Latest & greatest articles for nivolumab

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Top results for nivolumab

21. Nivolumab-induced cold agglutinin syndrome successfully treated with rituximab Full Text available with Trip Pro

Nivolumab-induced cold agglutinin syndrome successfully treated with rituximab 30072374 2019 03 18 2473-9537 2 15 2018 08 14 Blood advances Blood Adv Nivolumab-induced cold agglutinin syndrome successfully treated with rituximab. 1865-1868 10.1182/bloodadvances.2018019000 Hasanov Merve M 0000-0002-6102-4917 Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX; and. Konoplev Sergej N SN Department of Hematopathology

2018 Blood advances

22. Nivolumab

Nivolumab Top results for nivolumab - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for nivolumab The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted

2018 Trip Latest and Greatest

23. Low-dose nivolumab can be effective in non-small cell lung cancer: alternative option for financial toxicity Full Text available with Trip Pro

Low-dose nivolumab can be effective in non-small cell lung cancer: alternative option for financial toxicity Nivolumab is used at 3 mg/kg or fixed doses of 240 mg every 2 weeks. There was no dose-response/toxicity relationship of nivolumab. This study evaluated the efficacy of low-dose nivolumab as an alternative to the financial toxicity of standard-dose nivolumab in treatment of non-small cell lung cancer (NSCLC).Outcomes of patients with NSCLC treated with nivolumab as a routine practice (...) at two tertiary hospitals in Korea were retrospectively analysed. Patients who could not afford standard nivolumab treatment received low-dose nivolumab (20 or 100 mg fixed dose every 3 weeks). Others received standard dose of 3 mg/kg every 2 weeks. Progression-free survival (PFS) and overall survival (OS) were measured and compared between low-dose and standard-dose groups in overall and stratified analyses according to programmed death-ligand 1 (PD-L1) status.Among the 47 patients with NSCLC, 18

2018 ESMO open

24. Nivolumab for adults with Hodgkin's lymphoma (a rapid review using the software RobotReviewer). Full Text available with Trip Pro

Nivolumab for adults with Hodgkin's lymphoma (a rapid review using the software RobotReviewer). Hodgkin's lymphoma (HL) is a cancer of the lymphatic system, and involves the lymph nodes, spleen and other organs such as the liver, lung, bone or bone marrow, depending on the tumour stage. With cure rates of up to 90%, HL is one of the most curable cancers worldwide. Approximately 10% of people with HL will be refractory to initial treatment or will relapse; this is more common in people (...) range of malignancies. Nivolumab is an anti-(PD)-1 monoclonal antibody and currently approved by the US Food and Drug Administration (FDA) for the treatment of melanoma, non-small cell lung cancer, renal cell carcinoma and, since 2016, for classical Hodgkin's lymphoma (cHL) after treatment with ASCT and brentuximab vedotin.To assess the benefits and harms of nivolumab in adults with HL (irrespective of stage of disease).We searched CENTRAL, MEDLINE, Embase, International Pharmaceutical Abstracts

2018 Cochrane

25. Nivolumab (squamous cell carcinoma of the head and neck) - Addendum to Commission A17-24

Nivolumab (squamous cell carcinoma of the head and neck) - Addendum to Commission A17-24 1 Translation of addendum A17-54 Nivolumab (Plattenepithelkarzinom des Kopf-Hals-Bereichs) – Addendum zum Auftrag A17-24 (Version 1.0; Status: 25 October 2017). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Addendum 25 October 2017 1.0 Commission: A17-54 Version: Status (...) : IQWiG Reports – Commission No. A17-54 Nivolumab (squamous cell carcinoma of the head and neck) – Addendum to Commission A17-24 1 Addendum A17-54 Version 1.0 Nivolumab – Addendum to Commission A17-24 25 October 2017 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Nivolumab (squamous cell carcinoma of the head and neck) – Addendum to Commission A17-24 Commissioning agency: Federal Joint Committee

2018 Institute for Quality and Efficiency in Healthcare (IQWiG)

26. Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapy

Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapy Niv Nivolumab for treating locally advanced olumab for treating locally advanced unresectable or metastatic urothelial unresectable or metastatic urothelial cancer after platinum-containing cancer after platinum-containing chemother chemotherap apy y T echnology appraisal guidance Published: 4 July 2018 nice.org.uk/guidance/ta530 © NICE 2018. All rights reserved. Subject (...) . They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

27. Multi-institutional report on toxicities of concurrent nivolumab and radiation therapy Full Text available with Trip Pro

