Latest & greatest articles for metformin

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Top results for metformin

101. Cardiovascular safety of glucose-lowering agents as add-on medication to metformin treatment in type 2 diabetes: report from the Swedish National Diabetes Register (Abstract)

Cardiovascular safety of glucose-lowering agents as add-on medication to metformin treatment in type 2 diabetes: report from the Swedish National Diabetes Register To investigate the relative safety of various glucose-lowering agents as add-on medication to metformin in type 2 diabetes in an observational study linking five national health registers.Patients with type 2 diabetes who had been on metformin monotherapy and started another agent in addition to metformin were eligible for inclusion (...) treatment was associated with significantly lower risks of CVD, fatal CVD, CHD, fatal CHD and CHF.This nationwide observational study showed that second-line treatment with TZD and DPP-4 inhibitor as add-on medication to metformin were associated with significantly lower risks of mortality and cardiovascular events compared with SU, whereas basal insulin was associated with a higher risk of mortality.© 2016 John Wiley & Sons Ltd.

2016 EvidenceUpdates

102. Glucose Control in Severely Burned Patients Using Metformin: An Interim Safety and Efficacy Analysis of a Phase II Randomized Controlled Trial (Abstract)

Glucose Control in Severely Burned Patients Using Metformin: An Interim Safety and Efficacy Analysis of a Phase II Randomized Controlled Trial To determine whether metformin can achieve glucose control no worse than insulin (noninferiority) without the danger of hypoglycemia (superiority). In addition, to assess whether metformin has any additional effects on lipolysis and inflammation that will enhance burn recovery (superiority).Hyperglycemia and insulin resistance after burn injury (...) are associated with increased morbidity and mortality. Insulin administration improves postburn infections, severity of sepsis, and morbidity, but also causes a 4-5-fold increase in hypoglycemia, which is associated with a 9-fold increase in mortality.Severely burned adult patients with burns over 20% total body surface area (TBSA) burn were prospectively randomized in this Phase II clinical trial to either metformin or insulin (standard of care) treatment. Primary outcomes were glucose levels and incidence

2016 EvidenceUpdates Controlled trial quality: uncertain

103. Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study. Full Text available with Trip Pro

Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study.  To determine the association between use of sulphonylureas and risk of hypoglycaemia in relation to renal function and sulphonylurea metabolic group compared with use of metformin. Population based cohort study using routinely collected data from general practices in England. Clinical Practice Research Datalink (CPRD) database (...) for age, sex, lifestyle, comorbidity, and drug use. The risk of hypoglycaemia in current users of sulphonylureas only was significantly increased compared with current users of metformin only (adjusted hazard ratio 2.50, 95% confidence interval 2.23 to 2.82). The higher risk in current users of sulphonylureas only was further increased in patients with an estimated glomerular filtration rate of less than 30 mL/min/1.73 m(2) (4.96, 3.76 to 6.55). The risk of hypoglycaemia was also significantly higher

2016 BMJ

104. Once-Daily Liraglutide Versus Lixisenatide as Add-on to Metformin in Type 2 Diabetes: A 26-Week Randomized Controlled Clinical Trial Full Text available with Trip Pro

Once-Daily Liraglutide Versus Lixisenatide as Add-on to Metformin in Type 2 Diabetes: A 26-Week Randomized Controlled Clinical Trial To compare the efficacy and safety of liraglutide versus lixisenatide as add-on to metformin in patients with type 2 diabetes not achieving adequate glycemic control on metformin alone.In this 26-week, randomized, parallel-group, open-label trial, 404 patients were randomized 1:1 to liraglutide 1.8 mg or lixisenatide 20 µg as add-on to metformin. Liraglutide (...) for lixisenatide; P = 0.23). The most common adverse events in both groups were gastrointestinal disorders. Greater increases in pulse, lipase, and amylase were observed with liraglutide. Hypoglycemic episodes were rare and similar between the two treatments.At the dose levels studied, liraglutide was more effective than lixisenatide as add-on to metformin in improving glycemic control. Body weight reductions were similar. Both treatments were well tolerated, with low risk of hypoglycemia and similar

