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Latest & greatest articles for osteoarthritis
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version of this Decision Box by . Osteoarthritis (OA) is condition where joint tissue breaks down causing joint pain , stiffness and swelling . It is most common in the knee, hip and hand and it worsens over time. There is no cure for progressive joint damage caused by OA but its symptoms can be managed and quality of life improved. Individuals with clinical symptoms or a diagnosis of OA. When choosing treatment, one should consider treatment costs, the severity of symptoms and an individual’s risk (...) for potentially adverse events. The following treatment options are presented from least to most invasive: Less invasive More invasive Medially wedged insoles Muscle strengthening, aerobic exercises and weight loss for overweight individuals Glucosamine Acetaminophen Acupuncture Oral or topical NSAID therapy Opioid therapy Corticosteroid injection (knee OA) Referral for joint replacement surgery There are pros and cons to each option: PROS : Depending on the option, more or less people have a chance
Summary According to the Centers for Disease Control and Prevention (CDC), 13.9 percent of adults age 25 years and older and 33.6 percent of adults age 65 years and older are affected by osteoarthritis (OA). Arthritis appears to be a significant burden among Veterans of the United States (US) Armed Forces.  Research suggests that military service-related overuse and injuries may be a contributing factor for the increased risk of developing OA. One study examined the incidence of OA among active (...) • Comparative effectiveness of non-pharmacologic therapies • Comparative effectiveness of complementary and alternative medicine • Referrals for surgical consultation OA is typically diagnosed based on the patient’s medical history and a physical examination. Patients with OA may have morning joint stiffness that usually resolves within 30 minutes. As the disease progresses, prolonged joint stiffness and joint enlargement may also become evident. Although radiographs are not required to make a diagnosis
Publication. 2014 Authors' objectives Physical therapy may be beneficial both before and after joint replacement surgery in patients with severe osteoarthritis (OA). In general, the goal of physical therapy in patients with OA is to increase function and physical activity despite pain and stiffness. Perioperative goals include faster recovery time, shorter hospital length of stay (LOS), and increased range of motion (ROM) and function. Final publication URL The report may be purchased from: Indexing (...) Status Subject indexing assigned by CRD MeSH Activities of Daily Living; Adults; Arthroplasty, Replacement, Knee; Exercise Therapy; Knee Joint; Osteoarthritis, Knee; Pain; Physical Therapy Modalities; Preoperative Care; Range of Motion, Articular; Recovery of Function; Treatment Outcome Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446
Obesity management interventions delivered in primary care for patients with osteoarthritis: a review of clinical effectiveness Obesity management interventions delivered in primary care for patients with osteoarthritis: a review of clinical effectiveness Obesity management interventions delivered in primary care for patients with osteoarthritis: a review of clinical effectiveness CADTH Record Status This is a bibliographic record of a published health technology assessment from a member (...) of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Obesity management interventions delivered in primary care for patients with osteoarthritis: a review of clinical effectiveness. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response. 2014 Authors' conclusions Dietary weight loss interventions, either alone or in combination with exercise produced greater reductions in the peak knee compressive force and plasma
' (NICE clinical guideline 59). The recommendations are labelled according to when they were originally published (see Update information for details). Osteoarthritis refers to a clinical syndrome of joint pain accompanied by varying degrees of functional limitation and reduced quality of life. It is the most common form of arthritis, and one of the leading causes of pain and disability worldwide. The most commonly affected peripheral joints are the knees, hips and small hand joints. Pain, reduced (...) morning joint-related stiffness, rapid worsening of symptoms or the presence of a hot swollen joint, may indicate alternative or additional diagnoses. Important differential diagnoses include gout, other inflammatory arthritides (for example, rheumatoid arthritis), septic arthritis and malignancy (bone pain). [new 2014] [new 2014] 1.2 Holistic approach to osteoarthritis assessment and management 1.2.1 Assess the effect of osteoarthritis on the person's function, quality of life, occupation, mood