Multi-institutional report on toxicities of concurrent nivolumab and radiation therapy Radiation therapy (RT) and nivolumab are standard therapies for a wide range of advanced and metastatic cancers, yet little is known about the toxicity profile of their combined treatment. The rate of grade ≥3 toxicities from nivolumab monotherapy and radiation-only palliative treatments has been reported at 10% to 18% and 0% to 26%, respectively. We reviewed our experience to assess the acute toxicity (...) profile of concurrent RT-nivolumab.A retrospective review of all consecutive patients from January 2015 to May 2017 who received concurrent RT-nivolumab was conducted at 4 separate centers. Concurrent RT-nivolumab was defined as RT completed between 3 days prior to initial nivolumab infusion and 28 days after the last nivolumab infusion.Of the 261 patients who received nivolumab, 46 (17.6%) had concurrent RT to 67 treatment sites. The median follow-up was 3.3 months (interquartile range, 1.7-6.1

2018 Advances in radiation oncology

28. Efficacy and safety of nivolumab in non‐small cell lung cancer with preexisting interstitial lung disease Full Text available with Trip Pro

Efficacy and safety of nivolumab in non‐small cell lung cancer with preexisting interstitial lung disease The risk of developing lung cancer is high in patients with interstitial lung disease (ILD), as few treatment options are available. Immune checkpoint inhibitors (ICI) are used for the treatment of non-small cell lung cancer (NSCLC) in clinical practice; however, in patients with preexisting ILD, the risk of ICI-related pneumonitis is unknown. We evaluated the efficacy and lung toxicity (...) of nivolumab in patients with NSCLC and ILD.We retrospectively reviewed the medical records of 216 NSCLC patients who had received nivolumab therapy. The existence of ILD in these patients was determined by lung computed tomography findings; 26 patients had ILD. We evaluated the efficacy of nivolumab by measuring the response rate (RR), progression-free survival (PFS) duration, and lung toxicity by incidence, severity, and outcome of nivolumab-related ILD.The RR and median PFS of the ILD and non-ILD groups

2018 Thoracic cancer

29. Efficacy of next treatment received after nivolumab progression in patients with advanced nonsmall cell lung cancer Full Text available with Trip Pro

Efficacy of next treatment received after nivolumab progression in patients with advanced nonsmall cell lung cancer Nivolumab for the treatment of advanced nonsmall cell lung cancer (NSCLC) evaluated in phase III trials showed 50% progression at first evaluation, but better overall survival (OS), suggesting regained efficacy of treatments given thereafter. We aimed to evaluate the efficacy of nivolumab and of next treatment received after nivolumab progression in patients with advanced NSCLC (...) . Our multicentre retrospective study included all patients receiving nivolumab between January and December 2015. The primary end-point was progression-free survival (PFS) of treatment given after nivolumab. The 303 patients had the following characteristics: median age 63 years, 69% males, 92% smokers, 67% performance status 0-1 and 61% adenocarcinoma. Nivolumab was given as second-line treatment in 40% of patients. With 13.7 months of median follow-up, nivolumab PFS and OS were 2.6 and 11.3

2018 ERJ open research

30. Successful treatment with nivolumab for lung cancer with low expression of PD‐L1 and prominent tumor‐infiltrating B cells and immunoglobulin G Full Text available with Trip Pro

Successful treatment with nivolumab for lung cancer with low expression of PD‐L1 and prominent tumor‐infiltrating B cells and immunoglobulin G Little is known about the anti-tumor activity of humoral immunity in lung cancer patients treated with nivolumab, an immune checkpoint inhibitor. Herein, we report a case of lung cancer with 5% expression of PD-L1, in which a partial response to nivolumab was sustained for > 7 months. Immunohistochemical analysis of the metastatic lymph node biopsy (...) specimen showed prominent accumulation of plasma cells and immunoglobulin G. These findings suggest that pre-existing humoral immunity may be worth considering as a candidate therapeutic biomarker of nivolumab in some lung cancer patients.© 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

2018 Thoracic cancer

31. Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden. Full Text available with Trip Pro

