Latest & greatest articles for multiple sclerosis

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Top results for multiple sclerosis

1. Siponimod and Cognition in Secondary Progressive Multiple Sclerosis: EXPAND Secondary Analyses

Siponimod and Cognition in Secondary Progressive Multiple Sclerosis: EXPAND Secondary Analyses Siponimod and Cognition in Secondary Progressive Multiple Sclerosis: EXPAND Secondary Analyses - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. National Institutes of Health National (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Randomized Controlled Trial Neurology Actions . 2021 Jan 19;96(3):e376-e386. doi: 10.1212/WNL.0000000000011275. Epub 2020 Dec 16. Siponimod and Cognition in Secondary Progressive Multiple Sclerosis: EXPAND Secondary Analyses , , , , , , , , , , , , , Affiliations Expand Affiliations 1 From the Department

2021 EvidenceUpdates

2. Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial Full Text available with Trip Pro

Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other (...) , and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. Electronic address: bnourba1@jhmi.edu. 2 Department of Neurology, University of California San Francisco, San Francisco, CA, USA. 3 Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. 4 Department of Epidemiology and Biostatistics, University

2021 EvidenceUpdates

3. Siponimod (Mayzent) for multiple sclerosis

Siponimod (Mayzent) for multiple sclerosis Siponimod (Mayzent) for multiple sclerosis - NPS MedicineWise Log In Menu During the COVID-19 pandemic, you need to continue to take your usual medicines and stay as healthy as possible. Health professionals also need to stay up to date with the latest evidence as it emerges. Our information hub has important information for everyone. Featured topics 17 Feb 2021 22 Feb 2021 24 Dec 2020 22 Dec 2020 Featured article Find out more about COVID-19 (...) (Mayzent) for multiple sclerosis Siponimod has been PBS listed for relapsing-remitting multiple sclerosis and for secondary progressive multiple sclerosis. 6 mins 19 November 2020 Key points On 1 November 2020, siponimod (Mayzent) was listed on the PBS General Schedule as an Authority Required (Streamlined) listing for patients with multiple sclerosis (MS) The intent of the listing is to enable use by patients with relapsing-remitting MS (RRMS) or secondary progressive MS (SPMS). The PBAC noted a high

2021 National Prescribing Service Limited (Australia)

4. Ozanimod (Zeposia) - relapsing remitting multiple sclerosis (RRMS)

Ozanimod (Zeposia) - relapsing remitting multiple sclerosis (RRMS) 1 Published 08 February 2021 1 SMC2309 ozanimod 0.23mg, 0.46mg and 0.92mg hard capsules (Zeposia®) Celgene Ltd 15 January 2021 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and, following review by the SMC executive, advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following a full submission (...) ozanimod (Zeposia®) is accepted for restricted use within NHSScotland. Indication under review: treatment of adult patients with relapsing remitting multiple sclerosis (RRMS) with active disease as defined by clinical or imaging features. SMC restriction: suitable for or requesting an oral treatment. In two phase III studies, ozanimod demonstrated a significantly greater reduction in annualised relapse rate compared with another disease-modifying treatment in patients with relapsing forms of multiple

2021 Scottish Medicines Consortium

5. Guidelines on use of anti?IFN?B antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN?B antibodies in multiple sclerosis

Guidelines on use of anti?IFN?B antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN?B antibodies in multiple sclerosis Guidelines on use of anti‐IFN‐B antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN‐B antibodies in multiple sclerosis - Burks - 2007 - European Journal of Neurology - Wiley Online Library Working off-campus? Learn about our By continuing to browse this site, you agree to its use of cookies as described in our . Search (...) within Search term Search term p. e8-e9 Free Access Guidelines on use of anti‐IFN‐B antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN‐B antibodies in multiple sclerosis Burks & Associates – University of Nevada School of Medicine, Reno, NV, USA University of Chicago, Department of Neurology – Chicago, IL, USA Burks & Associates – University of Nevada School of Medicine, Reno, NV, USA University of Chicago, Department of Neurology – Chicago, IL, USA First published: 29

2021 European Academy of Neurology

6. Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial

Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several (...) navigation Clinical Trial Lancet Neurol Actions . 2020 Dec;19(12):988-997. doi: 10.1016/S1474-4422(20)30347-1. Epub 2020 Oct 23. Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial , , , , , , , , , , , , , Collaborators, Affiliations Expand Collaborators SPI2 investigative teams

2021 EvidenceUpdates

7. Siponimod for treating secondary progressive multiple sclerosis

Siponimod for treating secondary progressive multiple sclerosis Siponimod for treating secondary progressive multiple sclerosis T echnology appraisal guidance Published: 18 November 2020 www.nice.org.uk/guidance/ta656 © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Your responsibility Your responsibility The recommendations in this guidance represent the view of NICE, arrived at after careful consideration (...) to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Siponimod for treating secondary progressive multiple sclerosis (TA656) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 20Contents Contents 1 Recommendations 4 2 Information about siponimod 5 Marketing authorisation indication 5 Dosage

