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Latest & greatest articles for osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on osteoarthritis or other clinical topics then use Trip today.
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Unloading Shoes for Self-Management of Knee Osteoarthritis: A Randomized Trial. Appropriate footwear is recommended for self-management of knee osteoarthritis. Shoes that reduce harmful knee loads are available, but symptomatic effects are uncertain.To evaluate the efficacy of unloading shoes in alleviating knee osteoarthritis symptoms.Participant- and assessor-blinded comparative effectiveness randomized, controlled trial. (Australian New Zealand Clinical Trials Registry: ACTRN12613000851763 (...) ).Community.164 persons with medial knee osteoarthritis.Walking shoes with triple-density, variable-stiffness midsoles and mild lateral-wedge insoles designed to unload the medial knee and worn daily (intervention) versus conventional walking shoes (comparator).Primary outcomes were pain with walking (assessed on a numerical rating scale [NRS]) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]) at 6 months. Secondary outcomes were knee pain and stiffness (WOMAC
Exploring Fatigue Trajectories in Early Symptomatic Knee and Hip Osteoarthritis: 6-year Results from the CHECK Study To examine whether different groups of fatigue trajectories can be identified among patients with early symptomatic osteoarthritis (OA) of the knee or hip, to describe the level of fatigue severity within each of these fatigue groups, and to investigate the involvement of age, sex, use of medication, comorbidity, and OA severity in relation to group membership.Six years (...) in comparison with each other and in comparison with the low fatigue group. Comorbidity, medication use, and sex were significantly associated with the identified trajectories. Women, individuals with a comorbid disease, and those who used medication were more likely to follow a high fatigue trajectory.These findings suggest heterogeneous development of fatigue in the early OA population associated with varying patient characteristics. Further, this study shows that a considerable number of patients with OA
compared with ibuprofen on the severity of disease in patients with knee OA. This study was designed as a randomized, double blind, active-controlled and parallel group trial. Patients with OA were randomized to receive 300 mg/day (n=33) or 600 mg/day (n=32) of EA aqueous extract, or 800 mg/day ibuprofen (n=32) for 7 weeks. EA extract contained 0.21 % (w/w) kaempferol according to HPLC. Efficacy of treatment was assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC (...) Efficacy of Elaeagnus Angustifolia extract in the treatment of knee osteoarthritis: a randomized controlled trial. Osteoarthritis (OA) is one of the most common musculoskeletal disorders all over the world. Available anti-arthritic medications have only partial efficacy and their long-term use is associated with adverse events. Elaeagnus Angustifolia (EA) is a medicinal plant with analgesic and anti-inflammatory properties. The present study evaluated the impact of two doses of EA extract
Physical Therapist-Delivered Pain Coping Skills Training and Exercise for Knee Osteoarthritis: Randomized Controlled Trial To investigate whether a 12-week physical therapist-delivered combined pain coping skills training (PCST) and exercise (PCST/exercise) is more efficacious and cost effective than either treatment alone for knee osteoarthritis (OA).This was an assessor-blinded, 3-arm randomized controlled trial in 222 people (73 PCST/exercise, 75 exercise, and 74 PCST) ages ≥50 years (...) with knee OA. All participants received 10 treatments over 12 weeks plus a home program. PCST covered pain education and training in cognitive and behavioral pain coping skills, exercise comprised strengthening exercises, and PCST/exercise integrated both. Primary outcomes were self-reported average knee pain (visual analog scale, range 0-100 mm) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index, range 0-68) at week 12. Secondary outcomes included other pain measures
Additional mesenchymal stem cell injection improves the outcomes of marrow stimulation combined with supramalleolar osteotomy in varus ankle osteoarthritis: short-term clinical results with second-look arthroscopic evaluation Supramalleolar osteotomy (SMO) is reported to be an effective treatment for varus ankle osteoarthritis by redistributing the load line within the ankle joint. Mesenchymal stem cells (MSCs) have been proposed as a new treatment option for osteoarthritis on the basis (...) of their cartilage regeneration ability. The purpose of this study was to compare the clinical, radiological, and second-look arthroscopic outcomes between MSC injection with marrow stimulation and marrow stimulation alone in patients with varus ankle osteoarthritis who have undergone SMO.In this retrospective study, 62 patients (64 ankles) with varus ankle osteoarthritis underwent second-look arthroscopy at a mean of 12.8 months after arthroscopic marrow stimulation combined with SMO; 33 ankles were subjected
