-Citrome A. Postgrad Med. 2012 Jan; 124(1):83-93. 7. Chappell A, Ossanna M, Liu-Seifert H, et al. Pain. 2009 Dec; 146(3):253-60. 8. Bannuru RR, Osani MC, Vaysbrot EE, et al. Osteoarthritis Cartilage. 2019 Nov; 27(11):1578-1589. 9. Kolasinski S, Neogi T, Hochberg MC, et al. Arthritis Rheumatol. 2020 Feb; 72(2):220-233. 10. Lindblad AJ, McCormack J, Korownyk CS, et al. Can Fam Physician. 2020 Mar; 66(3):191-193. Available at: https://www.cfp.ca/content/66/3/191 Accessed 08- APR-2020. (...) Osteoarthritis pain getting you down? Duloxetine July 13, 2020 Osteoarthritis pain getting you down? Duloxetine Clinical Question: Do Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), specifically duloxetine, improve pain in patients with osteoarthritis? Bottom Line: Duloxetine can meaningfully reduce osteoarthritis pain scores (by at least 30%) for ~60% of patients compared to ~40% on placebo. An average pain of ~6 (scale 0-10) will be reduced by ~2.5 points, compared to 1.7 on placebo

Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Prescrire IN ENGLISH - Spotlight ''Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated?'', 1 July 2020 {1} {1} {1} | | > > > Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |  (...)  |   |   |   |   |   |   |   |  Spotlight Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Queries and Comments Prescrire concluded in 2016 that the harm-benefit balance of hyaluronic acid by intra-articular injection seemed unfavourable. Several readers have since expressed their profound disagreement, citing the effects noted in their daily practice. How can

Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Ann Fam Med Actions . 2020 May;18(3):235-242. doi: 10.1370/afm.2520. Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial , , , , , , , Affiliations Expand Affiliations 1 Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong reginasit@cuhk.edu.hk. 2 Jockey Club School of Public Health and Primary Care

Exercise-induced osteoarthritis: Running into problems? Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca June 15, 2020 (...) Exercise-induced osteoarthritis: Running into problems? Clinical Question: Does running increase the risk of developing osteoarthritis? Bottom Line: Based on low-quality observational data, running likely does not increase the risk of developing osteoarthritis, except possibly in elite athletes. Additionally, recreational running may be associated with lowering the risk of knee osteoarthritis. Exercise is one of the most effective treatments for reducing osteoarthritic pain. Evidence: • Systematic

The effectiveness of Kinesio Taping((R)) for mobility and functioning improvement in knee osteoarthritis: a randomized, double-blind, controlled trial The Effectiveness of Kinesio Taping ® for Mobility and Functioning Improvement in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 May 6;269215520916859. doi: 10.1177/0269215520916859. Online ahead of print. The Effectiveness of Kinesio Taping ® for Mobility and Functioning Improvement in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial , Affiliations Expand Affiliation 1 Department of Rehabilitation, Medical Academy

Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial. Individually calibrated biomechanical footwear therapy may improve pain and physical function in people with symptomatic knee osteoarthritis, but the benefits of this therapy are unclear.To assess the effect of a biomechanical footwear therapy vs control footwear over 24 weeks of follow-up.Randomized clinical trial conducted at a Swiss university hospital. Participants (N (...)  = 220) with symptomatic, radiologically confirmed knee osteoarthritis were recruited between April 20, 2015, and January 10, 2017. The last participant visit occurred on August 15, 2017.Participants were randomized to biomechanical footwear involving shoes with individually adjustable external convex pods attached to the outsole (n = 111) or to control footwear (n = 109) that had visible outsole pods that were not adjustable and did not create a convex walking surface.The primary outcome was knee

