Latest & greatest articles for nsaids

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Top results for nsaids

81. Clinical trial: healing of NSAID-associated gastric ulcers in patients continuing NSAID therapy - a randomized study comparing ranitidine with esomeprazole (Abstract)

Clinical trial: healing of NSAID-associated gastric ulcers in patients continuing NSAID therapy - a randomized study comparing ranitidine with esomeprazole BACKGROUND: The use of non-steroidal anti-inflammatory drugs (NSAID) is associated with an increased risk of gastric ulcer (GU) development. METHODS: This multicentre, randomized, double-blind, parallel-group trial compared endoscopic healing rates at 4 and 8 weeks after treatment with oral esomeprazole 40 or 20 mg once daily, or ranitidine (...) 150 mg twice daily, in patients with 1 baseline GU > or = 5 mm but no GUs or duodenal ulcers >25 mm in diameter who received continued cyclooxygenase-2-selective or non-selective NSAID therapies. The primary outcome was the percentage of patients in each treatment group who had no GUs at week 8. RESULTS: Four hundred and forty patients were randomized to treatment. At week 8, GU healing rates (95% CI) with esomeprazole 40 mg, esomeprazole 20 mg and ranitidine were 85.7 (79.8-91.7)%, 84.8

2007 EvidenceUpdates Controlled trial quality: predicted high

82. Using non-steroidal anti-inflammatory drugs (NSAIDs) following pleurodesis

Using non-steroidal anti-inflammatory drugs (NSAIDs) following pleurodesis BestBets: Using non-steroidal anti-inflammatory drugs (NSAIDs) following pleurodesis Using non-steroidal anti-inflammatory drugs (NSAIDs) following pleurodesis Report By: Ian Hunt, Elaine Teh, Rachel Southon - Specialist Registrars in Cardiothoracic Surgery Search checked by Tom Treasure - Library Services Manager, Royal Surrey County Hospital, Guildford Institution: Department of Thoracic Surgery, Guy's Hospital (...) and Department of Cardiothoracic Surgery, Brompton, London Date Submitted: 6th February 2007 Date Completed: 9th May 2007 Last Modified: 9th May 2007 Status: Green (complete) Three Part Question In [patients undergoing pleurodesis] is the use of [NSAIDs] detrimental in terms of [successful pleurodesis]. Clinical Scenario A 25 year old man with his second spontaneous right-sided pneumothorax has undergone VATS bullectomy and talc pleurodesis this morning. Patient controlled analgesia (PCA) was set up

2007 BestBETS

83. Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of ankylosing spondylitis in the UK

Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of ankylosing spondylitis in the UK Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of ankylosing spondylitis in the UK Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of ankylosing spondylitis in the UK Jansen J P, Pellissier J, Choy E H, Ostor A, Nash J T, Bacon P, Hunsche E Record Status This is a critical abstract of an economic evaluation that meets (...) acknowledged the limitations of their study in their discussion. Concluding remarks: Overall the methodology of the study was adequate and the methods and results were well reported. Given the scope of the analysis, the author’s conclusions appear to be valid. Funding Funded by Merck & Co., Inc. Bibliographic details Jansen J P, Pellissier J, Choy E H, Ostor A, Nash J T, Bacon P, Hunsche E. Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of ankylosing spondylitis in the UK

2007 NHS Economic Evaluation Database.

84. Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review Full Text available with Trip Pro

Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review | The Medical Journal of Australia mja-search search Use the for more specific terms. Title contains Body contains Date range from Date range to Article type Author's surname Volume First page doi: 10.5694/mja__.______ Search Reset  close Individual Login Purchase options Connect person_outline (...) Login keyboard_arrow_down Individual Login Purchase options menu search Advertisement close Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review Delia Schaffer, Timothy Florin, Craig Eagle, Ian Marschner, Gurkirpal Singh, Mendel Grobler, Chris Fenn, Manjula Schou and Kathleen M Curnow Med J Aust 2006; 185 (9): 501-506. || doi: 10.5694/j.1326-5377.2006.tb00665.x Published online: 6 November 2006 Topics Abstract Objective: N on-selective non-steroidal