Comparative Effectiveness of Tai Chi Versus Physical Therapy for Knee Osteoarthritis: A Randomized Trial. Few remedies effectively treat long-term pain and disability from knee osteoarthritis. Studies suggest that Tai Chi alleviates symptoms, but no trials have directly compared Tai Chi with standard therapies for osteoarthritis.To compare Tai Chi with standard physical therapy for patients with knee osteoarthritis.Randomized, 52-week, single-blind comparative effectiveness trial (...) . (ClinicalTrials.gov: NCT01258985).An urban tertiary care academic hospital.204 participants with symptomatic knee osteoarthritis (mean age, 60 years; 70% women; 53% white).Tai Chi (2 times per week for 12 weeks) or standard physical therapy (2 times per week for 6 weeks, followed by 6 weeks of monitored home exercise).The primary outcome was Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at 12 weeks. Secondary outcomes included physical function, depression, medication use
Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study To evaluate the effectiveness of spironolactone as a treatment for osteoarthritis (OA)-related knee effusion in comparison to ibuprofen, cold compresses, and placebo.This study was carried out on 200 patients, aged 40 years or older, attending the outpatient clinic of the Rheumatology Department of Sohag University Hospital with unilateral knee effusion related to OA (...) , 10% partial improvement, and 84% no response.Low-dose spironolactone is a safe and effective medical treatment for OA-related knee effusion.
Cost-Utility and Cost-Effectiveness Analyses of Face-to-Face Versus Telephone-Based Nonpharmacologic Multidisciplinary Treatments for Patients With Generalized Osteoarthritis To evaluate, from a societal perspective, the cost utility and cost effectiveness of a nonpharmacologic face-to-face treatment program compared with a telephone-based treatment program for patients with generalized osteoarthritis (GOA).An economic evaluation was carried out alongside a randomized clinical trial involving
Therapy, Gachon University College of Health Science, Incheon, South Korea Department of Physiology, Korea University College of Medicine, Seoul, South Korea. Yoon Young Wook YW eng Letter Comment United States Am J Phys Med Rehabil 8803677 0894-9115 AIM IM Am J Phys Med Rehabil. 2015 Mar;94(3):192-200 25706053 Am J Phys Med Rehabil. 2016 Jan;95(1):e7 26390398 Athletic Tape Female Humans Knee Joint physiopathology Male Osteoarthritis, Knee therapy Proprioception Range of Motion, Articular 2015 10 27 6 (...) Re: "Kinesio Taping Improves Pain, Range of Motion, and Proprioception in Older Patients with Knee Osteoarthritis: A Randomized Controlled Trial". 26495811 2016 04 11 2018 12 02 1537-7385 95 1 2016 Jan American journal of physical medicine & rehabilitation Am J Phys Med Rehabil Re: "Kinesio Taping Improves Pain, Range of Motion, and Proprioception in Older Patients with Knee Osteoarthritis: A Randomized Controlled Trial". e7-8 10.1097/PHM.0000000000000394 Cho Hwi-Young HY Department of Physical
Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2016 Authors' conclusions Osteoarthritis is the most common type of arthritis in the UK and leads to painful and stiff joints. Osteoarthritis can affect any joint, but commonly affects knee joints. Daily routine activities can become difficult for patients with osteoarthritis of the knee. There is no cure for osteoarthritis of the knee but there are treatments which help to reduce the pain. In cases where treatment does not work (...) , knee surgery may be offered. Ampion is a new drug for the treatment of osteoarthritis of the knee given as an injection into the affected joint. Some studies have suggested that Ampion may help in reducing knee pain in patients who have osteoarthritis of the knee. If Ampion is licensed for use in the UK, it could be a new treatment option for patients with osteoarthritis of the knee which may improve patient quality of life better than existing treatments. Final publication URL Indexing Status
Feasibility of a Randomized Controlled Trial of Self-Administered Acupressure for Symptom Management in Older Adults with Knee Osteoarthritis. To assess the feasibility of a study to evaluate the efficacy of self-administered acupressure in pain and related symptom management for older people with symptomatic knee osteoarthritis. Feasibility with regard to (1) sample recruitment and retention, (2) treatment fidelity and adherence, and (3) tolerability and adverse events was examined.The study (...) from performing the acupressure. Thirty adverse events were reported; most were related to pre-existing health conditions.It is feasible to conduct a study of self-administered acupressure for symptom management in community-living older adults with knee osteoarthritis, although sample recruitment may be challenging.