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden. Nivolumab plus ipilimumab showed promising efficacy for the treatment of non-small-cell lung cancer (NSCLC) in a phase 1 trial, and tumor mutational burden has emerged as a potential biomarker of benefit. In this part of an open-label, multipart, phase 3 trial, we examined progression-free survival with nivolumab plus ipilimumab versus chemotherapy among patients with a high tumor mutational burden (≥10 mutations per (...) megabase).We enrolled patients with stage IV or recurrent NSCLC that was not previously treated with chemotherapy. Those with a level of tumor programmed death ligand 1 (PD-L1) expression of at least 1% were randomly assigned, in a 1:1:1 ratio, to receive nivolumab plus ipilimumab, nivolumab monotherapy, or chemotherapy; those with a tumor PD-L1 expression level of less than 1% were randomly assigned, in a 1:1:1 ratio, to receive nivolumab plus ipilimumab, nivolumab plus chemotherapy, or chemotherapy

2018 NEJM Controlled trial quality: uncertain

32. Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma. Full Text available with Trip Pro

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma. Nivolumab plus ipilimumab produced objective responses in patients with advanced renal-cell carcinoma in a pilot study. This phase 3 trial compared nivolumab plus ipilimumab with sunitinib for previously untreated clear-cell advanced renal-cell carcinoma.We randomly assigned adults in a 1:1 ratio to receive either nivolumab (3 mg per kilogram of body weight) plus ipilimumab (1 mg per kilogram) intravenously every 3 (...) weeks for four doses, followed by nivolumab (3 mg per kilogram) every 2 weeks, or sunitinib (50 mg) orally once daily for 4 weeks (6-week cycle). The coprimary end points were overall survival (alpha level, 0.04), objective response rate (alpha level, 0.001), and progression-free survival (alpha level, 0.009) among patients with intermediate or poor prognostic risk.A total of 1096 patients were assigned to receive nivolumab plus ipilimumab (550 patients) or sunitinib (546 patients); 425 and 422

2018 NEJM Controlled trial quality: predicted high

33. Combination nivolumab with transcatheter arterial chemoembolization for clinical remission of small cell lung cancer: A case report Full Text available with Trip Pro

Combination nivolumab with transcatheter arterial chemoembolization for clinical remission of small cell lung cancer: A case report The outcome of small cell lung cancer (SCLC) patients is poor because rapid metastasis develops after first-line chemotherapy and few drugs are available for second-line chemotherapy. The median survival rate has not significantly changed in recent years. In this report, we discuss the case of a 71-year-old Chinese female non-smoker diagnosed with extensive-stage (...) SCLC who was treated with nivolumab for a short period and obtained a prolonged clinical benefit. We report the clinical history, clinical features, potential mechanism, benefits, and the best therapeutic window. The patient was treated with transcatheter arterial chemoembolization because of liver metastasis and then with four doses of nivolumab as third-line systemic treatment. There was no disease progression for 15 months. The lesions became larger than before, suggesting disease progression

2018 Thoracic cancer

34. Nivolumab (Opdivo) - metastatic colorectal cancer

Nivolumab (Opdivo) - metastatic colorectal cancer 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 26 January 2018 EMA/51006/2018 EMEA/H/C/003985/II/0030 Withdrawal of the application for a change to the marketing authorisation (...) for Opdivo (nivolumab) On 13 December 2017, Bristol-Myers Squibb Pharma EEIG officially notified the Committee for Medicinal Products for Human Use (CHMP) that it wishes to withdraw its application to extend the use of Opdivo to treat colorectal cancer. What is Opdivo? Opdivo is a cancer medicine that contains the active substance nivolumab and is available as a concentrate that is made up into a solution for infusion (drip) into a vein. Opdivo has been authorised since June 2015. It is already used

2018 European Medicines Agency - EPARs

35. Axitinib, cabozantinib, everolimus, nivolumab, sunitinib and best supportive care in previously treated renal cell carcinoma: a systematic review and economic evaluation

Axitinib, cabozantinib, everolimus, nivolumab, sunitinib and best supportive care in previously treated renal cell carcinoma: a systematic review and economic evaluation Axitinib, cabozantinib, everolimus, nivolumab, sunitinib and best supportive care in previously treated renal cell carcinoma: a systematic review and economic evaluation Axitinib, cabozantinib, everolimus, nivolumab, sunitinib and best supportive care in previously treated renal cell carcinoma: a systematic review and economic (...) evaluation Edwards S J, Wakefield V, Cain P, Karner C, Kew K, Bacelar M, Masento N & Salih F Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Edwards S J, Wakefield V, Cain P, Karner C, Kew K, Bacelar M, Masento N & Salih F. Axitinib, cabozantinib, everolimus, nivolumab, sunitinib and best supportive care in previously treated renal cell carcinoma

2018 Health Technology Assessment (HTA) Database.

36. Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis Full Text available with Trip Pro

Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab.Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary (...) discontinuation of nivolumab and cabiralizumab as well as systemic prednisone.Ophthalmologists should be aware of the possibility of acute ocular inflammation developing with cancer immunotherapy. Systemic corticosteroids play a first-line role in managing such immune-mediated side effects.