2020 National Institute for Health and Clinical Excellence - Technology Appraisals

8. Ozanimod (supplied as ozanimod hydrochloride) - Zeposia - relapsing remitting multiple sclerosis

Ozanimod (supplied as ozanimod hydrochloride) - Zeposia - relapsing remitting multiple sclerosis Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product. The for is located below. Recent Activity for SBDs

2020 Health Canada - Drug and Health Product Register

9. Siponimod (multiple sclerosis) - Addendum to Commission A20-10

Siponimod (multiple sclerosis) - Addendum to Commission A20-10 1 Translation of addendum A20-51 Siponimod (multiple Sklerose) – Addendum zum Auftrag A20-10 (Version 1.0; Status: 16 July 2020). Please note: This translation is provided as a service by IQWiG to English- language readers. However, solely the German original text is absolutely authoritative and legally binding. Addendum 16 July 2020 1.0 Commission: A20-51 Version: Status: IQWiG Reports – Commission No. A20-51 Siponimod (multiple (...) sclerosis) – Addendum to Commission A20-10 1 Addendum A20-51 Version 1.0 Siponimod – Addendum to Commission A20-10 16 July 2020 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher Institute for Quality and Efficiency in Health Care Topic Siponimod (multiple sclerosis) – Addendum to Commission A20-10 Commissioning agency Federal Joint Committee Commission awarded on 23 June 2020 Internal Commission No. A20-51 Address of publisher Institut für Qualität und

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

10. Siponimod (multiple sclerosis) - Benefit assessment according to §35a Social Code Book V

Siponimod (multiple sclerosis) - Benefit assessment according to §35a Social Code Book V 1 Translation of Sections 2.1 to 2.5 of the dossier assessment Siponimod (multiple Sklerose) – Nutzenbewertung gemäß § 35a SGB V (Version 1.0; Status: 13 May 2020). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Extract IQWiG Reports – Commission No. A20-10 Siponimod (...) (multiple sclerosis) – Benefit assessment according to §35a Social Code Book V 1 Extract of dossier assessment A20-10 Version 1.0 Siponimod (multiple sclerosis) 13 May 2020 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher Institute for Quality and Efficiency in Health Care Topic Siponimod (multiple sclerosis) – Benefit assessment according to §35a Social Code Book V Commissioning agency Federal Joint Committee Commission awarded on 5 February 2020 Internal

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

11. Siponimod (Mayzent) - secondary progressive multiple sclerosis (SPMS)

Siponimod (Mayzent) - secondary progressive multiple sclerosis (SPMS) 1 Published 12 October 2020 1 SMC2265 siponimod 250 microgram and 2mg film-coated tablets (Mayzent®) Novartis Pharmaceuticals UK Ltd 04 September 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following a full submission siponimod (...) (Mayzent®) is accepted for use within NHSScotland. Indication under review: treatment of adult patients with secondary progressive multiple sclerosis (SPMS) with active disease evidenced by relapses or imaging features of inflammatory activity. In a randomised, double-blind, placebo-controlled phase III study, siponimod was associated with a reduction in disability progression confirmed after 3 months in patients with SPMS. This advice applies only in the context of an approved NHSScotland Patient

2020 Scottish Medicines Consortium

12. Fampridine - multiple sclerosis (MS)

Fampridine - multiple sclerosis (MS) Official address Domenico Scarlattilaan 6 ? 1083 HS Amsterdam ? The Netherlands An agency of the European Union Address for visits and deliveries Refer to www.ema.europa.eu/how-to-find-us Send us a question Go to www.ema.europa.eu/contact Telephone +31 (0)88 781 6000 © European Medicines Agency, 2020. Reproduction is authorised provided the source is acknowledged. EMA/410661/2020 EMEA/H/C/005359 Fampridine Accord (fampridine) An overview of Fampridine Accord (...) and why it is authorised in the EU What is Fampridine Accord and what is it used for? Fampridine Accord is a medicine used to improve walking ability in adults with multiple sclerosis (MS) who have a walking disability. MS is a disease in which the immune system (the body’s defences) attacks and damages the covering around the nerves and the nerves themselves in the brain and spinal cord. Fampridine Accord is a ‘generic medicine’. This means that Fampridine Accord contains the same active substance

2020 European Medicines Agency - EPARs

13. Efficacy of probiotics on multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials Full Text available with Trip Pro

Efficacy of probiotics on multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials Inplasy Protocol 749 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

14. Ofatumumab versus Teriflunomide in Multiple Sclerosis. Full Text available with Trip Pro

Ofatumumab versus Teriflunomide in Multiple Sclerosis. Ofatumumab, a subcutaneous anti-CD20 monoclonal antibody, selectively depletes B cells. Teriflunomide, an oral inhibitor of pyrimidine synthesis, reduces T-cell and B-cell activation. The relative effects of these two drugs in patients with multiple sclerosis are not known.In two double-blind, double-dummy, phase 3 trials, we randomly assigned patients with relapsing multiple sclerosis to receive subcutaneous ofatumumab (20 mg every 4 weeks (...) neurofilament light chain levels, but not the change in brain volume, were in the same direction as the primary end point. Injection-related reactions occurred in 20.2% in the ofatumumab group and in 15.0% in the teriflunomide group (placebo injections). Serious infections occurred in 2.5% and 1.8% of the patients in the respective groups.Among patients with multiple sclerosis, ofatumumab was associated with lower annualized relapse rates than teriflunomide. (Funded by Novartis; ASCLEPIOS I and II

