Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients <60 Years of Age With Osteoarthritis Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) )31149-9. doi: 10.1016/j.arth.2020.10.050. Online ahead of print. Long-Term (Up to 27 Years) Prospective, Randomized Study of Mobile-Bearing and Fixed-Bearing Total Knee Arthroplasties in Patients , , Affiliations Expand Affiliations 1 The Joint Replacement Center of Seoul Metropolitan SeoNam Hospital, Seoul, Republic of Korea. 2 The Joint Replacement Center of Ewha Womans University Seoul Hospital, Seoul, Republic of Korea. PMID: 33223412 DOI: Item in Clipboard Long-Term (Up to 27 Years) Prospective

Abstract Purpose: To evaluate the efficacy and safety of intra-articular mesenchymal stromal cells (MSCs) injections for knee osteoarthritis (OA) treatment. Methods: We performed a systematic literature search in PubMed, Embase, Scopus, and the Cochrane Library through April 2020 to identify level I randomized controlled trials (RCTs) that evaluated the clinical efficacy of MSCs versus control treatments for knee OA. Outcomes were analyzed on an intention-to-treat basis with random-effects models (...) Intra-articular Mesenchymal Stromal Cell Injections Are No Different From Placebo in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials Intra-Articular Mesenchymal Stromal Cell Injections Are No Different From Placebo in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set

options Format Abstract Objectives: To evaluate the safety of low-dose tanezumab in the treatment of knee or hip osteoarthritis (OA). Methods: Databases were searched up to September 2019 for phase III randomized controlled trials (RCTs). Eleven phase III RCTs comprising 11,455 patients were eligible. The pooled estimates of safety outcomes were assessed and expressed using relative risks (RRs) and 95% confidence intervals with a random-effects model. Results: Tanezumab significantly increased (...) the incidence of rapidly progressive OA (RPOA; RR = 9.07, 95% CI = 1.21-67.90, P = 0.03) and abnormal peripheral sensation (APS; RR = 2.68, 95% CI = 1.64-4.37, P < 0.00001) compared with placebo. No significant difference was found in terms of incidence of total joint replacement (TJR; RR = 1.13, 95% CI = 0.76-1.68, P = 0.55) or withdrawal due to adverse effects (AEs; RR = 1.26, 95% CI = 0.79-2.00, P = 0.33). The tanezumab group showed a statistically higher incidence of RPOA (RR = 3.96, 95% CI = 2.23-7.04

Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function - PubMed This site needs JavaScript to work properly (...) Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Arthroscopy Actions . 2020 Oct 20;S0749-8063(20)30843-4. doi: 10.1016/j.arthro.2020.10.013. Online ahead of print. Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function , , , , , Affiliations Expand Affiliations 1 Department

Department of Sport, Health Sciences and Social Work, Oxford Brookes University, Oxford. 13 Primary Care Centre of Excellence Versus Arthritis, School of Primary Community and Social Care, Keele University, Staffordshire. PMID: 33254239 DOI: Item in Clipboard Full-text links Cite Display options Display options Format Abstract Objectives: To investigate the clinical effectiveness, efficacy and cost effectiveness of splints (orthoses) in people with symptomatic basal thumb joint OA (BTOA). Methods (...) . The clinical and cost effectiveness of splints for thumb base osteoarthritis: a randomized controlled clinical trial , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Health Sciences, University of Southampton, Southampton. 2 Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Southampton. 3 Oxford Clinical Trials Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS). 4 NDORMS

osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73:1323-1330. Zagra L, Gallazzi E. Bearing surfaces in primary total hip arthroplasty. EFORT Open Rev. 2018;3:217-224. Learmonth ID, Young C, Rorabeck C. The operation of the century: total hip replacement. Lancet. 2007;370:1508-1519. 15th Annual Report, (n.d.). . Accessed July 20, 2019. Scottish Arthroplasty Project, Scottish Arthroplasty Project: Annual Report 2018; 2018. . Accessed July 17, 2019. Show all 67 (...) Cost effectiveness analyses of total hip arthroplasty for hip osteoarthritis: A PRISMA systematic review Cost effectiveness analyses of total hip arthroplasty for hip osteoarthritis: A PRISMA systematic review - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public

Effectiveness of pain coping skills training on pain, physical function, and psychological outcomes in patients with osteoarthritis: A systemic review and meta-analysis Effectiveness of pain coping skills training on pain, physical function, and psychological outcomes in patients with osteoarthritis: A systemic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several (...) navigation Clin Rehabil Actions . 2020 Oct 26;269215520968251. doi: 10.1177/0269215520968251. Online ahead of print. Effectiveness of pain coping skills training on pain, physical function, and psychological outcomes in patients with osteoarthritis: A systemic review and meta-analysis , , , Affiliations Expand Affiliations 1 Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China. 2 Key Laboratory of Rehabilitation Medicine, West China

