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Latest & greatest articles for osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on osteoarthritis or other clinical topics then use Trip today.
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90-day mortality after 409,096 total hip replacements for osteoarthritis, from the National Joint Registry for England and Wales: a retrospective analysis. Death within 90 days after total hip replacement is rare but might be avoidable dependent on patient and treatment factors. We assessed whether a secular decrease in death caused by hip replacement has occurred in England and Wales and whether modifiable perioperative factors exist that could reduce deaths.We took data about hip replacements (...) done in England and Wales between April, 2003, and December, 2011, from the National Joint Registry for England and Wales. Patient identifiers were used to link these data to the national mortality database and the Hospital Episode Statistics database to obtain details of death, sociodemographics, and comorbidity. We assessed mortality within 90 days of operation by Kaplan-Meier analysis and assessed the role of patient and treatment factors by Cox proportional hazards model.409,096 primary hip
Efficacy, safety, and tolerability of fulranumab, an anti-nerve growth factor antibody, in the treatment of patients with moderate to severe osteoarthritis pain Nerve growth factor (NGF) is increased in chronic pain conditions. This study examined analgesic efficacy and safety of fulranumab, a fully human monoclonal anti-NGF antibody, in adults with chronic osteoarthritis pain. Patients (n=466, intent-to-treat) were randomized to receive, in addition to their current pain therapy, subcutaneous (...) on the Western Ontario and McMaster Universities Osteoarthritis Index subscales of pain, stiffness, and physical function (P < 0.040) across all fulranumab groups except 1mgQ4wk, on the Brief Pain Inventory-Short Form subscales of pain intensity (P < or = 0.016) and pain interference (P < or = 0.030) in the 3mgQ4wk and 10mgQ8wk groups, and on the Patient Global Assessment score (P < or = 0.040) in the 3mgQ4wk, 6mgQ8wk, and 10mgQ8wk groups. The most common (> or = 5% of patients) treatment-emergent adverse
Metacarpophalangeal and proximal interphalangeal joint arthroplasty in patients with severe arthritis or osteoarthritis Metacarpophalangeal and proximal interphalangeal joint arthroplasty in patients with severe arthritis or osteoarthritis Metacarpophalangeal and proximal interphalangeal joint arthroplasty in patients with severe arthritis or osteoarthritis Nilsson A, Bergh C, Hjalmarsson Y, Ibsen-Sörensen A, Sollerman C, Wikberg U, Samuelsson O Record Status This is a bibliographic record (...) of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Nilsson A, Bergh C, Hjalmarsson Y, Ibsen-Sörensen A, Sollerman C, Wikberg U, Samuelsson O. Metacarpophalangeal and proximal interphalangeal joint arthroplasty in patients with severe arthritis or osteoarthritis . Gothenburg: The Regional Health Technology Assessment Centre (HTA-centrum). HTA-rapport 2013:63. 2013 Authors' conclusions The main indication for prosthetic
Topical herbal therapies for treating osteoarthritis. Before extraction and synthetic chemistry were invented, musculoskeletal complaints were treated with preparations from medicinal plants. They were either administered orally or topically. In contrast to the oral medicinal plant products, topicals act in part as counterirritants or are toxic when given orally.To update the previous Cochrane review of herbal therapy for osteoarthritis from 2000 by evaluating the evidence on effectiveness (...) for topical medicinal plant products.Databases for mainstream and complementary medicine were searched using terms to include all forms of arthritis combined with medicinal plant products. We searched electronic databases (Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, AMED, CINAHL, ISI Web of Science, World Health Organization Clinical Trials Registry Platform) to February 2013, unrestricted by language. We also searched the reference lists from retrieved trials.Randomised
Meniscectomy in Patients with Knee Osteoarthritis and a Meniscal Tear? 23506467 2013 05 21 2018 12 02 1533-4406 368 18 2013 May 02 The New England journal of medicine N. Engl. J. Med. Meniscectomy in patients with knee osteoarthritis and a meniscal tear? 1740-1 10.1056/NEJMe1302696 Buchbinder Rachelle R eng Editorial Comment 2013 03 18 United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2013 May 2;368(18):1675-84 23506518 Female Humans Male Osteoarthritis, Knee surgery therapy
of motion values (P=0.300).Joint traction was found to be beneficial for the improvement of pain and physical function loss related to knee osteoarthritis. (...) A randomized controlled trial on the efficacy of intermittent and continuous traction for patients with knee osteoarthritis To investigate the efficacy of intermittent and continuous traction in the treatment of knee osteoarthritis.A randomized, controlled, observer-blind seven-week trial.Hospital-based outpatient practice.Ninety-eight patients with stage 3 knee osteoarthritis according to Kellgren-Lawrence radiological rating scale.All 98 patients were randomly assigned to three treatment
Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial Strontium ranelate is currently used for osteoporosis. The international, double-blind, randomised, placebo-controlled Strontium ranelate Efficacy in Knee OsteoarthrItis triAl evaluated its effect on radiological progression of knee osteoarthritis.Patients with knee osteoarthritis (Kellgren and Lawrence grade 2 or 3, and joint space width (JSW) 2.5-5 (...) mm) were randomly allocated to strontium ranelate 1 g/day (n=558), 2 g/day (n=566) or placebo (n=559). The primary endpoint was radiographical change in JSW (medial tibiofemoral compartment) over 3 years versus placebo. Secondary endpoints included radiological progression, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and knee pain. The trial is registered (ISRCTN41323372).The intention-to-treat population included 1371 patients. Treatment with strontium ranelate
Diagnostic Evaluation of Temporomandibular JointOsteoarthritis using Cone Beam Computed Tomography Compared With Conventional Radiographic Technology UTCAT2435, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Diagnostic Evaluation of Temporomandibular JointOsteoarthritis using Cone Beam Computed Tomography Compared With Conventional Radiographic Technology Clinical Question In Patients with possible osteoarthritis (...) of the temporomandibular joint (TMJ), how effectively will panoramic radiography produce an image diagnostic of osteoarthritis as compared to cone beam computerized tomography (CBCT)? Clinical Bottom Line No significant difference in image accuracy was detected between panoramic radiography and CBCT. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Meng/2007 511 joints from 350 patients Retrospective study Key results Both
Osteoarthritis Hand Index (AUSCAN) and the Dreiser Functional Index (DFI), used for subjective functional evaluation, loss of range of motion (ROM), grip and pinch strength, painful and tender joint counts, and paracetamol intake. A researcher blind to group allocation recorded the measures for both hands at baseline, 3 weeks, and 12 weeks at the hospital setting.At baseline, there were no significant differences between groups in any of the parameters (P>.05). After treatment, the paraffin group exhibited (...) , and the number of painful and tender joints at 12 weeks significantly decreased in the paraffin group (P<.05). Bilateral hand-grip strength and the left lateral and chuck pinch strength of the paraffin group were significantly higher than the control group at 12 weeks (P<.05).Paraffin bath therapy seemed to be effective both in reducing pain and tenderness and maintaining muscle strength in hand osteoarthritis. It may be regarded as a beneficial short-term therapy option, which is effective for a 12-week
WITHDRAWN: Intensity of exercise for the treatment of osteoarthritis. Therapeutic exercise is used as one modality to treat people with osteoarthritis (OA).To evaluate the effectiveness of therapeutic exercise of differing intensities on objective and subjective measures of disease activity in people with OA.We searched MEDLINE, EMBASE, Pedro, Current Contents, Sports Discus and CINAHL up to and including December 2002. The Cochrane Field of Rehabilitation and Related Therapies and the Cochrane (...) Musculoskeletal Review Group were also contacted for a search of their specialized registers. Handsearching was conducted on all retrieved articles for additional studies.Comparative controlled studies, such as randomized controlled trials, controlled clinical trials, cohort studies or case/control studies, of therapeutic exercises compared to control or active interventions in people with OA were eligible. No language restrictions were applied. Abstracts were also accepted.Two independent reviewers
, using the same search criteria. This identified one additional trial, the Celecoxib versus Omeprazole and Diclofenac in patients with Osteoarthritis and Rheumatoid arthritis (CONDOR) trial. The relative risks were adjusted for the higher doses used in the trials, compared with clinical practice, and for the addition of a PPI to celecoxib in the CONDOR trial. These data were synthesised with data from the Celecoxib Long-term Arthritis Safety Study (CLASS), in a fixed-effect meta-analysis. The adverse (...) The cost-effectiveness of celecoxib vs diclofenac in the treatment of osteoarthritis in the UK: an update to the NICE model using data from the CONDOR trial The cost-effectiveness of celecoxib vs diclofenac in the treatment of osteoarthritis in the UK: an update to the NICE model using data from the CONDOR trial The cost-effectiveness of celecoxib vs diclofenac in the treatment of osteoarthritis in the UK: an update to the NICE model using data from the CONDOR trial Brereton N, Winn B, Akehurst
Osteoarthritis of the Knee TREATMENT OF OSTEOARTHRITIS OF THE KNEE EVIDENCE-BASED GUIDELINE 2 ND EDITION Adopted by the American Academy of Orthopaedic Surgeons Board of Directors May 18, 2013 i Disclaimer This clinical practice guideline was developed by an AAOS work group comprised of volunteer physicians and interdisciplinary clinicians as well as staff researchers with expertise in systematic reviews and statistical methods used to evaluate empirical evidence. It is an educational tool (...) 7 Patient Population 8 Scope 8 Etiology 8 Incidence and Prevalence 8 Burden of Disease 9 Emotional and Physical Impact 9 Potential Benefits, Harm, and Contraindications 9 Differences Between the Present and Previous Guidelines 9 Preventing Bias in an AAOS Clinical Practice Guideline 11 Methods 14 Formulating Preliminary Recommendations 14 Full Disclosure Information 14 Study Selection Criteria 14 Best Evidence Synthesis 15 Outcomes Considered 16 iii Literature Searches 16 Appraising Evidence