Hallux valgus, ankle osteoarthrosis and adult acquired flatfoot deformity: a review of three common foot and ankle pathologies and their treatments The pathogenesis of hallux valgus deformity is multifactorial. Conservative treatment can alleviate pain but is unable to correct the deformity. Surgical treatment must be adapted to the type and severity of the deformity. Success of surgical treatment ranges from 80% to 95%, and complication rates range from 10% to 30%.Ankle osteoarthrosis most (...) commonly occurs as a consequence of trauma. Ankle arthrodesis and total ankle replacement are the most common surgical treatments of end stage ankle osteoarthrosis. Both types of surgery result in similar clinical improvement at midterm; however, gait analysis has demonstrated the superiority of total ankle replacement over arthrodesis. More recently, conservative surgery (extraarticular alignment osteotomies) around the ankle has gained popularity in treating early- to mid-stage ankle
Patient-reported quality indicators for osteoarthritis: a patient and public generated self-report measure for primary care People with osteoarthritis desire high quality care, support and information. However, the quality of care for people with OA in general practice is not routinely collected. Quality Indicators can be used to benefit patients by measuring whether minimum standards of quality care are being met from a patient perspective. The aim of this study was to describe how a Research (...) User Group (RUG) worked alongside researchers to co-produce a set of self-reported quality indicators for people with osteoarthritis when visiting their general practitioner or practice nurse (primary care). These were required in the MOSAICS study, which developed and evaluated a new model of supported self-management of OA to implement the NICE quality standards for OA. This article describes the public involvement in the MOSAICS study. This was 1) the co-development by RUG members
Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial. Observational studies suggest that vitamin D supplementation is associated with benefits for knee osteoarthritis, but current trial evidence is contradictory.To compare the effects of vitamin D supplementation vs placebo on knee pain and knee cartilage volume in patients with symptomatic knee osteoarthritis and low vitamin D levels.A (...) multicenter randomized, double-blind, placebo-controlled clinical trial in Tasmania and Victoria, Australia. Participants with symptomatic knee osteoarthritis and low 25-hydroxyvitamin D (12.5-60 nmol/L) were enrolled from June 2010 to December 2011. The trial was completed in December 2013.Participants were randomly assigned to receive monthly treatment with oral vitamin D3 (50,000 IU; n = 209) or an identical placebo (n = 204) for 2 years.Primary outcomes were change in tibial cartilage volume (assessed
function was evaluated in patients with osteoarthritis (OA).Using a randomized study design, 48 sedentary middle-aged and older adults with OA underwent 3 months of either swimming or cycling exercise training. Supervised exercise training was performed for 45 min/day, 3 days/week at 60-70% heart rate reserve for 12 weeks. The Western Ontario and McMaster Universities Arthritis Index was used to measure joint pain, stiffness, and physical limitation.After the exercise interventions, there were (...) Improved Function and Reduced Pain after Swimming and Cycling Training in Patients with OsteoarthritisArthritis and its associated joint pain act as significant barriers for adults attempting to perform land-based physical activity. Swimming can be an ideal form of exercise for patients with arthritis. Yet there is no information on the efficacy of regular swimming exercise involving patients with arthritis. The effect of a swimming exercise intervention on joint pain, stiffness, and physical