2018 American journal of ophthalmology case reports

37. Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study Full Text available with Trip Pro

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study Immune checkpoint inhibitors, including anti-programmed cell death-1 (PD-1) antibodies, have become promising treatments for a variety of advanced malignancies. However, these medicines can cause immune-related adverse events (irAEs), including endocrinopathies.This study examined the incidence of endocrine irAEs induced by nivolumab.Sixty-six patients treated with nivolumab (...) at Nagoya University Hospital were prospectively evaluated for pituitary hormones, thyroid function, antithyroid antibodies (Abs), and glucose levels every 6 weeks after the initiation of nivolumab for 24 weeks.Four out of 66 patients developed destructive thyroiditis, and three patients developed hypothyroidism requiring levothyroxine replacement. The prevalence of positive anti-thyroglobulin Abs (TgAbs) and/or anti-thyroid peroxidase Abs (TPOAbs) at baseline was significantly higher in the group

2018 Journal of the Endocrine Society

38. [Nivolumab (urothelial carcinoma) - benefit assessment according to õ35a Social Code Book V]

[Nivolumab (urothelial carcinoma) - benefit assessment according to õ35a Social Code Book V] Nivolumab (urothelkarzinom): nutzenbewertung gemäß § 35a SGB V; dossierbewertung; auftrag A17-29 [Nivolumab (urothelial carcinoma) - benefit assessment according to §35a Social Code Book V] Nivolumab (urothelkarzinom): nutzenbewertung gemäß § 35a SGB V; dossierbewertung; auftrag A17-29 [Nivolumab (urothelial carcinoma) - benefit assessment according to §35a Social Code Book V] Institut für Qualität und (...) Wirtschaftlichkeit im Gesundheitswesen Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. Nivolumab (urothelkarzinom): nutzenbewertung gemäß § 35a SGB V; dossierbewertung; auftrag A17-29. [Nivolumab (urothelial carcinoma) - benefit assessment according to §35a Social Code Book V] Cologne

2018 Health Technology Assessment (HTA) Database.

39. [Nivolumab (squamous cell carcinoma of the head and neck). Second addendum to A-17-24]

[Nivolumab (squamous cell carcinoma of the head and neck). Second addendum to A-17-24] Nivolumab (plattenepithelkarzinom des kopf-hals-nereichs): 2. Addendum zum auftrag A17-24; auftrag G17-10 [Nivolumab (squamous cell carcinoma of the head and neck). Second addendum to A-17-24] Nivolumab (plattenepithelkarzinom des kopf-hals-nereichs): 2. Addendum zum auftrag A17-24; auftrag G17-10 [Nivolumab (squamous cell carcinoma of the head and neck). Second addendum to A-17-24] Institut für Qualität und (...) Wirtschaftlichkeit im Gesundheitswesen Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. Nivolumab (plattenepithelkarzinom des kopf-hals-nereichs): 2. Addendum zum auftrag A17-24; auftrag G17-10. [Nivolumab (squamous cell carcinoma of the head and neck). Second addendum to A-17-24] Cologne

2018 Health Technology Assessment (HTA) Database.

40. [Nivolumab (squamous cell carcinoma of the head and neck) - addendum to Commission A17-24 ]

[Nivolumab (squamous cell carcinoma of the head and neck) - addendum to Commission A17-24 ] Nivolumab (plattenepithelkarzinom des kopf-hals-bereichs): addendum zum auftrag A17-24; Auftrag A17-54 [Nivolumab (squamous cell carcinoma of the head and neck) - addendum to Commission A17-24 ] Nivolumab (plattenepithelkarzinom des kopf-hals-bereichs): addendum zum auftrag A17-24; Auftrag A17-54 [Nivolumab (squamous cell carcinoma of the head and neck) - addendum to Commission A17-24 ] Institut für (...) Qualität und Wirtschaftlichkeit im Gesundheitswesen Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. Nivolumab (plattenepithelkarzinom des kopf-hals-bereichs): addendum zum auftrag A17-24; Auftrag A17-54. [Nivolumab (squamous cell carcinoma of the head and neck) - addendum

2018 Health Technology Assessment (HTA) Database.