2016 EvidenceUpdates Controlled trial quality: uncertain

105. XIGDUO (dapagliflozin/metformin), antidiabetic - type-2 diabetes

XIGDUO (dapagliflozin/metformin), antidiabetic - type-2 diabetes XIGDUO SUMMARY CT14263

2016 Haute Autorite de sante

106. Durable response of glioblastoma to adjuvant therapy consisting of temozolomide and a weekly dose of AMD3100 (plerixafor), a CXCR4 inhibitor, together with lapatinib, metformin and niacinamide Full Text available with Trip Pro

Durable response of glioblastoma to adjuvant therapy consisting of temozolomide and a weekly dose of AMD3100 (plerixafor), a CXCR4 inhibitor, together with lapatinib, metformin and niacinamide Glioblastoma multiforme (GBM) is a CNS (central nervous system) malignancy with a low cure rate. Median time to progression after standard treatment is 7 months and median overall survival is 15 months [1]. Post-treatment vasculogenesis promoted by recruitment of bone marrow derived cells (BMDCs, CD11b

2016 Oncoscience

107. Efficacy and Safety of Titrated Canagliflozin in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin and Sitagliptin Full Text available with Trip Pro

Efficacy and Safety of Titrated Canagliflozin in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin and Sitagliptin To evaluate the efficacy and safety of titrated canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus (T2DM) inadequately controlled on metformin and sitagliptin.In this randomized, double-blind study, patients with T2DM (N = 218) on metformin ≥1500 mg/day and sitagliptin 100 mg received canagliflozin 100 mg (...) with placebo (p < 0.001). The overall AE incidence was 39.8 and 44.4% for canagliflozin and placebo, respectively. Canagliflozin was associated with an increased incidence of genital mycotic infections.Titrated canagliflozin significantly improved HbA1c, FPG, body weight and SBP, and was generally well tolerated over 26 weeks in patients with T2DM as add-on to metformin and sitagliptin.© 2016 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.

2016 EvidenceUpdates Controlled trial quality: uncertain

108. Efficacy and safety of liraglutide versus sitagliptin, both in combination with metformin, in Chinese patients with type 2 diabetes: a 26-week, open-label, randomised, active comparator clinical trial Full Text available with Trip Pro

Efficacy and safety of liraglutide versus sitagliptin, both in combination with metformin, in Chinese patients with type 2 diabetes: a 26-week, open-label, randomised, active comparator clinical trial To compare the efficacy and safety of liraglutide versus sitagliptin as add-on to metformin after 26 weeks of treatment in Chinese patients with type 2 diabetes mellitus (T2DM).This 26-week open-label, active comparator trial (NCT02008682) randomized patients (aged 18-80 years) with T2DM (...) inadequately controlled with metformin [glycated haemoglobin (HbA1c) 7.0-10.0% (53-86 mmol/mol)] 1 : 1 to once-daily subcutaneously administered liraglutide 1.8 mg (n = 184) or once-daily oral sitagliptin 100 mg (n = 184), both as add-on to metformin. The primary endpoint was change in HbA1c from baseline to week 26.Liraglutide was superior to sitagliptin in reducing HbA1c from baseline [8.1% (65 mmol/mol)] to 26 weeks, as evidenced by estimated mean HbA1c change of -1.65% (-18.07 mmol/mol) versus -0.98

2016 EvidenceUpdates Controlled trial quality: uncertain

109. Empagliflozin and metformin (Synjardy)

Empagliflozin and metformin (Synjardy) Empagliflozin and metformin | CADTH.ca Find the information you need Empagliflozin and metformin Empagliflozin and metformin Last Updated: April 4, 2016 Result type: Reports Project Number: SR0489-000 Product Line: Generic Name: Empagliflozin and metformin Brand Name: Synjardy Manufacturer: Boehringer Ingelheim (Canada) Ltd. Indications: Diabetes mellitus (Type 2) Submission Type: New Project Status: Complete Date Recommendation Issued: October 25, 2016

2016 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

110. The effect of ranolazine on glycemic control in patients with type 2 diabetes treated with either glimepiride or metformin (Abstract)

