Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for lung cancer
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on lung cancer or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on lung cancer and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via email@example.com
Prognostic value of TP53 concurrent mutations for EGFR- TKIs and ALK-TKIs based targeted therapy in advanced non-small cell lungcancer: a meta-analysis. The prognostic significance of TP53 concurrent mutations in patients with epidermal growth factor receptor (EGFR)- or anaplastic lymphoma kinase (ALK)- mutated advanced non-small-cell lungcancer (NSCLC) who received EGFR-tyrosine kinase inhibitors (TKIs) or ALK-TKIs based targeted therapy remains controversial. Therefore, the present meta (...) , pathological type of cancer (adenocarcinoma only or all NSCLC subtypes) and line of treatment (first-line only or all lines) all showed that TP53 mutations was associated with shorter survivals of patients with EGFR-TKIs or ALK-TKIs treatments. Particularly, in patients with first-line EGFR-TKIs treatment, significantly poorer prognosis was observed in patients with TP53 concurrent mutations (pooled HR for PFS: 1.69, 95% CI 1.25-2.27, P < 0.001, I2 = 0.0%, P = 0.473; pooled HR for OS: 1.94, 95% CI 1.36
Prognostic value of pretreatment platelet counts in lungcancer: a systematic review and meta-analysis. The prognostic value of elevated pretreatment platelet counts remains controversial in lungcancer patients. We performed the present meta-analysis to determine its precise role in these patients.We employed a multiple search strategy in the PubMed, EMBASE and Cochrane Library databases to identify eligible studies. Disease-free survival (DFS)/progression-free survival (PFS)/time (...) to progression (TTP) and overall survival (OS) were used as outcomes with hazard ratios (HRs) and 95% confidence intervals (CIs). Heterogeneity among the studies and publication bias were also evaluated.A total of 40 studies including 16,696 lungcancer patients were eligible for the analysis. Overall, the pooled analysis showed that compared with normal platelet counts, elevated pretreatment platelet counts were associated with poorer OS (HR = 1.54, 95% CI: 1.37-1.72, P < 0.001) and poorer DFS/PFS/TTP (HR
The landscape of immune checkpoint inhibitor plus chemotherapy versus immunotherapy for advanced non-small-cell lungcancer: A systematic review and meta-analysis. Lungcancer is the leading cause of cancer-related deaths worldwide and the prognosis remains poor. The recent introduction of the immune checkpoint inhibitor (ICI), or plus chemotherapy, both resulted in the survival benefit for patients with advanced non-small-cell lungcancer (NSCLC), but it remains unanswered which is superior
Effect of Exercise Interventions on Quality of Life in Patients With LungCancer: A Systematic Review of Randomized Controlled Trials. Improving quality of life (QOL) is a key issue for patients with lungcancer. Exercise interventions could positively affect patients' QOL; however, there is no clear-cut understanding of the role of exercise in improving QOL in patients with lung cancer.The PubMed®, Embase®, Cochrane Library, and Web of Science electronic databases were searched from inception (...) to September 6, 2019.16 randomized controlled trials met the inclusion criteria. A qualitative synthesis method was used to identify the effect of exercise interventions on QOL in patients with lung cancer.This review indicates that exercise interventions may have beneficial effects on the QOL of patients with lungcancer. The effectiveness seems to be affected by the duration of the intervention, as well as exercise frequency, intensity, and adherence.Exercise interventions can be integrated
Appraising the causal relevance of DNA methylation for risk of lungcancer. DNA methylation changes in peripheral blood have recently been identified in relation to lungcancer risk. Some of these changes have been suggested to mediate part of the effect of smoking on lungcancer. However, limitations with conventional mediation analyses mean that the causal nature of these methylation changes has yet to be fully elucidated.We first performed a meta-analysis of four epigenome-wide association (...) studies (EWAS) of lungcancer (918 cases, 918 controls). Next, we conducted a two-sample Mendelian randomization analysis, using genetic instruments for methylation at CpG sites identified in the EWAS meta-analysis, and 29 863 cases and 55 586 controls from the TRICL-ILCCO lungcancer consortium, to appraise the possible causal role of methylation at these sites on lung cancer.Sixteen CpG sites were identified from the EWAS meta-analysis [false discovery rate (FDR) < 0.05], for 14 of which we could