Joint sparing treatments in early ankle osteoarthritis: current procedures and future perspectives Ankle osteoarthritis (AOA) is a severe pathology, mostly affecting a post-traumatic young population. Arthroscopic debridement, arthrodiastasis, osteotomy are the current joint sparing procedures, but, in the available studies, controversial results were achieved, with better outcomes in case of limited degeneration. Only osteotomy in case of malalignment is universally accepted as a joint sparing (...) procedure in case of partial AOA. Recently, the biological mechanism of osteoarthritis has been intensively studied: it is a whole joint pathology, affecting cartilage, bone and synovial membrane. In particular, the first stage is characterized by a reversible catabolic activity with a state of chondropenia. Thus, biological procedures for early AOA were proposed in order to delay or to avoid end stage procedures. Mesenchymal stem cells (MSCs) may be a good solution to prevent or reverse degeneration
The Incremental Effects of Manual Therapy or Booster Sessions in Addition to Exercise Therapy for Knee Osteoarthritis: A Randomized Clinical Trial A factorial randomized controlled trial.To investigate the addition of manual therapy to exercise therapy for the reduction of pain and increase of physical function in people with knee osteoarthritis (OA), and whether "booster sessions" compared to consecutive sessions may improve outcomes.The benefits of providing manual therapy in addition (...) to exercise therapy, or of distributing treatment sessions over time using periodic booster sessions, in people with knee OA are not well established.All participants had knee OA and were provided 12 sessions of multimodal exercise therapy supervised by a physical therapist. Participants were randomly allocated to 1 of 4 groups: exercise therapy in consecutive sessions, exercise therapy distributed over a year using booster sessions, exercise therapy plus manual therapy without booster sessions
is limited by adverse effects such as increased cardiovascular events, gastrointestinal (GI) perforation, ulceration, and bleeding, and renal impairment. The risks of these complications increase with age, drug-drug and drug-disease interactions, and probably duration of use. These risks are especially important concerning the typically older population affected by osteoarthritis (OA) who often have comorbidities and take multiple medications. Alternative therapies to reduce these risks are limited. All (...) and Quality (AHRQ); 2016 Jun. [cited YYYY Mon DD]. Available: http://www.guideline.gov. A direct comparison of recommendations presented in the above guidelines for nonsurgical management of osteoarthritis (OA) of the knee is provided. The AAOS guideline provides recommendations for surgical interventions that are less invasive than knee replacement, which are beyond the scope of this synthesis. The VA/DoD guideline addresses OA of the hip, which is also beyond the scope of this synthesis (recommendations
Media Releases 2013 Media Releases 2012 Media Releases Search Knee taping for osteoarthritis Knee taping for osteoarthritis Introduction Knee osteoarthritis is the most common cause of knee pain in people older than 50. Intervention Application of strong, adhesive tape or strapping aiming to unload painful soft tissues. Indication Chronic pain related to knee osteoarthritis (OA). Malalignment of the patella, with abnormal distribution of force on the lateral facet, is thought to contribute to pain (...) in knee osteoarthritis. Taping increases patellofemoral contact area, decreasing joint stress and thereby reducing pain. Taping is a very effective pain-relieving strategy and can assist participation in other strongly recommended therapies for knee osteoarthritis, such as cardiovascular and resistance land-based and aquatic exercises. Precautions A physiotherapist experienced in assessment and taping techniques should show the patient how to apply the tape: Precise placement of tape is needed