The effect of ranolazine on glycemic control in patients with type 2 diabetes treated with either glimepiride or metformin To report the results of two phase III trials assessing the efficacy of ranolazine for glycaemic control in patients with type 2 diabetes on metformin or glimepiride background therapy.In two double-blind trials we randomized 431 and 442 patients with type 2 diabetes to ranolazine 1000 mg twice daily versus placebo added to either glimepiride (glimepiride add-on study (...) ) or metformin background therapy (metformin add-on study). Patients receiving ranolazine added to metformin had their metformin dose halved (with the addition of a metformin-matched placebo) relative to the placebo group to correct for a metformin-ranolazine pharmacokinetic interaction. The primary endpoint of the trials was the change from baseline in glycated haemoglobin (HbA1c) at week 24.When added to glimepiride, ranolazine caused a 0.51% least squares mean [95% confidence interval (CI) 0.71, 0.32

2016 EvidenceUpdates Controlled trial quality: predicted high

111. Canagliflozin and metformin hydrochloride (TBC)

Canagliflozin and metformin hydrochloride (TBC) Canagliflozin and metformin hydrochloride | CADTH.ca Find the information you need Canagliflozin and metformin hydrochloride Canagliflozin and metformin hydrochloride Last Updated: October 10, 2018 Result type: Reports Project Number: SR0480-000 Product Line: Generic Name: Canagliflozin and metformin hydrochloride Brand Name: Invokamet Manufacturer: Janssen Inc. Indications: Diabetes mellitus, type 2 Submission Type: New Project Status: Complete

2016 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

112. Could Metformin be the First Anti-Aging Drug?

Could Metformin be the First Anti-Aging Drug? Could Metformin be the First Anti-Aging Drug? – Clinical Correlations Search Could Metformin be the First Anti-Aging Drug? February 11, 2016 6 min read By Amy Shen Tang, MD P eer Reviewed “I would pay you if you took it away from me. I’d try to buy it back,” said Irving Kahn, the late Wall Street [1]. Mr. Kahn, who founded Kahn Brothers Group, Inc. with his sons more than 40 years ago, took an active role as chair of his company until his passing (...) colleagues at the Institute for Aging Research are looking to make a cheap, generic, widely used drug—metformin—the first to be Food and Drug Association (FDA)-approved for the indication of aging. Metformin is an oral biguanide antidiabetic medication that has been used for over 50 years. It is commonly prescribed as a first-line treatment for type 2 diabetes mellitus and often in combination with other antidiabetic medications including insulin. Metformin reduces blood glucose levels by preventing

2016 Clinical Correlations

113. Initial Combination Therapy With Canagliflozin Plus Metformin Versus Each Component as Monotherapy for Drug-Naive Type 2 Diabetes Full Text available with Trip Pro

Initial Combination Therapy With Canagliflozin Plus Metformin Versus Each Component as Monotherapy for Drug-Naive Type 2 Diabetes This study assessed the efficacy/safety of canagliflozin (CANA), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, plus metformin extended-release (MET) initial therapy in drug-naïve type 2 diabetes.This 26-week, double-blind, phase 3 study randomized 1,186 patients to CANA 100 mg (CANA100)/MET, CANA 300 mg (CANA300)/MET, CANA100, CANA300, or MET. Primary end point

2016 EvidenceUpdates Controlled trial quality: uncertain

114. dapagliflozin/metformin hydrochloride (XigDuo)

dapagliflozin/metformin hydrochloride (XigDuo) dapagliflozin/metformin hydrochloride | CADTH.ca Find the information you need dapagliflozin/metformin hydrochloride dapagliflozin/metformin hydrochloride Last Updated: December 1, 2015 Result type: Reports Project Number: SR0468-000 Product Line: Generic Name: dapagliflozin/metformin hydrochloride Brand Name: XigDuo Manufacturer: AstraZeneca Canada Inc. Indications: Diabetes Mellitus, Type 2 Submission Type: New Project Status: Complete Date

2016 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

115. Systematic review with meta analysis: Existing evidence is insufficient to justify metformin or other agents as first-line therapy for type 2 diabetes