Media Releases 2015 Media Releases 2014 Media Releases 2013 Media Releases 2012 Media Releases Search Aquatic exercise for knee and hip osteoarthritis Aquatic exercise for knee and hip osteoarthritis Introduction Warm-water therapy is one of the oldest recorded treatments, with effects lasting well beyond the period of immersion. Intervention Physical exercise while immersed in water (typically 32–36°C). Indication People with osteoarthritis (OA) of the knee or hip with the aim of reducing pain (...) relaxation in people with arthritis water buoyancy reduces load on weight bearing joints and reduces risk of falls water resistance can help strengthen muscles. Passive aquatic treatment (spa or hot bath immersion) does not produce the same effects as active aquatic exercise. Grading NHMRC level I evidence. References Bartels EM, Juhl CB, Christensen R, et al. . Cochrane Database Syst Rev 2016;(3): CD005523. doi: 10.1002/14651858.CD005523.pub3. The results of this review are also available on Consumer
with early OA and not overweight or obese. However, the evidence is limited. In terms of safety, no major complications were reported in patients treated with PRP. Final publication URL INAHTA brief and checklist INAHTA brief and checklist Indexing Status Subject indexing assigned by CRD MeSH Humans; Osteoarthritis, Knee; Platelet-Rich Plasma Language Published English Country of organisation Malaysia English summary An English language summary is available. Address for correspondence Health Technology (...) Platelet rich plasma for treatment of osteoarthritis Platelet rich plasma for treatment of osteoarthritis Platelet rich plasma for treatment of osteoarthritis Malaysian Health Technology Assessment (MaHTAS) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Malaysian Health Technology Assessment (MaHTAS). Platelet rich plasma for treatment
Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity.To determine whether a ≥10% reduction in body weight induced by diet, with or without exercise, would improve mechanistic and clinical outcomes more than (...) , or exercise.Mechanistic primary outcomes: knee joint compressive force and plasma IL-6 levels; secondary clinical outcomes: self-reported pain (range, 0-20), function (range, 0-68), mobility, and health-related quality of life (range, 0-100).Three hundred ninety-nine participants (88%) completed the study. Mean weight loss for diet + exercise participants was 10.6 kg (11.4%); for the diet group, 8.9 kg (9.5%); and for the exercise group, 1.8 kg (2.0%). After 18 months, knee compressive forces were lower in diet
to those at 6 months. The frequency of adverse events did not differ significantly between the groups.In the intention-to-treat analysis, we did not find significant differences between the study groups in functional improvement 6 months after randomization; however, 30% of the patients who were assigned to physical therapy alone underwent surgery within 6 months. (Funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases; METEOR ClinicalTrials.gov number, NCT00597012.). (...) Surgery versus physical therapy for a meniscal tear and osteoarthritis. Whether arthroscopic partial meniscectomy for symptomatic patients with a meniscal tear and knee osteoarthritis results in better functional outcomes than nonoperative therapy is uncertain.We conducted a multicenter, randomized, controlled trial involving symptomatic patients 45 years of age or older with a meniscal tear and evidence of mild-to-moderate osteoarthritis on imaging. We randomly assigned 351 patients to surgery
Cost-utility of metal-on-metal hip resurfacing compared to conventional total hip replacement in young active patients with osteoarthritis Cost-utility of metal-on-metal hip resurfacing compared to conventional total hip replacement in young active patients with osteoarthritis Cost-utility of metal-on-metal hip resurfacing compared to conventional total hip replacement in young active patients with osteoarthritis Heintzbergen S, Kulin NA, Ijzerman MJ, Steuten LM, Werle J, Khong H, Marshall DA (...) Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study compared the cost-utility of metal-on-metal hip resurfacing arthroplasty with that of total hip arthroplasty, for active patients under 65 years old, with osteoarthritis
Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. Knee osteoarthritis (OA), a disorder of cartilage and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression.To determine whether vitamin D supplementation reduces symptom and structural progression of knee OA.A 2 (...) -year randomized, placebo-controlled, double-blind, clinical trial involving 146 participants with symptomatic knee OA (mean age, 62.4 years [SD, 8.5]; 57 women [61%], 115 white race [79%]). Patients were enrolled at Tufts Medical Center in Boston between March 2006 and June 2009.Participants were randomized to receive either placebo or oral cholecalciferol, 2000 IU/d, with dose escalation to elevate serum levels to more than 36 ng/mL.Primary outcomes were knee pain severity (Western Ontario