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Latest & greatest articles for lung cancer
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on lung cancer or other clinical topics then use Trip today.
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-disease small-cell lung cancer.We searched the PubMed, Embase, Medline, and China National Knowledge Infrastructure databases to identify articles that assessed the efficacy of PCI in treating extensive-stage small-cell lungcancer patients.We identified 8 studies that involved a total of 982 patients who received PCI (PCI group) and a total of 4509 patients who did not receive PCI (control group). The results showed that PCI significantly improved the 1-year overall survival rate (HR=1.50; 95% CI (...) Meta-analysis of prophylactic cranial irradiation or not in treatment of extensive-stage small-cell lungcancer: The dilemma remains. The role of prophylactic cranial irradiation (PCI) in treatment of extensive-stage small-cell lungcancer (SCLC) is controversial. The aim of this study was to systematically evaluate the efficacy and safety of using PCI in the treatment of extensive-stage SCLC. In the present study, we examined whether PCI was essential for the optimal treatment of extensive
Efficacy and adverse events of five targeted agents in the treatment of advanced or metastatic non-small-cell lungcancer: A network meta-analysis of nine eligible randomized controlled trials involving 5,059 patients. Recently, targeted agents were reported to improve overall survival, progression-free survival (PFS), response rate, and quality of life compared with cytotoxic chemotherapies, which provides hope for the treatment of non-small-cell lungcancer (NSCLC). The network meta-analysis (...) , the overall response rate (ORR) of advanced or metastatic NSCLC patients treated with gefitinib was relatively higher than those treated with placebo. Compared with patients treated with placebo, the disease control rate (DCR) of patients treated with erlotinib and with gefitinib was relatively higher. Furthermore, in terms of PFS and DCR, the SUCRA value of icotinib was the highest among the five targeted drugs. With regard to ORR, the SUCRA value of gefitinib was the highest among the five targeted
First-line treatments in EGFR-mutated advanced non-small cell lungcancer: A network meta-analysis. It remains unknown which is the optimal first-line treatment regimen for patients with advanced epidermal growth factor receptor (EGFR)-mutated non-small cell lungcancer (NSCLC). We performed a network meta-analysis to address this important issue.PubMed, Embase, Cochrane Library, Web of Science and major international scientific meetings were searched for relevant randomized controlled trials
Surgical treatment to multiple primary lungcancer patients: a systematic review and meta-analysis. As there is no consensus on the optimal surgery strategy for multiple primary lungcancer (MPLC), we conducted this study to address this issue by comparing the prognosis of MPLC patients underwent different surgical strategies including sublobar resection and the standard resection through a systemic review and meta-analysis.Relevant literature was obtained from three databases including PubMed
Smoking cessation interventions for potential use in the lungcancer screening setting: A systematic review and meta-analysis. Current guidelines recommend delivery of smoking cessation interventions with lungcancer screening (LCS). Unfortunately, there are limited data to guide clinicians and policy-makers in choosing cessation interventions in this setting. Several trials are underway to fill this evidence gap, but results are not expected for several years.We conducted a systematic review
A meta-analysis of ABCG2 gene polymorphism and non-small cell lungcancer outcomes. We aimed to analyze the correlation between ABCG2 gene polymorphisms of 34 GG/(GA + AA) loci, 421 CC/(AC + AA) loci, and non-small cell lungcancer (NSCLC) therapeutic effects via meta-analysis. With key words, the databases PubMed and EMBASE were searched for clinical studies on ABCG2 polymorphism and NSCLC. RR and 95% CIs were used to compute combined effects, followed by heterogeneity testing. Publication
