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Nitroglycerin for treatment of retained placenta: A randomised, placebo-controlled, multicentre, double-blind trial in the UK Retained placenta following vaginal delivery is a major cause of postpartum haemorrhage. Currently, the only effective treatments for a retained placenta are the surgical procedures of manual removal of placenta (MROP) and uterine curettage, which are not universally available, particularly in low- and middle-income countries. The objective of the trial was to determine (...) whether sublingual nitroglycerin spray was clinically effective and cost-effective for medical treatment of retained placenta following vaginal delivery.A randomised, placebo-controlled, double-blind trial was undertaken between October 2014 and July 2017 at 29 delivery units in the UK (Edinburgh, Glasgow, Manchester, Newcastle, Preston, Warrington, Chesterfield, Crewe, Durham, West Middlesex, Aylesbury, Furness, Southampton, Bolton, Sunderland, Oxford, Nottingham [2 units], Burnley, Chertsey
Prehospital transdermal glyceryltrinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial. High blood pressure is common in acute stroke and is a predictor of poor outcome; however, large trials of lowering blood pressure have given variable results, and the management of high blood pressure in ultra-acute stroke remains unclear. We investigated whether transdermal glyceryltrinitrate (GTN; also known (...) as nitroglycerin), a nitric oxide donor, might improve outcome when administered very early after stroke onset.We did a multicentre, paramedic-delivered, ambulance-based, prospective, randomised, sham-controlled, blinded-endpoint, phase 3 trial in adults with presumed stroke within 4 h of onset, face-arm-speech-time score of 2 or 3, and systolic blood pressure 120 mm Hg or higher. Participants were randomly assigned (1:1) to receive transdermal GTN (5 mg once daily for 4 days; the GTN group) or a similar sham
2019LancetControlled trial quality: predicted high
It is safe to use transdermal glyceryltrinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis. There is concern that blood pressure (BP) lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis. We assessed the effect of glyceryltrinitrate (GTN) in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke (ENOS) Trial.ENOS randomised 4011 patients with acute stroke (...) and raised systolic BP (140-220 mm Hg) to transdermal GTN or no GTN within 48 hours of onset. Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days. The primary outcome was the modified Rankin Scale (mRS) at day 90. Ipsilateral carotid stenosis was split: <30%; 30-<50%; 50-<70%; ≥70%. Data are ORs with 95% CIs adjusted for baseline prognostic factors.2023 (60.5%) ischaemic stroke participants had carotid imaging. As compared with <30%, ≥70% ipsilateral
Effect of topical glyceryltrinitrate cream on pain perception during intrauterine device insertion in multiparous women: A randomized double-blinded placebo-controlled study. Intrauterine contraceptive device (IUD) insertion-related pain presents a push beyond the decline of women to use IUD for family planning. We aimed to investigate the analgesic effect of glyceryltrinitrate cream (GTN) in reducing pain during IUD insertion.We conducted a randomized double-blinded placebo-controlled study (...) (NCT02708251, clinicaltrials.gov) in a tertiary University hospital. Reproductive-aged women requesting Copper IUD for contraception were considered. Eligible women for IUD insertion were randomized (1:1) to glyceryltrinitrate cream (GTN arm) or Placebo. Three minutes before IUD insertion, 1 ml of GTN cream or placebo was applied to the cervical lip at the planned tenaculum site, followed by 1 ml placed in the cervical canal up to the level of the internal os using a Q-tip applicator. Our outcomes were