2020 NEJM

15. The Effect of Transcranial Direct Current Stimulation on Chronic Neuropathic Pain in Patients with Multiple Sclerosis: Randomized Controlled Trial

The Effect of Transcranial Direct Current Stimulation on Chronic Neuropathic Pain in Patients with Multiple Sclerosis: Randomized Controlled Trial The Effect of Transcranial Direct Current Stimulation on Chronic Neuropathic Pain in Patients with Multiple Sclerosis: Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) on Chronic Neuropathic Pain in Patients with Multiple Sclerosis: Randomized Controlled Trial , , , Affiliations Expand Affiliations 1 Rehabilitation Department, Royal Melbourne Hospital, Royal Park Campus, Melbourne, Australia. 2 Department of Medicine and Radiology, Integrated Critical Care, University of Melbourne, Melbourne, Australia. 3 Department of Rehabilitation, Nutrition and Sport, Discipline of Physiotherapy, School of Allied Health, La Trobe University, Melbourne, Australia. 4 Department

2020 EvidenceUpdates

16. Social cognition in multiple sclerosis and its subtypes: a protocol for systematic review and meta-analysis Full Text available with Trip Pro

Social cognition in multiple sclerosis and its subtypes: a protocol for systematic review and meta-analysis Inplasy Protocol 492 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

17. Empathy and theory of mind in multiple sclerosis: a protocol for systematic review and meta-analysis Full Text available with Trip Pro

Empathy and theory of mind in multiple sclerosis: a protocol for systematic review and meta-analysis Inplasy Protocol 493 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

18. Fingolimod - relapsing-remitting multiple sclerosis (RRMS)

Fingolimod - relapsing-remitting multiple sclerosis (RRMS) Official address Domenico Scarlattilaan 6 ? 1083 HS Amsterdam ? The Netherlands An agency of the European Union Address for visits and deliveries Refer to www.ema.europa.eu/how-to-find-us Send us a question Go to www.ema.europa.eu/contact Telephone +31 (0)88 781 6000 © European Medicines Agency, 2020. Reproduction is authorised provided the source is acknowledged. EMA/336317/2020 EMEA/H/C/005191 Fingolimod Accord (fingolimod (...) ) An overview of Fingolimod Accord and why it is authorised in the EU What is Fingolimod Accord and what is it used for? Fingolimod Accord is a type of medicine known as a ‘disease-modifying therapy’ that is used to treat adults and children over 10 years of age with highly active relapsing-remitting multiple sclerosis (RRMS). ‘Relapsing-remitting’ means that the patient has flare-ups of symptoms (relapses) followed by periods with milder or no symptoms (remissions). Fingolimod Accord is used when

2020 European Medicines Agency - EPARs

19. Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT Full Text available with Trip Pro

Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try (...) Stutters 1 , David MacManus 1 , Ferran Prados 1, 4, 5 , Ian Marshall 2 , Bhavana Solanky 1 , Rebecca S Samson 1 , Frederik Barkhof 1, 4, 6 , Sebastien Ourselin 7 , Marie Braisher 1 , Moira Ross 3 , Gina Cranswick 3 , Sue H Pavitt 8 , Sharmilee Gnanapavan 9 , Gavin Giovannoni 9 , Claudia AM Gandini Wheeler-Kingshott 1, 10 , Clive Hawkins 11 , Basil Sharrack 12 , Roger Bastow 13 , Christopher J Weir 3 , Nigel Stallard 14 , Siddharthan Chandran 2 , Jeremy Chataway 1, 15, * 1 Queen Square Multiple

2020 NIHR HTA programme

20. Ozanimod (Zeposia) - relapsing-remitting multiple sclerosis (RRMS)

Ozanimod (Zeposia) - relapsing-remitting multiple sclerosis (RRMS) Official address Domenico Scarlattilaan 6 ? 1083 HS Amsterdam ? The Netherlands An agency of the European Union Address for visits and deliveries Refer to www.ema.europa.eu/how-to-find-us Send us a question Go to www.ema.europa.eu/contact Telephone +31 (0)88 781 6000 © European Medicines Agency, 2020. Reproduction is authorised provided the source is acknowledged. EMA/171870/2020 EMEA/H/C/004835 Zeposia (ozanimod) An overview (...) of Zeposia and why it is authorised in the EU What is Zeposia and what is it used for? Zeposia is a medicine used to treat adults with relapsing-remitting multiple sclerosis (RRMS), where the patient has flare-ups (relapses) followed by periods with milder or no symptoms (remission). It is used in patients with active disease, which means that patients have relapses or signs of active inflammation on scans. Zeposia contains the active substance ozanimod. How is Zeposia used? Zeposia can only be obtained

2020 European Medicines Agency - EPARs