that history of chronic obstructive pulmonary disease (OR = 2.59, 95% CI: 1.09, 6.15; P = 0.03), adenocarcinoma (OR = 2.28, 95% CI: 1.88, 2.77; P < 0.01), advanced tumour stage (TNM III-IV vs. I-II, OR = 2.38, 95% CI: 1.99, 2.86; P < 0.01), history of central venous catheter (OR = 1.95, 95% CI: 1.36, 2.78; P < 0.01), history of chemotherapy (OR = 2.32, 95% CI: 1.80, 2.99, P < 0.01), high levels of D-dimer (WMD = 4.31, 95% CI: 2.53, 6.10; P < 0.01) and carcinoembryonic antigen (WMD = 10.30, 95% CI: 9.95 (...) Clinical features of pulmonary embolism in patients with lungcancer: A meta-analysis. Pulmonary embolism (PE) is correlated with increased mortality among patients with lungcancer (LC). The characteristics of patients with LC presenting with PE have not been fully established, and our meta-analysis aims to comprehensively investigate the clinical characteristics associated with PE in patients with LC to help physicians identify PE earlier in these patients.Multiple databases were searched
Comment on "Robotic Versus Video-assisted Lobectomy/Segmentectomy for LungCancers-A Meta-analysis". 31714305 2020 03 12 2020 03 12 1528-1140 270 6 2019 12 Annals of surgery Ann. Surg. Comment on "Robotic Versus Video-assisted Lobectomy/Segmentectomy for LungCancers-A Meta-analysis". e147-e148 10.1097/SLA.0000000000003611 Chen Dali D Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, People's (...) Republic of China Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China. Tan Qunyou Q eng Letter Comment United States Ann Surg 0372354 0003-4932 AIM IM Ann Surg. 2018 Aug;268(2):254-259 28628562 Humans LungNeoplasms surgery Mastectomy, Segmental Pneumonectomy Robotic Surgical Procedures 2019 11 13 6 0 2020 3 13 6 0 2019 11 13 6 0 ppublish 31714305 10.1097/SLA.0000000000003611
Sensitivity of chest X-ray for detecting lungcancer in people presenting with symptoms: a systematic review. Despite increasing use of computed tomography (CT), chest X-ray remains the first-line investigation for suspected lungcancer in primary care in the UK. No systematic review evidence exists as to the sensitivity of chest X-ray for detecting lungcancer in people presenting with symptoms.To estimate the sensitivity of chest X-ray for detecting lungcancer in symptomatic people.A (...) , for example, specific presentations, histological subtypes, or comorbidities. Only three studies had a low risk of bias. Two primary care studies reported sensitivities of 76.8% (95% confidence interval [CI] = 64.5 to 84.2%) and 79.3% (95% CI = 67.6 to 91.0%). One secondary care study reported a sensitivity of 79.7% (95% CI = 72.7 to 86.8%).Though there is a paucity of evidence, the highest-quality studies suggest that the sensitivity of chest X-ray for symptomatic lungcancer is only 77% to 80%. GPs
Initial management of small-cell lungcancer (limited- and extensive-stage) and the role of thoracic radiotherapy and first-line chemotherapy: a systematic review. Patients with limited-stage (ls) or extensive-stage (es) small-cell lungcancer (sclc) are commonly given platinum-based chemotherapy as first-line treatment. Standard chemotherapy for patients with ls sclc includes a platinum agent such as cisplatin combined with the non-platinum agent etoposide. The objective of the present
Surgery after chemoradiotherapy in patients with stage III (N2 or N3, excluding T4) non-small-cell lungcancer: a systematic review. Chemoradiation with curative intent is considered the standard of care in patients with locally advanced, stage iii non-small-cell lungcancer (nsclc). However, some patients with stage iii (N2 or N3, excluding T4) nsclc might be eligible for surgery. The objective of the present systematic review was to investigate the efficacy of surgery after chemoradiotherapy
Clinicopathologic Features and Prognostic Implications of Golgi Phosphoprotein 3 in Non-small Cell LungCancer: A Meta-analysis. Background: A number of studies have investigated the role of Golgi phosphoprotein-3 (GOLPH3) in the pathogenesis and progression of non-small cell lungcancer (NSCLC). However, the results of previous studies are heterogeneous and controversial. The aim of this meta-analysis was to clarify its association with the clinicopathological characteristics of patients (...) and evaluate the prognostic significance of GOLPH3 in NSCLC. Methods: A systematic search was conducted through PMC, PubMed, Medline, Web of Science, Chinese National Knowledge Infrastructure and Wanfang database. The odds ratio (OR) and hazard ratio (HR) with 95 % CI were calculated by STATA 12.0. Results: 8 qualified studies with a total of 1001 patients with NSCLC were included. Pooled results showed that GOLPH3 was highly expressed in tumor tissues compared with adjacent lung tissues (OR, 7.55
