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Latest & greatest articles for osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on osteoarthritis or other clinical topics then use Trip today.
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Meta-analysis: acupuncture for osteoarthritis of the knee Meta-analysis: acupuncture for osteoarthritis of the knee Meta-analysis: acupuncture for osteoarthritis of the knee Manheimer E, Linde K, Lao L, Bouter L M, Berman B M CRD summary This review concluded that acupuncture showed clinical benefits compared to usual care and waiting-list for the treatment of knee osteoarthritis, and clinically irrelevant short-term benefits compared to sham. This was a generally well-conducted piece (...) of research. The authors' cautious conclusions reflected the limitations of the evidence and appeared reliable. Authors' objectives To assess the safety and effects of acupuncture for the treatment of knee osteoarthritis. Searching MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched to January 2007 for publications in any language. Search terms were broadly stated. Study selection Studies eligible for inclusion were: randomised controlled trials (RCTs) with an observation
Splinting for osteoarthritis of the carpometacarpal joint: a review of the evidence Splinting for osteoarthritis of the carpometacarpal joint: a review of the evidence Splinting for osteoarthritis of the carpometacarpal joint: a review of the evidence Egan M Y, Brousseau L CRD summary This review concluded that splinting may help to relieve pain and improve function in patients with carpometacarpal osteoarthritis, but there was no clear evidence of the superiority of one type of splint over (...) International were searched up to June 2006. Studies published in English or French were sought. The search terms used are available on request from the authors. Study selection Study designs of evaluations included in the review All studies that addressed the study question, regardless of design, were eligible for inclusion. Specific interventions included in the review Studies investigating splinting for osteoarthritis of the CMC joint were eligible for inclusion. Studies were excluded if they reported
-07598. Bibliographic details Vlad S C, LaValley M P, McAlindon T E, Felson D T. Glucosamine for pain in osteoarthritis: why do trial results differ? Arthritis and Rheumatism 2007; 56(7): 2267-2277 PubMedID DOI Indexing Status Subject indexing assigned by NLM MeSH Clinical Trials as Topic; Glucosamine /therapeutic use; Humans; Osteoarthritis /physiopathology; Pain /drug therapy; Patient Selection; Reproducibility of Results AccessionNumber 12007002654 Date bibliographic record published 09/08/2008 (...) Glucosamine for pain in osteoarthritis: why do trial results differ? Glucosamine for pain in osteoarthritis: why do trial results differ? Glucosamine for pain in osteoarthritis: why do trial results differ? Vlad S C, LaValley M P, McAlindon T E, Felson D T CRD summary This review concluded that glucosamine hydrochloride is not effective in treating osteoarthritic pain, and that definitive conclusions could not be drawn on the efficacy of glucosamine sulphate because of significant variation
Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
CJ, Ziegler KM, Aronson N.. Treatment of primary and secondary osteoarthritis of the knee. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 157. 2007 Authors' objectives "Systematic review of outcomes of three treatments for osteoarthritis (OA) of the knee: intra-articular viscosupplementation; oral glucosamine, chondroitin or the combination; and arthroscopic lavage or debridement." (Structured abstract) Authors' conclusions Osteoarthritis (...) Treatment of primary and secondary osteoarthritis of the knee Treatment of primary and secondary osteoarthritis of the knee Treatment of primary and secondary osteoarthritis of the knee Samson DJ, Grant MD, Ratko TA, Bonnell CJ, Ziegler KM, Aronson N. Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Samson DJ, Grant MD, Ratko TA, Bonnell
justifi ed to contemplate public funding for viscosupplementation for patients with knee OA in Quebec. However, this treatment could be offered to some people, who would meet strict eligibility criteria similar to those adopted by other third-party payers presented in this report. Project page URL INAHTA brief and checklist Indexing Status Subject indexing assigned by CRD MeSH Osteoarthritis, Knee /therapy Language Published French Country of organisation Canada Province or state Quebec English (...) Viscosupplementation for the treatment of osteoarthritis of the knee Viscosupplementation for the treatment of osteoarthritis of the knee Viscosupplementation for the treatment of osteoarthritis of the knee Dagenais P, Framarin A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Dagenais P, Framarin A. Viscosupplementation for the treatment