nursing Systematic review Review: exercise interventions improve pain and function in people with knee osteoarthritis compared with no exercise Kim Bennell 1 , Fiona Dobson 2 Statistics from Altmetric.com Commentary on: Uthman OA , van der Windt DA , Jordan JL , et al . Exercise for lower limb osteoarthritis: systematic review incorporating trial sequential analysis and network meta-analysis . Implications for practice and research Conclusive evidence has established the overall benefits of exercise (...) in patients with lower limb osteoarthritis (OA). Although there are no distinct differences in the benefit estimates of different types of exercises, those designed to improve strength, flexibility and aerobic capacity seem to provide the most benefit to patients with lower limb OA. Context Therapeutic exercise is an integral component of conservative OA management and is universally recommended by current clinical guidelines. 1–3 However, when it comes to choosing which types of exercises are best
Homeopathic remedies in the treatment of migraine and osteoarthritis File Name: AS Homeopathy Version: 1.0 Date: 19 August 2014 Produced by: Secretariat Page: 1 Review date: n/a Advice Statement 003/14 August 2014 Are homeopathic remedies clinically and cost effective in the treatment of migraine and osteoarthritis? This advice has been produced following completion of evidence note 53 by Healthcare Improvement Scotland, in response to an enquiry from the NHS Highland Clinical Advisory Group (...) of four active treatment controlled randomised trials of homeopathy for osteoarthritis published between 1983 and 2000. The quality of the evidence was low to moderate. ? Homeopathy for migraine has not been compared with active treatment in randomised controlled trials (RCTs). Of four RCTs comparing homeopathy with placebo, only one found homeopathy to be superior. ? Three RCTs in osteoarthritis comparing homeopathy with medicines for pain relief found either no difference between the interventions
: A meta-analysis of randomized controlled trials. World J Meta-Anal 2014; 2(3): 78-90 URL: DOI: INTRODUCTION Knee osteoarthritis (OA) is a highly prevalent chronic condition and a leading cause of lower extremity disability in community-dwelling older adults in North America [ ] . To date, no treatment exists which modifies the disease and, despite symptom management, pain and functional limitations may progress to the point where total joint replacement is required [ ] . As the population ages (...) ≥ 6 mo; 8 knee joint replacement; 51 bilateral OA Age approximately 55 (7.5) yr; 54 F; Newly diagnosed; 31 mild OA, 36 moderate OA Age approximately 60 (3) yr; 56 F; Disease duration 6.5 yr; 48 mild OA, 34 moderate OA Age 58.3 yr; 72 F; Disease duration 2.8 yr Age approximately 61.8 (10) yr; 21 F; 8 had mild OA, 19 had moderate OA; 24 bilateral OA Age approximately 60.5 (9.5) yr; 34 F; disease duration 8.9(8.7) yr; 17 mild OA, 23 moderate OA; all bilateral OA Ultrasound device Chattanooga
' duration in patients with knee osteoarthritis (OA). Methods : We collected data on randomized controlled trials (RCTs) comparing the effects of exercise intervention with those of either nonintervention or psychoeducational intervention in patients with knee OA. Data were collected on pain, stiffness, muscle strength, range of motion, flexibility, maximal oxygen uptake, proprioception, time to climb a flight of stairs, disability as assessed by the Western Ontario and McMaster Universities Arthritis (...) Effect of Therapeutic Exercises beyond 150 Days from the Onset of Treatment for Osteoarthritis of the Knee : A Systematic Review 変形性膝関節症罹患者に対する運動療法は治療開始150日を超えても有効か？—システマティックレビュー— Toggle navigation The Japanese Journal of Rehabilitation Medicine Online ISSN : 1881-8560 Print ISSN : 1881-3526 ISSN-L : 1881-3526 / / / 書誌 総説 変形性膝関節症罹患者に対する運動療法は治療開始150日を超えても有効か？—システマティックレビュー— , , , , 著者情報 田中 亮 広島国際大学総合リハビリテーション学部リハビリテーション学科 小澤 淳也 広島国際大学総合リハビリテーション学部リハビリテーション学科 木藤 伸宏 広島国際大学総合リハビリテーション学部リハビリテーション学科 森
, and reproduction in any medium, provided the original author and source are credited. Keywords: IDEA-033; Osteoarthritis; Placebo response; Sequessome; TDT 064; Transfersome Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for osteoarthritis (OA)-associated pain, but these agents are not without limitations. Oral NSAIDs carry a risk of significant, age-related, systemic adverse effects on the cardiovascular, renal, hepatic, and gastrointestinal systems [1-3]. Furthermore (...) trials in knee osteoarthritis (OA). A pronounced treatment effect was reported for TDT 064, with an effect size (ES) comparable with celecoxib in one trial. Our meta-analysis determined whether these TDT 064 effects are beyond any expected placebo effect. Methods: Five randomized, placebo-controlled studies of IDEA-033 in knee OA using TDT 064 as a control were included. Change from baseline in Western Ontario and McMaster Universities (WOMAC) OA Index pain and function subscale scores from each