Inferior stabilization of cementless compared with cemented dual-mobility cups in elderly osteoarthrosis patients: a randomized controlled radiostereometry study on 60 patients with 2 years` follow-up Inferior Stabilization of Cementless Compared With Cemented Dual-Mobility Cups in Elderly Osteoarthrosis Patients: A Randomized Controlled Radiostereometry Study on 60 Patients With 2 Years' Follow-Up - PubMed This site needs JavaScript to work properly. Please enable it to take advantage (...) any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation Acta Orthop Actions . 2020 Feb 6;1-8. doi: 10.1080/17453674.2020.1720978. Online ahead of print. Inferior Stabilization of Cementless Compared With Cemented Dual-Mobility Cups in Elderly Osteoarthrosis Patients: A Randomized Controlled Radiostereometry Study on 60 Patients With 2 Years' Follow-Up , , , Affiliations Expand

weeks (three doses). Co-primary end points were change from baseline to week 24 in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Physical Function, and Patient's Global Assessment of OA (PGA-OA). Joint safety and neurological assessments continued throughout the 48-week study. Results: From March 2016 to December 2017, 849 patients were randomised and evaluated (placebo n=282, tanezumab 2.5 mg n=283, tanezumab 5 mg n=284). At week 24, there was a statistically (...) Full-text links Cite Abstract Objective: Tanezumab, a nerve growth factor inhibitor, was investigated for osteoarthritis (OA) of the hip or knee in a study with 24-week treatment and 24-week safety follow-up. Methods: This double-blind, randomised, phase III study enrolled adults in Europe and Japan with moderate-to-severe OA who had not responded to or could not tolerate standard-of-care analgesics. Patients were randomised to tanezumab 2.5 mg or 5 mg subcutaneously or matching placebo every 8

of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Paper presented at: Seminars in arthritis and rheumatism; 1990. doi:10.1099/00221287-136-2-327 - - Kon E, Filardo G, Drobnic M, et al. Non-surgical management of early knee osteoarthritis. Knee Surg Sports Traumatol Arthroscopy. 2012;20(3):436–449. doi:10.1007/s00167-011-1713-8 - - Raeissadat SA, Tabibian E, Rayegani SM, Rahimi-Dehgolan S, Babaei-Ghazani A. An inestigation into the efficacy of intra-articular ozone (O2-O3 (...) MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial) - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show

Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you

Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial. A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are lacking.To determine the effects of intravenous zoledronic acid on knee cartilage volume loss in patients with symptomatic knee (...) osteoarthritis and bone marrow lesions.A 24-month multicenter, double-blind placebo-controlled randomized clinical trial conducted at 4 sites in Australia (1 research center and 3 hospitals). Adults aged 50 years or older with symptomatic knee osteoarthritis and subchondral bone marrow lesions detected by magnetic resonance imaging (MRI) were enrolled from November 2013 through September 2015. The final date of follow-up was October 9, 2017.Intravenous infusion with either 5 mg of zoledronic acid in a 100-mL

Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee. Both physical therapy and intraarticular injections of glucocorticoids have been shown to confer clinical benefit with respect to osteoarthritis of the knee. Whether the short-term and long-term effectiveness for relieving pain and improving physical function differ between these two therapies is uncertain.We conducted a randomized trial to compare physical therapy with glucocorticoid injection in the primary care (...) setting in the U.S. Military Health System. Patients with osteoarthritis in one or both knees were randomly assigned in a 1:1 ratio to receive a glucocorticoid injection or to undergo physical therapy. The primary outcome was the total score on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 1 year (scores range from 0 to 240, with higher scores indicating worse pain, function, and stiffness). The secondary outcomes were the time needed to complete the Alternate Step Test

J, et al. Sports Med. 2019 May; 49(5):743-61. 6. Kolasinski SL, Neogi T, Hochberg MC, et al. Arthritis Rheumatol. 2020 Feb; 72(2):220-33. 7. McAlindon TE, Bannuru RR, Sullivan MC, et al. Osteoarthritis Cartilage. 2014 Mar; 22(3):363-88. 8. Juhl C, Christensen R, Roos EM, et al. Arthritis Rheumatol. 2014; 66(3):626-36. Tools for Practice is a biweekly article summarizing medical evidence with a focus on topical issues and practice modifying information. It is coordinated by G. Michael Allan, MD (...) Exercise for osteoarthritis pain: how strong is the evidence? Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca March

an evidence- based guideline for the comprehensive management of osteoarthritis (OA) as a collabora- tion between the American College of Rheumatology (ACR) and the Arthritis Foundation, updating the 2012 ACR recommenda- tions for the management of hand, hip, and knee OA. Methods. We identified clinically relevant population, intervention, comparator, outcomes questions and critical outcomes in OA. A Literature Review T eam performed a systematic literature review to summarize evidence supporting (...) , technology, and practice. ACR recommendations are not intended to dictate payment or insurance decisions. These recommendations cannot adequately convey all uncertainties and nuances of patient care. The American College of Rheumatology is an independent, professional, medical and scientific society that does not guarantee, warrant, or endorse any commercial product or service.KOLASINSKI ET AL 2 ???| INTRODUCTION Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 302 million

Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized Controlled Trial. MIV-711 is a novel selective cathepsin K inhibitor with beneficial effects on bone and cartilage in preclinical osteoarthritis models.To evaluate the efficacy, safety, and tolerability of MIV-711 in participants with symptomatic, radiographic knee osteoarthritis.26-week randomized, double-blind, placebo-controlled phase 2a study with a 26-week open-label safety extension substudy (...) . This treatment may merit further evaluation as a disease-modifying osteoarthritis drug.Medivir.

PMCID: DOI: Item in Clipboard Technology-assisted Rehabilitation Following Total Knee or Hip Replacement for People With Osteoarthritis: A Systematic Review and Meta-Analysis Xia Wang et al. BMC Musculoskelet Disord . 2019 Show details BMC Musculoskelet Disord Actions , 20 (1), 506 Authors , , , , Affiliations 1 Level 10 Kolling Institute, Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Reserve Road, St. Leonards, Sydney, NSW, 2065, Australia. xia.wang (...) … Show more similar articles References Disease GBD, Injury I, Prevalence C. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the global burden of disease study 2015. Lancet. 2016;388(10053):1545–1602. doi: 10.1016/S0140-6736(16)31678-6. - - - Australian Orthopaedic Association National Joint Replacement Registry . Analysis of state and territory health data all arthroplasty, annual report

Partial knee replacement could be first choice for some patients with osteoarthritis. The studyBeard D, Davies L, Cook J, et al. The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial. Lancet 2019;394:746-56.The study was funded by the NIHR Health Technology Assessment Programme (project number 08/14/08).To read the full NIHR Signal, go to https

Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study. To compare the clinical effectiveness of the triple intra-articular injection of platelet-rich plasma (PRP) with respect to the single injection in patients with mild osteoarthritis of the knee.A total of 35 patients with a clinical and radiographic diagnosis of osteoarthritis grade I and II were analyzed. They were randomized into two groups: single application (18 (...) ±7.3; p lt 0.05) at the end of the study. The triple application showed better improvement in the VAS (p= 0.0007) and the total WOMAC (p= 0.0209) scores when comparing the final results between groups.The triple infiltration of PRP in patients with mild knee osteoarthritis is clinically more effective than the single application at 48 weeks of follow-up.

Temporomandibular Joints with Larger-Than-Average Horizontal Condylar Angles May Be Indicative of Internal Derangement and Degenerative Joint Disease UTCAT3418, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Temporomandibular Joints with Larger-Than-Average Horizontal Condylar Angles May Be Indicative of Internal Derangement and Degenerative Joint Disease Clinical Question Are temporomandibular joints with a greater (...) -than-average horizontal condylar angle, as measured by cone-beam computed tomography, at greater risk for joint disease in the long term? Clinical Bottom Line A greater-than-average horizontal condylar angle (HCA) is associated with degenerative joint changes. This is supported by a retrospective study of patients with unilateral osteoarthritic joint changes. Two small studies show that a 3D reconstructed model based on CBCT is a more accurate method of measuring the HCA than 2D CBCT images. Best

Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial. Hand osteoarthritis is a prevalent joint condition that has a high burden of disease and an unmet medical need for effective therapeutic options. Since local inflammation is recognised as contributing to osteoarthritic complaints, the Hand Osteoarthritis Prednisolone Efficacy (HOPE) study aimed to investigate the efficacy and safety of short (...) discontinued the study because of an adverse event: one (2%) patient receiving prednisolone (for a myocardial infarction) and three (7%) patients receiving placebo (for surgery of the bowel and for an infected leg haematoma and for Lyme disease arthritis of the knee).Treatment with 10 mg prednisolone for 6 weeks is efficacious and safe for the treatment of patients with painful hand osteoarthritis and signs of inflammation. The results of our study provide clinicians with a new short-term treatment option