2006 EvidenceUpdates

85. Intravenous NSAID's in the Management of Renal Colic

Intravenous NSAID's in the Management of Renal Colic BestBets: Intravenous NSAID's in the Management of Renal Colic Intravenous NSAID's in the Management of Renal Colic Report By: Debasis Das - SHO Urology Search checked by Stuart Teece - Research Fellow, MRI Institution: Guy's and St. Thomas' Hospital Date Submitted: 5th January 2006 Date Completed: 1st March 2006 Last Modified: 5th January 2006 Status: Green (complete) Three Part Question [In patients presenting with suspected renal colic (...) of prostaglandins which subsequently stimulate pain. While opiates can offer pain relief by subduing patients' awareness of these stimuli, NSAID's can actually treat the pathophysiological mechanisms that cause them in the first place. You wonder whether they would be more effective at providing analgesia? Search Strategy Medline database using Ovid interface: 1966–November 2005. The Cochrane Database of Systematic Reviews was also searched. {{{(exp Injections, Intravenous/ or intravenous. mp.) AND {(exp

2006 BestBETS

86. Review: paracetamol reduces pain in osteoarthritis but is less effective than NSAIDs Full Text available with Trip Pro

Review: paracetamol reduces pain in osteoarthritis but is less effective than NSAIDs Review: paracetamol reduces pain in osteoarthritis but is less effective than NSAIDs | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional (...) accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: paracetamol reduces pain in osteoarthritis but is less effective than NSAIDs Article Text Treatment Review: paracetamol reduces pain in osteoarthritis but is less effective than NSAIDs Free Cathy R Kessenich , RN, DSN

2006 Evidence-Based Mental Health

87. Review: topical NSAIDs reduce pain in osteoarthritis only during the first 2 weeks of use Full Text available with Trip Pro

Review: topical NSAIDs reduce pain in osteoarthritis only during the first 2 weeks of use Review: topical NSAIDs reduce pain in osteoarthritis only during the first 2 weeks of use | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: topical NSAIDs reduce pain in osteoarthritis only during the first 2 weeks of use Article Text Treatment Review: topical NSAIDs reduce pain in osteoarthritis only during the first 2 weeks of use Free Cathy R

2006 Evidence-Based Mental Health

88. Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review

Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review Risk of serious NSAID-related gastrointestinal events during long-term exposure: a systematic review Schaffer D, Florin T, Eagle C, Marschner I, Singh G, Grobler M, Fenn C, Schou M, Curnow K M CRD summary This review investigated whether the occurrence of serious gastrointestinal events decrease (...) over time in studies of long-term use of non-steroidal anti-inflammatory drugs (NSAIDs). The authors found that the probability of having a serious NSAID-related ulcer bleed, perforation or hospitalisation did not meaningfully decline over time. The use of meta-regression with few studies implies cautious interpretation of these results. Authors' objectives To assess whether the occurrence of serious gastrointestinal (GI) events reduces over time in studies of long-term use of non-steroidal anti

2006 DARE.

89. A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience

A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2006 DARE.

90. Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs

Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2006 DARE.

91. NSAID-analgesia, pain control and morbidity in cardiothoracic surgery

NSAID-analgesia, pain control and morbidity in cardiothoracic surgery Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2006 DARE.

92. Review: selective COX 2 inhibitors increase vascular events more than placebo and naproxen but not more than other NSAIDs Full Text available with Trip Pro

Review: selective COX 2 inhibitors increase vascular events more than placebo and naproxen but not more than other NSAIDs Review: selective COX 2 inhibitors increase vascular events more than placebo and naproxen but not more than other NSAIDs | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using (...) your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: selective COX 2 inhibitors increase vascular events more than placebo and naproxen but not more than other NSAIDs Article Text

2006 Evidence-Based Medicine

93. NSAIDS or paracetamol, alone or combined with opioids, for cancer pain. (Abstract)

NSAIDS or paracetamol, alone or combined with opioids, for cancer pain. NSAIDs are widely applied to treat cancer pain and are frequently combined with opioids in combination preparations for this purpose. However, it is unclear which agent is most clinically efficacious for relieving cancer-related pain, or even what may be the additional benefit of combining an NSAID with an opioid in this setting.To assess the effects of NSAIDs, alone or combined with opioids, for the treatment of cancer (...) pain.We searched the Cochrane Central Register of Controlled Trials (Issue 2, 2002), MEDLINE (January 1966 to March 2003), EMBASE (January 1980 to December 2001), LILACS (January 1984 to December 2001) and reference list of articles.Randomized controlled trials and controlled clinical trials that compared NSAID versus placebo; NSAID versus NSAID; NSAID versus NSAID plus opioid; opioid versus opioid plus NSAID; or NSAID versus opioid.Two reviewers independently assessed trial quality and extracted data

2005 Cochrane

94. Meta-analysis: role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users

Meta-analysis: role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

95. Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies

Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2005 DARE.

