twelve randomized controlled trials comparing the effect of LBP combination pharmacotherapy to monotherapy or placebo (...) were included. In chronic LBP, combination pharmacotherapy was more effective than placebo in pain relief (P<0.001; standardized mean difference [SMD], -0.50; 95% confidence interval [CI], -0.70 to -0.29; I²=0%) and function improvement (P<0.001; SMD, -0.27; 95% CI, -0.41 to -0.13; I²=0%) and showed improved pain relief compared with monotherapy (P<0.001; SMD, -0.84; 95% CI, -1.12 to -0.56; I²=0%). Combination pharmacotherapy did not outperform monotherapy pain relief and function improvement

2018 EvidenceUpdates

170. The association of high-intensity zones on MRI and low back pain: a systematic review (Full text)

The association of high-intensity zones on MRI and low back pain: a systematic review Magnetic resonance imaging (MRI) of the lumbar spine is commonly used to identify the source of low back pain (LBP); however, its use has been questionable. Throughout the years, numerous lumbar phenotypes (e.g., endplate abnormalities, Modic changes, black disc) have been studied as possible pain generators. High-intensity zones (HIZs) are of particular interest as they may represent annular tears. However (...) , for over three decades, there has been heated debate as to whether these imaging biomarkers are synonymous with LBP. Therefore, the following study addressed a systematic review of the reported literature addressing the relationship of HIZs and LBP.A systematic review was conducted via MEDLINE, SCOPUS, Cochrane, PubMed, PubMed Central, EMBASE via Ovid, and Web of Science with the following search terms: "HIZ," "high intensity zone," or "high intensity zones" and "low back pain," "pain," "lumbago

2018 Scoliosis and spinal disorders PubMed abstract

171. Exercise for the prevention and treatment of low back, pelvic girdle and lumbopelvic pain during pregnancy: a systematic review and meta-analysis. (Full text)

Exercise for the prevention and treatment of low back, pelvic girdle and lumbopelvic pain during pregnancy: a systematic review and meta-analysis. The purpose of this review was to investigate the relationship between prenatal exercise, and low back (LBP), pelvic girdle (PGP) and lumbopelvic (LBPP) pain.Systematic review with random effects meta-analysis and meta-regression.Online databases were searched up to 6 January 2017.Studies of all designs were eligible (except case studies and reviews (...) and symptom severity of LBP, PGP and LBPP).The analyses included data from 32 studies (n=52 297 pregnant women). 'Very low' to 'moderate' quality evidence from 13 randomised controlled trials (RCTs) showed prenatal exercise did not reduce the odds of suffering from LBP, PGP and LBPP either in pregnancy or the postpartum period. However, 'very low' to 'moderate' quality evidence from 15 RCTs identified lower pain severity during pregnancy and the early postpartum period in women who exercised during

2018 British Journal of Sports Medicine PubMed abstract

172. Effectiveness of primary care interventions using a biopsychosocial approach in chronic low back pain: a systematic review. (Full text)

Effectiveness of primary care interventions using a biopsychosocial approach in chronic low back pain: a systematic review. Recent systematic reviews show promising effects for multidisciplinary biopsychosocial (BPS) interventions in patients with chronic low back pain (CLBP). Nowadays, BPS interventions have also been developed for primary care physiotherapy settings. Our aim was to systematically review the evidence on the effectiveness of primary care BPS interventions in improving (...) RCTs were included (1,426 participants). Results show moderate-quality evidence (3 trials; 991 participants) that a BPS intervention is more effective than education/advice for reducing disability and pain in the short, medium, and long term. Low-quality evidence (4 trials; 435 participants) was found for no difference with physical activity treatments.BPS interventions seem more effective than education/advice and were found to be as effective as physical activity interventions in patients

2018 Pain Practice PubMed abstract

173. Prediction of clinical outcomes in individuals with chronic low back pain: a protocol for a systematic review with meta-analysis. (Full text)

Prediction of clinical outcomes in individuals with chronic low back pain: a protocol for a systematic review with meta-analysis. Low back pain (LBP) is one of the most prevalent and recurrent conditions in the general population, with personal, professional, social and economic impact. However, there is a lack of consistent evidence about chronic low back pain (CLBP) prognosis, especially highlighting predictors that influence CLBP outcome. Existing systematic reviews are scarce, outdated (...) and incomplete. The primary aim of this systematic review is to identify multivariable models and/or predictors associated with clinical outcomes in subjects with CLBP (namely pain intensity, disability, return to work, psychological well-being and quality of life).We will systematically search Ovid MEDLINE (PubMed), Scopus and Web of Science databases for longitudinal studies, published until June 2017, including adults with CLBP (defined as persistent pain with ≥ 3 months duration), which studied

2018 Systematic reviews PubMed abstract

174. Effectiveness and Downstream Healthcare Utilization for Patients That Received Early Physical Therapy Versus Usual Care for Low Back Pain: A Randomized Clinical Trial (Abstract)

Effectiveness and Downstream Healthcare Utilization for Patients That Received Early Physical Therapy Versus Usual Care for Low Back Pain: A Randomized Clinical Trial Randomized controlled trial.The aim of this study was to compare early physical therapy versus usual care in patients with low back pain.Early physical therapy (PT) has been associated with reduced downstream healthcare utilization in retrospective studies, but not investigated prospectively in the military health system.Military (...) significantly between groups (UC $5037; 95 CI $4171-$6082 and PT $5299; 95 CI $4367-$6431). The portion of total mean healthcare costs related to low back pain was lower for UC ($1096; 95% CI $855-$1405) compared to PT ($2016, 95% CI $1570-$2590).There was no difference between usual care and early PT after 1 year. PT provided greater improvement in disability after 4 weeks. As both groups improved, the impact of the education may have been underestimated. Patients in the PT group utilized greater back-pain