Systematic review with meta analysis: Existing evidence is insufficient to justify metformin or other agents as first-line therapy for type 2 diabetes Existing evidence is insufficient to justify metformin or other agents as first-line therapy for type 2 diabetes | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see (...) our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Existing evidence is insufficient to justify metformin or other agents as first-line therapy for type 2 diabetes Article Text

2016 Evidence-Based Medicine

116. Systematic review with meta-analysis: Most add-on therapies to metformin have similar effects on HbA1c

Systematic review with meta-analysis: Most add-on therapies to metformin have similar effects on HbA1c Most add-on therapies to metformin have similar effects on HbA1c | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional (...) accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Most add-on therapies to metformin have similar effects on HbA1c Article Text Therapeutics/Prevention Systematic review with meta-analysis Most add-on therapies to metformin have similar effects on HbA1c Thomas Karagiannis 1

2016 Evidence-Based Medicine

117. Randomised controlled trial: Metformin reduces weight gain in overweight/obese adolescents with type 1 diabetes

Randomised controlled trial: Metformin reduces weight gain in overweight/obese adolescents with type 1 diabetes Metformin reduces weight gain in overweight/obese adolescents with type 1 diabetes | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Metformin reduces weight gain in overweight/obese adolescents with type 1 diabetes Article Text Therapeutics/Prevention Randomised controlled trial Metformin reduces weight gain in overweight/obese

2016 Evidence-Based Medicine

118. Saxagliptin + saxagliptin/metformin: Addendum to Commission A16-42 + A16-43

Saxagliptin + saxagliptin/metformin: Addendum to Commission A16-42 + A16-43 Saxagliptin und Saxagliptin/Metformin (Diabetes mellitus Typ 2): Addendum zu den Aufträgen A16-42 und A16-43; Auftrag A16-71 [Saxagliptin + saxagliptin/metformin: Addendum to Commission A16-42 + A16-43] Saxagliptin und Saxagliptin/Metformin (Diabetes mellitus Typ 2): Addendum zu den Aufträgen A16-42 und A16-43; Auftrag A16-71 [Saxagliptin + saxagliptin/metformin: Addendum to Commission A16-42 + A16-43] Institut für (...) Qualität und Wirtschaftlichkeit im Gesundheitswesen Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. Saxagliptin und Saxagliptin/Metformin (Diabetes mellitus Typ 2): Addendum zu den Aufträgen A16-42 und A16-43; Auftrag A16-71. [Saxagliptin + saxagliptin/metformin: Addendum

2016 Health Technology Assessment (HTA) Database.

119. Observational study: Prescribing of metformin based on estimated GFR rather than serum creatinine expands the eligible population and is likely safe

Observational study: Prescribing of metformin based on estimated GFR rather than serum creatinine expands the eligible population and is likely safe Prescribing of metformin based on estimated GFR rather than serum creatinine expands the eligible population and is likely safe | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies (...) , please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Prescribing of metformin based on estimated GFR rather than serum creatinine expands the eligible population

2016 Evidence-Based Medicine

120. Effect of Metformin Added to Insulin on Glycemic Control Among Overweight/Obese Adolescents With Type 1 Diabetes: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Metformin Added to Insulin on Glycemic Control Among Overweight/Obese Adolescents With Type 1 Diabetes: A Randomized Clinical Trial. Previous studies assessing the effect of metformin on glycemic control in adolescents with type 1 diabetes have produced inconclusive results.To assess the efficacy and safety of metformin as an adjunct to insulin in treating overweight adolescents with type 1 diabetes.Multicenter (26 pediatric endocrinology clinics), double-blind, placebo-controlled (...) randomized clinical trial involving 140 adolescents aged 12.1 to 19.6 years (mean [SD] 15.3 [1.7] years) with mean type 1 diabetes duration 7.0 (3.3) years, mean body mass index (BMI) 94th (4) percentile, mean total daily insulin 1.1 (0.2) U/kg, and mean HbA1c 8.8% (0.7%).Randomization to receive metformin (n = 71) (≤2000 mg/d) or placebo (n = 69).Primary outcome was change in HbA1c from baseline to 26 weeks adjusted for baseline HbA1c. Secondary outcomes included change in blinded continuous glucose

2015 JAMA Controlled trial quality: predicted high