96. Cost-effectiveness analysis of NSAIDs, NSAIDs with concomitant therapy to prevent gastrointestinal toxicity, and COX-2 specific inhibitors in the treatment of rheumatoid arthritis

Cost-effectiveness analysis of NSAIDs, NSAIDs with concomitant therapy to prevent gastrointestinal toxicity, and COX-2 specific inhibitors in the treatment of rheumatoid arthritis Cost-effectiveness analysis of NSAIDs, NSAIDs with concomitant therapy to prevent gastrointestinal toxicity, and COX-2 specific inhibitors in the treatment of rheumatoid arthritis Cost-effectiveness analysis of NSAIDs, NSAIDs with concomitant therapy to prevent gastrointestinal toxicity, and COX-2 specific inhibitors (...) in the treatment of rheumatoid arthritis Yun H R, Bae S C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined the use of non-steroidal anti-inflammatory agents (NSAIDs) with and without concomitant therapy to prevent

2005 NHS Economic Evaluation Database.

97. Nonsteroidal anti-inflammatory drugs (NSAIDs) versus opioids for acute renal colic. (Abstract)

Nonsteroidal anti-inflammatory drugs (NSAIDs) versus opioids for acute renal colic. Renal colic is a common cause of acute severe pain. Both opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for treatment, but the relative efficacy of these drugs is uncertain.To examine the benefits and disadvantages of NSAIDs and opioids for the management of pain in acute renal colic.We searched the Cochrane Renal Group's specialised register (May 2003), the Cochrane Central Register (...) of Randomised Controlled Trials (CENTRAL - The Cochrane Library issue 2, 2003), MEDLINE (1966 - 31 January 2003), EMBASE (1980 - 31 January 2003) and handsearched reference lists of retrieved articles.Randomised controlled trials (RCTs) comparing any opioid with any NSAID, regardless of dose or route of administration were included.Data was extracted and quality assessed independently by two reviewers, with differences resolved by discussion. Dichotomous outcomes are reported as relative risk (RR

2004 Cochrane

98. Non steroidal anti-inflammatory drugs (NSAID) and Aspirin for preventing colorectal adenomas and carcinomas. (Abstract)

Non steroidal anti-inflammatory drugs (NSAID) and Aspirin for preventing colorectal adenomas and carcinomas. There is evidence from experimental animals studies, prospective and retrospective observational studies that nonsteroidal anti-inflammatory drugs (NSAIDS) may reduce the development of sporadic colorectal adenomas (CRAs) and cancer (CRC) and may induce the regression of adenomas in familial adenomatous polyposis (FAP).To conduct a systematic review to determine the effect of NSAIDS

2004 Cochrane

99. Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK

Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK Moore A, Phillips C, Hunsche E, Pellissier J, Crespi S Record Status (...) was derived from a synthesis of completed studies. Modelling A decision tree model was used to assess the expected costs and consequences of ETO, compared with different options of non-selective NSAIDs, in a hypothetical cohort of 10,000 patients. GI events, major (clinically evident gastroduodenal perforations, symptomatic gastroduodenal ulcers or upper GI bleeding) and minor (those that could lead to treatment), were calculated and entered into the model to derive the total costs associated with each

2004 NHS Economic Evaluation Database.

100. Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs

Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs Henry D, McGettigan P CRD summary This review assessed the risk of serious gastrointestinal complications with non-steroidal anti-inflammatory drugs (NSAIDs). The authors concluded that, at low doses, the risk is lower with ibuprofen than with other NSAIDs. Wide variation (...) in the estimate of risk between different studies of the same drugs, which the authors were unable to explain, casts doubt on the reliability of the conclusion. Authors' objectives The objectives were three-fold: to update previous systematic reviews; to determine the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of serious gastrointestinal complications; and to examine the place of drug dose in explaining the variation in this risk. Searching MEDLINE, EMBASE, the Cochrane Library

2003 DARE.