2018 EvidenceUpdates

175. Osteopathic Manipulative Treatment Including Specific Diaphragm Techniques Improves Pain and Disability in Chronic Nonspecific Low Back Pain: A Randomized Trial (Abstract)

Osteopathic Manipulative Treatment Including Specific Diaphragm Techniques Improves Pain and Disability in Chronic Nonspecific Low Back Pain: A Randomized Trial To investigate the effects of an osteopathic manipulative treatment (OMT), which includes a diaphragm intervention compared to the same OMT with a sham diaphragm intervention in chronic nonspecific low back pain (NS-CLBP).Parallel group randomized controlled trial.Private and institutional health centers.Participants (N=66) (18-60y (...) ) with a diagnosis of NS-CLBP lasting at least 3 months.Participants were randomized to receive either an OMT protocol including specific diaphragm techniques (n=33) or the same OMT protocol with a sham diaphragm intervention (n=33), conducted in 5 sessions provided during 4 weeks.The primary outcomes were pain (evaluated with the Short-Form McGill Pain Questionnaire [SF-MPQ] and the visual analog scale [VAS]) and disability (assessed with the Roland-Morris Questionnaire [RMQ] and the Oswestry Disability Index

2018 EvidenceUpdates

176. Can Beta-Endorphin Be Used as a Biomarker for Chronic Low Back Pain? A Meta-analysis of Randomized Controlled Trials. (Abstract)

Can Beta-Endorphin Be Used as a Biomarker for Chronic Low Back Pain? A Meta-analysis of Randomized Controlled Trials. Chronic low back pain (CLBP) is usually quantified using the visual analog scale (VAS). However, the VAS is a subjective measure and prone to reporting bias, therefore making it difficult to differentiate patients with true pain from those seeking to obtain secondary gain. This study aimed to evaluate the feasibility of using plasma β-endorphin as an objective biomarker (...) of CLBP (explanatory power: 66%).A change in plasma β-endorphin level may be a surrogate marker of the treatment response for patients with CLBP. Advancements in β-endorphin measurements may help us better quantify pain intensity.

2018 Pain Medicine

177. Assessment of variability in traction interventions for patients with low back pain: a systematic review (Full text)

Assessment of variability in traction interventions for patients with low back pain: a systematic review Previous systematic reviews have concluded that lumbar traction is not effective for patients with low back pain (LBP), yet many clinicians continue to assert its clinical effectiveness.To systematically identify randomized controlled trials (RCTs) of traction and explore the variability of traction interventions used in each RCT.A literature search started in September 2016 to retrieve

2018 Chiropractic & manual therapies PubMed abstract

178. A systematic review and meta-analysis of pain neuroscience education for chronic low back pain: short- and long-term outcomes of pain and disability. (Abstract)

A systematic review and meta-analysis of pain neuroscience education for chronic low back pain: short- and long-term outcomes of pain and disability. Pain neuroscience education (PNE) has shown promising ability in previous reviews to improve pain and disability in chronic low back pain (CLBP). This review aimed to evaluate randomized controlled trials comparing the effectiveness of PNE on pain and disability in CLBP.A systematic search was performed using the databases of EBSCO, Medline (...) back pain. These results provide greater support for the addition of pain neuroscience education in routine physiotherapy practice in chronic low back pain.© 2018 European Pain Federation - EFIC®.

2018 European Journal of Pain

179. Low back pain: no corticosteroids

Low back pain: no corticosteroids Prescrire IN ENGLISH - Spotlight ''Low back pain: no corticosteroids '', 1 September 2018 {1} {1} {1} | | > > > Low back pain: no corticosteroids Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Low back pain: no corticosteroids There is no evidence that systemic corticosteroids have any efficacy on low back pain (...) , beyond a placebo effect. Furthermore, they expose patients to numerous adverse effects. Low back pain is common in adults. It is sometimes accompanied by pain spreading into the lower limbs (radiculalgia). In most cases, it improves spontaneously, within a few days or weeks. When low back pain persists for more than three months, it is termed chronic. In most cases, there is no identifiable cause. Several trials have compared systemic corticosteroid therapy with a placebo. Their results converge

2018 Prescrire

180. Whole-body vibration exercise for low back pain: A meta-analysis protocol of randomized controlled trial. (Full text)

Whole-body vibration exercise for low back pain: A meta-analysis protocol of randomized controlled trial. Low back pain (LBP) affects about 80% of the population at some time in their lives. Exercise therapy is the most widely used nonsurgical intervention for low back pain in practice. Thus, whole-body vibration (WBV) exercise is becoming increasingly popular in relieving musculoskeletal pain and in improving function. However, the efficacy of WBV exercise is not without dispute for low back (...) exercise for patients with LBP. Data extraction will be done independently by the same 2 reviewers who selected the studies. The primary outcome will be to assess pain, back-specific disability index, and adverse effect. Continuous data will be pooled by calculating the mean difference using the random-effects model.The results of the final meta-analysis will provide an evidence of WBV exercise for low back pain.This meta-analysis will provide a detailed summary of the evidence on the effects of WBV

2018 Medicine PubMed abstract