Cotton dust exposure and risk of lungcancer: A meta-analysis of observational studies. Findings on the association between cotton dust exposure and lungcancer risk in epidemiologic studies have been inconsistent. Therefore, we conducted a meta-analysis of data from observational studies to quantify this association.PubMed, EMBASE, and the Cochrane library databases were searched for observational studies with data on cotton dust exposure and lungcancer risk. Studies that reported adjusted (...) relative risks (RRs) with 95% confidence intervals (CIs) of lungcancer associated with cotton dust exposure were included. Subgroup analyses were conducted according to key characteristics.Fifteen studies involving a total of 73,812 individuals were included in the meta-analysis. Combining estimates from all the 15 observational studies, cotton dust exposure was associated with a decreased risk of lungcancer (combined RR, 0.78; 95% CI, 0.66-0.91; P = .002). Pooled estimates of multivariate RRs
Gender-specific differences in care-seeking behaviour among lungcancer patients: a systematic review. In the literature, men are often described as unwilling to use healthcare services, whereas women as frequent users. We conducted a systematic literature review to examine the gender differences in healthcare utilisation of lungcancer patients. Our aim was to synthesise evidence to assess whether men and women utilise cancer diagnosis and treatments differently.The databases of PubMed, Scopus (...) , Web of Science, EBSCO Host, Ovid nursing, and Cochrane was systematically searched. We used pre-defined eligibility criteria to identify peer-reviewed published literature that reported healthcare use of lungcancer patients. Two reviewers independently screened the title, abstract, full texts and retrieved relevant data.A total of 42 studies met the eligibility criteria from 1356 potential studies. In these studies, the most commonly measured healthcare utilisation is surgery (n = 19), followed
The incidence and relative risk of PD-1/PD-L1 inhibitors-related colitis in non-small cell lungcancer: A meta-analysis of randomized controlled trials. The programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors have shown encouraging merits in non-small cell lungcancer (NSCLC) patients, however, they are often related to potentially fatal immune-related adverse events (irAEs) including colitis. Considering the incidence and characteristics of immune-related colitis
A Systematic Review of Economic Evaluations Assessing the Cost-Effectiveness of Licensed Drugs Used for Previously Treated Epidermal Growth Factor Receptor (EGFR) and Anaplastic Lymphoma Kinase (ALK) Negative Advanced/Metastatic Non-Small Cell LungCancer Non-small cell lungcancer (NSCLC) is one of the most commonly diagnosed cancers. There are many published studies of cost-effectiveness analyses of licensed treatments, but no study has compared these studies or their approaches
Brigatinib and Alectinib for ALK Rearrangement-Positive Advanced Non-Small Cell LungCancer With or Without Central Nervous System Metastasis: A Systematic Review and Network Meta-Analysis. To date, no head-to-head trials have compared the efficacy of brigatinib and alectinib against anaplastic lymphoma kinase (ALK) rearrangement-positive (ALK-p), ALK-inhibitor-naïve, advanced non-small cell lungcancer (NSCLC) with central nervous system (CNS) metastasis. We conducted an indirect treatment
Efficacy of Crizotinib, Ceritinib, and Alectinib in ALK-Positive Non-Small Cell LungCancer Treatment: A Meta-Analysis of Clinical Trials. This study aimed to evaluate the efficacy of anaplastic lymphoma kinase (ALK)-inhibitors in the treatment of ALK-positive non-small cell lungcancer (NSCLC) by using a meta-analysis of clinical trials. We searched PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov by using keywords related to the topic in August 2018. The pooled effect sizes were (...) calculated based on a random-effects model. We also performed subgroup meta-analysis by types of ALK inhibitors (crizotinib, ceritinib, and alectinib). A total of 20 clinical trials with 10 single-arm trials and 10 double-arm trials were included in the final meta-analysis. The median overall survival (OS), progression-free survival (PFS), overall response rate (ORR), disease control rate (DCR), 1 year survival rate, and 2 year survival rate were 19.14 months, 8.47 months, 62%, 78%, 74%, and 62
