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Latest & greatest articles for measles
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Application of the World Health Organization Programmatic Assessment Tool for Risk of Measles Virus Transmission-Lessons Learned from a Measles Outbreak in Senegal WHO | Measles Programmatic Risk Assessment Tool WHO Regional websites Access Immunization, Vaccines and Biologicals Menu Measles Programmatic Risk Assessment Tool The World Health Organization (WHO) measles programmatic risk assessment tool was developed to help national programmes to identify areas not meeting measles programmatic (...) targets, and based on the findings, guide and strengthen measles elimination program activities and reduce the risk of outbreaks. This Excel-based tool assesses subnational programmatic risk as the sum of indicator scores in four categories: population immunity, surveillance quality, program performance, and threat assessment. Each subnational area is assigned to a programmatic risk category of low, medium, high, or very high risk based on the overall risk score. Scoring for each indicator
Costs of Contact Tracing Activities Aimed at Reducing the Transmission of Measles in Canada Costs of Contact Tracing Activities Aimed at Reducing the Transmission of Measles in Canada | CADTH.ca Find the information you need Costs of Contact Tracing Activities Aimed at Reducing the Transmission of Measles in Canada Costs of Contact Tracing Activities Aimed at Reducing the Transmission of Measles in Canada Published on: June 1, 2015 Project Number: CP0010 Product Line: Result type: Report (...) Background and Context Measles is a highly communicable infectious disease that is spread through droplets from the nose or throat. Vaccination programs have eliminated indigenous measles in Canada; however, outbreaks continue to occur through importations. Recent outbreaks in Canada and the US have highlighted the importance of immunization for the containment of outbreaks. Contact tracing has been implemented to mitigate the spread of measles by identifying susceptible contacts for treatment
Costs of Contact Tracing Activities Aimed at Reducing the Transmission of Measles in Canada Canadian Agency for Drugs and Technologies in Health Agence canadienne des médicaments et des technologies de la santé Supporting Informed Decisions HTA Costs of Contact Tracing Activities Aimed at Reducing the Transmission of Measles in Canada May 2015 Cite as: Budden A, Lee KM, Lam P. Costs of Contact Tracing Activities Aimed at Reducing the Transmission of Measles in Canada [Internet]. Ottawa: CADTH (...) – May 2015 Costs of Contact Tracing Activities Aimed at Reducing the Transmission of Measles in Canada i TABLE OF CONTENTS ABBREVIATIONS ii EXECUTIVE SUMMARY iii 1. BACKGROUND 1 2. CONTEXT AND POLICY ISSUES 2 3. RESEARCH OBJECTIVE 2 4. METHODS 2 4.1 Literature Search 2 4.2 Overview of the Evidence 3 4.1.1 Appraisal 4 4.1.2 Summary 5 5. ECONOMIC EVALUATION 6 5.1 Methods 6 5.1.1 Type of Economic Evaluation 6 5.1.2 Target Population 6 5.1.3 Perspective 6 5.1.4 Scenarios and Data Sources 6 5.1.5 Model
Public Health Interventions to Reduce the Secondary Spread of Measles Canadian Agency for Drugs and Technologies in Health Agence canadienne des médicaments et des technologies de la santé Supporting Informed Decisions Rapid Response Report: Systematic Review Public Health Interventions to Reduce the Secondary Spread of Measles CADTH May 2015Cite as: Foerster V, Perras C, Spry C, Weeks L. Public health interventions to reduce the secondary spread of measles [Internet]. Ottawa: CADTH; 2015 May (...) . (CADTH rapid response report: systematic review). [cited YYYY-MM-DD]. Available from: https://www.cadth.ca/public-health-interventions-reduce-secondary- spread-measles Disclaimer: This report is a review of existing public literature, studies, materials, and other information and documentation (collectively the “source documentation”) that are available to CADTH. The accuracy of the contents of the source documentation on which this report is based is not warranted, assured, or represented in any way
Zinc supplementation for the treatment of measles in children. Measles is still an important cause of childhood morbidity and mortality globally, despite increasing vaccine coverage. Zinc plays a significant role in the maintenance of normal immunological functions, therefore supplements given to zinc-deficient children will increase the availability of zinc and could reduce measles-related morbidity and mortality.To assess the effects of zinc supplementation in reducing morbidity and mortality (...) in India and included 85 children diagnosed with measles and pneumonia. The trial showed that there was no significant difference in mortality between the two groups (risk ratio (RR) 0.34, 95% confidence interval (CI) 0.01 to 8.14). Also, there was no significant difference in time to absence of fever between the two groups (hazard ratio (HR) 1.08, 95% CI 0.67 to 1.74). No treatment-related side effects were reported in either group. The overall quality of the evidence can be described as very low.We
Safety of measles-containing vaccines in 1-year-old children All measles-containing vaccines are associated with several types of adverse events, including seizure, fever, and immune thrombocytopenia purpura (ITP). Because the measles-mumps-rubella-varicella (MMRV) vaccine compared with the separate measles-mumps-rubella (MMR) and varicella (MMR + V) vaccine increases a toddler's risk for febrile seizures, we investigated whether MMRV is riskier than MMR + V and whether either vaccine elevates