Brain metastases from non-small cell lungcancer with EGFR or ALK mutations: A systematic review and meta-analysis of multidisciplinary approaches. To analyze outcomes of non-small cell lungcancer (NSCLC) patients with brain metastases harboring EGFR or ALK mutations and examine for differences between tyrosine kinase inhibitors (TKIs) alone, radiotherapy (RT) alone (either whole brain radiation therapy (WBRT) or stereotactic radiosurgery (SRS)), or combined TKIs and RT.Thirty studies were
Does hypermethylation of CpG island in the promoter region of the E-cadherin gene increase the risk of lungcancer? A meta-analysis. Hypermethylation of the CpG island in the promoter regions of tumor suppressor genes is common in the cancer tissue of non-small cell lungcancer (NSCLC) patients. Epithelial cadherin (E-cadherin) is a classic tumor suppressor gene of the cadherin superfamily and its promoter region is usually hypermethylated in malignantcarcinomas. However, whether (...) hypermethylation of the CpG island in the promoter region of E-cadherin increases the risk of lungcancer is unknown. We conducted a meta-analysis of E-cadherin gene promoter methylation status in cancer tissue (CT) and autologous controls (AC).Electronic databases were searched for E-cadherin gene promoter methylation and NSCLC. The hypermethylation status between CT and AC of NSCLC patients were compared and pooled by random or fixed effect models according to statistical heterogeneity across the included
The relationship of cigarette smoking in Japan to lungcancer, COPD, ischemic heart disease and stroke: A systematic review. Background: To present up-to-date meta-analyses of evidence from Japan relating smoking to major smoking-related diseases. Methods: We restricted attention to lungcancer, chronic obstructive pulmonary disease (COPD), ischemic heart disease (IHD) and stroke, considering relative risks (RRs) for current and ex-smokers relative to never smokers. Evidence by amount (...) smoked and time quit was also considered. For IHD and stroke only, studies had to provide age-adjusted RRs, with age-specific results considered. For each disease we extended earlier published databases to include more recent studies. Meta-analyses were conducted, with random-effects RRs and tests of heterogeneity presented. Results: Of 40 studies, 26 reported results for lungcancer and 7 to 9 for each other disease. For current smoking, RRs (95%CIs) were lungcancer 3.59 (3.25-3.96), COPD
Immune-checkpoint inhibitor plus chemotherapy versus conventional chemotherapy for first-line treatment in advanced non-small cell lungcarcinoma: a systematic review and meta-analysis. Immune-checkpoint inhibitors plus chemotherapy are emerging as effective first-line treatment in advanced non-small-cell lungcarcinoma (NSCLC), but little is known about the magnitude of benefits and potential clinical predictors.We performed a meta-analysis of randomized trials that compared PD-1/PD-L1
Stereotactic Body Radiation Therapy for Extracranial Oligometastatic Non-small-cell LungCancer: A Systematic Review. Stereotactic body radiation therapy (SBRT) has emerged as a treatment modality for selected patients with oligometastatic non-small-cell lungcancer (NSCLC). The objectives of this systematic review were to explore the benefits and risks of SBRT for extracranial oligometastatic NSCLC. The MEDLINE, Embase, PubMed, and CENTRAL databases were searched for relevant articles from
Prognostic Value of Pretreatment Albumin to Globulin Ratio in LungCancer: A Meta-Analysis. Objective: To explore the predictive role of pretreatment albumin to globulin ratio (AGR) for prognosis in lung cancer.Methods: A comprehensive literature retrieval was performed in the PubMed, Cochrane Library, Web of Science and EMBASE databases up to May 20, 2019. The pooled hazard ratio (HR) and 95% confidence interval (CI) were applied to assess the correlation of pretreatment AGR with overall (...) <0.001) and sensitivity analysis indicated the stability of above results. Publication bias test showed that there were two potentially unpublished articles, but they did not have a significant influence on the results of our meta-analysis.Conclusion: Our study manifested that pretreatment AGR was a reliable predictor for survival and it may contribute to the risk evaluation and therapy strategy formulation of lungcancer patients.