Comparative Efficacy of Targeted Therapies in Patients with Non-Small Cell LungCancer: A Network Meta-Analysis of Clinical Trials. This study aims to investigate the efficacy of targeted therapies in the treatment of non-small cell lungcancer (NSCLC) by using a network meta-analysis of clinical trials. PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov were searched by using keywords related to the topic on 19 September 2018. Two investigators independently selected relevant trials
suggested that MMP1 -1607 1G/2G and MMP7 -181 A/G were risk factors for lungcancer, while MMP2 -1306 C/T, MMP2 -735 C/T, MMP9 -1562 C/T, and MMP13 -77A/G might be protective factors. However, results for MMP9 -1562 C/T and MMP13 -77A/G should be interpreted with caution due to the probability of false-positive reports.2020 Journal of Thoracic Disease. All rights reserved. (...) Matrix metalloproteinase family gene polymorphisms and lungcancer susceptibility: an updated meta-analysis. Many studies have investigated the association between matrix metalloproteinase polymorphisms and lungcancer susceptibility. However, the results are still controversial. To clarify these associations, we conducted a meta-analysis.A systematic search of studies was conducted in PubMed, Embase, and China National Knowledge Infrastructure. Overall and subgroup analysis stratified
Prognostic role of dysregulated circRNAs in patients with non-small cell lungcancer: a meta-analysis. Lungcancer is the leading cause of cancer incidence and mortality. Non-small cell lungcancer (NSCLC) accounts for the vast majority of lungcancer, which lacks comprehensive prognostic biomarkers to predict the prognosis of patients. This research was performed to assess the potential prognostic role of circular RNAs (circRNAs) in patients with NSCLC.We searched the following databases (...) prospective studies about the clinical significance of circRNAs are of great need in order to obtain conclusive results.2020 Journal of Thoracic Disease. All rights reserved.
in this systematic review assessed psychosocial interventions for caregivers of lungcancer patients that were published in English between January 2009 and December 2017. These interventions focused on burden, mental health, quality of life, self-efficacy, and/or coping as outcome measures. CINAHL, PubMed, PsycInfo, Science Direct, and Web of Science databases were searched using the terms (lungcancer OR lungneoplasms OR thoracic cancer) AND (caregiver OR caregiving) AND (intervention OR program (...) Psychosocial interventions for informal caregivers of lungcancer patients: A systematic review. Caregivers of patients with lungcancer often face physical, emotional, and financial distress, which not only negatively affects the caregivers' mental health and quality of life but may also impact patients' well-being. The purpose of this systematic review is to examine the content, delivery, and efficacy of psychosocial interventions targeting caregivers of lungcancer patients.Studies included
Do lungcancer patients require routine anticoagulation treatment? A meta-analysis. 31948304 2020 04 10 1473-2300 48 1 2020 Jan The Journal of international medical research J. Int. Med. Res. Do lungcancer patients require routine anticoagulation treatment? A meta-analysis. 300060519896919 10.1177/0300060519896919 Zhang Mengying M https://orcid.org/0000-0001-7492-3666 Department of Respiratory Medicine, National Key Clinical Specialty, Xiangya Hospital, Central South University, Changsha (...) , Hunan, China. Wu Shuxie S Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, Hunan, China. Hu Chengping C Department of Respiratory Medicine, National Key Clinical Specialty, Xiangya Hospital, Central South University, Changsha, Hunan, China. eng Journal Article England J Int Med Res 0346411 0300-0605 IM Lungcancer anticoagulation prognosis risk factor thromboprophylaxis thrombosis 2020 1 18 6 0 2020 1 18 6 0 2020 1 18 6 0 ppublish 31948304 10.1177/0300060519896919
Meta-analysis of case-control studies on the relationship between lungcancer and indoor radon exposure. Indoor exposure to natural radon is a factor that influences lungcancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lungcancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR) estimates are included in the meta-analysis. Weighted median