Modeling the economic and health consequences of managing chronic osteoarthritis pain with opioids in Germany: comparison of extended-release oxycodone and OROS hydromorphone Modeling the economic and health consequences of managing chronic osteoarthritis pain with opioids in Germany: comparison of extended-release oxycodone and OROS hydromorphone Modeling the economic and health consequences of managing chronic osteoarthritis pain with opioids in Germany: comparison of extended-release (...) delivery System hydromorphone compared with an equally analgesic dose of extended-release oxycodone, administered two or three times a day, in patients with chronic osteoarthritis and severe pain. The hydromorphone was a cost-effective alternative to oxycodone from the perspective of the German health insurance system. The study used validated methodology, with a clear presentation of data sources. The authors’ conclusions are likely to be valid and robust. Type of economic evaluation Cost-utility
Posterior versus lateral surgical approach for total hip arthroplasty in adults with osteoarthritis. Osteoarthritis (OA) of the hip is a progressive condition that has no cure and often requires a total hip arthroplasty (THA). The principal methods for THA are the posterior and direct lateral approaches. The posterior approach is considered to be easy to perform, however, increased rates of dislocation have been reported. The direct lateral approach facilitates cup positioning which may (...) decrease rates of hip dislocation and diminishes the risk of injury to the sciatic nerve. However, there is an increased risk of limp. Dislocation of a hip prosthesis is a clinically important complication after THA, in terms of morbidity implications and costs.To determine the risks of prosthesis dislocation, postoperative Trendelenburg gait and sciatic nerve palsy after a posterior approach, compared to a direct lateral approach, for adult patients undergoing THA for primary OA and to update
Tramadol for osteoarthritis. Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage.We sought to determine the analgesic effectiveness, the effect on physical function, the duration of benefit and the safety of oral tramadol in people with osteoarthritis.We searched the Cochrane Central Register (...) of Controlled Trials (CENTRAL), MEDLINE, EMBASE and LILACS databases up to August 2005.We included randomized controlled trials (RCTs) that evaluated the effect of tramadol or tramadol plus paracetamol on pain levels and/or physical function in people with osteoarthritis. No language restriction was applied.We analyzed separately placebo-controlled and active-controlled studies. We used fixed-effect models for the meta-analyses as the results across studies were similar.We included eleven RCTs with a total
% women, mean age 62 y) and had primary OA in ⩾1 knee (verified radiologically within the previous 6 mo) and at least moderate pain (identified with the Western Ontario and McMaster Universities [WOMAC] LK3.0 OA Index pain subscale). Exclusion criteria included secondary arthritis related to syphilitic neuropathy; ochronosis; metabolic bone disease or acute trauma; sensitivity to intervention ingredients; and active renal, hepatic, or peptic ulcer disease. Intervention: patients were allocated to TD (...) Therapeutics Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee Free Ann Cranney , MD, MSc , Siobhan O’Donnell , PT, MSc Statistics from Altmetric.com Bookman AA, Williams KS, Shainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004 ; 171 : 333 –8. Q In patients with primary osteoarthritis (OA) of the knee, is a topical diclofenac (TD
to –10.03). View this table: Intra-articular corticosteroid injections (ICI) v placebo for osteoarthritis of the knee* CONCLUSION In patients with osteoarthritis of the knee, intra-articular corticosteroid injections are more effective than placebo for improving symptoms in the short and long term. Commentary The biological mechanism of corticosteroids suggests that they should be effective in jointdisease with significant inflammation—a fact established in the treatment of rheumatoid arthritis (...) : intra-articular corticosteroid injections are better than placebo for improving symptoms of knee osteoarthritis Free Stanford Shoor , MD Statistics from Altmetric.com Arroll B, Goodyear-Smith F. Corticosteroid injections for osteoarthritis of the knee: meta-analysis. BMJ 2004 ; 328 : 869 . Q In patients with osteoarthritis (OA) of the knee, are intra-articular corticosteroid injections more effective than placebo for improving symptoms? Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM
of the knee preferred to avoid total knee replacement surgery Free Faith J Forster , RN, MSN, APRN, BC Statistics from Altmetric.com Figaro MK, Russo PW, Allegrante JP. Preferences for arthritis care among urban African Americans: “I don’t want to be cut.” Health Psychol 2004 ; 23 : 324 –9. Q What are the preferences and expectations of older urban African-Americans regarding total knee replacement (TKR) for osteoarthritis (OA) of the knee? DESIGN Qualitative study based on the theory of reasoned action (...) and open ended questions. Responses to open ended questions were recorded and transcribed verbatim. Major themes were developed through a process of categorisation. MAIN FINDINGS Preference for natural remedies . 36% of patients thought that OA was caused by cold or dampness, either to the joint or from the environment. They tended to think that OA was a natural, irremediable, inevitable deterioration and a sign of ageing. A strong trend toward an external locus of control of their illness
, ARNP Statistics from Altmetric.com Zhang W, Jones A, Doherty M. Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials. Ann Rheum Dis 2004 ; 63 : 901 –7. Q Is paracetamol efficacious for treatment of osteoarthritis (OA)? METHODS Data sources: Medline, CINAHL, EMBASE/Excerpta Medica, Scientific Citation Index, and Cochrane Library (up to July 2003); reference lists; and conference abstracts from international societies of rheumatology (...) WOMAC scores than those who received paracetamol (table ). NSAIDs were associated with greater gastrointestinal discomfort, but groups did not differ for nausea, headache, or dizziness. View this table: Paracetamol v placebo or non-steroidal anti-inflammatory drugs (NSAIDs) for osteoarthritis (OA)* CONCLUSIONS Paracetamol reduces osteoarthritis pain more than placebo but does not affect functioning or stiffness. Non-steroidal anti-inflammatory drugs are more effective than paracetamol for pain
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis.We randomly assigned 1583 patients with symptomatic knee osteoarthritis to receive 1500 mg of glucosamine daily, 1200 mg (...) that in the placebo control group (P=0.008). For patients with moderate-to-severe pain at baseline, the rate of response was significantly higher with combined therapy than with placebo (79.2 percent vs. 54.3 percent, P=0.002). Adverse events were mild, infrequent, and evenly distributed among the groups.Glucosamine and chondroitin sulfate alone or in combination did not reduce pain effectively in the overall group of patients with osteoarthritis of the knee. Exploratory analyses suggest that the combination
A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
suggest that the authors' conclusion should be interpreted with caution. Authors' objectives To determine the long-term efficacy (at least 4 weeks) of topical non-steroidal anti-inflammatory drugs (NSAIDs) for pain control in primary knee osteoarthritis (OA). Searching MEDLINE, PubMed, EMBASE and the Cochrane CENTRAL Register were searched from inception to the end of December 2004; the search terms were reported. Relevant journals and related conference abstracts (2003 to 2004), including the British (...) consisted of topical diclofenac or diclofenac or eltenac gel. The comparator in all but one trial was placebo; one trial used a vehicle control (dimethyl sulphoxide). The duration of treatment varied between studies and lasted between 4 and 12 weeks. Studies of patients with primary knee OA, confirmed by radiology, were eligible for inclusion. Studies of mixed patient populations, of patients with nonarthritic joint pain, or of patients with OA of joints other than the knee, were excluded. Most
for 18 months. The duration of the self-management component ranged from a single session to 15 months. Interventions were delivered in community, clinic or hospital settings. Studies of patients with knee or hip osteoarthritis were eligible for inclusion. Studies in which joint pathology resulted from inflammatory or systemic disorders were excluded. The majority of studies included patients with knee pain only. The mean age of the participants ranged from 65 to 75 years. Studies measuring pain (...) Integrated exercise and self-management programmes in osteoarthritis of the hip and knee: a systematic review of effectiveness Integrated exercise and self-management programmes in osteoarthritis of the hip and knee: a systematic review of effectiveness Integrated exercise and self-management programmes in osteoarthritis of the hip and knee: a systematic review of effectiveness Walsh N E, Mitchell H L, Reeves B C, Hurley M V CRD summary The authors concluded that combined exercise and self