Effect of physical therapy on pain and function in patients with hip osteoarthritis: a randomized clinical trial. There is limited evidence supporting use of physical therapy for hip osteoarthritis.To determine efficacy of physical therapy on pain and physical function in patients with hip osteoarthritis.Randomized, placebo-controlled, participant- and assessor-blinded trial involving 102 community volunteers with hip pain levels of 40 or higher on a visual analog scale of 100 mm (range, 0-100 (...) mm; 100 indicates worst pain possible) and hip osteoarthritis confirmed by radiograph. Forty-nine patients in the active group and 53 in the sham group underwent 12 weeks of intervention and 24 weeks of follow-up (May 2010-February 2013) INTERVENTIONS: Participants attended 10 treatment sessions over 12 weeks. Active treatment included education and advice, manual therapy, home exercise, and gait aid if appropriate. Sham treatment included inactive ultrasound and inert gel. For 24 weeks after
No Difference Between Intra-Articular Injection of Hyaluronic Acid and Placebo for Mild to Moderate Knee Osteoarthritis: A Randomized, Controlled, Double-Blind Trial The main goal of our study was to examine the effectiveness and safety of Fermathron plus, a specific brand of hyaluronic acid (HA), in patients with mild to moderate knee osteoarthritis. In a randomized, controlled, double-blind trial, 196 patients with symptomatic knee osteoarthritis (mean age ± SD, 59.4 ± 9.9 years, Kellgren
The relation between total joint arthroplasty and risk for serious cardiovascular events in patients with moderate-severe osteoarthritis: propensity score matched landmark analysis. To examine whether total joint arthroplasty of the hip and knee reduces the risk for serious cardiovascular events in patients with moderate-severe osteoarthritis.Propensity score matched landmark analysis.Ontario, Canada.2200 adults with hip or knee osteoarthritis aged 55 or more at recruitment (1996-98 (...) ) and followed prospectively until death or 2011.Rates of serious cardiovascular events for those who received a primary total joint arthroplasty compared with those did not within an exposure period of three years after baseline assessment.The propensity score matched cohort consisted of 153 matched pairs of participants with moderate-severe arthritis. Over a median follow-up period of seven years after the landmark date (start of the study), matched participants who underwent a total joint arthroplasty
of as a disease of “wear and tear” on the joints. Is running a risk factor for developing osteoarthritis? If so, is the damage worse for marathon runners? Maybe we should be advising our patients to stick to water aerobics. Approximately OA is a degenerativejointdisease characterized by articular cartilage failure, although all structures of the joint are involved in the pathologic process. Risks for developing osteoarthritis include systemic factors (age, female gender, genetic susceptibility), intrinsic (...) to the individual or their joints. The T1rho technique was previously validated in patients with OA, and the T2 relaxation time measurements has also been found to be a reliable means of detecting early degenerative changes of the cartilage. However, whether changes in T1rho and T2 after running lead to joint degeneration over time is not known. In addition, it is not clear Another interesting article assessing OA with advanced MRI techniques showed In this study, 45 subjects who underwent a partial medial
with hip or knee osteoarthritis (OA) pain.Patients (N=604) with moderate to severe knee or hip OA tolerating stable DSR were randomised and treated with DSR 75 mg twice daily combined with intravenous tanezumab 10, 5 or 2.5 mg or placebo at weeks 0, 8 and 16. Co-primary efficacy endpoints (Western Ontario and McMaster Universities OA Index (WOMAC) Pain and Physical Function subscales and patient's global assessment of OA) were assessed at week 16.All co-primary endpoints were significantly improved (...) Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial Tanezumab, a monoclonal antibody, inhibits nerve growth factor and reduces chronic pain. This randomised, double-blind, controlled multicentre study was conducted to evaluate the efficacy and safety of tanezumab added to oral diclofenac sustained release (DSR) in patients