(12 and 18 months) of the standard Fit & Strong! physical activity program to Fit & Strong! Plus, which combined physical activity and dietary weight loss. Outcomes were weight, diet quality, physical activity, osteoarthritis symptoms, performance measures, and anxiety/depression. In this study, 413 overweight/obese participants with OA, ≥60 years old and primarily African American, were randomly assigned to Fit & Strong! (F&S!) or Fit & Strong! Plus (F&S! Plus), with outcomes assessed at 2, 6, 12 (...) Fit and Strong! Plus: Twelve and eighteen month follow-up results for a comparative effectiveness trial among overweight/obese older adults with osteoarthritis Fit and Strong! Plus: Twelve and eighteen month follow-up results for a comparative effectiveness trial among overweight/obese older adults with osteoarthritis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced

Glucosamine & Chondroitin: Natural remedies for osteoarthritis? November 2, 2020 Glucosamine & Chondroitin: Natural remedies for osteoarthritis? Clinical Question: Does glucosamine and/or chondroitin improve pain for patients with osteoarthritis? Bottom Line: Glucosamine and chondroitin do not appear to be effective in higher-quality, larger and/or publicly funded studies. If studies at high risk of bias are included, at best ~10% more people will have meaningful reduction in pain with either (...) : • Only one RCT examined meaningful pain reductions: effect similar to components alone. 12 • Change in 100-point pain scale: not different from placebo. 3,18 o Limits: mostly knee osteoarthritis studied. 1 No benefit of glucosamine or chondroitin over placebo in publicly funded 1 , high-quality, or larger RCTs. 4,12 Context: • Many meta-analyses report “standard mean differences” which are difficult to apply clinically and are not reported here. 2,4,5,7,9-17 • Pain studies should consider both

via the GJO CPG eAppendix 1 View data summaries via the GJO CPG eAppendix 2 15 osteoarthritis (i.e. rheumatoid arthritis, inflammatory arthritis, post traumatic arthritis, avascular necrosis, rotator cuff tear arthropathy, capsulorrhaphy arthropathy, post-infectious arthropathy, etc.). BURDEN OF DISEASE Chronic shoulder pain can result in significant dysfunction, disability, and increased health care costs. Shoulder pain has been reported as one of the most commonly affected joints for chronic (...) pain, affecting 22.3 million in patients over 18 years of age in 2015.(Weinstein et al., Burden of Musculoskeletal Disease) It is estimated that shoulder pain affects 5-21% of the adult population in the United states and glenohumeral joint arthritis affects nearly a third of the world’s population over the age of 60. 10,22 (Singh et al 2010) The economic burden for the management of glenohumeral joint osteoarthritis is directly correlated with duration of conservative management, surgical costs

Disease, Chinese PLA General Hospital, Beijing, China. PMID: 32954819 DOI: Item in Clipboard Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis Lidong Hu et al. Clin Rehabil . 2020 . Show details Display options Display options Format Clin Rehabil Actions . 2020 Sep 21;269215520954343. doi: 10.1177/0269215520954343. Online ahead of print. Authors , , , , , , , , Affiliations 1 Department of Rheumatology, Xiang'an (...) Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19

Acupuncture of different treatment frequencies in knee osteoarthritis: a pilot randomised controlled trial Acupuncture of different treatment frequencies in knee osteoarthritis: a pilot randomised controlled trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest (...) frequencies in knee osteoarthritis: a pilot randomised controlled trial , , , , , , , , , Affiliations Expand Affiliations 1 Acupuncture Research Center, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China. 2 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, affiliated with Capital Medical University, Beijing, China. PMID: 32483056 DOI: Item in Clipboard Acupuncture of different treatment frequencies in knee

osteoarthritis (pain ≥40 on a 0-100 mm visual analogue scale (VAS) despite analgesics and non-steroidal anti-inflammatory drugs; at least three painful joints, Kellgren-Lawrence grade ≥2) were randomised to receive two infusions 4 weeks apart (weeks 0 and 4) of tocilizumab (8 mg/kg intravenous) or placebo. The primary endpoint was changed in VAS pain at week 6. Secondary outcomes included the number of painful and swollen joints, duration of morning stiffness, patients' and physicians' global assessment (...) Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly

of knee OA. © 2020 Samumed, LLC. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. Similar articles Yazici Y, McAlindon TE, Fleischmann R, Gibofsky A, Lane NE, Kivitz AJ, Skrepnik N, Armas E, Swearingen CJ, DiFrancesco A, Tambiah JRS, Hood J, Hochberg MC. Yazici Y, et al. Osteoarthritis Cartilage. 2017 Oct;25(10):1598-1606. doi: 10.1016/j.joca.2017.07.006. Epub 2017 Jul 13. Osteoarthritis Cartilage. 2017. PMID: 28711582 Clinical Trial. Deshmukh (...) of musculoskeletal diseases in the United States (BMUS). 4th ed. Rosemont (IL): United States Bone and Joint Initiative; 2019. Conaghan PG, Hunter DJ, Maillefert JF, Reichmann WM, Losina E. Summary and recommendations of the OARSI FDA Osteoarthritis Assessment of Structural Change working group. Osteoarthritis Cartilage 2011;19:606-10. Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic

and catastrophizing are common in patients with OA,[25,26] and sleep problems were reported in 72% of adults older than 55 years with OA.[27] Other OA-related sequelae may include muscle weakness, instability, and poor balance leading to falls and other comorbid musculoskeletal conditions, given that musculoskeletal conditions frequently overlap (e.g., fibromyalgia).[28] B. Disease Course, Clinical Presentation, and Risk Factors for Osteoarthritis The age of OA onset, sequence, and distribution of joint (...) involvement and disease progression varies. Osteoarthritis is diagnosed at a median of 55 years of age, and patients may live approximately 30 years with the disease. Patients with OA may present to providers with minimal symptoms or have incidental findings on physical examination or radiologic testing. Patients with symptomatic OA typically present with joint pain, aching, stiffness, and limited walking ability.[29] Knee OA is usually bilateral but one knee may be affected more severely; hip OA

Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Current pharmacologic therapies for patients with osteoarthritis are suboptimal.To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion-synovitis in patients with symptomatic knee osteoarthritis and knee effusion-synovitis.Randomized, double-blind, placebo-controlled trial. (Australian New Zealand Clinical Trials (...) Registry: ACTRN12618000080224).Single-center study with patients from southern Tasmania, Australia.70 participants with symptomatic knee osteoarthritis and ultrasonography-defined effusion-synovitis.2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks.The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion-synovitis volume on magnetic resonance imaging (MRI). The key secondary outcomes were change in Western Ontario and McMaster Universities

In knee OA, physical therapy reduced pain and improved function more than glucocorticoid injections at 1 year. Deyle GD, Allen CS, Allison SC, et al. Physical therapy versus glucocorticoid injection for osteoarthritis of the knee. N Engl J Med. 2020;382:1420-9. 32268027.

), the visual analog scale (VAS), the EuroQol VAS, the International Knee Documentation Committee, the Tegner score, the Lequesne Scale, the Knee injury Osteoarthritis Outcome Score, satisfaction rate, and adverse events. Subgroup analyses was performed for patients with different doses, types, and times of PRP interventions and grades of OA. The Review Manager Database was used to analyze the included studies. Results: Twenty-six randomized controlled trials involving 2430 patients were included. The WOMAC (...) Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19

demonstrated that there were significant differences between Kinesio Taping groups and control groups in terms of visual analog scale (VAS), Western Ontario and MacMaster Universities Osteoarthritis Index (WOMAC) scale and flexion range of motion. Kinesio Taping is effective in improving pain and joint function in patients with knee OA. Keywords: Kinesio Taping; knee joint; osteoarthritis; systematic review. © 2020 Melese et al. Conflict of interest statement The authors report no conflicts of interest (...) /0269215520917747. Epub 2020 May 12. Clin Rehabil. 2020. PMID: 32397751 Nelson NL. Nelson NL. J Bodyw Mov Ther. 2016 Jul;20(3):672-81. doi: 10.1016/j.jbmt.2016.04.018. Epub 2016 Apr 27. J Bodyw Mov Ther. 2016. PMID: 27634093 Review. Show more similar articles References Ofluoglu D, Ofluoglu O. Assessment of disease activity and progression of osteoarthritis with using molecular markers of cartilage and synovium turnover. Curr Rheumatol Rev. 2005;1(1):29–32. doi:10.2174/1573397052954181 - Johnson VL, Hunter DJ

DH, et al. Number of persons with symptomatic knee osteoarthritis in the US: impact of race and ethnicity, age, sex, and obesity: symptomatic knee OA in the US. Arthritis Care Res. 2016;68(12):1743–1750. doi: 10.1002/acr.22897. - - - KS&R, Inc. Halyard-sponsored qualitative market research, OA Pain Landscape & Patient Journey. 2015. Brown GA. AAOS clinical practice guideline: treatment of osteoarthritis of the knee: evidence-based guideline, 2nd Edition. J Am Acad Orthop Surg. 2013;21(9):577–9 (...) PMCID: DOI: Item in Clipboard Full-text links Cite Abstract Background: Safe and effective non-surgical treatments are an important part of the knee osteoarthritis (OA) treatment algorithm. Cooled radiofrequency ablation (CRFA) and hyaluronic acid (HA) injections are two commonly used modalities to manage symptoms associated with knee OA. Methods: A prospective 1:1 randomized study was conducted in 177 patients comparing CRFA to HA injection with follow-ups at 1, 3, 6 and 12 months. HA subjects