Measly protection: passive immunization for measles, past and present http://www.evidentlycochrane.net/wp-content/uploads/2014/04/ Search and hit Go By April 11, 2014 // Mother (to District Visitor). “Lumme Miss, there ain’t no danger of infection. Them children wot’s got the measles is at the ‘ead of the bed, and them wot aint is at the foot.” Wood engraving by S. Wood, 1915. : Wellcome Library, London. When I was about seven, I spent a year going through every infectious disease that children (...) could get in those days: whooping cough, rubella, mumps, chickenpox and measles. With measles, you got sore eyes, a hacking cough, a high fever and a rash that covered you all over. At the time, bed rest in a darkened room was compulsory. My mother left the house to do some quick shopping while I was lying abed, but her timing was poor: a thunderstorm was brewing, and while I lay alone with the curtains closed, the chimney was struck by lightning, the room was shaken by a loud explosion and I
Live vaccine against measles, mumps, and rubella and the risk of hospital admissions for nontargeted infections. In low-income countries, live measles vaccine reduces mortality from causes other than measles infection. Such nonspecific effects of vaccines might also be important for the health of children in high-income settings.To examine whether the live vaccine against measles, mumps, and rubella (MMR) is associated with lower rates of hospital admissions for infections among children
Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine versus one dose of monovalent varicella vaccine: a multicentre, observer-blind, randomised, controlled trial. Rates of varicella have decreased substantially in countries implementing routine varicella vaccination. Immunisation is possible with monovalent varicella vaccine or a combined measles-mumps-rubella-varicella vaccine (MMRV). We assessed protection against varicella in naive children
2014LancetControlled trial quality: predicted high
Routine vitamin A supplementation for the prevention of blindness due to measles infection in children. Reduced vitamin A concentration increases the risk of blindness in children infected with the measles virus. Promoting vitamin A supplementation in children with measles contributes to the control of blindness in children, which is a high priority within the World Health Organization (WHO) VISION 2020 The Right to Sight Program.To assess the efficacy of vitamin A in preventing blindness (...) in children with measles without prior clinical features of vitamin A deficiency.We searched CENTRAL 2013, Issue 2, MEDLINE (1950 to November week 2, 2013), EMBASE (1974 to November 2013) and LILACS (1985 to November 2013).Randomised controlled trials (RCTs) assessing the efficacy of vitamin A in preventing blindness in well-nourished children diagnosed with measles but with no prior clinical features of vitamin A deficiency.For the original review, two review authors independently assessed studies
Effects of the live attenuated measles-mumps-rubella booster vaccination on disease activity in patients with juvenile idiopathic arthritis: a randomized trial. The immunogenicity and the effects of live attenuated measles-mumps-rubella (MMR) vaccination on disease activity in patients with juvenile idiopathic arthritis (JIA) are matters of concern, especially in patients treated with immunocompromising therapies.To assess whether MMR booster vaccination affects disease activity and to describe (...) in the modified intention-to-treat analysis, including 60 using methotrexate and 15 using biologics. Disease activity during complete follow-up did not differ between 63 revaccinated patients (JADAS-27, 2.8; 95% CI, 2.1-3.5) and 68 controls (JADAS-27, 2.4; 95% CI, 1.7-3.1), with a difference of 0.4 (95% CI, -0.5 to 1.2), within the equivalence margin of 2.0. At 12 months, seroprotection rates were higher in revaccinated patients vs controls (measles, 100% vs 92% [95% CI, 84%-99%]; mumps, 97% [95% CI, 95%-100
Assessment of the 2010 global measles mortality reduction goal: results from a model of surveillance data. In 2008 all WHO member states endorsed a target of 90% reduction in measles mortality by 2010 over 2000 levels. We developed a model to estimate progress made towards this goal.We constructed a state-space model with population and immunisation coverage estimates and reported surveillance data to estimate annual national measles cases, distributed across age classes. We estimated deaths (...) by applying age-specific and country-specific case-fatality ratios to estimated cases in each age-country class.Estimated global measles mortality decreased 74% from 535,300 deaths (95% CI 347,200-976,400) in 2000 to 139,300 (71,200-447,800) in 2010. Measles mortality was reduced by more than three-quarters in all WHO regions except the WHO southeast Asia region. India accounted for 47% of estimated measles mortality in 2010, and the WHO African region accounted for 36%.Despite rapid progress in measles