A Model-Based Meta-Analysis Evaluating Gender Differences on Blood Flow Responses to Brachial Artery Infusions of Acetylcholine, Albuterol, ATP, Bradykinin, Estradiol, GlycerylTrinitrate, L-NMMA, Nevibolol, Norepinephrine, Sodium Nitroprusside, Substance Numerous studies have emerged over the course of several decades describing the properties of drugs eliciting vasodilatory or vasoconstrictor responses in the human vasculature. During drug development, decisions to move forward with testing (...) with a new chemical entity are very costly. To fund or not to fund development, go or no-go, decisions are often limited by efficacy comparisons with the current products on the market. The primary aim of this paper is to use dose-response modeling and simulations to quantify differences in blood flow to Acetylcholine, Albuterol, ATP, Bradykinin, 17β-Estradiol, GlycerylTrinitrate, L-NMMA, Nevibolol, Norepinephrine, Sodium Nitroprusside, Substance P, and Verapamil.Five studies were identified
Efficacy of egg yolk and nitroglycerin ointment as treatments for acute anal fissures: A randomized clinical trial study. Acute anal fissure as a common disease in society has several etiologies and manifestations such as severe anal pain and bleeding. Nitroglycerin ointment 0.2% is the most common topical treatment used. The most common side effect of nitroglycerin is headache, which is annoying for patients and often leads to discontinuation of the drug.Comparison of egg yolk as a natural (...) substance with analgesic and anti-inflammatory properties and minimal side effects with nitroglycerin ointment in the treatment of acute anal fissure.This randomized clinical trial was carried out during a 10-day period in the Gastroenterology clinic of Ghaem Hospital, Mashhad, Iran (year 2015). 126 patients who filled the inclusion criteria were enrolled. The patients were randomly divided into two groups. Nitroglycerin ointment (0.2%) was applied by patients in the first group, twice daily for 10 days
Randomized clinical trial of the use of glyceryltrinitrate patches to aid arteriovenous fistula maturation Arteriovenous fistulas are critical for haemodialysis, but maturation rates remain poor. Experimental and anecdotal evidence has supported the use of transdermal glyceryltrinitrate (GTN) patches. The aim of this RCT was to determine whether use of a GTN patch aids arteriovenous fistula maturation.Patients referred for arteriovenous fistula formation were eligible. The GTN or placebo (...) patch was applied immediately after surgery and left in situ for 24 h. The primary outcome measure was the change in venous diameter at 6 weeks after fistula formation. The secondary outcome measure was clinical fistula patency at 6 weeks.Of 200 patients recruited (533 screened), 101 were randomized to the placebo group and 99 to the GTN group. Of these, 81 and 86 respectively completed surgery, and had follow-up data available at 6 weeks. Improvements in venous diameter were similar in the two
Notice of Retraction: Jamal SA, et al. Effect of Nitroglycerin Ointment on Bone Density and Strength in Postmenopausal Women: A Randomized Trial. JAMA. 2011;305(8):800-807. 26719994 2016 02 04 2019 02 25 1538-3598 315 4 2016 Jan 26 JAMA JAMA Notice of Retraction: Jamal SA, et al. Effect of Nitroglycerin Ointment on Bone Density and Strength in Postmenopausal Women: A Randomized Trial. JAMA. 2011;305(8):800-807. 418-9 10.1001/jama.2015.18431 Eastell Richard R Metabolic Bone Centre, Northern
Nitroglycerin for management of retained placenta. Retained placenta affects 0.5% to 3% of women following delivery, with considerable morbidity if left untreated. Use of nitroglycerin (NTG), either alone or in combination with uterotonics, may be of value to minimise the need for manual removal of the placenta in theatre under anaesthesia.To evaluate the benefits and harms of NTG as a tocolytic, either alone or in addition to uterotonics, in the management of retained placenta.We searched (...) and no differences were observed (mean difference (MD) -115.31, 95% CI -306.25 to 75.63; women = 169; I² = 83%). Nitroglycerin administration was not associated with an increase in headaches (RR 1.09, 95% CI 0.80 to 1.47; women = 174; studies = three; I² = 0%). However, nitroglycerin administration was associated with a significant, though mild, decrease in systolic and diastolic blood pressure and a significant increase in pulse rate (MD -3.75, 95% CI -7.47 to -0.03) for systolic blood pressure, and (MD 6.00