Chinese medicinal herbs for measles. Measles is an infectious disease caused by the Morbillivirus. Chinese physicians believe that medicinal herbs are effective in alleviating symptoms and preventing complications. Chinese herbal medicines are dispensed according to the particular symptoms. This is the second update of a Cochrane Review first published in 2006.To assess the effectiveness and possible adverse effects of Chinese medicinal herbs for measles.We searched the Cochrane Central (...) 2011) and the metaRegister of Controlled Trials for ongoing trials.Randomised controlled trials (RCTs) of Chinese medicinal herbs in patients with measles (without complications).Two review authors (SC, TW) independently assessed trial quality and extracted data. We telephone interviewed the trial authors for missing information regarding participant allocation. Some trials allocated participants according to the sequence they were admitted to the trials, that is to say, by using a pseudo-random
Measles. Measles is a highly contagious disease caused by measles virus and is one of the most devastating infectious diseases of man--measles was responsible for millions of deaths annually worldwide before the introduction of the measles vaccines. Remarkable progress in reducing the number of people dying from measles has been made through measles vaccination, with an estimated 164,000 deaths attributed to measles in 2008. This achievement attests to the enormous importance of measles (...) vaccination to public health. However, this progress is threatened by failure to maintain high levels of measles vaccine coverage. Recent measles outbreaks in sub-Saharan Africa, Europe, and the USA show the ease with which measles virus can re-enter communities if high levels of population immunity are not sustained. The major challenges for continued measles control and eventual eradication will be logistical, financial, and the garnering of sufficient political will. These challenges need to be met
in the United States. Dev Biol Stand 65: 13-21.  Parker, A. A., W. Staggs, G. H. Dayan, I. R. Ortega-Sanchez, P. A. Rota, L. Lowe, P. Boardman, R. Teclaw, C. Graves, and C. W. LeBaron. 2006. Implications of a 2005 Measles Outbreak in Indiana for Sustained Elimination of Measles in the United States. N Engl J Med 355: 447-455.  Parker, A. A., and A. Uzicanin. 2009. The Pre-Travel Consultation: Measles (Rubeola). In G. W. Brunette, P. E. Kozarsky, A. J. Magill, and D. R. Shlim (ed.), CDC Health (...) The Challenge of Measles Control The Challenge of Measles Control – Clinical Correlations Search The Challenge of Measles Control September 15, 2010 13 min read By Taher Modarressi Faculty Peer Reviewed Measles remains one of the leading causes of preventable child mortality worldwide, despite the development of an effective vaccine in the 1960s. Even as late as the early 1990s, measles continued to infect tens of millions of people and claimed over a million lives each year (51]. Although
Early waning of maternal measles antibodies in era of measles elimination: longitudinal study. To investigate the duration of the presence of maternal antibodies to measles in infants.Prospective study (May 2006 to November 2008).Five hospitals in the Province of Antwerp, Belgium.Of 221 pregnant women recruited, 207 healthy woman-infant pairs were included-divided into a vaccinated group (n=87) and naturally immune group (n=120), according to vaccination documents and history.Measles IgG (...) study describes a very early susceptibility to measles in infants of both vaccinated women and women with naturally acquired immunity. This finding is important in view of recent outbreaks and is an argument for timeliness of the first dose of a measles vaccine and vaccination of travelling or migrating children under the age of 1 year.
Effectiveness of measles vaccination and vitamin A treatment Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial. To examine in a randomised trial whether a 25% difference in mortality exists between 4.5 months and 3 years of age for children given two standard doses of Edmonston-Zagreb measles vaccines at 4.5 and 9 months of age compared with those given one dose of measles vaccine at 9 months of age (current policy).Randomised controlled trial.The Bandim Health Project, Guinea (...) -Bissau, which maintains a health and demographic surveillance system in an urban area.6648 children aged 4.5 months of age who had received three doses of diphtheria-tetanus-pertussis vaccine at least four weeks before enrolment. A large proportion of the children (80%) had previously taken part in randomised trials of neonatal vitamin A supplementation.Children were randomised to receive Edmonston-Zagreb measles vaccine at 4.5 and 9 months of age (group A), no vaccine at 4.5 months and Edmonston
Chinese medicinal herbs for measles. Measles is an infectious disease caused by the Morbilli virus. Chinese physicians believe that medicinal herbs are effective in alleviating symptoms and preventing complications. Chinese herbal medicines are dispensed according to the particular symptoms. This is an update of a Cochrane review first published in 2006.To assess the effectiveness and possible adverse effects of Chinese medicinal herbs in treating measles.We searched the Cochrane Central (...) ) in which patients with measles without complications were treated with Chinese medicinal herbs.Three review authors (YZ, RG, TW) independently assessed trial quality and extracted data. We telephone interviewed the study authors for missing information regarding participant allocation. Some trials allocated participants according to the sequence they were admitted to the trials, that is to say, by using a pseudo-random allocation method; none of the trials concealed the allocation or blinding method.We