Nitroglycerin and Nitric Oxide - A Rondo of Themes in Cardiovascular Therapeutics. 26510043 2015 10 30 2018 12 02 1533-4406 373 18 2015 10 29 The New England journal of medicine N. Engl. J. Med. Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. 1789 10.1056/NEJMc1510178 Michel Thomas T Loscalzo Joseph J eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Vasodilator Agents 31C4KY9ESH Nitric Oxide G59M7S0WS3 Nitroglycerin AIM IM N Engl J Med. 2015 (...) Jul 16;373(3):277-80 26176386 N Engl J Med. 2015 Oct 29;373(18):1788-9 26510044 Humans Nitric Oxide history Nitroglycerin history Vasodilator Agents history 2015 10 29 6 0 2015 10 29 6 0 2015 10 31 6 0 ppublish 26510043 10.1056/NEJMc1510178 10.1056/NEJMc1510178#SA2
Nitroglycerin and Nitric Oxide - A Rondo of Themes in Cardiovascular Therapeutics. 26510044 2015 10 30 2018 12 02 1533-4406 373 18 2015 10 29 The New England journal of medicine N. Engl. J. Med. Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. 1788-9 10.1056/NEJMc1510178 Sauri Michael A MA eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Vasodilator Agents 31C4KY9ESH Nitric Oxide G59M7S0WS3 Nitroglycerin AIM IM N Engl J Med. 2015 Jul 16;373(3 (...) ):277-80 26176386 N Engl J Med. 2015 Oct 29;373(18):1789 26510043 Humans Nitric Oxide history Nitroglycerin history Vasodilator Agents history 2015 10 29 6 0 2015 10 29 6 0 2015 10 31 6 0 ppublish 26510044 10.1056/NEJMc1510178 10.1056/NEJMc1510178#SA1
action on thrombophlebitis induced by sclerosis of leg varicose veins. Angiology. 1994 May;45(5):347-51. PubMed: PM8172381 6. Fischer M, Reinhold B, Falck H, Torok M, Alexander K. Topical nitroglycerin ointment in Raynaud's phenomenon. Z Kardiol. 1985 May;74(5):298-302. PubMed: PM3925656 7. Franks AG, Jr. Topical glyceryltrinitrate as adjunctive treatment in Raynaud's disease. Lancet. 1982 Jan 9;1(8263):76-7. PubMed: PM6119495 Non-Randomized Studies Unclear Population Age 8. Anderson ME, Moore TL (...) , Hollis S, Jayson MI, King TA, Herrick AL. Digital vascular response to topical glyceryltrinitrate, as measured by laser Doppler imaging, in primary Raynaud's phenomenon and systemic sclerosis. Rheumatology (Oxford). 2002 Mar;41(3):324-8. PubMed: PM11934971 Topical Nitroglycerin for Peripheral Circulation and Wound Healing in the Elderly 5 9. Fletcher S, Wright M, Wilkinson A, Farr M, Sellars L. Locally applied transdermal nitrate patches for the treatment of ischaemic rest pain. Int J Clin Pract
Nitroglycerin for the treatment of pulmonary edema following submersion: clinical effectiveness and guidelines Nitroglycerin for the treatment of pulmonary edema following submersion: clinical effectiveness and guidelines Nitroglycerin for the treatment of pulmonary edema following submersion: clinical effectiveness and guidelines CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation CADTH. Nitroglycerin for the treatment of pulmonary edema following submersion: clinical effectiveness and guidelines. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response - Summary of Abstracts. 2014 Authors' conclusions No relevant health technology assessments, systematic reviews, meta-analyses, randomized controlled trials, non-randomized studies, or evidence-based guidelines were identified regarding the use
Clevidipine compared with nitroglycerin for blood pressure control in coronary artery bypass grafting: a randomized double-blind study We tested the hypothesis that clevidipine, a rapidly acting dihydropyridine calcium channel blocker, is not inferior to nitroglycerin (NTG) in controlling blood pressure before cardiopulmonary bypass (CPB) during coronary artery bypass grafting (CABG).In this double-blind study from October 4, 2003 to April 26, 2004, 100 patients undergoing CABG with CPB were
: Additional References 1. Gempp E, Louge P, Henckes A, Demaistre S, Heno P, Blatteau J-E. Reversible Myocardial Dysfunction and Clinical Outcome in Scuba Divers With Immersion Pulmonary Edema. The American Journal of Cardiology [Internet]. 2013 June [cited 2014 Mar 6]; 111(11): 1655–1659. Abstract available from: http://www.sciencedirect.com/science/article/pii/S0002914913005419 2. Best evidence topic reports. Bet 1. Managing acute pulmonary oedema: high or standard dose glyceryltrinitrate? Emerg Med J (...) Nitroglycerin for the Treatment of Pulmonary Edema Following Submersion TITLE: Nitroglycerin for the Treatment of Pulmonary Edema Following Submersion: Clinical Effectiveness and Guidelines DATE: 11 March 2014 RESEARCH QUESTIONS 1. What is the clinical effectiveness of nitroglycerin for the treatment of pulmonary edema secondary to submersion, in pre- or in-hospital settings? 2. What are the evidence-based guidelines regarding the use of nitroglycerin for the treatment of pulmonary edema
. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 25 of 291. (Rectiv or Rectogesic or Glyceryltrinitrate or glyceryltrinitrate).tw. (2144) 2. (T opical adj3 nitroglycerin).tw. (144) 3. (topical adj3 nitric oxide).tw. (37) 4. glyceryltrinitrate/ (23129) 5. 1 or 2 or 3 or 4 (23459) 6. Fissure in Ano/ (1971) 7. (anal adj3 fissure?).tw. (1407) 8. (ano adj3 fissure?).tw. (121) 9. 6 or 7 or 8 (2145) 10. 5 and 9 (467) 11. limit 10 to english language (401 (...) Chronic anal fissure: 0.2% topical glyceryltrinitrate ointment Chronic anal fissure: 0.2% topical gly Chronic anal fissure: 0.2% topical glyceryl ceryl trinitrtrinitrate ointment ate ointment Evidence summary Published: 26 March 2013 nice.org.uk/guidance/esuom7 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2013. See summaries of product characteristics (SPCs), British national formulary (BNF), BNF
Topical glyceryltrinitrate may be effective in rotator cuff disease PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Topical glyceryltrinitrate may be effective in rotator cuff disease Clinical question How effective is topical glyceryltrinitrate (GTN) for rotator cuff disease? Bottom line Three small studies, 1 at moderate risk of bias and 2 at high risk of bias, assessed the effectiveness (...) disease because of the very low quality of the evidence. Improvement in people's physical function was not measured by any of the studies included in the review. Context Topical GTN has been used to treat chest pain for many years, and has been proposed as a promising treatment for muscle and tendon injuries. For treatment of soft tissue conditions, GTN is delivered topically, through the skin, using medicated patches. Cochrane Systematic Review Cumpston M et al. Topical glyceryltrinitrate
Rectiv (nitroglycerin) Oinment Drug Approval Package: Rectiv (nitroglycerin) NDA #021359 Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Rectiv (nitroglycerin) Oinment 0.4% Company: ProStrakan, Inc. Application No.: 021359 Approval Date: 06/21/2011 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created
Effect of nitroglycerin ointment on bone density and strength in postmenopausal women: a randomized trial. Nitroglycerin stimulates bone formation and inhibits bone resorption, is inexpensive, and is widely available. Its effects on bone density, bone structure, and bone strength are unknown.To determine if nitroglycerin increases lumbar spine bone mineral density (BMD) and to evaluate changes in hip BMD, bone geometry, and density at the radius and tibia, and markers of bone turnover.A single (...) -center, double-blind, placebo-controlled randomized trial conducted in Toronto, Ontario, Canada, for 24 months starting in November 2005 and completed in March 2010, of 243 postmenopausal women with lumbar spine T scores of between 0 and -2.0 who completed a 1-week run-in period taking nitroglycerin ointment. Intervention Nitroglycerin ointment (15 mg/d) or placebo applied at bedtime for 24 months.Areal BMD at the lumbar spine, femoral neck, and total hip. Secondary outcomes included indices of bone